Is Isorhamnetin safe in cosmetics?
Isorhamnetin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Isorhamnetin
Also known as: 4H-1-Benzopyran-4-one, 2-(3-methoxy-4-hydroxyphenyl)-3,5,7-trihydroxy-, BRN 0044723, EINECS 207-545-5, Flavone, 3'-methoxy-3,4',5,7-tetrahydroxy-, 3'-Methoxy-3,4',5,7-tetrahydroxyflavone (+8 more)
INCI: ISORHAMNETIN
Isorhamnetin (CAS 480-19-3) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Isorhamnetin is classified GHS CMR hazard (H351) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Antioxidant, skin conditioning.
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
InChIKey
IZQSVPBOUDKVDZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - no specific prohibition or restriction.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isorhamnetin.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Editorial summary
Preliminary editorial summary for Isorhamnetin — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
endocrine_disruptor
Known Synonyms
4H-1-Benzopyran-4-one, 2-(3-methoxy-4-hydroxyphenyl)-3,5,7-trihydroxy-
BRN 0044723
EINECS 207-545-5
Flavone, 3'-methoxy-3,4',5,7-tetrahydroxy-
3'-Methoxy-3,4',5,7-tetrahydroxyflavone
3,5,7,4'-Tetrahydroxy-3'-methoxyflavone
UNII-07X3IB4R4Z
3,4',5,7-Tetrahydroxy-3'-methoxy-Flavone
3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-benzopyran-4-one
3-Methylquercetine
4'-Methoxyquercetin
4'-Methylquercetin
4'-O-Methylquercetin
Chemical Function
Humectant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ISORHAMNETIN
ChEMBL ID
CHEMBL379064
Frequently Asked Questions
Is Isorhamnetin allowed in the EU?
Isorhamnetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isorhamnetin do in cosmetics?
Isorhamnetin functions as: Antioxidant, skin conditioning.. It is classified as a cosmetic ingredient in our database. CAS number: 480-19-3.
Is Isorhamnetin used outside cosmetics?
Isorhamnetin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isorhamnetin have different safety status in cosmetics vs industrial chemicals?
Isorhamnetin is classified GHS CMR hazard (H351) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isorhamnetin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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