NOAEL Studies Active Ingredient

Kojic Acid NOAEL Studies

INCI: KOJIC ACID

CAS: 501-30-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =0.5 % rat oral - oral toxicity 2; 0; 5, p.18
CIR Safety Assessment NOAEL =1 % guinea pig - - NOAEL study 4; 1, p.26
CIR Safety Assessment NOAEL =100 mg/kg rat oral Subchronic repeated dose toxicity 300; 100; 56, p.7
CIR Safety Assessment NOAEL =125 mg/kg rat dermal Chronic NOAEL study 500; 2; 125, p.8
CIR Safety Assessment NOAEL =150 mg/kg mouse oral 3 weeks repeated dose toxicity 3; 900; 18, p.11
COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 5.84999990463 mg/kg bw/day rat oral 28 day Short Term Toxicity SCCP; Tamura T et al. Inhibition of Thyroid Iodine Uptake and Organification in Rats Treatedwith Kojic Acid. Toxicological Sciences47, 170-175
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 2000 IARC Monographs -
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=3166; Record_ID=cancer_1714; Data_Type=WOE; Formulation_Name=Kojic acid; Mixture=Chemical; DTXSID=DTXSID2040236; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/97; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2040236
SCCS Opinion 32 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.003 % rat oral subchronic repeated dose toxicity p.70
SCCS Opinion NOAEL =0.03 % rat oral 8 weeks NOAEL study p.50
SCCS Opinion NOAEL =0.069 mg/kg rat oral 4-week dermal absorption p.69
SCCS Opinion NOAEL =0.079 mg/kg rat oral 28 days repeated dose toxicity p.15
SCCS Opinion NOAEL =0.104 mg/kg rat oral 28-days dermal absorption p.69
SCCS Opinion NOAEL =0.12 mg/kg rat oral 28 days repeated dose toxicity p.15
SCCS Opinion NOAEL =0.173 mg/kg rat oral 28-days dermal absorption p.69
SCCS Opinion NOAEL =0.199 mg/kg rat oral 28 days repeated dose toxicity p.15
SCCS Opinion NOAEL =0.5 % rat oral 28 days NOAEL study p.70
SCCS Opinion NOAEL =2 mg/kg bw/d rat oral 28 days repeated dose toxicity p.15
SCCS Opinion NOAEL =2 % rat oral 4 weeks NOAEL study p.68
SCCS Opinion NOAEL =2 - - - - NOAEL study p.40
SCCS Opinion NOAEL =2.38 µg/cm human dermal - genotoxicity (Ref. 11), p.14
SCCS Opinion NOAEL =5.85 mg/kg bw/day rat oral 4 weeks NOAEL study p.21
SCCS Opinion NOAEL =6 mg/kg bw/day rat oral 28 days NOAEL study p.22
SCCS Opinion NOAEL =6 mg/kg/day rat oral 28-day repeated dose toxicity (Ref. 11), p.14
SCCS Opinion NOAEL =8.39 µg/cm rat oral 28 days repeated dose toxicity p.15
SCCS Opinion NOAEL =15 mg/kg bw/day rat - 4 weeks NOAEL study p.71
SCCS Opinion NOAEL =15.5 mg/kg bw rat oral 2 weeks NOAEL study p.57
SCCS Opinion NOAEL =15.5 mg/kg bw/day rat - subchronic repeated dose toxicity p.70
SCCS Opinion NOAEL =23.8 mg/kg bw/day rat oral 4 weeks NOAEL study p.21
SCCS Opinion NOAEL =30 mg/kg bw/day mouse - - reproductive toxicity p.61
SCCS Opinion NOAEL =40 - - - - NOAEL study p.40
SCCS Opinion NOAEL =62.5 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity Ref.: 32 Comment A NOAEL of 62, p.22
SCCS Opinion NOAEL =68 - - - - NOAEL study p.68
SCCS Opinion NOAEL =100 mg/kg/day rat oral 28 days NOAEL study p.20
SCCS Opinion NOAEL =100 mg/kg bw/day rat - - NOAEL study p.62
SCCS Opinion NOAEL =125 mg/kg bw/day rat dermal 28 day NOAEL study p.6
SCCS Opinion NOAEL =150 mg/kg bw/day rat - 21 days reproductive toxicity p.59
SCCS Opinion NOAEL =227 mg/kg bw/day rat oral 55-week dermal absorption (Ref. 5), p.11
SCCS Opinion NOAEL =1637 - human - - NOAEL study p.40
SCCS Opinion NOAEL =2600 mg/kg bw rat oral 28-day repeated dose toxicity p.41
Regulatory source 70 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 1 % guinea pig - - - p.26
Regulatory source - 125 mg/kg rat dermal Chronic - p.8
Regulatory source oral toxicity 0.5 % rat oral - oral toxicity p.18
Regulatory source repeated dose toxicity 100 mg/kg rat oral Subchronic repeated dose toxicity p.7
Regulatory source repeated dose toxicity 150 mg/kg mouse oral 3 weeks repeated dose toxicity p.11
Regulatory source - 0.03 % rat oral 8 weeks - p.50
Regulatory source - 0.03 % rat - 20 weeks - p.77
Regulatory source - 0.5 % rat oral 28 days - p.70
Regulatory source - 2 % rat oral 4 weeks - p.68
Regulatory source - 2 - - - - - p.40
Regulatory source - 5.85 mg/kg bw/day rat oral 4 weeks - p.21
Regulatory source - 6 mg/kg bw/day rat oral 28 days - p.22
Regulatory source - 6 mg/kg bw rat oral 28 day - p.73
Regulatory source - 6 mg/kg bw/day rat oral 28 day - p.9
Regulatory source - 6 mg/kg bw/day rat oral - - p.26
Regulatory source - 6 mg/kg bw/day - - - - p.69
Regulatory source - 6 mg/kg bw/day rat oral 4 weeks - p.69
Regulatory source - 15 mg/kg bw/day rat - 4 weeks - p.71
Regulatory source - 15.5 mg/kg bw rat oral 2 weeks - p.57
Regulatory source - 23.8 mg/kg bw/day rat oral 4 weeks - p.21
Regulatory source - 40 - - - - - p.40
Regulatory source - 62.5 mg/kg bw/day rat - - - p.70
Regulatory source - 62.5 mg/kg bw/day rat oral 28 days - p.70
Regulatory source - 68 - - - - - p.68
Regulatory source - 100 mg/kg/day rat oral 28 days - p.20
Regulatory source - 100 mg/kg bw/day rat - - - p.62
Regulatory source - 100 mg/kg bw rat oral - - p.73
Regulatory source - 100 mg/kg bw rat - - - p.16
Regulatory source - 100 mg/kg/day rat oral 28-day - p.25
Regulatory source - 125 mg/kg bw/day rat dermal 28 day - p.6
Regulatory source - 150 mg/kg bw/day mouse - 13-week - p.60
Regulatory source - 150 mg/kg bw/day mouse oral - - p.29
Regulatory source - 227 mg/kg bw/day rat oral 26 weeks - p.28
Regulatory source - 1637 - human - - - p.40
Regulatory source dermal absorption =0.069 mg/kg rat oral 4-week dermal absorption p.69
Regulatory source dermal absorption =0.104 mg/kg rat oral 28-days dermal absorption p.69
Regulatory source dermal absorption =0.173 mg/kg rat oral 28-days dermal absorption p.69
Regulatory source dermal absorption 6 mg/kg bw/day rat oral 4-week dermal absorption p.69
Regulatory source dermal absorption =6 mg/kg rat oral 4-week dermal absorption p.69
Regulatory source dermal absorption =6 mg/kg rat oral 28-days dermal absorption p.69
Regulatory source dermal absorption 6 mg/kg bw/day rat dermal 28-day dermal absorption p.10
Regulatory source dermal absorption 6 mg/kg bw/day rat oral 28-day dermal absorption p.13
Regulatory source dermal absorption 227 mg/kg bw/day rat oral 55-week dermal absorption p.11
Regulatory source developmental toxicity 6 mg/kg bw/day rat - developmental developmental toxicity p.38
Regulatory source genotoxicity 2.38 µg/cm human dermal - genotoxicity p.14
Regulatory source genotoxicity 100 mg/kg/day rat - 4-week genotoxicity p.7
Regulatory source irritation 100 mg/kg bw/day rat dermal 19 weeks irritation p.70
Regulatory source repeated dose toxicity 0.003 % rat oral subchronic repeated dose toxicity p.70
Regulatory source repeated dose toxicity =0.079 mg/kg rat oral 28 days repeated dose toxicity p.15
Regulatory source repeated dose toxicity =0.12 mg/kg rat oral 28 days repeated dose toxicity p.15
Regulatory source repeated dose toxicity =0.199 mg/kg rat oral 28 days repeated dose toxicity p.15
Regulatory source repeated dose toxicity =2 mg/kg bw/d rat oral 28 days repeated dose toxicity p.15
Regulatory source repeated dose toxicity =2 mg/kg bw/d rat oral subchronic repeated dose toxicity p.15
Regulatory source repeated dose toxicity =2 mg/kg bw/d rat oral 6-month repeated dose toxicity p.15
Regulatory source repeated dose toxicity 2 mg/kg bw/day rat oral 28-day repeated dose toxicity p.39
Regulatory source repeated dose toxicity 6 mg/kg/day rat oral 28-day repeated dose toxicity p.14
Regulatory source repeated dose toxicity =6 mg/kg bw/d rat oral 28 days repeated dose toxicity p.15
Regulatory source repeated dose toxicity 6 mg/kg bw/day rat oral subchronic repeated dose toxicity p.29
Regulatory source repeated dose toxicity 6 mg/kg bw/day rat oral 28-day repeated dose toxicity p.39
Regulatory source repeated dose toxicity =8.39 µg/cm rat oral 28 days repeated dose toxicity p.15
Regulatory source repeated dose toxicity 15.5 mg/kg bw/day rat - subchronic repeated dose toxicity p.70
Regulatory source repeated dose toxicity 23.8 mg/kg bw/day rat oral subchronic repeated dose toxicity p.6
Regulatory source repeated dose toxicity 62.5 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.22
Regulatory source repeated dose toxicity 2600 mg/kg bw rat oral 28-day repeated dose toxicity p.41
Regulatory source reproductive toxicity 30 mg/kg bw/day mouse - - reproductive toxicity p.61
Regulatory source reproductive toxicity 30 mg/kg bw/day rat - 21 days reproductive toxicity p.31
Regulatory source reproductive toxicity 100 mg/kg bw/day rat - 1 to day reproductive toxicity p.72
Regulatory source reproductive toxicity 100 mg/kg bw/day rat - - reproductive toxicity p.32
Regulatory source reproductive toxicity 100 mg/kg bw/day rat oral 28-day reproductive toxicity p.41
Regulatory source reproductive toxicity 150 mg/kg bw/day rat - 21 days reproductive toxicity p.59
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6K23F1TT52 UNII - - - chemical -