Excellent Active Ingredient

Lactobacillus Ferment

INCI: LACTOBACILLUS FERMENT

CAS Number
1686112-36-6
Function
Postbiotic Skin Conditioning, Microbiome Support, S. epidermidis Proliferation Stimulator, Skin pH Normalizer, Anti-inflammatory, Barrier Strengthening, Competitive Pathogen Exclusion
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR June 2025 Final Safety Assessment: safe as used in cosmetics at current concentrations.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Clinically validated postbiotic with documented S. epidermidis proliferation increase of approximately 34%. Acidic fermentation byproducts (lactic acid, short-chain fatty acids) actively maintain the skin acid mantle at optimal pH 4.5–5.5 range, creating systemic unfavorable conditions for opportunistic pathogens. 2023 split-face study shows 41% IL-1α/TNF-α reduction when combined with Bifida Ferment Lysate. Inter-batch variability is the primary quality challenge; standardized fermentation parameters and batch-specific bioactive profiling are critical for reproducible clinical outcomes.

⚠️
Concern Level: None

Regulatory Flags

postbiotic no-live-organisms s-epidermidis-proliferation skin-ph-normalization il1a-tnfa-reduction synergistic-with-bifida-ferment-lysate inter-batch-variability-critical microbiome-friendly

Frequently Asked Questions

Is Lactobacillus Ferment safe in cosmetics?

Clinically validated postbiotic with documented S. epidermidis proliferation increase of approximately 34%. Acidic fermentation byproducts (lactic acid, short-chain fatty acids) actively maintain the skin acid mantle at optimal pH 4.5–5.5 range, creating systemic unfavorable conditions for opportunistic pathogens. 2023 split-face study shows 41% IL-1α/TNF-α reduction when combined with Bifida Ferment Lysate. Inter-batch variability is the primary quality challenge; standardized fermentation parameters and batch-specific bioactive profiling are critical for reproducible clinical outcomes. The EU classifies Lactobacillus Ferment as "permitted". Safety rating: EXCELLENT.

Is Lactobacillus Ferment allowed in the EU?

Lactobacillus Ferment EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lactobacillus Ferment do in cosmetics?

Lactobacillus Ferment functions as: Postbiotic Skin Conditioning, Microbiome Support, S. epidermidis Proliferation Stimulator, Skin pH Normalizer, Anti-inflammatory, Barrier Strengthening, Competitive Pathogen Exclusion. It is classified as a Active Ingredient in our database. CAS number: 1686112-36-6.

What is the Margin of Safety for Lactobacillus Ferment?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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