NOAEL Studies Cosmetic Ingredient

Lawsonia Inermis Extract NOAEL Studies

INCI: LAWSONIA INERMIS EXTRACT

CAS: 84988-66-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCNFP Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =20 % rabbit dermal - dermal absorption p.14
SCCNFP Opinion NOAEL =40 mg/kg bw - - - irritation Ref. : 3 2, p.5
SCCNFP Opinion NOAEL =40 mg/kg/day rat oral sub-chronic repeated dose toxicity p.14
SCCNFP Opinion NOAEL =200 mg/kg/day rat - - dermal absorption Ref. : 12 2, p.9
SCCS Opinion 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.00833 mg/kg bw/d - dermal - dermal absorption p.37
SCCS Opinion NOAEL =2 mg/kg bw/d - dermal - dermal absorption p.4
SCCS Opinion NOAEL =7 mg/kg bw rat oral 90-day genotoxicity Ref.: 3 (subm, p.22
SCCS Opinion NOAEL =40 mg/kg bw - - Chronic genotoxicity Ref.: 3 (subm, p.13
SCCS Opinion NOAEL =40 mg/kg bw/day rat oral 90-day genotoxicity Ref.: 3 (subm, p.22
SCCS Opinion NOAEL =200 mg/kg/day rat - - NOAEL study Ref.: 12 (subm, p.21
SCCS Opinion NOAEL =200 mg/kg bw/day rat oral 13 week irritation p.38
SCCS Opinion NOAEL >2000 mg/kg bw rat oral 13 week irritation p.22
Regulatory source 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption 20 % rabbit dermal - dermal absorption p.14
Regulatory source dermal absorption 200 mg/kg/day rat - - dermal absorption p.9
Regulatory source irritation 40 mg/kg bw - - - irritation p.5
Regulatory source repeated dose toxicity 40 mg/kg/day rat oral sub-chronic repeated dose toxicity p.14
Regulatory source - 200 mg/kg/day rat - - - p.21
Regulatory source dermal absorption =0.00833 mg/kg bw/d - dermal - dermal absorption p.37
Regulatory source dermal absorption 2 mg/kg bw/d - dermal - dermal absorption p.4
Regulatory source genotoxicity 2 mg/kg bw/d rat oral 90-day genotoxicity p.22
Regulatory source genotoxicity 7 mg/kg bw rat oral 90-day genotoxicity p.22
Regulatory source genotoxicity 40 mg/kg bw - - Chronic genotoxicity p.13
Regulatory source genotoxicity 40 mg/kg bw/day rat oral 90-day genotoxicity p.22
Regulatory source irritation 200 mg/kg/day rat oral 13 week irritation p.22
Regulatory source irritation 200 mg/kg bw/day rat oral 13 week irritation p.38
Regulatory source irritation >2000 mg/kg bw rat oral 13 week irritation p.22