Litsea Cubeba Fruit Extract
INCI: LITSEA CUBEBA FRUIT EXTRACT
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Litsea Cubeba Fruit Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 745 mg/kg bw/day | oral | mouse | oral | REACH |
| LOAEL | 345 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 60 mg/kg bw/day | oral | mouse | oral | REACH |
| LOAEL | 210 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 210 mg/kg bw/day | oral | - | oral | REACH |
| LOAEL | 60 mg/kg bw/day | oral | - | oral | REACH |
| LOAEL | 345 mg/kg bw/day | oral | - | oral | REACH |
| LOAEL | 745 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
May contain citral, limonene, and linalool as residual components; allergen declaration requirements apply. Lower concentration of sensitizers compared to the essential oil form. Solvent-extracted from Litsea cubeba fruits; retains antimicrobial and antioxidant properties of the plant; milder than the essential oil with broader formulation compatibility
Regulatory Flags
Frequently Asked Questions
Is Litsea Cubeba Fruit Extract safe in cosmetics?
May contain citral, limonene, and linalool as residual components; allergen declaration requirements apply. Lower concentration of sensitizers compared to the essential oil form. Solvent-extracted from Litsea cubeba fruits; retains antimicrobial and antioxidant properties of the plant; milder than the essential oil with broader formulation compatibility The EU classifies Litsea Cubeba Fruit Extract as "permitted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.
Is Litsea Cubeba Fruit Extract allowed in the EU?
Litsea Cubeba Fruit Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Litsea Cubeba Fruit Extract do in cosmetics?
Litsea Cubeba Fruit Extract functions as: Skin conditioning, perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 90063-59-5.
What is the Margin of Safety for Litsea Cubeba Fruit Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Litsea Cubeba Fruit Extract?
The NOAEL (No Observed Adverse Effect Level) for Litsea Cubeba Fruit Extract is 745 mg/kg bw/day based on a oral study via oral route in mouse. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
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