NOAEL Studies Cosmetic Ingredient

m-Phenylenediamine NOAEL Studies

INCI: M-PHENYLENEDIAMINE

CAS: 108-45-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =5 mg/kg rat - - developmental toxicity 5; 7; (99, p.25
CIR Safety Assessment NOAEL =6 mg/kg rat dermal Subchronic repeated dose toxicity 2; 0; 6, p.18
CIR Safety Assessment NOAEL =134 mg/kg/day rat oral 2-week repeated dose toxicity 250; 500; (3, p.48
Regulatory source 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source NOEL =6 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=bfcae381f66e6e79; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOEL : 6.0 mg/kg-day; system=Hepatic; basis=Increased relative and absolute liver weights and degenerative liver lesions; point_of_departure=NOEL : 6.0 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID4021137; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=87; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0087_summary.pdf
Regulatory source RfD =0.006 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=991c4dbb3102b104; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=6e-3; system=Hepatic; basis=Increased relative and absolute liver weights and degenerative liver lesions; point_of_departure=NOEL : 6.0 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID4021137; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=87; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0087_summary.pdf
Regulatory source developmental toxicity 5 mg/kg rat - - developmental toxicity p.25
Regulatory source repeated dose toxicity 6 mg/kg rat dermal Subchronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 134 mg/kg/day rat oral 2-week repeated dose toxicity p.48
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs -
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =280 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_736; row=6983; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Benzenediamine; preferred_name=1,3-Benzenediamine; dtxsid=DTXSID4021137; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4021137; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =650 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_737; row=6984; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Benzenediamine; preferred_name=1,3-Benzenediamine; dtxsid=DTXSID4021137; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4021137; source_file=acute_oral.xlsx
NTP ICE adme parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 0 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=1584; Record_ID=adme_parameters_806; Data_Type=Measured; DTXSID=DTXSID4021137; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021137
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=4565; Record_ID=cancer_4704; Data_Type=WOE; Formulation_Name=1,3-Benzenediamine; Mixture=Chemical; DTXSID=DTXSID4021137; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/34; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021137
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=628; RecordID=ARPathway2016_511; DatasetName=ARPathway2016; DTXSID=DTXSID4021137; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021137
NTP ICE eye irritation 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation GHS Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=1187; Record_ID=eye_irritation_218; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4021137; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021137
NTP ICE eye irritation Intensity 0.35 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1189; Record_ID=eye_irritation_1324; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4021137; Assay=Vitrigel; Endpoint=Intensity; Response=0.35; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021137
NTP ICE eye irritation Lag time 10 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1188; Record_ID=eye_irritation_1324; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4021137; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021137
NTP ICE eye irritation Plateau level 62 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1190; Record_ID=eye_irritation_1324; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4021137; Assay=Vitrigel; Endpoint=Plateau level; Response=62; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021137
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 0.49 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13546; Record_ID=skin_sensitization_invivo_3754; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4021137; Assay=LLNA; Endpoint=EC3; Response=0.49; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021137; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021137
ECHA 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =25 mg/kg bw/day Cat oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/2?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15812401:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8827c155942f37a3b5f84ed3a3ab8ba2
ECHA LEL >100 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e4d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/6/2?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15831863:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c0f4ea26b8be33751e092107096ceca
ECHA LEL >=200 mg/kg bw/day Cat injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d0de4b096bca87747e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/5?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15816031_15816032:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_324bdf3407dcb906b15e364eaa522af2
ECHA LEL =370 mg/kg bw/day Rabbit injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c45e4b096bca877148b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/5?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815317_15816037_15816038:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b96791b88ae985d47d54ec4e1379597
ECHA LEL =400 mg/kg bw/day Mouse injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61bf1e4b096bca8770079; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/5?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15815110:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fd5b5db047af25bd69c06185419a72c9
ECHA LEL <=435 mg/kg bw/day Cat injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d0de4b096bca87747e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/5?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15816031_15816032:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_262e5d09b7648a2856a703f2d3d70979
ECHA LEL <=440 mg/kg bw/day Rabbit injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d2ae4b096bca8774e00; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/5?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815317_15816037_15816038:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_62f305c170e65247ffc001d294c6332a
ECHA LEL =450 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/2?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15799724_15801029_15805452:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e1bbf396d54ad6ec198950810467ca7a
ECHA LEL =460 mg/kg bw/day Rat injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c89e4b096bca8772637; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/5?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15815510:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_996b0d81ab1b44b0291a3b627bee8ef5
ECHA LEL =720 mg/m3 Rat inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/3?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15799165_15799166:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6539c6ee33c5de22efe17e843f50d1f6
ECHA LEL =1000 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61bb0e4b096bca876f187; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/3/2?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15799724_15801029_15805452:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7596e54c928d1dfe36be148df33911d3
ECHA NOAEL =6 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e4f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/6/2?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15846192:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b48c7ed7ee2ea074c7ad4fbf3889f0de
ECHA NOAEL =20 mg/kg bw/day Rat oral - repeat dose other GUIDELINE=EPA OTS 798.6050 (Neurotoxicity Screening Battery); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d2180e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/10/1?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825726_15825727_15825796:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3d104ac276b1cb3907a4f8772eaf037
ECHA NOAEL =30 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb707; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/9/3?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15821078:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_253f32af249f3404a1a60f3b611461bd
ECHA NOAEL =38.2 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cee4b0a7c65d1b2ce8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/8?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15819543:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a44b7db88ee525151117f319b2a1a17d
ECHA NOAEL =41.8 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cee4b0a7c65d1b2ce8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/8?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15819544:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_656189ddde8f3b034ab36ff1ec9608a8
ECHA NOAEL >=300 mg/kg bw/day Rat oral - repeat dose other QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ec5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/10/1?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825726_15825727_15825796:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_78199babda421d27ade45cc18a10699d
ECHA NOEL =5 mg/kg bw/day Rat oral - repeat dose other GUIDELINE=EPA OTS 798.6050 (Neurotoxicity Screening Battery); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d2180e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24112/7/10/1?documentUUID=2c44e6c1-a585-4f9e-8cec-c2b81d39768b; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food efficiency; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|other; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825726_15825727_15825796:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fc5a9178233e18e718162b08cfb6d5d8
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.24 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634098:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_978e764e922bebdc2f1f25dd566abf3a
ToxValDB IRIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB IRIS LOAEL =18 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=Hofer, H., R. Hruby, E Hruby, et al. 1982. Ninety-day toxicity study with m- phenylenediamine on rats. Oestrr. Forschungszent. Seibersdorf (Ber.) OEFZS Ber. No. 4155. p. 1-46.; TITLE=p; AUTHOR=Hofer, H., R. Hruby, E Hruby, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d5e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=87; TOXICOLOGICAL_EFFECT=increased relative and absolute liver weight and degenerative liver lesions; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15645393_15645394:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_57e1dffbe556b4a3fe38ac40762b8842
ToxValDB IRIS RfD =0.006 mg/kg bw/day Human oral - Toxicity Value LONG_REF=Hofer, H., R. Hruby, E Hruby, et al. 1982. Ninety-day toxicity study with m- phenylenediamine on rats. Oestrr. Forschungszent. Seibersdorf (Ber.) OEFZS Ber. No. 4155. p. 1-46.; TITLE=p; AUTHOR=Hofer, H., R. Hruby, E Hruby, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d5e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=87; TOXICOLOGICAL_EFFECT=Increased relative and absolute liver weights and degenerative liver lesions in male/female rats; STUDY_GROUP=IRIS:15645141:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4c40d7c3351d53557765d5616655c21f
ToxValDB RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfD =0.06 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663670:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_365ac5accfd4553e3ca2ca1ff8456aa1
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier OE624J2447 UNII - - - chemical -