Moderate Cosmetic Ingredient NOAEL Data

m-tert-Butylphenyl Isobutyraldehyde

INCI: M-TERT-BUTYLPHENYL ISOBUTYRALDEHYDE

CAS Number
62518-65-4
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted. Not specifically restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for m-tert-Butylphenyl Isobutyraldehyde. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 50 mg/kg bw/day oral rat oral REACH

Expert Verdict

Structural analog of EU-banned Lilial; safety data relies on read-across from Lilial with reproductive toxicity data gap; monitor for future EU regulatory action targeting this isomer.

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Concern Level: High

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is m-tert-Butylphenyl Isobutyraldehyde safe in cosmetics?

Structural analog of EU-banned Lilial; safety data relies on read-across from Lilial with reproductive toxicity data gap; monitor for future EU regulatory action targeting this isomer. The EU classifies m-tert-Butylphenyl Isobutyraldehyde as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is m-tert-Butylphenyl Isobutyraldehyde allowed in the EU?

m-tert-Butylphenyl Isobutyraldehyde EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does m-tert-Butylphenyl Isobutyraldehyde do in cosmetics?

m-tert-Butylphenyl Isobutyraldehyde functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 62518-65-4.

What is the Margin of Safety for m-tert-Butylphenyl Isobutyraldehyde?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for m-tert-Butylphenyl Isobutyraldehyde?

The NOAEL (No Observed Adverse Effect Level) for m-tert-Butylphenyl Isobutyraldehyde is 50 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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