Regulatory Status
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Safety Data
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Expert Verdict
A dibenzylbutane lignan derived from Myristica fragrans (nutmeg). Studies demonstrate anti-inflammatory and UV-protective properties, including suppression of MMP-1 expression via MAPK pathway inhibition. No significant adverse effects reported at typical cosmetic use levels, but limited long-term human safety data exists.. Potent antimicrobial activity against Streptococcus mutans (MIC = 3.9 µg/mL); inhibits UV-induced matrix metalloproteinase expression; anti-inflammatory via MAPK and PI3K/...
Frequently Asked Questions
Is Macelignan safe in cosmetics?
A dibenzylbutane lignan derived from Myristica fragrans (nutmeg). Studies demonstrate anti-inflammatory and UV-protective properties, including suppression of MMP-1 expression via MAPK pathway inhibition. No significant adverse effects reported at typical cosmetic use levels, but limited long-term human safety data exists.. Potent antimicrobial activity against Streptococcus mutans (MIC = 3.9 µg/mL); inhibits UV-induced matrix metalloproteinase expression; anti-inflammatory via MAPK and PI3K/... The EU classifies Macelignan as "prohibited". Safety rating: MODERATE.
Is Macelignan allowed in the EU?
Macelignan EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Macelignan do in cosmetics?
Macelignan functions as: Antimicrobial, antioxidant, deodorant, oral care. It is classified as a cosmetic ingredient in our database. CAS number: 107534-93-0.
What is the Margin of Safety for Macelignan?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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