NOAEL Studies Cosmetic Ingredient

Maleic Acid NOAEL Studies

INCI: MALEIC ACID

CAS: 110-16-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >0.72 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4390; Record_ID=acute_inhalation_3037; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021517; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.72; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021517; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021517
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=11140; RecordID=ARPathway2016_537; DatasetName=ARPathway2016; DTXSID=DTXSID8021517; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021517; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021517
NTP ICE skin irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation Breakthrough Time 9.56 min - Dermal - In Vitro; Corrositex sheet=Data_invitro; excel_row=5118; Record_ID=skin_irritation_invitro_115; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021517; Assay=Corrositex; Endpoint=Breakthrough Time; Response=9.56; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021517; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021517
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13457; Record_ID=skin_sensitization_invivo_3610; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8021517; Assay=LLNA; Endpoint=EC3; Response=7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=EFfCI personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021517; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021517
ECHA 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =20 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d22035f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/6/2?documentUUID=198f9af6-680d-44de-a110-579a594a722d; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15850381:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_13707b9497faca6106b697a623e23457
ECHA LOEL =20 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5667; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/9/2?documentUUID=198f9af6-680d-44de-a110-579a594a722d; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15855123:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71906de4b2a072f6d7f85b05e20cef5d
ECHA NOAEL ~19.5 mg/kg bw/day Rat oral chronic; 2 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1189; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/6/2?documentUUID=198f9af6-680d-44de-a110-579a594a722d; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15850382:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_de16d9ef63f599321873886fb530964b
ECHA NOAEL <=20 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb76d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/9/3?documentUUID=ac9eb4e4-e118-48fd-b1e3-a9d8c9a7d7b7; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: changes in litter size and weights|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15823985:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d851001f830e7147b503f9b1b670dd11
ECHA NOAEL =140 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb76d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/9/3?documentUUID=ac9eb4e4-e118-48fd-b1e3-a9d8c9a7d7b7; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: necropsy findings|maternal: organ weights and organ / body weight ratios|maternal: pre and post implantation loss|maternal: total litter losses by resorption|maternal: changes in number of pregnant|maternal: changes in pregnancy duration|maternal: clinical signs|maternal: dead fetuses|maternal: early or late resorptions|maternal: food consumption and compound intake|maternal: gross pathology|maternal: maternal abnormalities|maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|development|food and/or water consumption|gross pathology|mortality/survival|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15823986:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_10ed2107f2d75dc4fe94a5965ec5dc12
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633145_15633146:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc803598fb3917bd5346be023eba7ffa
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 91XW058U2C UNII - - - chemical -