Menthane Carboxamide Ethylpyridine

INCI: MENTHANE CARBOXAMIDE ETHYLPYRIDINE

CAS Number
Not widely published in open databases; proprietary cooling agent (found in Givaudan's Evercool Skin blend alongside Menthyl PCA and Lactamide MEA)
Function
Oral Care (cooling agent)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition or restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Low irritation risk; mild tingling, temporary oral/skin irritation, and rare allergic contact dermatitis are possible; eye irritation if splashed; comedogenic rating 0/5. Synthetic menthol alternative with a cyclohexane ring bonded to an ethyl-linked pyridine group; up to 100ร— stronger cooling than menthol with longer duration; no strong mint odor; stable and supply-chain predictable; activates cold receptors (TRPM8) without the harshness of high menthol doses

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Concern Level: Moderate

Frequently Asked Questions

Is Menthane Carboxamide Ethylpyridine safe in cosmetics?

Low irritation risk; mild tingling, temporary oral/skin irritation, and rare allergic contact dermatitis are possible; eye irritation if splashed; comedogenic rating 0/5. Synthetic menthol alternative with a cyclohexane ring bonded to an ethyl-linked pyridine group; up to 100ร— stronger cooling than menthol with longer duration; no strong mint odor; stable and supply-chain predictable; activates cold receptors (TRPM8) without the harshness of high menthol doses The EU classifies Menthane Carboxamide Ethylpyridine as "permitted". Safety rating: MODERATE.

Is Menthane Carboxamide Ethylpyridine allowed in the EU?

Menthane Carboxamide Ethylpyridine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Menthane Carboxamide Ethylpyridine do in cosmetics?

Menthane Carboxamide Ethylpyridine functions as: Oral Care (cooling agent). It is classified as a cosmetic ingredient in our database. CAS number: Not widely published in open databases; proprietary cooling agent (found in Givaudan's Evercool Skin blend alongside Menthyl PCA and Lactamide MEA).

What is the Margin of Safety for Menthane Carboxamide Ethylpyridine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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