NOAEL Studies
Active Ingredient
Menthol NOAEL Studies
INCI: MENTHOL
CAS: 89-78-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 23 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | ca.375 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=586b8360-849d-49c8-8713-2fffa77f8acd_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=586b8360-849d-49c8-8713-2fffa77f8acd/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; key_result=false; entry_uuid=99a886c6-fae7-4a7d-9c4d-1ffad9acec11 |
| ECHA | NOAEL | ca.188 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=586b8360-849d-49c8-8713-2fffa77f8acd_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=586b8360-849d-49c8-8713-2fffa77f8acd/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=f1e4f3b2-ae58-4568-8d3d-fabfac14d608 |
| ECHA | NOAEL | >=419 | mg/kg bw/day | rat | oral: feed | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=c0ad864d-6d77-4bbd-93d4-e0a763ddfd3f_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=c0ad864d-6d77-4bbd-93d4-e0a763ddfd3f/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-06-23; basis=histopathology: non-neoplastic; key_result=true; upper_value=499; entry_uuid=01320892-f712-46a0-b72a-cdee57f41069 |
| ECHA | NOAEL | >=455 | mg/kg bw/day | rat | oral: feed | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=c0ad864d-6d77-4bbd-93d4-e0a763ddfd3f_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=c0ad864d-6d77-4bbd-93d4-e0a763ddfd3f/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-06-23; basis=histopathology: non-neoplastic; key_result=true; upper_value=594; entry_uuid=8c796403-ec6e-4c84-b67c-ac4f1a155e20 |
| ECHA | NOAEL | ca.667 | mg/kg bw/day | mouse | oral: feed | - | carcinogenicity: oral | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=f440fe2b-b3eb-4e86-9f53-4ba4e2464b39_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=f440fe2b-b3eb-4e86-9f53-4ba4e2464b39/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=530d1a29-8da2-4392-812c-3ba4938187cb |
| ECHA | NOAEL | ca.1000 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=078eb158-2acb-4ab1-b13c-789f6d550972_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=078eb158-2acb-4ab1-b13c-789f6d550972/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-10-21; key_result=false; entry_uuid=f17d9321-da89-462c-b5b8-cf84c2a388a6 |
| ECHA | NOAEL | ca.2143 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=bf564ca4-d749-4b7c-af04-f16a29eea5b4_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=bf564ca4-d749-4b7c-af04-f16a29eea5b4/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-10-21; key_result=false; entry_uuid=c10153cb-6a61-4c91-85c0-45e4726559b2 |
| ECHA | NOEL | 218 | mg/kg bw/day | - | - | - | developmental toxicity | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=b8db8c12-53be-4b2e-b5da-86e8f3554905_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=b8db8c12-53be-4b2e-b5da-86e8f3554905/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=DevelopmentalToxicityTeratogenicity; key_result=false; entry_uuid=29927213-ff8f-4beb-8772-7d97192f5242 |
| ECHA | NOEL | 405 | mg/kg bw/day | - | - | - | developmental toxicity | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=60ac03a3-d365-42c2-982b-ea6e3a81e6c7_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=60ac03a3-d365-42c2-982b-ea6e3a81e6c7/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=DevelopmentalToxicityTeratogenicity; basis=other:; key_result=false; entry_uuid=4f2db2bd-a8db-41d1-84bb-36f7ef6503a5 |
| ECHA | NOEL | >=512 | mg/kg bw/day | rat | oral: feed | - | extended one-generation reproductive toxicity - with F2 generation (Cohorts 1A, and 1B with extension) | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=c0ad864d-6d77-4bbd-93d4-e0a763ddfd3f_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=c0ad864d-6d77-4bbd-93d4-e0a763ddfd3f/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-06-23; basis=histopathology: non-neoplastic; key_result=true; upper_value=611; entry_uuid=65f2730e-cad4-4d52-8c39-62eaaa90bb67 |
| ECHA | NOEL | 425 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=117585af-390f-4c6d-99a3-c5c16e6e0f62_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=117585af-390f-4c6d-99a3-c5c16e6e0f62/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; key_result=false; entry_uuid=789766dd-5687-4739-bf11-6781b838919e |
| ECHA | NOEL | 200 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=13a51599-9f0d-4d7f-80c6-e733ddd33349_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=13a51599-9f0d-4d7f-80c6-e733ddd33349/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1961; basis=other:; key_result=false; entry_uuid=3b005e9a-5dfe-4ca1-9eac-ad6ce6f837cc |
| ECHA | NOEL | 185 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=124f7b9a-3bb6-424d-9bf3-28e33c851952.i6z; document=2679ed8c-958c-443a-a4b3-d9e8ce5ab0af_124f7b9a-3bb6-424d-9bf3-28e33c851952.i6d; document_key=2679ed8c-958c-443a-a4b3-d9e8ce5ab0af/124f7b9a-3bb6-424d-9bf3-28e33c851952; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=false; entry_uuid=cdf0ff6e-bcf4-4f28-a8cf-df151fd85db8 |
| ECHA | NOAEL | >667 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3cbd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/8?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816340_15820455:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15a4d57c3ae8d07e3c8fab6ad326fb98 |
| ECHA | NOAEL | >740 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3cbd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/8?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816340_15820455:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cc4d8c874006fcaeda61a423d9d9637f |
| ECHA | NOAEL | >937 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/6/2?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830955_15849429:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a58fcade141a0dc5b279e156261f111 |
| ECHA | NOAEL | =1250 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7cdc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/6/2?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832178_15849430:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d39194e6096ced413adc6d6d3672367b |
| ECHA | NOAEL | >1440 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/6/2?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830955_15849429:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_91de3e324d732b3140de441c03d3ee84 |
| ECHA | NOAEL | =1477.5 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7cdc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22569/7/6/2?documentUUID=a844226f-4e84-432f-8be8-04a61f19865f; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832178_15849430:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_356dff24df8944663f0a6cfc04f3b2c8 |
| ECHA | NOEL | =185 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce78; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15383/7/9/3?documentUUID=e4a370de-a3f3-4a8c-b975-d5df3cd6b858; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15824600:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_634de7046b8f2de78eaba4e45e951266 |
| ECHA | NOEL | =218 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15383/7/9/3?documentUUID=e4a370de-a3f3-4a8c-b975-d5df3cd6b858; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15824602:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_66bdfee13380a851b2b09daf7e0774ba |
| ECHA | NOEL | =405 | mg/kg bw/day | Hamster | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c1e4b0a7c65d23007d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15383/7/9/3?documentUUID=e4a370de-a3f3-4a8c-b975-d5df3cd6b858; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823106:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f202bcf689eec8ad57089973a31e932 |
| ECHA | NOEL | =425 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce7c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15383/7/9/3?documentUUID=e4a370de-a3f3-4a8c-b975-d5df3cd6b858; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15824601:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_33d775e713de0f89a882aaa245d9ab01 |
EFSA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =600 | mg/kg bw/day | Mouse | oral: feed | 721 days | chronic/long term toxicity | EFSA FEEDAP - 2016 - OutputID 2822 - mortality - systemic - Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4475 |
| EFSA | NOAEL | =375 | mg/kg bw/day | Rat | oral: feed | 721 days | chronic/long term toxicity | EFSA FEEDAP - 2016 - OutputID 2822 - histopathology neoplastic - systemic - Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4475 |
| EFSA | ADI | =4 | mg/kg bw/day | Consumers | - | - | ADI | EFSA FEEDAP - 2019 - OutputID 3204 - Consumers - Safety and efficacy of Biomin DC-P as a zootechnical feed additive for chickens for fattening, chickens reared for laying and minor avian species to the point of lay - doi:10.2903/j.efsa.2019.5724 |
| EFSA | NOAEL | =375 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4475.; TITLE=Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4475; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15624559:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f1aff2cfbf9da38ce7fa88a91b28eea |
| EFSA | NOAEL | =600 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4475.; TITLE=Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4475; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA:15624560:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8dc1fcc66dde634c2f71183a0669c709 |
WHO/JECFA 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | range:0-0.20.2 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v042je04; title=930. Menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je04.htm; row_hash=f036e3a686553854; raw_unit=mg/kg bw; context=EXPLANATION Menthol was first evaluated at the eleventh meeting of the Committee (Annex 1, reference 14), when it was allocated an unconditional ADI of 0-0.2 mg/kg bw and a conditional ADI of 0.2-2 mg/kg bw. |
| WHO/JECFA | ADI | range:0-44 | mg/kg bw/day | Rat; Mouse | - | long-term | Health guidance value | document_id=jecfa_jecmono_v042je04; title=930. Menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je04.htm; row_hash=54b790c5bd882b71; raw_unit=mg/kg bw; context=As the survival of mice was reduced at the high dose of 600 mg/kg bw per day, the Committee allocated an ADI of 0-4 mg/kg bw on the basis of the NOEL of 380 mg/kg bw per day in the long-term study in rats, applying a safety factor of 100 and rounding to one significant figure. |
| WHO/JECFA | NOEL | =560 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je04; title=930. Menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je04.htm; row_hash=9b9ee21ccc342203; raw_unit=mg/kg bw per day; context=The NOEL was 560 mg/kg bw per day (US National Cancer Institute, 1979). |
| WHO/JECFA | NOEL | =750 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je04; title=930. Menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je04.htm; row_hash=bfb7474a14fc4abf; raw_unit=mg/kg bw per day; context=The NOEL was 750 mg/kg bw per day (US National Cancer Institute, 1979). |
| WHO/JECFA | NOEL | =600 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je04; title=930. Menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je04.htm; row_hash=ee118e90fab91e4b; raw_unit=mg/kg bw per day; context=The NOEL was 600 mg/kg bw per day. |
| WHO/JECFA | NOEL | =380 | mg/kg bw/day | Rat | oral | two-year | Carcinogenicity | document_id=jecfa_jecmono_v042je04; title=930. Menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je04.htm; row_hash=d6b87c7a6ad01659; raw_unit=mg/kg bw per day; context=In a two-year study of toxicity and carcinogenicity in rats given (±)-menthol in the diet at concentrations equivalent to 190 or 380 mg/kg bw per day, the NOEL was 380 mg/kg bw per day. |
| WHO/JECFA | ADI | range:0-44 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=fbd739e8755f102e; raw_unit=mg/kg bw; context=At the present meeting, the Committee allocated an ADI of 0-4 mg/kg bw to menthol (see monograph, this volume). |
| WHO/JECFA | NOEL | =0.017 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=1bb5f70d4a075e3e; raw_unit=ug/kg bw; unit_normalization=converted from micrograms; context=There is a safety margin of > 1000 between this NOEL and the daily per capita intake of menthone itself (42 or 17 ug/kg bw) and the total daily per capita intake of menthone including its derivatives (46 or 17 ug/kg bw). |
| WHO/JECFA | NOEL | =50 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=b7a85a6e07ce7c22; raw_unit=mg/kg bw per day; context=The NOEL was 50 mg/kg bw per day (Reijnders, 1991b), which is more than 10 000 times the daily per capita intake ('eaters only') of 3 ug/kg bw from its use as a flavouring agent in the United States (see Table 2). |
| WHO/JECFA | NOEL | =400 | mg/kg bw/day | Rat | - | 28-day | Toxicology study | document_id=jecfa_jecmono_v042je21; title=947. Substances structurally related to menthol (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je21.htm; row_hash=25f190365e719aa7; raw_unit=mg/kg bw per day; context=For menthone, a NOEL of 400 mg/kg bw per day was reported in a 28-day study of toxicity in rats (Madsen et al., 1986). |
| WHO/JECFA | ADI | <=4 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650affb9e4b0d99f5a882930; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1519; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=WHO JECFA ADI:15715612:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_34271237536f4b43be4327f967209c66 |
NTP ICE acute oral 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =3180 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2916; row=13994; data_type=In Vivo; mixture=Chemical; chemical_name=Menthol; preferred_name=Menthol; dtxsid=DTXSID8029650; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029650; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2900 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2914; row=13995; data_type=In Vivo; mixture=Chemical; chemical_name=Menthol; preferred_name=Menthol; dtxsid=DTXSID8029650; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029650; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <2615 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2912; row=13996; data_type=In Vivo; mixture=Chemical; chemical_name=Menthol; preferred_name=Menthol; dtxsid=DTXSID8029650; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029650; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2602 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2910; row=13997; data_type=In Vivo; mixture=Chemical; chemical_name=Menthol; preferred_name=Menthol; dtxsid=DTXSID8029650; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029650; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2426 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2908; row=13998; data_type=In Vivo; mixture=Chemical; chemical_name=Menthol; preferred_name=Menthol; dtxsid=DTXSID8029650; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029650; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2046 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2906; row=13999; data_type=In Vivo; mixture=Chemical; chemical_name=Menthol; preferred_name=Menthol; dtxsid=DTXSID8029650; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029650; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2918; row=14000; data_type=In Vivo; mixture=Chemical; chemical_name=Menthol; preferred_name=Menthol; dtxsid=DTXSID8029650; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029650; source_file=acute_oral.xlsx |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 4000 | ppm | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1384; Record_ID=cancer_4710; Data_Type=In Vivo; Formulation_Name=dl-menthol; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=4000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Reference=TR-098; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr098/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020805 |
| NTP ICE cancer | Top dose | 7500 | ppm | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1381; Record_ID=cancer_4708; Data_Type=In Vivo; Formulation_Name=dl-menthol; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=7500; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-098; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr098/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020805 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=11220; RecordID=ARPathway2016_872; DatasetName=ARPathway2016; DTXSID=DTXSID8029650; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8029650 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10942; Record_ID=skin_sensitization_invivo_2390; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80199-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805 |
| NTP ICE skin sensitization | Induction dose per skin area | 5184 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10940; Record_ID=skin_sensitization_invivo_2390; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80199-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10946; Record_ID=skin_sensitization_invivo_2390; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020805; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80199-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020805 |
ToxValDB ECOTOX 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =20 | mg/kg bw/day | Rat | oral | short-term; 4 days | short-term | LONG_REF=Environ. Res.5(2): 164-171 Sperling,F., H.K.U. Ewenike, and T. Farber Changes in LD50 of Parathion and Heptachlor Following Turpentine Pretreatment 1972; TITLE=Changes in LD50 of Parathion and Heptachlor Following Turpentine Pretreatment; AUTHOR=Sperling,F., H.K.U. Ewenike, and T. Farber; DOI=10.1016/0013-9351(72)90031-x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117775; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1972; ORIGINAL_YEAR=1972; TOXICOLOGICAL_EFFECT=Enzyme(s): Aniline hydroxylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15597083:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ed4c3214653b5e1e63102031c99b9583 |
| ToxValDB ECOTOX | LOEL | =25 | mg/kg bw/day | Rat | injection | acute; 0.0208 days | acute | LONG_REF=PTR. Phytother.Res.8(5): 305-307 Trabace,L., P. Avato, M. Mazzoccoli, and G. Siro-Brigiani Choleretic Activity of Thapsia Chem I, II, and III in Rats: Comparison with Terpenoid Constituents and Peppermint Oil 1994; TITLE=Choleretic Activity of Thapsia Chem I, II, and III in Rats: Comparison with Terpenoid Constituents and Peppermint Oil; AUTHOR=Trabace,L., P. Avato, M. Mazzoccoli, and G. Siro-Brigiani; DOI=10.1002/ptr.2650080511; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=105648; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Physiology: Secretion; STUDY_GROUP=ECOTOX:15599320:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7e3d79ebdc9bce9fbd543d99586be70c |
| ToxValDB ECOTOX | LOEL | =3 | mmol/kg | Rat | oral | acute; 0.7083 days | acute | LONG_REF=Biochem. Pharmacol.29(15): 2125-2127 Clegg,R.J., B. Middleton, G.D. Bell, and D.A. White Inhibition of Hepatic Cholesterol Synthesis and S-3-Hydroxy-3-Methylglutaryl-CoA Reductase by Mono and Bicyclic Monoterpenes Administered In Vivo 1980; TITLE=Inhibition of Hepatic Cholesterol Synthesis and S-3-Hydroxy-3-Methylglutaryl-CoA Reductase by Mono and Bicyclic Monoterpenes Administered In Vivo; AUTHOR=Clegg,R.J., B. Middleton, G.D. Bell, and D.A. White; DOI=10.1016/0006-2952(80)90183-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117777; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Enzyme(s): beta-Hydroxy-beta-methylglutaryl-CoA reductase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15609704:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0f5ae2326bec6a604f6141cf60d2794e |
| ToxValDB ECOTOX | NOEL | =0.19 | % | Mouse | oral | chronic; 728 days | chronic | LONG_REF=Tech.Rep.Ser.No.98, DHEW Publ.No.(NIH) 79-1348, Natl.Cancer Inst., Bethesda, MD:131 p. National Cancer Institute Bioassay of dl-Menthol for Possible Carcinogenicity 1979; TITLE=Bioassay of dl-Menthol for Possible Carcinogenicity; AUTHOR=National Cancer Institute; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=105632; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601951_15601952_15608481:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8c97fe52b1ae61d4bfcc7b0f73f94a33 |
| ToxValDB ECOTOX | NOEL | =0.36 | % | Mouse | oral | chronic; 728 days | chronic | LONG_REF=Tech.Rep.Ser.No.98, DHEW Publ.No.(NIH) 79-1348, Natl.Cancer Inst., Bethesda, MD:131 p. National Cancer Institute Bioassay of dl-Menthol for Possible Carcinogenicity 1979; TITLE=Bioassay of dl-Menthol for Possible Carcinogenicity; AUTHOR=National Cancer Institute; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=105632; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Injury: Lymphoma|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|mortality/survival; STUDY_GROUP=ECOTOX:15598463:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=40f9164814f903caf6a88f107b321d77 |
| ToxValDB ECOTOX | NOEL | =0.7 | % | Rat | oral | chronic; 735 days | chronic | LONG_REF=Tech.Rep.Ser.No.98, DHEW Publ.No.(NIH) 79-1348, Natl.Cancer Inst., Bethesda, MD:131 p. National Cancer Institute Bioassay of dl-Menthol for Possible Carcinogenicity 1979; TITLE=Bioassay of dl-Menthol for Possible Carcinogenicity; AUTHOR=National Cancer Institute; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=105632; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX:15598154:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b30fa34d750154079c713e8cded1547e |
| ToxValDB ECOTOX | NOEL | =1450 | mg/kg bw/day | Rat | oral | short-term; 1.625 days | short-term | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15606800:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0ac24b5164dbe3868bf0ff5168ef73ed |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =46.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633218:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_21436312fc5048c56509fbe395204460 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | YS08XHA860 | UNII | - | - | - | chemical | - |