NOAEL Studies
Cosmetic Ingredient
Mercury Compounds NOAEL Studies
INCI: MERCURY COMPOUNDS
CAS: 7439-97-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL (ADJ) | =0.009 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=97976ef7cdf518a0; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL (ADJ): 9e-3 mg/m^3; system=Nervous; basis=Hand tremor; increases in memory disturbances; slight subjective and objective evidence of autonomic dysfunction; point_of_departure=LOAEL (ADJ): 9e-3 mg/m^3; composite_uf=30; confidence=Medium; dtxsid=DTXSID1024172; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=370; rfc_last_updated=06/01/1995; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0370_summary.pdf |
| Regulatory source | RfC | =0.0003 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=3272b8719c732302; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=3e-4; system=Nervous; basis=Hand tremor; increases in memory disturbances; slight subjective and objective evidence of autonomic dysfunction; point_of_departure=LOAEL (ADJ): 9e-3 mg/m^3; composite_uf=30; confidence=Medium; dtxsid=DTXSID1024172; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=370; rfc_last_updated=06/01/1995; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0370_summary.pdf |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1993 | IARC Monographs | {"additional_info":"volume_publication_year=1993","evaluation_year":1993,"source_table":"iarc_classifications","volume":"58"} |
WHO/JECFA 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =0.86 | mg/m3 | Rat | inhalation | 11 weeks | Reproductive toxicity | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=e0b8d8123d8bbc05; raw_unit=mg/m 3; context=posure to 6 mg/m 3 for up to 11 weeks produced effects that ranged from mild pathological changes to marked cellular degeneration and widespread necrosis (Ashe et al., 1953). (The LOAEL for renal effects was 0.86 mg/m 3 .) Dense deposits in tubule cells and lysosomal inclusions in the renal tubular epithelium were evident following exposure of rats to mercury vapour at 3 mg/m 3 for 3 h/day, 5 days/week, for 1242 weeks (Kishi et al., 1978). |
| WHO/JECFA | LOAEL | =1 | mg/m3 | Monkey | inhalation | 5 days | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=cbeb565eb29d092c; raw_unit=mg/m 3; context=avioural tests conducted on the offspring of mother squirrel monkeys that had been exposed during the last two-thirds or more of gestation to mercury vapour concentrations of 0.5 (LOAEL) or 1.0 mg/m 3 for 4 or 7 h/day, 5 days/week, long-term effects included instability in lever-press durations and steady-state performance under concurrent schedules of reinforcement, as well as aberrant transitions (Newland et al., 1996). |
| WHO/JECFA | LOAEL | =1.9 | mg/kg bw | - | - | 2-year | Chronic toxicity | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=5b45b35471d27872; raw_unit=mg/kg body weight; context=Use of a LOAEL of 1.9 mg/kg body weight in a 2-year study as a starting point yields a similar tolerable intake. |
| WHO/JECFA | LOAEL | =1.9 | mg/kg bw/day | - | oral | long-term | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=b1f23aeba403bc8f; raw_unit=mg/kg body weight per day; context=The LOAEL for renal effects resulting from long-term oral exposure is 1.9 mg/kg body weight per day. |
| WHO/JECFA | LOAEL | =8 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=86144e15aa2ac953; raw_unit=mg/kg body weight per day; context=The NOAEL for males in this study was 1 mg/kg body weight per day; the LOAEL was 8 mg/kg body weight per day for increased liver weights and slight histopathological changes to the renal cortex. |
| WHO/JECFA | LOAEL | =9 | mg/kg bw | - | oral | - | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=d5556282b3ec8553; raw_unit=mg/kg; context=En partant dune LOAEL de 1,9 mg/kg de poids corporel obtenue ΰ la suite dune étude de 2 ans, on parvient à un résultat analogue pour la dose tolérable par ingestion. |
| WHO/JECFA | LOAEL | =10 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=9f23b32e65efe8d7; raw_unit=mg/kg body weight per day; context=The LOAEL for hepatic effects was 10 mg/kg body weight per day. |
| WHO/JECFA | LOAEL | =20 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=10943bffdf1a1cef; raw_unit=mg/kg body weight per day; context=The LOAEL for adrenal effects was 20 mg/kg body weight per day. |
| WHO/JECFA | NOAEL | =0.0002 | mg/m3 | Human | inhalation | long-term | Inhalation toxicity | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=03666409ddfe79c4; raw_unit=ug/m 3; unit_normalization=converted from micrograms; context=Use of uncertainty factors of 10 for interindividual variation in sensitivity to mercury within the human population and 3 for use of a LOAEL (subclinical effects) rather than a NOAEL yields a tolerable concentration of 0.2 ug/m 3 for long-term inhalation exposure to elemental mercury vapour. |
| WHO/JECFA | NOAEL | =0.002 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=e9c963051f76322a; raw_unit=ug/m 3; unit_normalization=converted from micrograms; context=riations interindividuelles et 3 pour lextrapolation de la dose minimale produisant un effet nocif observable, ou LOAEL (effets légers), à la dose sans effet nocif observable, ou NOAEL), on obtient une concentration tolérable de 0,2 ug/m 3 . |
| WHO/JECFA | NOAEL | =0.0328571428571429 | mg/kg bw/day | Human | - | 5 days | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=edcb7cf4da5d8fdd; raw_unit=mg/kg body weight per day; unit_normalization=converted from weekly dose; context=Using the NOAEL for renal effects of 0.23 mg/kg body weight per day as the starting point, adjusting the 5 days/week dosing pattern to daily exposure, and applying an uncertainty factor of 100 (10 for extrapolation from animals to humans and 10 for human variability), a tolerable intake of 2 ug/kg body weight per day can be d |
| WHO/JECFA | NOAEL | =0.23 | mg/kg bw | - | oral | 26-week | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=3673aa1364e39fe3; raw_unit=mg/kg body weight; context=In a 26-week study, a NOAEL for the critical effect, nephrotoxicity, of 0.23 mg/kg body weight was identified for oral exposure to mercuric chloride. |
| WHO/JECFA | NOAEL | =0.23 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=4bed79a183f959d5; raw_unit=mg/kg body weight per day; context=A NOAEL from this study was identified at 0.23 mg/kg body weight per day. |
| WHO/JECFA | NOAEL | =1 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=12e5e1bb9eb84e26; raw_unit=mg/kg body weight per day; context=The NOAEL for males in this study was 1 mg/kg body weight per day; the LOAEL was 8 mg/kg body weight per day for increased liver weights and slight histopathological changes to the renal cortex. |
| WHO/JECFA | NOAEL | =23 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad50; title=Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects (Cicads 50, 2003); path=mirror/documents/cicads/cicads/cicad50.htm; row_hash=aa17980b68c2469e; raw_unit=mg/kg; context=Lors dune étude de 26 semaines avec administration de chlorure mercurique par voie orale, on a obtenu une NOAEL égale à 0,23 mg/kg de poids corporel, leffet critique considéré étant la néphrotoxicité. |
| WHO/JECFA | NOEL | =0.399 | mg/g | - | - | - | Toxicology study | document_id=ehc_ehc_ehc101; title=Methylmercury (EHC 101, 1990); path=mirror/documents/ehc/ehc/ehc101.htm; row_hash=310359be549c8f86; raw_unit=ug/g; unit_normalization=converted from micrograms; context=The lowest level (maximum maternal hair mercury concentration during pregnancy) at which severe effects were observed was 404 ug/g in the Iraqi outbreak and the highest no-observed-effect level for severe effects was 399 ug/g. |
| WHO/JECFA | NOEL | =0.399 | mg/g | - | - | - | Toxicology study | document_id=ehc_ehc_ehc101; title=Methylmercury (EHC 101, 1990); path=mirror/documents/ehc/ehc/ehc101.htm; row_hash=310359be549c8f86; raw_unit=ug/g; unit_normalization=converted from micrograms; context=The lowest level (maximum maternal hair mercury concentration during pregnancy) at which severe effects were observed was 404 ug/g in the Iraqi outbreak and the highest no-observed-effect level for severe effects was 399 ug/g. |
| WHO/JECFA | LOAEL | =0.05 | mg/kg bw | Human | inhalation | - | Inhalation toxicity | document_id=ehc_ehc_ehc118; title=Mercury, inorganic (EHC 118, 1991); path=mirror/documents/ehc/ehc/ehc118.htm; row_hash=c2964c852ac6c808; raw_unit=mg/kg; context=Using this animal LOAEL (0.05 mg/kg), equivalent human oral and inhalation LOAEL values for kidney effects can be determined as follows: |
| WHO/JECFA | LOAEL | =0.05 | mg/kg bw | Human | inhalation | - | Inhalation toxicity | document_id=ehc_ehc_ehc118; title=Mercury, inorganic (EHC 118, 1991); path=mirror/documents/ehc/ehc/ehc118.htm; row_hash=c2964c852ac6c808; raw_unit=mg/kg; context=Using this animal LOAEL (0.05 mg/kg), equivalent human oral and inhalation LOAEL values for kidney effects can be determined as follows: |
| WHO/JECFA | LOAEL | =16 | mg/kg bw/day | - | dermal | - | Toxicology study | document_id=ehc_ehc_ehc118; title=Mercury, inorganic (EHC 118, 1991); path=mirror/documents/ehc/ehc/ehc118.htm; row_hash=97f72f2188177f72; raw_unit=mg/kg per day; context=The lowest-observed-adverse-effect level found in these studies was 16 mg/kg per day via the subcutaneous route of exposure. |
| WHO/JECFA | LOAEL | =16 | mg/kg bw/day | - | dermal | - | Toxicology study | document_id=ehc_ehc_ehc118; title=Mercury, inorganic (EHC 118, 1991); path=mirror/documents/ehc/ehc/ehc118.htm; row_hash=97f72f2188177f72; raw_unit=mg/kg per day; context=The lowest-observed-adverse-effect level found in these studies was 16 mg/kg per day via the subcutaneous route of exposure. |
| WHO/JECFA | BMDL (10) | =0.06 | mg/kg bw/day | Mouse, Rat | oral | chronic; 27 weeks | chronic | LONG_REF=NTP (1993). Toxicology and carcinogenesis studies of mercuric chloride (CAS No. 7487-94-7) in F344 rats and B3C3F1 mice (gavage studies). Research Triangle Park, NC, United States Department of Health and Human Services, National Toxicology Program (NTP Technical Report Series, No. 408).; TITLE=Toxicology and carcinogenesis studies of mercuric chloride (CAS No. 7487-94-7) in F344 rats and B3C3F1 mice (gavage studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650affb9e4b0d99f5a8829a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1806; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Kidney weight changes, proximal tubule damage and progressive nephropathy; STUDY_GROUP=WHO JECFA Tox Studies:15716035:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9b389ba75f7b2a917c65f777d0e295ff |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=1843; Record_ID=cancer_3560; Data_Type=WOE; Formulation_Name=Mercury; Mixture=Chemical; DTXSID=DTXSID1024172; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/76; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024172 |
ToxValDB ATSDR MRLs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | MRL | =0.0003 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2022; ORIGINAL_YEAR=2022; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs:15447149:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c069267df2ef54dc12d1b3663db92e3 |
ToxValDB Cal OEHHA REL derivations 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | LOAEL | =0.025 | mg/m3 | Human | inhalation | chronic; 15.6 years | occupational | LONG_REF=Piikivi L and Hanninen H (1989). Subjective symptoms and psychological performance of chlorine-alkali workers. Scand J Work Environ Health 15(1): 69-74. Piikivi L (1989). Cardiovascular reflexes and low long-term exposure to mercury vapour. Int Arch Occup Environ Health 61(6): 391-5. Piikivi L and Tolonen U (1989). EEG findings in chlor-alkali workers subjected to low long term exposure to mercury vapour. Br J Ind Med 46(6): 370-5. Fawer RF, de Ribaupierre Y, Guillemin MP, Berode M and Lob M (1983). Measurement of hand tremor induced by industrial exposure to metallic mercury. Br J Ind Med 40(2): 204-8; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Neurotoxicity as measured by: intention tremor; memory and sleep disturbances; decreased performance on neurobehavioral tests (finger tapping, visual scan, visuomotor coordination, visual memory); decreased EEG activity; STUDY_GROUP=Cal OEHHA REL derivations:15951890:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f887f2e2470ded2ed685426622bb2ed |
| ToxValDB Cal OEHHA REL derivations | LOAEL | =1.8 | mg/m3 | Rat | inhalation | (developmental) | reproduction developmental | LONG_REF=Danielsson BR, Fredriksson A, Dahlgren L, Gardlund AT, Olsson L, Dencker L and Archer T (1993). Behavioural effects of prenatal metallic mercury inhalation exposure in rats. Neurotoxicol Teratol 15(6): 391-6.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=CNS disturbances in offspring; STUDY_GROUP=Cal OEHHA REL derivations:15951889:-:-pregnant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e87359bf3c46cc2d4f5d7cabec7487e |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =0.16 | mg Hg/kg-day | Rat | oral | - | - | LONG_REF=OEHHA. (1999). Public Health Goal for Inorganic Mercury in Drinking Water. Office of Environmental Health Hazard Assessment. California Environmental Protection Agency. Scramento, CA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=renal toxicity; STUDY_GROUP=Cal OEHHA REL derivations:15951891:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9e6e803807c4badda44ca051648500e8 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.02 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633232:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_521e265aff38422e0e34b00810ecdb36 |
ToxValDB Health Canada 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Health Canada | LOAEL | =0.317 | mg/kg bw/day | Rat | oral | subchronic; 2 months | subchronic | LONG_REF=Bernaudin et al., 1981; AUTHOR=Bernaudin et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=Health Canada:15637549:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8aed1e85d22cd1fd478cbbccf4333b82 |
| ToxValDB Health Canada | LOAEL | =0.633 | mg/kg bw/day | Rat | oral | subchronic; 2 months | subchronic | LONG_REF=Andres, 1984; AUTHOR=Andres; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=Health Canada:15637550:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a6d6dc15802eb871bc45755124a200ee |
| ToxValDB Health Canada | TDI | =0.0003 | mg/kg bw/day | Human | injection | subchronic; 8 weeks | Toxicity Value | LONG_REF=CSQG: CCME, 1999a,b; RfD from U.S. EPA, 1995 (based on several studies, including Druet et al., 1978; Bernaudin et al., 1981; Andres, 1984); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=nephrotoxicity; STUDY_GROUP=Health Canada:15637437:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_60d3bc64c6c451b40528f9732021c0eb |
ToxValDB IRIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL (ADJ) | =0.009 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=Fawer, R.F., U. DeRibaupierre, M.P. Guillemin, M. Berode and M. Lobe. 1983. Measurement of hand tremor induced by industrial exposure to metallic mercury. J. Ind. Med. 40: 204-208. ; Piikivi, L. and U. Tolonen. 1989. EEG findings in chlor-alkali workers subjected to low long term exposure to mercury vapor. Br. J. Ind. Med. 46: 370-375. ; Piikivi, L. and H. Hanninen. 1989. Subjective symptoms and psychological performance of chlorine-alkali workers. Scand. J. Work Environ. Health. 15: 69-74. ; Piikivi, L. 1989. Cardiovascular reflexes and low long-term exposure to mercury vapor. Int. Arch. Occup. Environ. Health. 61: 391-395. ; Ngim, C.H., S.C. Foo, K.W. Boey and J. Jeyaratnam. 1992. Chronic neurobehavioral effects of elemental mercury in dentists. Br. J. Ind. Med. 49: 782-790. ; Liang, Y-X., R-K. Sun, Y. Sun, Z-Q. Chen and L-H. Li. 1993. Psychological effects of low exposure to mercury vapor: Application of a computer-administered neurobehavioral evaluation system. Environ. Res. 60: 320-327.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a57c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=370; TOXICOLOGICAL_EFFECT=Hand tremor|increases in memory disturbances|slight subjective and objective evidence of autonomic dysfunction; STUDY_GROUP=IRIS_dup_IRIS Summary_15645047_15645048:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_066df1466f6ea0532195486976c0a5b1 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | FXS1BY2PGL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"Hg","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FXS1BY2PGL"} |
| openFDA substances | FDA UNII substance identifier | FXS1BY2PGL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"Hg","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FXS1BY2PGL"} |
| openFDA substances | FDA UNII substance identifier | FXS1BY2PGL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"Hg","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FXS1BY2PGL"} |
| openFDA substances | FDA UNII substance identifier | FXS1BY2PGL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"Hg","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FXS1BY2PGL"} |