Methionyl sh-Polypeptide-9

INCI: METHIONYL SH-POLYPEPTIDE-9

CAS Number
None specifically assigned for the methionyl variant; the base sh-Polypeptide-9 carries CAS 127464-60-2
Function
Hair conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Recombinant fusion peptide produced in E. coli; standard biotech purity and endotoxin QC apply. The base peptide (VEGFA analog) has potent angiogenic activity - topical use concentration must be carefully controlled.. sh-Polypeptide-9 is a recombinant Vascular Endothelial Growth Factor A (VEGFA) analog; it stimulates cutaneous microvessel renewal, promotes lymphatic vessel formation, and in comparative tests with Minoxidil showed higher activity in increasing VEGF and ฮฒ-catenin production. Th...

โš ๏ธ
Concern Level: Moderate

Frequently Asked Questions

Is Methionyl sh-Polypeptide-9 safe in cosmetics?

Recombinant fusion peptide produced in E. coli; standard biotech purity and endotoxin QC apply. The base peptide (VEGFA analog) has potent angiogenic activity - topical use concentration must be carefully controlled.. sh-Polypeptide-9 is a recombinant Vascular Endothelial Growth Factor A (VEGFA) analog; it stimulates cutaneous microvessel renewal, promotes lymphatic vessel formation, and in comparative tests with Minoxidil showed higher activity in increasing VEGF and ฮฒ-catenin production. Th... The EU classifies Methionyl sh-Polypeptide-9 as "permitted". Safety rating: MODERATE.

Is Methionyl sh-Polypeptide-9 allowed in the EU?

Methionyl sh-Polypeptide-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methionyl sh-Polypeptide-9 do in cosmetics?

Methionyl sh-Polypeptide-9 functions as: Hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: None specifically assigned for the methionyl variant; the base sh-Polypeptide-9 carries CAS 127464-60-2.

What is the Margin of Safety for Methionyl sh-Polypeptide-9?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Methionyl sh-Polypeptide-9 in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methionyl sh-Polypeptide-9 in your formulation.