Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
The methotrexate pharmacophore is a potent antifolate; even in conjugated form, potential cytotoxicity, skin sensitization, and systemic absorption must be evaluated. Limited published safety data for this specific conjugate.. Peptide-drug conjugate approach; designed for enhanced skin penetration or receptor targeting.
Regulatory Flags
Frequently Asked Questions
Is Methotrexoyl Oligopeptide-59 safe in cosmetics?
The methotrexate pharmacophore is a potent antifolate; even in conjugated form, potential cytotoxicity, skin sensitization, and systemic absorption must be evaluated. Limited published safety data for this specific conjugate.. Peptide-drug conjugate approach; designed for enhanced skin penetration or receptor targeting. The EU classifies Methotrexoyl Oligopeptide-59 as "prohibited". Safety rating: MODERATE.
Is Methotrexoyl Oligopeptide-59 allowed in the EU?
Methotrexoyl Oligopeptide-59 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methotrexoyl Oligopeptide-59 do in cosmetics?
Methotrexoyl Oligopeptide-59 functions as: Skin conditioning - the parent Oligopeptide-59 is a synthetic peptide of 11 amino acids (Arg, Asn, Asp, Leu, Lys, Phe, Trp) used in anti-aging applications. The "methotrexoyl" prefix indicates conjugation with a methotrexate-derived acyl moiety, likely intended to enhance targeted delivery or bioactivity.. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned. The base peptide Oligopeptide-59 (COSING Ref 85512) also lacks a published CAS..
What is the Margin of Safety for Methotrexoyl Oligopeptide-59?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Methotrexoyl Oligopeptide-59 compliance across multiple jurisdictions:
Related Ingredients
Is Methotrexoyl Oligopeptide-59 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methotrexoyl Oligopeptide-59 in your formulation.