Is Methotrexoyl Oligopeptide-59 safe in cosmetics?
Methotrexoyl Oligopeptide-59 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Methotrexoyl Oligopeptide-59
INCI: METHOTREXOYL OLIGOPEPTIDE-59
Methotrexoyl Oligopeptide-59 (CAS Not publicly assigned. The base peptide Oligopeptide-59 (COSING Ref 85512) also lacks a published CAS.) is a cosmetic cosmetic ingredient functioning as Skin conditioning - the parent Oligopeptide-59 is a synthetic peptide of 11. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
Not publicly assigned. The base peptide Oligopeptide-59 (COSING Ref 85512) also lacks a published CAS.
View industrial chemical safety profile →
Function
Skin conditioning - the parent Oligopeptide-59 is a synthetic peptide of 11 amino acids (Arg, Asn, Asp, Leu, Lys, Phe, Trp) used in anti-aging applications. The "methotrexoyl" prefix indicates conjugation with a methotrexate-derived acyl moiety, likely intended to enhance targeted delivery or bioactivity.
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not specifically prohibited or restricted. FDA regulates cosmetic ingredients under FD&C Act - ingredients are allowed unless specifically banned, but the methotrexate connection could trigger drug-cosmetic classification questions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methotrexoyl Oligopeptide-59.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Methotrexoyl Oligopeptide-59.
Regulatory Flags
potential-allergen
Frequently Asked Questions
Is Methotrexoyl Oligopeptide-59 allowed in the EU?
Methotrexoyl Oligopeptide-59 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methotrexoyl Oligopeptide-59 do in cosmetics?
Methotrexoyl Oligopeptide-59 functions as: Skin conditioning - the parent Oligopeptide-59 is a synthetic peptide of 11 amino acids (Arg, Asn, Asp, Leu, Lys, Phe, Trp) used in anti-aging applications. The "methotrexoyl" prefix indicates conjugation with a methotrexate-derived acyl moiety, likely intended to enhance targeted delivery or bioactivity.. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned. The base peptide Oligopeptide-59 (COSING Ref 85512) also lacks a published CAS..
Compliance Tools
Check Methotrexoyl Oligopeptide-59 compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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