Is Methotrexoyl Oligopeptide-59 safe in cosmetics?
Methotrexoyl Oligopeptide-59 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
MODERATE
Cosmetic Ingredient
Methotrexoyl Oligopeptide-59
INCI: METHOTREXOYL OLIGOPEPTIDE-59
Methotrexoyl Oligopeptide-59 (CAS Not publicly assigned. The base peptide Oligopeptide-59 (COSING Ref 85512) also lacks a published CAS.) is a cosmetic cosmetic ingredient functioning as Skin conditioning - the parent Oligopeptide-59 is a synthetic peptide of 11. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
CAS Number
Not publicly assigned. The base peptide Oligopeptide-59 (COSING Ref 85512) also lacks a published CAS.
View industrial chemical safety profile →
Function
Skin conditioning - the parent Oligopeptide-59 is a synthetic peptide of 11 amino acids (Arg, Asn, Asp, Leu, Lys, Phe, Trp) used in anti-aging applications. The "methotrexoyl" prefix indicates conjugation with a methotrexate-derived acyl moiety, likely intended to enhance targeted delivery or bioactivity.
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not specifically prohibited or restricted. FDA regulates cosmetic ingredients under FD&C Act - ingredients are allowed unless specifically banned, but the methotrexate connection could trigger drug-cosmetic classification questions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methotrexoyl Oligopeptide-59.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Methotrexoyl Oligopeptide-59 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
Frequently Asked Questions
Is Methotrexoyl Oligopeptide-59 allowed in the EU?
Methotrexoyl Oligopeptide-59 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methotrexoyl Oligopeptide-59 do in cosmetics?
Methotrexoyl Oligopeptide-59 functions as: Skin conditioning - the parent Oligopeptide-59 is a synthetic peptide of 11 amino acids (Arg, Asn, Asp, Leu, Lys, Phe, Trp) used in anti-aging applications. The "methotrexoyl" prefix indicates conjugation with a methotrexate-derived acyl moiety, likely intended to enhance targeted delivery or bioactivity.. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned. The base peptide Oligopeptide-59 (COSING Ref 85512) also lacks a published CAS..
Compliance Tools
Check Methotrexoyl Oligopeptide-59 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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