Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Thioctic acid (alpha-lipoic acid) is a potent antioxidant but can cause contact dermatitis in some individuals; PEGylation may modify this profile; 1,4-dioxane trace potential from PEG moiety. Combines the antioxidant activity of alpha-lipoic acid with the solubility and delivery benefits of a ~45 EO unit PEG chain; synthetic origin
Regulatory Flags
Frequently Asked Questions
Is Methoxy PEG-45 Thioctate safe in cosmetics?
Thioctic acid (alpha-lipoic acid) is a potent antioxidant but can cause contact dermatitis in some individuals; PEGylation may modify this profile; 1,4-dioxane trace potential from PEG moiety. Combines the antioxidant activity of alpha-lipoic acid with the solubility and delivery benefits of a ~45 EO unit PEG chain; synthetic origin The EU classifies Methoxy PEG-45 Thioctate as "permitted". Safety rating: MODERATE.
Is Methoxy PEG-45 Thioctate allowed in the EU?
Methoxy PEG-45 Thioctate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methoxy PEG-45 Thioctate do in cosmetics?
Methoxy PEG-45 Thioctate functions as: Antioxidant (thioctate = thioctic acid/alpha-lipoic acid ester) - PEGylated form improves water solubility of lipoic acid. It is classified as a cosmetic ingredient in our database. CAS number: Not confirmed from databases accessed.
What is the Margin of Safety for Methoxy PEG-45 Thioctate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Methoxy PEG-45 Thioctate compliance across multiple jurisdictions:
Related Ingredients
Is Methoxy PEG-45 Thioctate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Methoxy PEG-45 Thioctate in your formulation.