Methoxychalcone

INCI: METHOXYCHALCONE

CAS Number
22252-15-9 (4-Methoxychalcone confirmed via PubChem; EC number 213-499-7)
Function
Skin conditioning (chalcones are known for antioxidant/anti-inflammatory properties)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Allowed - not specifically prohibited

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited toxicological data in cosmetic context; chalcones as a class show generally favorable safety profiles but may cause photosensitivity in some individuals. Molecular formula C₁₆H₁₄O₂. Chalcones are α,β-unsaturated carbonyl compounds (open-ring flavonoid precursors). The (2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one structure provides potential antioxidant and anti-inflammatory bioactivity

⚠️
Concern Level: High

Frequently Asked Questions

Is Methoxychalcone safe in cosmetics?

Limited toxicological data in cosmetic context; chalcones as a class show generally favorable safety profiles but may cause photosensitivity in some individuals. Molecular formula C₁₆H₁₄O₂. Chalcones are α,β-unsaturated carbonyl compounds (open-ring flavonoid precursors). The (2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one structure provides potential antioxidant and anti-inflammatory bioactivity The EU classifies Methoxychalcone as "permitted". Safety rating: MODERATE.

Is Methoxychalcone allowed in the EU?

Methoxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methoxychalcone do in cosmetics?

Methoxychalcone functions as: Skin conditioning (chalcones are known for antioxidant/anti-inflammatory properties). It is classified as a cosmetic ingredient in our database. CAS number: 22252-15-9 (4-Methoxychalcone confirmed via PubChem; EC number 213-499-7).

What is the Margin of Safety for Methoxychalcone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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