NOAEL Studies
Cosmetic Ingredient
Methoxyethanol NOAEL Studies
INCI: METHOXYETHANOL
CAS: 109-86-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 MADL | SQEoral=63 | ug/day | - | - | 1989-01-01 | Maximum allowable dose level | {"cancer_reproductive":"developmental, male","listed_date":"1989-01-01","listing_mechanism":"SQE","madl":"oral=63","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | SQEoral=63 | ug/day | - | - | 1989-01-01 | Maximum allowable dose level | {"cancer_reproductive":"developmental, male","listed_date":"1989-01-01","listing_mechanism":"SQE","madl":"oral=63","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | SQEoral=63 | ug/day | - | - | 1989-01-01 | Maximum allowable dose level | {"cancer_reproductive":"developmental, male","listed_date":"1989-01-01","listing_mechanism":"SQE","madl":"oral=63","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | SQEoral=63 | ug/day | - | - | 1989-01-01 | Maximum allowable dose level | {"cancer_reproductive":"developmental, male","listed_date":"1989-01-01","listing_mechanism":"SQE","madl":"oral=63","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental, male | listing type | - | - | 1989-01-01 | California Proposition 65 listing | {"cancer_reproductive":"developmental, male","listed_date":"1989-01-01","listing_mechanism":"SQE","madl":"oral=63","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental, male | listing type | - | - | 1989-01-01 | California Proposition 65 listing | {"cancer_reproductive":"developmental, male","listed_date":"1989-01-01","listing_mechanism":"SQE","madl":"oral=63","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental, male | listing type | - | - | 1989-01-01 | California Proposition 65 listing | {"cancer_reproductive":"developmental, male","listed_date":"1989-01-01","listing_mechanism":"SQE","madl":"oral=63","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEdevelopmental, male | listing type | - | - | 1989-01-01 | California Proposition 65 listing | {"cancer_reproductive":"developmental, male","listed_date":"1989-01-01","listing_mechanism":"SQE","madl":"oral=63","nsrl":null,"source_table":"prop65_listings"} |
EFSA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =6 | mg/kg bw/day | Rat | - | - | chronic/long term toxicity | EFSA CEF - 2011 - OutputID 2078 - Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87. - doi:10.2903/j.efsa.2011.1924 |
| EFSA | NOAEL | =6 | mg/kg bw/day | Rat | - | - | chronic/long term toxicity | EFSA CEF - 2011 - OutputID 2078 - Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87. - doi:10.2903/j.efsa.2011.1924 |
| EFSA | NOAEL | =6 | mg/kg bw/day | Rat | oral | - | chronic | LONG_REF=EFSA CEF (2011). Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87. doi:10.2903/j.efsa.2011.1924.; TITLE=Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2011.1924; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=EFSA:15622609:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7f06ae40db063ed4532fbd9fa355980 |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL (HEC) | =17 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=37cb8ef2153fab2f; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 1.7e1 mg/m^3; system=Reproductive; basis=Testicular effects; point_of_departure=NOAEL (HEC): 1.7e1 mg/m^3; composite_uf=1000; confidence=Medium; dtxsid=DTXSID5024182; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=525; rfc_last_updated=05/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0525_summary.pdf |
| Regulatory source | RfC | =0.02 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=e7d8f6f1be36dc8c; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=2e-2; system=Reproductive; basis=Testicular effects; point_of_departure=NOAEL (HEC): 1.7e1 mg/m^3; composite_uf=1000; confidence=Medium; dtxsid=DTXSID5024182; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=525; rfc_last_updated=05/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0525_summary.pdf |
WHO/JECFA 42 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOEL | =31.25 | mg/kg bw/day | Rat; Mouse; Monkey | oral | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=1bb29da41d17a46b; raw_unit=mg/kg per day; context=The lowest-observed-effect level (LOEL) for oral administration of 2-ME was 31.25 mg/kg per day for mice, 25 mg/kg per day for rats, and 0.16 mmol/kg per day for monkeys. |
| WHO/JECFA | LOEL | =31.25 | mg/kg bw/day | Rat; Mouse; Monkey | oral | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=1bb29da41d17a46b; raw_unit=mg/kg per day; context=The lowest-observed-effect level (LOEL) for oral administration of 2-ME was 31.25 mg/kg per day for mice, 25 mg/kg per day for rats, and 0.16 mmol/kg per day for monkeys. |
| WHO/JECFA | NOEL | =31 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=5c8bcd4b8ddeaaee; raw_unit=mg/m 3; context=For all three species, the NOEL for developmental effects was 31 mg/m 3 . |
| WHO/JECFA | NOEL | =31 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=5c8bcd4b8ddeaaee; raw_unit=mg/m 3; context=For all three species, the NOEL for developmental effects was 31 mg/m 3 . |
| WHO/JECFA | NOEL | =37 | mg/m3 | Rat; Rabbit | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=8c11c0f1e5789a99; raw_unit=mg/m 3; context=NOEL values for developmental effects were 37 mg/m 3 for rats and 184 mg/m 3 for rabbits. |
| WHO/JECFA | NOEL | =37 | mg/m3 | Rat; Rabbit | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=8c11c0f1e5789a99; raw_unit=mg/m 3; context=NOEL values for developmental effects were 37 mg/m 3 for rats and 184 mg/m 3 for rabbits. |
| WHO/JECFA | NOEL | =50 | mg/kg bw | - | - | 11 days | Acute toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=a8e492f331edb3c5; raw_unit=mg/kg; context=The NOEL in a sub- acute (11 days) study was 50 mg/kg. |
| WHO/JECFA | NOEL | =50 | mg/kg bw | - | - | 11 days | Acute toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=a8e492f331edb3c5; raw_unit=mg/kg; context=The NOEL in a sub- acute (11 days) study was 50 mg/kg. |
| WHO/JECFA | NOEL | =93 | mg/m3 | Rabbit | inhalation | 13 weeks | Subchronic toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=e65ffdeb6ccdadd2; raw_unit=mg/m 3; context=Repeated inhalation exposure of the most sensitive species, the rabbit, to 2-ME for 13 weeks, 5 times per week, yielded a NOEL of 93 mg/m 3 . |
| WHO/JECFA | NOEL | =93 | mg/m3 | Rabbit | inhalation | 13 weeks | Subchronic toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=e65ffdeb6ccdadd2; raw_unit=mg/m 3; context=Repeated inhalation exposure of the most sensitive species, the rabbit, to 2-ME for 13 weeks, 5 times per week, yielded a NOEL of 93 mg/m 3 . |
| WHO/JECFA | NOEL | =93.3 | mg/m3 | Rabbit | - | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=b7cca9b789a2b9fa; raw_unit=mg/m 3; context=A NOEL could not be ident- ified, but 93.3 mg/m 3 was near the minimal effective dose in rabbits. |
| WHO/JECFA | NOEL | =93.3 | mg/m3 | Rabbit | - | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=b7cca9b789a2b9fa; raw_unit=mg/m 3; context=A NOEL could not be ident- ified, but 93.3 mg/m 3 was near the minimal effective dose in rabbits. |
| WHO/JECFA | NOEL | =100 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=df7ba566baec9752; raw_unit=mg/kg; context=In this study, the NOEL for the single ex- posure (day 11) was 100 mg/kg. |
| WHO/JECFA | NOEL | =100 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=df7ba566baec9752; raw_unit=mg/kg; context=In this study, the NOEL for the single ex- posure (day 11) was 100 mg/kg. |
| WHO/JECFA | NOEL | =125 | mg/kg bw/day | Mouse | oral | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=87f6a2f17ef96a37; raw_unit=mg/kg per day; context=In this gavage study using mice, (2-ME was administered on days 7 to 14 of gestation), the NOEL for maternal toxicity was 125 mg/kg per day. |
| WHO/JECFA | NOEL | =125 | mg/kg bw/day | Mouse | oral | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=87f6a2f17ef96a37; raw_unit=mg/kg per day; context=In this gavage study using mice, (2-ME was administered on days 7 to 14 of gestation), the NOEL for maternal toxicity was 125 mg/kg per day. |
| WHO/JECFA | NOEL | =135 | mg/m3 | Rabbit | inhalation | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=c62b29d1ac7b517b; raw_unit=mg/m 3; context=Inhalation exposure of rabbits to 2-EEA on gestation days 6-18 produced teratogenic responses at 2176 mg/m 3 and 544 mg/m 3 in two different studies, the developmental NOEL values in these two studies being 135 mg/m 3 and 270 mg/m 3 . |
| WHO/JECFA | NOEL | =135 | mg/m3 | Rabbit | inhalation | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=c62b29d1ac7b517b; raw_unit=mg/m 3; context=Inhalation exposure of rabbits to 2-EEA on gestation days 6-18 produced teratogenic responses at 2176 mg/m 3 and 544 mg/m 3 in two different studies, the developmental NOEL values in these two studies being 135 mg/m 3 and 270 mg/m 3 . |
| WHO/JECFA | NOEL | =170 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=9f704b4ad3245561; raw_unit=mg/m 3; context=The developmental NOEL was 170 mg/m 3 . |
| WHO/JECFA | NOEL | =170 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=9f704b4ad3245561; raw_unit=mg/m 3; context=The developmental NOEL was 170 mg/m 3 . |
| WHO/JECFA | NOEL | =184 | mg/m3 | Rabbit | - | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=d89f9002152c17c8; raw_unit=mg/m 3; context=In this study the author considered the NOEL in rabbits to be 184 mg/m 3 for 2-EE and 135 mg/m 3 for 2-EEA. |
| WHO/JECFA | NOEL | =184 | mg/m3 | Rabbit | - | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=d89f9002152c17c8; raw_unit=mg/m 3; context=In this study the author considered the NOEL in rabbits to be 184 mg/m 3 for 2-EE and 135 mg/m 3 for 2-EEA. |
| WHO/JECFA | NOEL | =250 | mg/kg bw | - | - | 11 days | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=81ff29cf1d7b5237; raw_unit=mg/kg; context=Similar effects were seen at dose levels of 500 mg 2-EE/kg or more, given for up to 11 days, the NOEL for 11-day treatment being 250 mg/kg. |
| WHO/JECFA | NOEL | =250 | mg/kg bw | - | - | 11 days | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=81ff29cf1d7b5237; raw_unit=mg/kg; context=Similar effects were seen at dose levels of 500 mg 2-EE/kg or more, given for up to 11 days, the NOEL for 11-day treatment being 250 mg/kg. |
| WHO/JECFA | NOEL | =270 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=714ebbc30f8e068a; raw_unit=mg per m 3; context=An exposure of 270 mg per m 3 was considered a NOEL in both species, no evi- dence of maternal or developmental toxicity being reported at this dose. |
| WHO/JECFA | NOEL | =270 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=714ebbc30f8e068a; raw_unit=mg per m 3; context=An exposure of 270 mg per m 3 was considered a NOEL in both species, no evi- dence of maternal or developmental toxicity being reported at this dose. |
| WHO/JECFA | NOEL | =311 | mg/m3 | Rat; Mouse | - | 13 weeks | Subchronic toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=f92814b28f87ea12; raw_unit=mg/m 3; context=NOEL values were 311 mg/m 3 in rats following exposure for 13 weeks (6 h/day, 5 day/week) and 933 mg/m 3 (6 h/day) in mice fol- lowing exposure on 9 occasions over 11 days. |
| WHO/JECFA | NOEL | =311 | mg/m3 | Rat; Mouse | - | 13 weeks | Subchronic toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=f92814b28f87ea12; raw_unit=mg/m 3; context=NOEL values were 311 mg/m 3 in rats following exposure for 13 weeks (6 h/day, 5 day/week) and 933 mg/m 3 (6 h/day) in mice fol- lowing exposure on 9 occasions over 11 days. |
| WHO/JECFA | NOEL | =368 | mg/m3 | Rat; Rabbit | - | 13 weeks | Subchronic toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=442181de0b4a0d2d; raw_unit=mg/m 3; context=The NOEL for haemato- logical effects in rats and rabbits exposed to 2-EE for 13 weeks, 5 times per week for 6 h/day, is 368 mg/m 3 . |
| WHO/JECFA | NOEL | =368 | mg/m3 | Rat; Rabbit | - | 13 weeks | Subchronic toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=442181de0b4a0d2d; raw_unit=mg/m 3; context=The NOEL for haemato- logical effects in rats and rabbits exposed to 2-EE for 13 weeks, 5 times per week for 6 h/day, is 368 mg/m 3 . |
| WHO/JECFA | NOEL | =478 | mg/m3 | Rat | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=b7cd7e87643f64a0; raw_unit=mg/m 3; context=08 mg 2-EE/m 3 on gestation days 7-15 (7 h/day), Nelson et al. (1984b) reported complete resorption of all rat fetuses at 2208 mg/m 3 , reduced fetal weight at 1435 mg/m 3 , and a NOEL of 478 mg/m 3 . |
| WHO/JECFA | NOEL | =478 | mg/m3 | Rat | - | - | Developmental toxicity | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=b7cd7e87643f64a0; raw_unit=mg/m 3; context=08 mg 2-EE/m 3 on gestation days 7-15 (7 h/day), Nelson et al. (1984b) reported complete resorption of all rat fetuses at 2208 mg/m 3 , reduced fetal weight at 1435 mg/m 3 , and a NOEL of 478 mg/m 3 . |
| WHO/JECFA | NOEL | =933 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=46377cd850b547ef; raw_unit=mg/m 3; context=The NOEL was 933 mg/m 3 . |
| WHO/JECFA | NOEL | =933 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc115; title=Methoxyethanol, 2- Ethoxyethanol, 2- and their acetates (EHC 115, 1990); path=mirror/documents/ehc/ehc/ehc115.htm; row_hash=46377cd850b547ef; raw_unit=mg/m 3; context=The NOEL was 933 mg/m 3 . |
| WHO/JECFA | ADI | =5 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v48je14; title=BENZYL DERIVATIVES (JECFA Food Additives Series 48); path=mirror/documents/jecfa/jecmono/v48je14.htm; row_hash=2996d1dbbcb136ff; raw_unit=mg/kg bw; context=A group ADI of 0–5 mg/kg bw was confirmed by the Committee at its forty-sixth meeting (Annex 1, reference 122) and maintained at the present meeting. d Further information is required to determine whether this substance is currently in use as a flavouring agent. |
| WHO/JECFA | ADI | =5 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v48je14; title=BENZYL DERIVATIVES (JECFA Food Additives Series 48); path=mirror/documents/jecfa/jecmono/v48je14.htm; row_hash=2996d1dbbcb136ff; raw_unit=mg/kg bw; context=A group ADI of 0–5 mg/kg bw was confirmed by the Committee at its forty-sixth meeting (Annex 1, reference 122) and maintained at the present meeting. d Further information is required to determine whether this substance is currently in use as a flavouring agent. |
| WHO/JECFA | NOEL | =6 | mg/kg bw/day | Rat | - | two-generation | Reproductive toxicity | document_id=jecfa_jecmono_v48je14; title=BENZYL DERIVATIVES (JECFA Food Additives Series 48); path=mirror/documents/jecfa/jecmono/v48je14.htm; row_hash=95430d50f219f15c; raw_unit=mg/kg bw per day; context=A two-generation study of reproductive toxicity with methoxyethanol in rats with a NOEL of 6 mg/kg bw per day provides a safety margin > 10 000 (Gulati et al., 1990a,b). |
| WHO/JECFA | NOEL | =6 | mg/kg bw/day | Rat | - | two-generation | Reproductive toxicity | document_id=jecfa_jecmono_v48je14; title=BENZYL DERIVATIVES (JECFA Food Additives Series 48); path=mirror/documents/jecfa/jecmono/v48je14.htm; row_hash=95430d50f219f15c; raw_unit=mg/kg bw per day; context=A two-generation study of reproductive toxicity with methoxyethanol in rats with a NOEL of 6 mg/kg bw per day provides a safety margin > 10 000 (Gulati et al., 1990a,b). |
| WHO/JECFA | NOEL | =12 | mg/kg bw/day | Rat; Mouse; Rabbit; Monkey | oral | - | Toxicology study | document_id=kemi_kemi_ah1999_13; title=Criteria Document for Swedish Occupational Standards. Ethylene glycol monomethyl ether and ethylene glycol monomethyl ether acetate; path=mirror/documents/kemi/kemi/ah1999_13.pdf; row_hash=2aafec709d57a1b1; raw_unit=mg/kg/d; context=The oral gavage data in Table 1 suggest a NOEL of 12 mg/kg/d for male rabbits, whereas no NOELs can be identified for monkeys, rats, and mice. |
| WHO/JECFA | NOEL | =12 | mg/kg bw/day | Rat; Mouse; Rabbit; Monkey | oral | - | Toxicology study | document_id=kemi_kemi_ah1999_13; title=Criteria Document for Swedish Occupational Standards. Ethylene glycol monomethyl ether and ethylene glycol monomethyl ether acetate; path=mirror/documents/kemi/kemi/ah1999_13.pdf; row_hash=2aafec709d57a1b1; raw_unit=mg/kg/d; context=The oral gavage data in Table 1 suggest a NOEL of 12 mg/kg/d for male rabbits, whereas no NOELs can be identified for monkeys, rats, and mice. |
| WHO/JECFA | NOEL | =12 | mg/kg bw/day | Rat; Mouse; Rabbit; Monkey | oral | - | Toxicology study | document_id=kemi_kemi_ah1999_13; title=Criteria Document for Swedish Occupational Standards. Ethylene glycol monomethyl ether and ethylene glycol monomethyl ether acetate; path=mirror/documents/kemi/kemi/ah1999_13.pdf; row_hash=2aafec709d57a1b1; raw_unit=mg/kg/d; context=The oral gavage data in Table 1 suggest a NOEL of 12 mg/kg/d for male rabbits, whereas no NOELs can be identified for monkeys, rats, and mice. |
| WHO/JECFA | NOEL | =12 | mg/kg bw/day | Rat; Mouse; Rabbit; Monkey | oral | - | Toxicology study | document_id=kemi_kemi_ah1999_13; title=Criteria Document for Swedish Occupational Standards. Ethylene glycol monomethyl ether and ethylene glycol monomethyl ether acetate; path=mirror/documents/kemi/kemi/ah1999_13.pdf; row_hash=2aafec709d57a1b1; raw_unit=mg/kg/d; context=The oral gavage data in Table 1 suggest a NOEL of 12 mg/kg/d for male rabbits, whereas no NOELs can be identified for monkeys, rats, and mice. |
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 4.6655 | mg/L | - | Inhalation | Duration=7 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2869; Record_ID=acute_inhalation_1161; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5024182; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.6655; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024182 |
| NTP ICE acute inhalation | LC50 | range12 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2871; Record_ID=acute_inhalation_2932; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5024182; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>12 and 18<; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/3/3/?documentUUID=c451920b-af12-4a3e-ac7a-af853b69b435; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024182 |
| NTP ICE acute inhalation | LC50 | >15.8 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2870; Record_ID=acute_inhalation_2574; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5024182; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=15.8; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/3/3/?documentUUID=79047d4a-75a5-4950-9892-36fd136ec962; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024182 |
NTP ICE acute oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =2257 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_874; row=8805; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methoxyethanol; preferred_name=2-Methoxyethanol; dtxsid=DTXSID5024182; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5024182; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2370 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_875; row=8806; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methoxyethanol; preferred_name=2-Methoxyethanol; dtxsid=DTXSID5024182; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5024182; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2460 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_876; row=8804; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methoxyethanol; preferred_name=2-Methoxyethanol; dtxsid=DTXSID5024182; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5024182; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_877; row=8803; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methoxyethanol; preferred_name=2-Methoxyethanol; dtxsid=DTXSID5024182; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5024182; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3930 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_878; row=8802; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methoxyethanol; preferred_name=2-Methoxyethanol; dtxsid=DTXSID5024182; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5024182; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2570; RecordID=ARPathway2016_533; DatasetName=ARPathway2016; DTXSID=DTXSID5024182; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024182; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024182 |
EPA ToxRefDB v3 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =71 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5530; toxval_study_source_id=studyid5530_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-testes-degeneration|organ weight-thymus-absolute|organ weight-epididymis-nos|in life observation-body weight-body weight|organ weight-testes-relative to body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology gross-sperm measure-sperm count|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|pathology gross-testes-reduced size|clinical chemistry-bile acids-bile acids|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|clinical chemistry-protein-protein|hematology-hematocrit (hct)-hematocrit (hct)|organ weight-testes-absolute|pathology microscopic-spleen-fibrosis|urinalysis-volume-volume|urinalysis-specific gravity/osmolality-specific gravity/osmolality|hematology-lymphocyte-lymphocyte|hematology-neutrophils-neutrophils|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-thymus-relative to body weight|clinical chemistry-albumin-albumin|clinical chemistry-creatinine-creatinine|pathology microscopic-bone marrow-depletion cellular|pathology microscopic-spleen-atrophy|pathology microscopic-thymus-atrophy|pathology microscopic-prostate-atrophy|in life observation-mortality-mortality|pathology microscopic-preputial gland-atrophy|in life observation-water consumption-water consumption|pathology microscopic-bone-atrophy; dose_level=1; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME rat); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =135 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5530; toxval_study_source_id=studyid5530_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal; dose_level=2; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME rat); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =295 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5529; toxval_study_source_id=studyid5529_Adult_F0_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm count|pathology gross-sperm measure-sperm motility|organ weight-testes-relative to body weight|organ weight-testes-absolute|pathology microscopic-testes-degeneration|pathology microscopic-spleen-hematopoietic cell proliferation|pathology gross-testes-reduced size|organ weight-epididymis-nos|pathology gross-thymus-reduced size|pathology microscopic-thymus-atrophy|organ weight-thymus-absolute|in life observation-body weight-body weight gain|organ weight-thymus-relative to body weight; dose_level=1; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME mouse); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =492 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5529; toxval_study_source_id=studyid5529_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal; dose_level=1; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME mouse); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =165 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5530; toxval_study_source_id=studyid5530_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|organ weight-testes-relative to body weight|pathology gross-sperm measure-sperm count|pathology microscopic-testes-degeneration|pathology gross-testes-reduced size|organ weight-testes-absolute|pathology microscopic-spleen-fibrosis; dose_level=2; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME rat); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =529 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5529; toxval_study_source_id=studyid5529_Adult_F0_M_systemic; toxval_effect_list=organ weight-testes-relative to body weight|pathology gross-sperm measure-sperm count|organ weight-testes-absolute|pathology microscopic-testes-degeneration|pathology microscopic-spleen-hematopoietic cell proliferation; dose_level=2; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME mouse); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =902 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5529; toxval_study_source_id=studyid5529_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-hematopoietic cell proliferation; dose_level=2; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME mouse); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=5529; toxval_study_source_id=studyid5529_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal; dose_level=0; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME mouse); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =70 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=5530; toxval_study_source_id=studyid5530_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal; dose_level=1; study_year=1993; study_citation=Dieter, M. (1993). 'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats and Mice.' Toxic Rep Ser 26: 1-G15. (2-ME rat); dsstox_substance_id=DTXSID5024182; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | NOAEL | =9.33686 | mg/m3 | Rabbit | inhalation | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Hanley TR Jr, Yano BL, Nitschke KD, John JA. Comparison of the teratogenic potential of inhaled ethylene glycol monomethyl ether in rats, mice, and rabbits. Toxicol Appl Pharmacol 1984;75:409-422.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=gross soft tissue and skeletal teratogenic effects and significantly decreased fetal body weights; STUDY_GROUP=Cal OEHHA REL derivations:15951932:F:-pregnant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b94b52b13b95f25f81f93569a784193a |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =93.3686 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller RR, Ayres JA, Young JT, and McKenna MJ. 1983. Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits. Fundam. Appl. Toxicol. 3:49-54.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Decreased testes weight and degenerative changes in the testicular germinal epithelium.; STUDY_GROUP=Cal OEHHA REL derivations:15952066:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a30bdfec018dfeb7e755385f4a85c2b9 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =56021.1 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15515445:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76fbadaf2abbc58aa15a3e561d300af8 |
ECHA 46 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | BMDL (10) | =25 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/10/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15825523:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_446553b40acb13df5e270ad09a8495c8 |
| ECHA | LEL | ~950 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/3/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796285_15796286_15799548_15799549:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aacf812ba00eccf127f4adf4c51435c8 |
| ECHA | LOAEC | =311.229 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829044_15829045:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e8699ef400adb1b85d6d9cf3d7abbdaf |
| ECHA | LOAEC | =933.686 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829046_15829047:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa9fd3038f3a20bb59f24cf52d5175d2 |
| ECHA | LOAEL | =25 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b564b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856268_15862117:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_81535fe875cacdcb2ee409927ffdd3f7 |
| ECHA | LOAEL | =100 | ppm | Rat | oral | short-term; 5 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0ee4b0a7c65d2201a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830493_15830494_15837618_15837619:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3e0fb8c967e04908cbfc37952b84a00 |
| ECHA | LOAEL | =114 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0d86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14177/7/6/2?documentUUID=50654057-4884-437a-abd4-8e14330da1c5; YEAR=2020; ORIGINAL_YEAR=2020; STUDY_GROUP=ECHA IUCLID:15850300:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ac679e8485a1378d504f89bf50226915 |
| ECHA | LOAEL | =933.686 | mg/m3 | Rat | inhalation | short-term; 10 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827210_15827211:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_295d5372429b83a50b93aa0f1adb981a |
| ECHA | LOAEL | =1000 | mg/kg bw/day | Rat | dermal | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f71e4b096bca877d800; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/4?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826845_15826846_15826847:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40d1d5020df1377955acecce017fedd3 |
| ECHA | LOAEL | =1556.14 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d21927c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855823_15856572:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c14d226dca59804b6b2162ee6b0be8f2 |
| ECHA | LOAEL | =3112.29 | mg/m3 | Mouse | inhalation | short-term; 9 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fd3e4b096bca877ef62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827073_15827075:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5964a6ee43fd67fe080972a6e1244324 |
| ECHA | NOAEC | =31.1229 | mg/m3 | Rabbit | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22f00b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECHA IUCLID:15822691:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be2141aa046db4ee334566c40e6049af |
| ECHA | NOAEC | =311.229 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15827958:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c06c1806bb97314bac8893cceb4b4d24 |
| ECHA | NOAEL | =9.33686 | mg/m3 | Rabbit | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22f00b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821384:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7463aba416ce0f570c7ad22538e53d33 |
| ECHA | NOAEL | <12 | mg/kg bw/day | Monkey | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22effd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821005:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b13fb7739c800659a688f694a5f18c33 |
| ECHA | NOAEL | =12.5 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb759; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15823974:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_09dbe89903e0bc80669aaff56d561a21 |
| ECHA | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb73d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822223_15822554_15823967_15823968_15823969_15823970:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_12b1de3cdab2b0e61629a6ab41cf1df1 |
| ECHA | NOAEL | =31.1229 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22efb1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820586_15821865:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d3eec34a349fa3ccac90fe10421503ed |
| ECHA | NOAEL | <32.5 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb74d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821344_15825389:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3ac0ed2ecc76965dd233e42f91ebfcfd |
| ECHA | NOAEL | =43 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca19e4b0a7c65d2202c7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846556_15846557:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_35a17e1b866b2036d1b9a094d17486fe |
| ECHA | NOAEL | <50 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb745; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15822117:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c10f8336ab654f9a554da241c392b201 |
| ECHA | NOAEL | <50 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb761; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820970_15825438:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d1ad035b46fde273c593bc6491925b31 |
| ECHA | NOAEL | <62.5 | mg/kg bw/day | Hamster | oral | subchronic; 5 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0ee4b0a7c65d22019c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837376_15837377:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f17bc96bff62eba4bd04bba51bd36ed |
| ECHA | NOAEL | =70 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22f003; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821344_15825389:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_59360edd106693deb02aefbc133153d7 |
| ECHA | NOAEL | <77.8071 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22efeb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15822274:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ff5e174d4ec6c4d1422652b8d506f08b |
| ECHA | NOAEL | =100 | ppm | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb763; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821779:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_91791a8c6161c8ad482a446744a9a408 |
| ECHA | NOAEL | =100 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb75b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820622_15820895_15821770_15823971_15823972:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2f6dc59c5a7418a3c3ec7aa262bf1763 |
| ECHA | NOAEL | =125 | mg/kg bw/day | Mouse | oral | subchronic; 5 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1175; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842675_15850380:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_41ced9d532f4fd221f274dcf38ec2b2c |
| ECHA | NOAEL | <150 | ppm | Rat | oral | short-term; 5 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0fe4b0a7c65d2201c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841760_15841761:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c33e4e5d161cceac4d137f6b1f3b2727 |
| ECHA | NOAEL | <155.614 | mg/m3 | Rat | inhalation | short-term; 2 weeks | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828185_15828186_15829203_15829204:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41f1f50a1e36fe32afc49ee2b2acbe81 |
| ECHA | NOAEL | <161 | ppm | Rat | oral | short-term; 21 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0ee4b0a7c65d220147; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15836237:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d0166106a8fcd4e547e4bb5ef010d8d |
| ECHA | NOAEL | <165 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb753; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15822597:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c7f012368b60f777587d5aae251cecb |
| ECHA | NOAEL | <200 | ppm | Rat | oral | short-term; 21 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca0ee4b0a7c65d220147; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15836238:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aa4ac1f7eabec6f7577b1505ad706d84 |
| ECHA | NOAEL | <200 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b563f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857230_15862522_15862523:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b7d88ab16fb6d58c495bc91dfbce73f |
| ECHA | NOAEL | <250 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb749; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820622_15820895_15821770_15823971_15823972:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f536843c9136c0e8bbb94d108839c52c |
| ECHA | NOAEL | =250 | ppm | Rat | dermal | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22f01c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822790_15823010:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_608f1ad662347862a220596824d26bac |
| ECHA | NOAEL | <300 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22efef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820970_15825438:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b1d2b0869de3a2c0a8b5d8e772e3e9b4 |
| ECHA | NOAEL | <304 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22efb5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820622_15820895_15821770_15823971_15823972:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3b88974080e468d77729028263d8b3d |
| ECHA | NOAEL | <311.229 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22f02f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821918:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a048472f01a57362fdf57a1028c3604a |
| ECHA | NOAEL | <500 | ppm | Rat | oral | acute; 1 days | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca19e4b0a7c65d2202c4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846434_15846435:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1b29d452c7ef533b4f0666f3a07585f |
| ECHA | NOAEL | =933.686 | mg/m3 | Mouse | inhalation | short-term; 9 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fd3e4b096bca877ef62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827073_15827075:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bea86695491be2f36769d7dd3069b39a |
| ECHA | NOAEL | =1250 | mg/kg bw/day | Rat | dermal | chronic; 14 weeks | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774f65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/6/4?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15826089:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_778c12397bb616a20cc48e2e720b4ff5 |
| ECHA | NOAEL | <1400 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22f01f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820622_15820895_15821770_15823971_15823972:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aecf6b9ff4344e2e048e0a748884abae |
| ECHA | NOAEL | <2000 | ppm | Rat | dermal | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22f017; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/3?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822790_15823010:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e0fd10ff4529865d766049d863ea728 |
| ECHA | NOAEL | <3112.29 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d219274; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857167_15857565_15857716:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fd5aa6c04a12449a68c0a84e2fdb48af |
| ECHA | NOAEL | <23342.1 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c891e4b0a7c65d219202; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14919/7/9/2?documentUUID=1eeea906-3a70-42ab-b9eb-08849269e4f6; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857167_15857565_15857716:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_955be1abe51e46dd772d9bf8c8addf39 |
ToxValDB ECOTOX 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.1 | % | Mouse | oral | chronic; 361 days | chronic | LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594927_15594928_15599569_15604363:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=578d0f45c92be9bb28af1532269a04c7 |
| ToxValDB ECOTOX | LOEL | =0.2 | % | Mouse | oral | chronic; 361 days | chronic | LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594927_15594928_15599569_15604363:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d7eac12d2665ff74e8950586ef26d6b7 |
| ToxValDB ECOTOX | LOEL | =300 | mg/kg bw/day | Rat | oral | short-term; 4 days | short-term | LONG_REF=Toxicol. Sci.121(2): 267-278 Taketa,Y., M. Yoshida, K. Inoue, M. Takahashi, Y. Sakamoto, G. Watanabe, K. Taya, J. Yamate, and A. Nishikawa Differential Stimulation Pathways of Progesterone Secretion from Newly Formed Corpora Lutea in Rats Treated with Ethylene Glycol Monomethyl Ether, Sulpiride, or Atrazine 2011; TITLE=Differential Stimulation Pathways of Progesterone Secretion from Newly Formed Corpora Lutea in Rats Treated with Ethylene Glycol Monomethyl Ether, Sulpiride, or Atrazine; AUTHOR=Taketa,Y., M. Yoshida, K. Inoue, M. Takahashi, Y. Sakamoto, G. Watanabe, K. Taya, J. Yamate, and A. Nishikawa; DOI=10.1093/toxsci/kfr062; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=165431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Genetics: Steroidogenic Acute Regulatory protein mRNA|Hormone(s): Progesterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597948_15597949:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6b13dfdb0c4b8bdfb54b969f88368e67 |
| ToxValDB ECOTOX | NOEL | =0.03 | % | Mouse | oral | chronic; 361 days | chronic | LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594927_15594928_15599569_15604363:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6230e7f4a2c4cad253c6a32a3e64b738 |
| ToxValDB ECOTOX | NOEL | =0.3 | % | Mouse | oral | chronic; 147 days | chronic | LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15601034:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=96b7e703d72fb59f3828a3773bbcaaa6 |
| ToxValDB ECOTOX | NOEL | =400 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin|Enzyme(s): beta-N-Acetylhexosaminidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15601721:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=40e17ebbda34ed91142da8550f146fa8 |
ToxValDB EPA HWIR 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA HWIR | NOAEL (HEC) | =17 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller, R.R., J.A. Ayres, J.T. Young, and M.J. McKenna. 1983. Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits. Fund Appl Toxicol 3(1):49-54.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/683eef73e4b096bca883dd65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/html/risk.html; SUBSOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/pdf/r99019b.pdf; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=testicular effects; STUDY_GROUP=EPA HWIR:15952209:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_90311260cd9a1998a84d0ffe96e07374 |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | NOAEL | =7.15826 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=Shih TS, Hsieh AT, Chen YH, Liao GD, Chen CY, Chou JS, Liou SH (2003) Follow up study of haematological effects in workers exposed to 2-methoxyethanol. Occup Environ Med 60:130-135. Shih TS, Liou SH, Chen CY, Chou JS (1999) Correlation between urinary 2-methoxyacetic acid and exposure of 2-methoxyethanol. Occup Environ Med 56:674-67; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d350f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/168_methoxyethanol_methoxyethylacetate_oel_en.pdf; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=haematologic effects; STUDY_GROUP=EU SCOEL:15952281:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_45a917846eb6ba7f630483215cdaec31 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.31 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633263:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a5260ccd3aeaf0c39f0974a2c8b6bbd |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | =70 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e16e4b0a676289df693; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical observation: tremors|Clinical observation: Diarrhea|Clinical observation: emaciation|Clinical observation: abnormal posture|Clinical observation: pallor|Clinical observation: tachypnea|Clinical observation: comatose state|Hematology: Hct decrease (males)|Hematology: Hgb decrease|Hematology: Plt decrease|Hematology: RBC decrease (males)|Hematology: Ret decrease (males)|Hematology: WBC decrease (females)|Hematology: Lymph decrease (females)|Blood chemistry: TP decrease|Blood chemistry: Alb decrease (males)|Blood chemistry: bile acid increase (males)|Absolute organ weight: Thymus decrease|Relative organ weight: Thymus decrease (females)|Histopathology: Spleen-Capsular fibrosis (males)|Histopathology: Testes-atrophy (males)|Reproductive tissue evaluation: Spermatozoal measurements-Motility decrease (males)|Reproductive tissue evaluation: Spermatid measurements-Spermatid count decrease (males); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|hematology|nonneoplastic histopathology|organ weight|other|reproduction; STUDY_GROUP=HESS:15638947:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_47016be52cd109ff8a02260ed5e2f453 |
ToxValDB IRIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =311 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller, R.R., J.A. Ayres, J.T. Young and M.J. McKenna. 1983. Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits. Fund. Appl. Toxicol. 3(1): 49- 54.; TITLE=Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits; AUTHOR=Miller, R.R., J.A. Ayres, J.T. Young and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=525; TOXICOLOGICAL_EFFECT=testicular effects; STUDY_GROUP=IRIS_dup_IRIS Summary_15644145_15644146_15644147_15644148_15644149_15644150:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_88b62b3a1fd7a98146c899eb2d0984a8 |
| ToxValDB IRIS | LOAEL (ADJ) | =56 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller, R.R., J.A. Ayres, J.T. Young and M.J. McKenna. 1983. Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits. Fund. Appl. Toxicol. 3(1): 49- 54.; TITLE=Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits; AUTHOR=Miller, R.R., J.A. Ayres, J.T. Young and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=525; TOXICOLOGICAL_EFFECT=testicular effects; STUDY_GROUP=IRIS_dup_IRIS Summary_15644145_15644146_15644147_15644148_15644149_15644150:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5307649a9983b65fc08a868e67282756 |
| ToxValDB IRIS | NOAEL | =93 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller, R.R., J.A. Ayres, J.T. Young and M.J. McKenna. 1983. Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits. Fund. Appl. Toxicol. 3(1): 49- 54.; TITLE=Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits; AUTHOR=Miller, R.R., J.A. Ayres, J.T. Young and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=525; TOXICOLOGICAL_EFFECT=testicular effects; STUDY_GROUP=IRIS_dup_IRIS Summary_15644145_15644146_15644147_15644148_15644149_15644150:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_17dedd78bf09733eddba72dbeefce890 |
| ToxValDB IRIS | RfC | =0.02 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Miller, R.R., J.A. Ayres, J.T. Young and M.J. McKenna. 1983. Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits. Fund. Appl. Toxicol. 3(1): 49- 54.; TITLE=Ethylene glycol monomethyl ether. I. Subchronic vapor inhalation study with rats and rabbits; AUTHOR=Miller, R.R., J.A. Ayres, J.T. Young and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=525; TOXICOLOGICAL_EFFECT=Testicular effects in male rabbits; STUDY_GROUP=IRIS:15644151:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a45501a4444f01e26c2d8c708f4be4c4 |
ToxValDB PPRTV (CPHEA) 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | BMCL (10 HEC) | =0.73 | mg/m3 | Rabbit | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller et al. 1983a; AUTHOR=Miller et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934af07; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1786; TOXICOLOGICAL_EFFECT=gross reduced testes size; STUDY_GROUP=PPRTV (CPHEA):15653304:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_15b90a227e19aef6051b406afc317cb7 |
| ToxValDB PPRTV (CPHEA) | BMDL (05) | =1.64 | mg/kg bw/day | Monkey | oral | short-term (developmental); 26 days | reproduction developmental | LONG_REF=Scott et al. 1989; AUTHOR=Scott et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934af07; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1786; TOXICOLOGICAL_EFFECT=embryo mortality; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=PPRTV (CPHEA):15653799:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5937df2ab9398dfea25e81464f809db8 |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.007 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Miller et al. 1983a; AUTHOR=Miller et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934af07; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1786; TOXICOLOGICAL_EFFECT=Gross reduction in male rabbits; STUDY_GROUP=PPRTV (CPHEA):15653303:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_87a08e7dbc96d75f3d57dfa287ffd3df |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Scott et al. 1989; AUTHOR=Scott et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934af07; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1786; TOXICOLOGICAL_EFFECT=Embryo lethality in female monkeys; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653393_15653481:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4c7cacce8f79fd5bace523927ae72502 |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.005 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650194:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6bd94b71e41572fde9051f6a3071402d |
ToxValDB ToxRefDB 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =71 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (2-ME rat); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5530; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-testes-degeneration|systemic: organ weight-thymus-absolute|systemic: in life observation-body weight-body weight|systemic: organ weight-testes-relative to body weight|systemic: clinical chemistry-bile acids-bile acids|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: clinical chemistry-protein-protein|systemic: pathology gross-sperm measure-sperm count|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: organ weight-testes-absolute|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: pathology gross-testes-reduced size|systemic: pathology microscopic-spleen-fibrosis|systemic: urinalysis-volume-volume|systemic: organ weight-epididymis-nos|systemic: clinical chemistry-albumin-albumin|systemic: clinical chemistry-creatinine-creatinine|systemic: hematology-neutrophils-neutrophils|systemic: hematology-lymphocyte-lymphocyte|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: organ weight-thymus-relative to body weight|systemic: pathology microscopic-preputial gland-atrophy|systemic: pathology microscopic-thymus-atrophy|systemic: pathology microscopic-prostate-atrophy|systemic: pathology microscopic-bone marrow-depletion cellular|systemic: in life observation-water consumption-water consumption|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-bone-atrophy|systemic: pathology microscopic-spleen-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15709503_15709504_15709505:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f1b29b8d3ef64d3ce719af0c49d3a57 |
| ToxValDB ToxRefDB | LEL | =135 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (2-ME rat); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5530; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709498_15709499:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db6e47c39253c9dfa1fc633ce6296d49 |
| ToxValDB ToxRefDB | LEL | =295 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (2-ME mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5529; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm count|systemic: pathology gross-sperm measure-sperm motility|systemic: organ weight-testes-relative to body weight|systemic: organ weight-testes-absolute|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: pathology microscopic-testes-degeneration|systemic: pathology gross-testes-reduced size|systemic: organ weight-epididymis-nos|systemic: pathology gross-thymus-reduced size|systemic: pathology microscopic-thymus-atrophy|systemic: organ weight-thymus-absolute|systemic: organ weight-thymus-relative to body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709495_15709496_15709497:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e854ff780b67db75912ded536c6eac0 |
| ToxValDB ToxRefDB | LEL | =492 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (2-ME mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5529; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB:15709491:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_011fc514e20a9808c6eb3b8dc048523c |
| ToxValDB ToxRefDB | LOAEL | =165 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (2-ME rat); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5530; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: organ weight-testes-relative to body weight|systemic: pathology gross-sperm measure-sperm count|systemic: pathology microscopic-testes-degeneration|systemic: organ weight-testes-absolute|systemic: pathology gross-testes-reduced size|systemic: pathology microscopic-spleen-fibrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709503_15709504_15709505:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b4bbe5e970b869d308d1987c6615c4f2 |
| ToxValDB ToxRefDB | LOAEL | =529 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (2-ME mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5529; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: organ weight-testes-relative to body weight|systemic: pathology gross-sperm measure-sperm count|systemic: organ weight-testes-absolute|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: pathology microscopic-testes-degeneration; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709495_15709496_15709497:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c88a474262fa4f742bcaadf3b0154972 |
| ToxValDB ToxRefDB | LOAEL | =902 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=Dieter, M. (1993). \'NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice.\' Toxic Rep Ser 26: 1-G15. (2-ME mouse); TITLE=NTP technical report on the tox studies of Ethylene Glycol Ethers: 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Admin in Drink Water to Rats & Mice; AUTHOR=Dieter, M; EXTERNAL_SOURCE_ID=5529; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hematopoietic cell proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709492_15709493_15709494:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26597d8067553e6430ffc1a870dc545e |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | EK1L6XWI56 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EK1L6XWI56"} |
| openFDA substances | FDA UNII substance identifier | EK1L6XWI56 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EK1L6XWI56"} |
| openFDA substances | FDA UNII substance identifier | EK1L6XWI56 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EK1L6XWI56"} |
| openFDA substances | FDA UNII substance identifier | EK1L6XWI56 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C3H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EK1L6XWI56"} |