Methyl Acetylglycyrrhetinoyl Hydroxyprolinate

INCI: THE COSING-REGISTERED INCI MAY APPEAR AS ACETYL METHYL HYDROXYPROLINATYL GLYCYRRHETINATE (NOTE: INCI NAMING CONVENTIONS SOMETIMES REORDER THE SUBSTITUENTS)

CAS Number
Not widely published in standard databases; this is a specialty bioactive peptide-glycyrrhetinate conjugate
Function
Skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no FDA prohibition; classified as a cosmetic ingredient (not a drug)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Derived from glycyrrhetinic acid (licorice root) conjugated with hydroxyproline; glycyrrhetinic acid is well-established in cosmetics with a strong safety profile; no significant adverse effects reported at typical cosmetic use levels. Combines the anti-inflammatory and skin-brightening benefits of glycyrrhetinic acid (inhibits tyrosinase, reduces hyperpigmentation) with hydroxyproline's collagen-supporting properties; designed as a multifunctional active for anti-aging and even-toning applic...

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Concern Level: Moderate

Frequently Asked Questions

Is Methyl Acetylglycyrrhetinoyl Hydroxyprolinate safe in cosmetics?

Derived from glycyrrhetinic acid (licorice root) conjugated with hydroxyproline; glycyrrhetinic acid is well-established in cosmetics with a strong safety profile; no significant adverse effects reported at typical cosmetic use levels. Combines the anti-inflammatory and skin-brightening benefits of glycyrrhetinic acid (inhibits tyrosinase, reduces hyperpigmentation) with hydroxyproline's collagen-supporting properties; designed as a multifunctional active for anti-aging and even-toning applic... The EU classifies Methyl Acetylglycyrrhetinoyl Hydroxyprolinate as "permitted". Safety rating: MODERATE.

Is Methyl Acetylglycyrrhetinoyl Hydroxyprolinate allowed in the EU?

Methyl Acetylglycyrrhetinoyl Hydroxyprolinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Acetylglycyrrhetinoyl Hydroxyprolinate do in cosmetics?

Methyl Acetylglycyrrhetinoyl Hydroxyprolinate functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: Not widely published in standard databases; this is a specialty bioactive peptide-glycyrrhetinate conjugate.

What is the Margin of Safety for Methyl Acetylglycyrrhetinoyl Hydroxyprolinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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