NOAEL Studies
Cosmetic Ingredient
Methyl Alcohol NOAEL Studies
INCI: METHYL ALCOHOL
CAS: 67-56-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =1 | g/kg | rat | - | - | NOAEL study | 48; 1; 0, p.10 |
| CIR Safety Assessment | NOAEL | =4.1 | g/kg | rat | oral | - | oral toxicity | 5; 6; 7, p.8 |
| CIR Safety Assessment | NOAEL | =7.5 | g/kg | rat | oral | - | oral toxicity | 5; 6; 7, p.8 |
| CIR Safety Assessment | NOAEL | =5000 | ppm | rat | oral | 7 h/day | developmental toxicity | 15; 7; 19, p.12 |
| CIR Safety Assessment | NOAEL | =10000 | ppm | human | inhalation | - | inhalation toxicity | 5; 10,000, p.1 |
COSMOS DB 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 2 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1584 | mg/kg bw/day | rat | oral | 21 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1600 | mg/kg bw/day | rat | oral | 8 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2500 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3200 | mg/kg bw/day | rat | oral | 8 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3250 | mg/kg bw/day | rat | oral | 1 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
California Proposition 65 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 MADL | ABinhalation=47000; oral=23000 | ug/day | - | - | 2012-03-16 | Maximum allowable dose level | - |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 2012-03-16 | California Proposition 65 listing | - |
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =500 | mg/kg bw/day | Rat | oral: gavage | 90 days | subchronic | EFSA FEEDAP - 2013 - OutputID 2209 - other - hepatotoxicity - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169 |
| EFSA | NOAEL | =500 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species. doi:10.2903/j.efsa.2013.3169.; TITLE=Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3169; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=other; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=EFSA:15614457:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0940db5ceaf5403e67ff316e5cbd872c |
Regulatory source 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | BMDL 1SD (INTERNAL) | =858 | mg-hr/L | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=2bbe5a08d5c30d95; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL 1SD (internal): 858 mg-hr/L; system=Nervous, Developmental; basis=Reduced brain weight in rat pups at 6 weeks of age; point_of_departure=BMDL 1SD (internal): 858 mg-hr/L; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID2021731; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; rfc_last_updated=09/30/2013; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0305_summary.pdf |
| Regulatory source | RfC | =20 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=f396f17950a646fd; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=2e1; system=Nervous, Developmental; basis=Reduced brain weight in rat pups at 6 weeks of age; point_of_departure=BMDL 1SD (internal): 858 mg-hr/L; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID2021731; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; rfc_last_updated=09/30/2013; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0305_summary.pdf |
| Regulatory source | BMDL 05 (INTERNAL) | =43.1 | mg/L | - | inhalation | chronic | IRIS chronic oral RfD system PoD | row_hash=364bfc32dc2ad550; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL 05 (internal): 43.1 mg/L; system=Developmental; basis=Extra cervical ribs; point_of_departure=BMDL 05 (internal): 43.1 mg/L; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID2021731; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; rfd_last_updated=09/30/2013; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0305_summary.pdf |
| Regulatory source | RfD | =2 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=6e1ea84ad79324ee; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2; system=Developmental; basis=Extra cervical ribs; point_of_departure=BMDL 05 (internal): 43.1 mg/L; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID2021731; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; rfd_last_updated=09/30/2013; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0305_summary.pdf |
WHO/JECFA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOAEL | =1300 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc196; title=Methanol (EHC 196, 1997); path=mirror/documents/ehc/ehc/ehc196.htm; row_hash=dd375c3979b8e15b; raw_unit=mg/m 3; context=The NOAEL for developmental toxicity was 1300 mg/m 3 (1000 ppm) methanol. |
| WHO/JECFA | NOAEL | =5000 | ppm | - | - | - | Toxicology study | document_id=ehc_ehc_ehc196; title=Methanol (EHC 196, 1997); path=mirror/documents/ehc/ehc/ehc196.htm; row_hash=bb23b9c002476517; raw_unit=ppm; context=Slight maternal toxicity was found at this exposure level, and no adverse effects to the mother or offspring were found in animals exposed to 6500 mg/m 3 (5000 ppm), which was interpreted as the no-observed-adverse-effect level (NOAEL) for this test system. |
| WHO/JECFA | NOEL | =100 | ppm | - | - | - | Toxicology study | document_id=ehc_ehc_ehc196; title=Methanol (EHC 196, 1997); path=mirror/documents/ehc/ehc/ehc196.htm; row_hash=582cd117f5a405e8; raw_unit=ppm; context=A concentration of 130 mg/m 3 (100 ppm) was found to be the NOEL in both species. |
NTP ICE acute inhalation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 83.8205 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1400; Record_ID=acute_inhalation_1697; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021731; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=83.8205; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP ICE acute inhalation | LC50 | 87.6187 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1402; Record_ID=acute_inhalation_2250; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021731; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=87.6187; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP ICE acute inhalation | LC50 | 128.2192 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1401; Record_ID=acute_inhalation_2248; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021731; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=128.2192; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP ICE acute inhalation | LC50 | 189.9059 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1399; Record_ID=acute_inhalation_1695; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021731; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=189.9059; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
NTP ICE acute oral 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =5628 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9219; row=3978; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9165; row=3979; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =7400 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9168; row=3970; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =7914 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9170; row=3971; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =8000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9172; row=3972; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =9100 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9174; row=3973; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =10283 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9176; row=3974; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =11303 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9178; row=3975; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =12880 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9180; row=3976; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =12900 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9182; row=3977; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0.8866 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=836; Record_ID=adme_parameters_1186; Data_Type=Measured; DTXSID=DTXSID2021731; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.8866; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP ICE adme parameters | Clint | 3.837 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=837; Record_ID=adme_parameters_1186; Data_Type=Measured; DTXSID=DTXSID2021731; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=3.837; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP ICE adme parameters | Fu | 0.9449 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=838; Record_ID=adme_parameters_1186; Data_Type=Measured; DTXSID=DTXSID2021731; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.9449; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP ICE adme parameters | Fu | 0.9505 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=839; Record_ID=adme_parameters_1186; Data_Type=Measured; DTXSID=DTXSID2021731; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.9505; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | BMC (05) | =399.708 | mg/m3 | Mouse | inhalation | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Rogers JM, Mole ML, Chernoff N, Barbee BD, Turner CI, Logsdon TR, and Kavlock JV. 1993. The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative doseresponse modeling for estimation of benchmark doses. Teratology 47:175-188.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Abnormal cervical ribs, exencephaly, cleft palate; STUDY_GROUP=Cal OEHHA REL derivations:15952100:-:-pregnant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69c4b137502623bde25fc82270639bec |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =251.619 | mg/m3 | Human | inhalation | acute; 75 minutes | clinical | LONG_REF=Cook MR, Bergman FJ, Cohen HD, Gerkovich MM, Graham C, Harris RK. Effects of methanol vapor on human neurobehavioral measures. Health Effects Institute (HEI) Research Report No. 42. Cambridge (MA): HEI; 1991.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=subtle impairment in the performance of complicated tasks; STUDY_GROUP=Cal OEHHA REL derivations:15951947:M:-healthy paid volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a62091e8c75f5c82245df969f4c7ef3f |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =72078.5 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15516998:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_62bf9577198a1ca91b6e632ca0b76b4f |
ToxValDB DOE Wildlife Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | LOAEL | =250 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511662_15511663:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06b2bce6a8b5cbe4756697b8d485c9d8 |
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511662_15511663:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c5939ffe5b429f14273c409e1593eda7 |
ECHA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | =2000 | mg/kg bw/day | Rabbit | injection | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d232355; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821806:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a3b2ef3de363e2fb12c26aafd751c4a1 |
| ECHA | LOAEC | =6650 | mg/m3 | Mouse | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d23231a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821038:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f9447c4539267f80be7d5866f8c256c |
| ECHA | LOAEC | =13105.2 | mg/m3 | Mouse | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d232343; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=fetus: external malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821100:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_836962e77fa82229af08814abf305009 |
| ECHA | LOAEL | >1800 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b48b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/8?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820009_15820243:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_02f3637f5e69e1f7a70d78970836eb8b |
| ECHA | LOAEL | <2100 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b48b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/8?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820009_15820243:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_355e53709533685945821c65b555c40e |
| ECHA | LOAEL | =2340 | mg/kg bw/day | Monkey | oral | short-term; 3 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9eae4b0a7c65d21f652; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11573/7/6/2?documentUUID=a86ef6cb-ea7a-4d79-a145-6a79d1a7d751; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832306_15836664:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b96f8951465c8a30a041bcc54698c6c7 |
| ECHA | LOAEL | =5000 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf819; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15825258:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_73080945d2df65138d3b2788361a66e7 |
| ECHA | NOAEC | >=1300 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217a00; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/8?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15817282:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_45b88ffdc2b6c4ae5ad957f9f61d4e5e |
| ECHA | NOAEC | =2390 | mg/m3 | Monkey | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d2322f8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15822334:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fa91e17bf31ad93ecea323053e0d5c0 |
| ECHA | NOAEC | =5980 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d2322d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15820899:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc282c2a21cded709ca0048d1a466f89 |
| ECHA | NOAEC | =6630 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fd3e4b096bca877ef0a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/6/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15827056:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54d2c045612e782afe63d4b42d840e15 |
| ECHA | NOAEC | =19940 | mg/m3 | Mouse | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d23230b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822350_15822514:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad44835e5014c40a82aaeacf87d31d60 |
| ECHA | NOAEL | =2000 | mg/kg bw/day | Rabbit | injection | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d232355; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15823089:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c8cee53f7d2102d9c694074e7fa93c3 |
| ECHA | NOAEL | =5000 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf81f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15825259_15825260:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1decd4361d83a13d522811e1e22501fd |
ToxValDB ECOTOX 33 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEC | =11.6 | ul/mL | Rat | environmental | short-term; 1.6667 days | developmental | LONG_REF=Teratology52(4): 233-243 Brown-Woodman,P.D.C., F. Huq, L. Hayes, C. Herlihy, K. Picker, and W.S. Webster In Vitro Assessment of the Effect of Methanol and the Metabolite, Formic Acid, on Embryonic Development of the Rat 1995; TITLE=In Vitro Assessment of the Effect of Methanol and the Metabolite, Formic Acid, on Embryonic Development of the Rat; AUTHOR=Brown-Woodman,P.D.C., F. Huq, L. Hayes, C. Herlihy, K. Picker, and W.S. Webster; DOI=10.1002/tera.1420520409; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112960; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Development: Slowed, Retarded, Delayed or Non-development; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606004_15606005:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6f102e826f8b6c2f9de8e894db6691f6 |
| ToxValDB ECOTOX | LOEL | =0.001 | mg | Mouse | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Crown to rump length|Development: Normal|Development: Organ/tissue formation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15611003:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=598066c211dde5b52f8551b61c3ef7e8 |
| ToxValDB ECOTOX | LOEL | =0.046 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611002_15611004_15611005_15611006:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a3bbbbc35671b5278d38a35d78c41e4 |
| ToxValDB ECOTOX | LOEL | =0.135 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611002_15611004_15611005_15611006:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=eeea29c60b365a05caf6e128632c7899 |
| ToxValDB ECOTOX | LOEL | =1.3 | mL/kg bw | Rat | oral | short-term; 20 days | developmental | LONG_REF=Reprod. Toxicol.11(4): 503-510 Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats 1997; TITLE=Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats; AUTHOR=Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller; DOI=10.1016/s0890-6238(97)00017-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112984; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development; STUDY_GROUP=ECOTOX:15595054:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1b24b2c9ef20ef7df357110d2b63ed58 |
| ToxValDB ECOTOX | LOEL | =2 | % v/v | Rat | oral | short-term; 15 days | reproduction developmental | LONG_REF=EPA/OTS Doc.#88-920000356:8 p. Amoco Corp. Initial Submission: Letter Submitting Preliminary Information from a Pilot Developmental Toxicity Study on Methanol with Attachment 1991; TITLE=Initial Submission: Letter Submitting Preliminary Information from a Pilot Developmental Toxicity Study on Methanol with Attachment; AUTHOR=Amoco Corp.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115033; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Morphology: Weight|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595465_15595466_15605069:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a66773946228b85811b32f660e4c7288 |
| ToxValDB ECOTOX | LOEL | =3 | mg/mL | Mouse | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.70(4): 179-184 Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture 2004; TITLE=Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture; AUTHOR=Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III; DOI=10.1002/bdra.20009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598649_15598650_15599861_15599862:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2f76c37c5ed8a635df3b9ada3b43d599 |
| ToxValDB ECOTOX | LOEL | =3.25 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | LONG_REF=Environ. Res.73(1/2): 52-62 Youssef,A.F., and B.W. Santi Simple Neurobehavioral Functional Observational Battery and Objective Gait Analysis Validation by the Use of Acrylamide and Methanol with a Built-in Recovery Period 1997; TITLE=Simple Neurobehavioral Functional Observational Battery and Objective Gait Analysis Validation by the Use of Acrylamide and Methanol with a Built-in Recovery Period; AUTHOR=Youssef,A.F., and B.W. Santi; DOI=10.1006/enrs.1997.3718; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=95030; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Behavior: Foot retraction; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597551_15610867:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=174a3118f4823991ec91bba9615df583 |
| ToxValDB ECOTOX | LOEL | =4 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595525_15595526_15595527:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=10cfe9cbf0ea53b2a7499f7d0124a4a2 |
| ToxValDB ECOTOX | LOEL | =5.2 | mL/kg bw | Rat | oral | short-term; 20 days | short-term | LONG_REF=Reprod. Toxicol.11(4): 503-510 Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats 1997; TITLE=Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats; AUTHOR=Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller; DOI=10.1016/s0890-6238(97)00017-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112984; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595908_15595909_15608902:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f36f0cfc6afb362fc499252c5219c4e2 |
| ToxValDB ECOTOX | LOEL | =6 | mg/mL | Mouse | environmental | acute; 0.3333 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.70(4): 179-184 Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture 2004; TITLE=Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture; AUTHOR=Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III; DOI=10.1002/bdra.20009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596545_15596546:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4caf62f343c3d3b0823015f74fa5814a |
| ToxValDB ECOTOX | LOEL | =6.5 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | LONG_REF=Environ. Res.73(1/2): 52-62 Youssef,A.F., and B.W. Santi Simple Neurobehavioral Functional Observational Battery and Objective Gait Analysis Validation by the Use of Acrylamide and Methanol with a Built-in Recovery Period 1997; TITLE=Simple Neurobehavioral Functional Observational Battery and Objective Gait Analysis Validation by the Use of Acrylamide and Methanol with a Built-in Recovery Period; AUTHOR=Youssef,A.F., and B.W. Santi; DOI=10.1006/enrs.1997.3718; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=95030; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Behavior: Behavioral changes, general; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597551_15610867:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fdf6c818bbc881948b6237b8e85295eb |
| ToxValDB ECOTOX | LOEL | =8 | mg/mL | Mouse | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation|Genetics: DNA concentration|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595523_15595524:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=66f057200cc608b2a3e3009476df1824 |
| ToxValDB ECOTOX | LOEL | =10 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595525_15595526_15595527:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=966f6cd5aff95072e95ffb3b00c8758f |
| ToxValDB ECOTOX | LOEL | =12 | mg/mL | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Toxicology97(1-3): 159-171 Abbott,B.D., M. Ebron-McCoy, and J.E. Andrews Cell Death in Rat and Mouse Embryos Exposed to Methanol in Whole Embryo Culture 1995; TITLE=Cell Death in Rat and Mouse Embryos Exposed to Methanol in Whole Embryo Culture; AUTHOR=Abbott,B.D., M. Ebron-McCoy, and J.E. Andrews; DOI=10.1016/0300-483x(94)02945-q; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113177; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Cell Viability|Development: Slowed, Retarded, Delayed or Non-development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597724_15597725_15599610:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0dccc928dcb166f02f5a68333d80676f |
| ToxValDB ECOTOX | LOEL | =16 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602475_15602476:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9cf5482376cd958d6c78f352cdf9c22d |
| ToxValDB ECOTOX | LOEL | =1600 | mg/kg bw/day | Rat | oral | short-term; 8 days | reproduction developmental | LONG_REF=- | Toxicology79(3): 205-214 Cummings,A.M. Evaluation of the Effects of Methanol During Early Pregnancy in the Rat 1993; TITLE=Evaluation of the Effects of Methanol During Early Pregnancy in the Rat; AUTHOR=Cummings,A.M.; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113328; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Pregnant uterine weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15613017_15613451:F:P0-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=24f2afc47fd5561aa47d7710fa8391c7 |
| ToxValDB ECOTOX | LOEL | =2000 | mg/kg bw/day | Mouse | oral | short-term; 11 days | developmental | LONG_REF=- | Teratology55(2): 138-144 Connelly,L.E., and J.M. Rogers Methanol Causes Posteriorization of Cervical Vertebrae in Mice 1997; TITLE=Methanol Causes Posteriorization of Cervical Vertebrae in Mice; AUTHOR=Connelly,L.E., and J.M. Rogers; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115462; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Development: Abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15613480:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=791ab0f287c4b23d45d3fd408d1d8d87 |
| ToxValDB ECOTOX | NOEC | =8.57 | ul/mL | Rat | environmental | short-term; 1.6667 days | developmental | LONG_REF=Teratology52(4): 233-243 Brown-Woodman,P.D.C., F. Huq, L. Hayes, C. Herlihy, K. Picker, and W.S. Webster In Vitro Assessment of the Effect of Methanol and the Metabolite, Formic Acid, on Embryonic Development of the Rat 1995; TITLE=In Vitro Assessment of the Effect of Methanol and the Metabolite, Formic Acid, on Embryonic Development of the Rat; AUTHOR=Brown-Woodman,P.D.C., F. Huq, L. Hayes, C. Herlihy, K. Picker, and W.S. Webster; DOI=10.1002/tera.1420520409; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112960; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Development: Slowed, Retarded, Delayed or Non-development; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606004_15606005:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=09e6a8e294108312cdb318005c87c22c |
| ToxValDB ECOTOX | NOEL | =0.001 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611002_15611004_15611005_15611006:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b57e45dd1d0b8c0d445b6c2f16a9200c |
| ToxValDB ECOTOX | NOEL | =0.09 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611002_15611004_15611005_15611006:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6dc730f11bc4892d0277a0cec494ab6d |
| ToxValDB ECOTOX | NOEL | =0.135 | mg | Rat | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=development|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611075_15611076_15611077:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d22e19c1019fe0569d8dda81c4dc4eb4 |
| ToxValDB ECOTOX | NOEL | =1 | % v/v | Rat | oral | short-term; 15 days | reproduction developmental | LONG_REF=EPA/OTS Doc.#88-920000356:8 p. Amoco Corp. Initial Submission: Letter Submitting Preliminary Information from a Pilot Developmental Toxicity Study on Methanol with Attachment 1991; TITLE=Initial Submission: Letter Submitting Preliminary Information from a Pilot Developmental Toxicity Study on Methanol with Attachment; AUTHOR=Amoco Corp.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115033; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Morphology: Weight|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595465_15595466_15605069:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=981214b2f8f0caf758b56bcf236570cf |
| ToxValDB ECOTOX | NOEL | =2 | mg/mL | Mouse | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.70(4): 179-184 Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture 2004; TITLE=Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture; AUTHOR=Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III; DOI=10.1002/bdra.20009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598649_15598650_15599861_15599862:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b79f947068ab56de9e0a462dc793719b |
| ToxValDB ECOTOX | NOEL | =2.6 | mL/kg bw | Rat | oral | short-term; 20 days | short-term | LONG_REF=Reprod. Toxicol.11(4): 503-510 Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats 1997; TITLE=Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats; AUTHOR=Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller; DOI=10.1016/s0890-6238(97)00017-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112984; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595908_15595909_15608902:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=310d06c5c1db6af927c51a483cd295d0 |
| ToxValDB ECOTOX | NOEL | =3 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.70(4): 179-184 Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture 2004; TITLE=Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture; AUTHOR=Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III; DOI=10.1002/bdra.20009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601567_15601568:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6fcb93d1662534b655c88cc63a5a3719 |
| ToxValDB ECOTOX | NOEL | =4 | mg/mL | Mouse | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation|Genetics: DNA concentration|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595523_15595524:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f8f8d76ee4ef8e0bd7b402279b6c9529 |
| ToxValDB ECOTOX | NOEL | =8 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595525_15595526_15595527:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=30f4f3d34eb6803db7f472a06d6ab591 |
| ToxValDB ECOTOX | NOEL | =10 | mmol/kg | Rat | oral | short-term; 1.75 days | short-term | LONG_REF=Fundam. Appl. Toxicol.15(3): 429-440 Ray,S.D., and H.M. Mehendale Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols 1990; TITLE=Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols; AUTHOR=Ray,S.D., and H.M. Mehendale; DOI=10.1016/0272-0590(90)90029-j; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=78954; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15598135:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=18da45c4f737bb8caad9c5ee4b99b0f6 |
| ToxValDB ECOTOX | NOEL | =12 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602475_15602476:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a40da8cb1163fbc484c879e148ddd73a |
| ToxValDB ECOTOX | NOEL | =16 | mg/mL | Rat | environmental | short-term; 2 days | short-term | LONG_REF=Toxicology97(1-3): 159-171 Abbott,B.D., M. Ebron-McCoy, and J.E. Andrews Cell Death in Rat and Mouse Embryos Exposed to Methanol in Whole Embryo Culture 1995; TITLE=Cell Death in Rat and Mouse Embryos Exposed to Methanol in Whole Embryo Culture; AUTHOR=Abbott,B.D., M. Ebron-McCoy, and J.E. Andrews; DOI=10.1016/0300-483x(94)02945-q; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113177; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Cell Viability|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX:15595825:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0c2636b2a2084d9477fb58d0730e0e28 |
| ToxValDB ECOTOX | NOEL | =1000 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin|Enzyme(s): beta-N-Acetylhexosaminidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15602992:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8b31b38f6b2264e9d0bd4b433b686f4f |
| ToxValDB ECOTOX | NOEL | =3200 | mg/kg bw/day | Rat | oral | short-term; 8 days | reproduction developmental | LONG_REF=- | Toxicology79(3): 205-214 Cummings,A.M. Evaluation of the Effects of Methanol During Early Pregnancy in the Rat 1993; TITLE=Evaluation of the Effects of Methanol During Early Pregnancy in the Rat; AUTHOR=Cummings,A.M.; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113328; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Development: Slowed, Retarded, Delayed or Non-development|Morphology: Yolk Sac Diameter, head and rump length, somite count |Morphology: Length|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other; STUDY_GROUP=ECOTOX:15612967:F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=e5d341770ecdc4fb120da824e92d3c8c |
ToxValDB EPA HWIR 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA HWIR | NOAEL | =1310 | mg/m3 | Mouse | inhalation | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Rogers, J.M., M.L. Mole, N. Chernoff, et al. 1993. The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology 47(3):175-188; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/683eef73e4b096bca883dd65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/html/risk.html; SUBSOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/pdf/r99019b.pdf; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Developmental malformations (increased cervical ribs, exencephaly, and cleft palate); TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EPA HWIR:15952207:F:-pregnant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7cdb1bc15128d9e121226ab29cfdb356 |
| ToxValDB EPA HWIR | RfC | =13 | mg/m3 | Human | inhalation | - | toxicity value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/683eef73e4b096bca883dd65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/html/risk.html; SUBSOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/pdf/r99019b.pdf; STUDY_GROUP=EPA HWIR:15952206:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_585e73e4d953d54eb651a5cb16673b2e |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =130 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633251_15633252:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8705c93eb205090b5c2799b97ad65858 |
ToxValDB HPVIS 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | LOAEL | =1310.52 | mg/m3 | Primate | inhalation | short-term; 12 days | reproduction developmental | LONG_REF=New Energy Development Organization (NEDO). (1986). Toxicological research of methanol as a fuel for power station. Tokyo, Japan. September.; TITLE=Toxicological research of methanol as a fuel for power station; AUTHOR=New Energy Development Organization (NEDO); QUALITY=2; EXTERNAL_SOURCE_ID=60803; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639657_15639985:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1676c8948807a014cc5ecf6f9bca17e |
| ToxValDB HPVIS | LOAEL | =2500 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=USEPA 1986.; AUTHOR=USEPA; QUALITY=2; EXTERNAL_SOURCE_ID=63179; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS:15639984:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_88358c2b9b8f2197e88213c0b58e3213 |
| ToxValDB HPVIS | LOAEL | =2621.04 | mg/m3 | Mouse | inhalation | short-term; 10 days | developmental | LONG_REF=Rogers,J.M.; M.L., Mole; N., Chernoff; B.D.,Barbee; C.L., Turner; T.R., Logsdon; R.J.,Kavlock, (1993), The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology 47(3):175-88; TITLE=The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses; AUTHOR=Rogers,J.M.; M.L., Mole; N., Chernoff; B.D.,Barbee; C.L., Turner; T.R., Logsdon; R.J.,Kavlock; QUALITY=2; EXTERNAL_SOURCE_ID=59856; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15642892:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0818f8528476f6e86649c4d92d3d966c |
| ToxValDB HPVIS | LOAEL | =6552.59 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Andrews,L.S., J.J.Clary, J.B.Terrill,and .F.Bolte. (1987). Subchronic inhalation toxicity of methanol. J Toxicol. Environ. Health 20:117-124.; TITLE=Subchronic inhalation toxicity of methanol; AUTHOR=Andrews,L.S., J.J.Clary, J.B.Terrill,and .F.Bolte; QUALITY=1; EXTERNAL_SOURCE_ID=61857; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639136_15639237:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d12a65c8ba03b66fa050f44ddc235ddb |
| ToxValDB HPVIS | LOAEL | <=19657.8 | mg/m3 | Mouse | inhalation | short-term; 20 days | reproduction developmental | LONG_REF=Bolon, B., D.C. Dorman, D. Janszen, K.T. Morgan, and F. Welsch. (1993). Phase-specific developmental toxicity in mice following maternal methanol inhalation. Fund. Appl. Toxicol.21:508-516.; TITLE=Phase-specific developmental toxicity in mice following maternal methanol inhalation; AUTHOR=Bolon, B., D.C. Dorman, D. Janszen, K.T. Morgan, and F. Welsch; QUALITY=2; EXTERNAL_SOURCE_ID=59456; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642528_15642756:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40b64160254975d4b09376769797889e |
| ToxValDB HPVIS | LOAEL | <=26210.4 | mg/m3 | Rat | inhalation | short-term; 19 days | reproduction developmental | LONG_REF=Nelson, B.K., W.S. Brightwell, D.R. MacKenzie, A. Khan, J.R. Burg, W.W. Weigel, and P.T. Goad. (1985). Teratological Assessment of methanol and ethanol at high inhalation levels in rats. Fundamental and Applied Toxicol 5: 727-736.; TITLE=Teratological assessment of methanol and ethanol at high inhalation levels in rats; AUTHOR=Nelson, B., Brightwell, W., MacKenzie, D., et al; QUALITY=2; EXTERNAL_SOURCE_ID=58249; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS:15642397:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fff0469c90c99a896c4a8cf8317e7a03 |
| ToxValDB HPVIS | NOAEL | =131.052 | mg/m3 | Rat | inhalation | chronic; 365 days | reproduction developmental | LONG_REF=New Energy Development Organization (NEDO). (1986). Toxicological research of methanol as a fuel for power station. Tokyo, Japan. September.; TITLE=Toxicological research of methanol as a fuel for power station; AUTHOR=New Energy Development Organization (NEDO); QUALITY=2; EXTERNAL_SOURCE_ID=65454; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS:15643239:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b2c5b821d930400cdcc98305c580cfe |
| ToxValDB HPVIS | NOAEL | >1310.52 | mg/m3 | Mouse | inhalation | chronic; 18 months | reproduction developmental | LONG_REF=New Energy Development Organization (NEDO). (1986). Toxicological research of methanol as a fuel for power station. Tokyo, Japan. September.; TITLE=Toxicological research of methanol as a fuel for power station; AUTHOR=New Energy Development Organization (NEDO); QUALITY=2; EXTERNAL_SOURCE_ID=64218; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS:15640302:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c634a14f794ada9ac7f830f283c36d4 |
| ToxValDB HPVIS | NOAEL | >2358.93 | mg/m3 | Primate | inhalation | chronic; 120 days | reproduction developmental | LONG_REF=Burbacher, T., D.,Shen, K.,Grant, L.,Sheppard, D.,Dumian, S.,Ellis andc N.,Liberato, (1999) Reproductive and offspring developmental effects following maternal inhalation exposure to methanol in non-human primates, Part 11: Developmental effects in infants exposed prenatally to methanol. Health Effects Institute Report 89 October 1999; TITLE=Reproductive and offspring developmental effects following maternal inhalation exposure to methanol in non-human primates, Part 11: Developmental effects in infants exposed prenatally to methanol; AUTHOR=Burbacher, T., D.,Shen, K.,Grant, L.,Sheppard, D.,Dumian, S.,Ellis andc N.,Liberato; QUALITY=1; EXTERNAL_SOURCE_ID=59058; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=HPVIS:15642655:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d675347f89adbb05809121e700603133 |
| ToxValDB HPVIS | NOAEL | >=3931.55 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Andrews,L.S., J.J.Clary, J.B.Terrill,and .F.Bolte. (1987). Subchronic inhalation toxicity of methanol. J Toxicol. Environ. Health 20:117-124.; TITLE=Subchronic inhalation toxicity of methanol; AUTHOR=Andrews,L.S., J.J.Clary, J.B.Terrill,and .F.Bolte; QUALITY=1; EXTERNAL_SOURCE_ID=61051; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639136_15639237:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3bb385a1a09c527cee00d391a8b1df1e |
| ToxValDB HPVIS | NOAEL | >=13105.2 | mg/m3 | Mouse | inhalation | short-term; 20 days | reproduction developmental | LONG_REF=Bolon, B., D.C. Dorman, D. Janszen, K.T. Morgan, and F. Welsch. (1993). Phase-specific developmental toxicity in mice following maternal methanol inhalation. Fund. Appl. Toxicol.21:508-516.; TITLE=Phase-specific developmental toxicity in mice following maternal methanol inhalation; AUTHOR=Bolon, B., D.C. Dorman, D. Janszen, K.T. Morgan, and F. Welsch; QUALITY=2; EXTERNAL_SOURCE_ID=58650; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642528_15642756:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6643235d6480a073b066ea2ae62799a8 |
ToxValDB IRIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | BMDL (05) | =43.1 | mg/L | Mouse | oral | short-term (developmental); 12 days | developmental | LONG_REF=Rogers, JM; Mole, ML; Chernoff, N; Barbee, BD; Turner, CI; Logsdon, TR; Kavlock, RJ. (1993b). The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology 47: 175-188.; TITLE=The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses; AUTHOR=Rogers, JM; Mole, ML; Chernoff, N; Barbee, BD; Turner, CI; Logsdon, TR; Kavlock, RJ; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; TOXICOLOGICAL_EFFECT=extra cervical ribs; STUDY_GROUP=IRIS:15644878:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_359050c72a7ba301c4ef259ae20ba8d4 |
| ToxValDB IRIS | BMDL (1SD) | =858 | mg-hr/L | Rat | inhalation | - | developmental | LONG_REF=NEDO (New Energy Development Organization). (1987). Toxicological research of methanol as a fuel for power station: summary report on tests with monkeys, rats and mice. Tokyo, Japan.; TITLE=Toxicological research of methanol as a fuel for power station: summary report on tests with monkeys, rats and mice; AUTHOR=NEDO (New Energy Development Organization); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; TOXICOLOGICAL_EFFECT=reduced brain weight in rat pups; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=IRIS:15645069:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_af156bc9e5f03b4ddb31c2fcc08fbafc |
| ToxValDB IRIS | RfC | =20 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=NEDO (New Energy Development Organization). (1987). Toxicological research of methanol as a fuel for power station: summary report on tests with monkeys, rats and mice. Tokyo, Japan.; TITLE=Toxicological research of methanol as a fuel for power station: summary report on tests with monkeys, rats and mice; AUTHOR=NEDO (New Energy Development Organization); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; TOXICOLOGICAL_EFFECT=Reduced brain weight in male rats; STUDY_GROUP=IRIS:15645068:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0445362795c05860c383c7ca6f3bbcde |
| ToxValDB IRIS | RfD | =2 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Rogers, JM; Mole, ML; Chernoff, N; Barbee, BD; Turner, CI; Logsdon, TR; Kavlock, RJ. (1993b). The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology 47: 175-188.; TITLE=The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses; AUTHOR=Rogers, JM; Mole, ML; Chernoff, N; Barbee, BD; Turner, CI; Logsdon, TR; Kavlock, RJ; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; TOXICOLOGICAL_EFFECT=extra cervical ribs; STUDY_GROUP=IRIS:15645066:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_925d9a26b5199f374a73effd3887b20d |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfD | =5 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663555:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d6febd60e0fea7943a913990d4ddd28d |
ToxValDB TX TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | LOAEL | =601.528 | mg/m3 | Human | inhalation | chronic; 7.8 years | occupational | LONG_REF=Kawai T, T Yasugi, K Mizunuma et al. 1991. Methanol in urine as a biological indicator of occupational exposure to methanol vapor. Int Arch Occup Environ Health, 63, 311-318; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ae7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/methanol.pdf; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=nasal irritation; STUDY_GROUP=TX TCEQ:15954522:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_95c6cccb0dda7d38d94deea201bf8509 |
| ToxValDB TX TCEQ | NOAEL | =266.69 | mg/m3 | Human | inhalation | acute; 4 hours | clinical | LONG_REF=Mann WJ, A Muttray, D Schaefer et al. 2002. Exposure to 200 ppm of methanol increases the concentrations of interleukin-1beta and interleukin-8 in nasal secretions of healthy volunteers. Ann Otol Rhinol Laryngol, 111, 633-638.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ae7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/methanol.pdf; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=Absence of irritation and subjective symptoms; STUDY_GROUP=TX TCEQ:15954523:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f11f3ab226cdc0948dbc285dfcb6a64b |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | Y4S76JWI15 | UNII | - | - | - | chemical | - |