NOAEL Studies
Cosmetic Ingredient
Methyl Alcohol NOAEL Studies
INCI: METHYL ALCOHOL
CAS: 67-56-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR_vision_codex 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR_vision_codex | NOAEL | =10000 | ppm | human | inhalation | - | inhalation toxicity | {"citation":"5; 10,000","dose":"Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for terato- genic effects of 5000 ppm.","effect":"aliphatic alcohol with use in a few cosmetic formulations as a solvent and denaturant. Concentrations up to 5 % are typically used to denature ethyl alcohol in cosmetic products. Methyl Alcohol is readily absorbed through the skin and from the gastrointestinal and respiratory tracts, is distributed throughout all organs and tissues (in direct relation to the body's water distribu- tion), and is eliminated primarily via the lungs. Undiluted Methyl Alcohol is an ocular and skin irritant. Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for terato- genic effects of 5000 ppm. Overall, Methyl Alcohol is not considered mutagenic. Carcinogenicity data were unavailable. The toxicity of Methyl Alcohol in humans results from the metabolism of the alco- hol to formate and formic acid through a formaldehyde intermedi- ate. Formate accumulation causes metabolic acidosis and inhibits cellular respiration. Methyl Alcohol toxicity is time and concentra- tion dependent, and its toxic effect is competitively inhibited with ethyl alcohol. Because of the moderating ef...","page":1,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_001"} |
| CIR_vision_codex | NOAEL | =7.5 | g/kg | rat | oral | - | oral toxicity | {"citation":"5; 6; 7","dose":"In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg).","effect":"otts 1955; Tephly and McMartin 1984). NO evidence of visual disturbances or changes in the appear- ance of the fundus were observed during studies using rabbits, chickens, dogs, and rats (Tephly and McMartin 1984). Acute Toxicity Oral Von Burg (1994) reported an acute oral LD50 of Methyl Al- cohol in the rat of 5.6 gncg and in the mouse of 7.3 gncg. In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg). The no-effect level (NOEL) was 7.5 g/kg. The IP LD50 in females ranged from 4.2 to 6.3 g/kg (ap- proximate lethal dose = 5.0 gncg), and the NOEL was 4.1 g/kg (Paumgartten et al. 1989). Dermal The acute derrnal IDSO of Methyl Alcohol using rabbits was 15.8 g/kg (NAS 1995).","page":8,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_002"} |
| CIR_vision_codex | NOAEL | =4.1 | g/kg | rat | oral | - | oral toxicity | {"citation":"5; 6; 7","dose":"In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg).","effect":"ng studies using rabbits, chickens, dogs, and rats (Tephly and McMartin 1984). Acute Toxicity Oral Von Burg (1994) reported an acute oral LD50 of Methyl Al- cohol in the rat of 5.6 gncg and in the mouse of 7.3 gncg. In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg). The no-effect level (NOEL) was 7.5 g/kg. The IP LD50 in females ranged from 4.2 to 6.3 g/kg (ap- proximate lethal dose = 5.0 gncg), and the NOEL was 4.1 g/kg (Paumgartten et al. 1989). Dermal The acute derrnal IDSO of Methyl Alcohol using rabbits was 15.8 g/kg (NAS 1995).","page":8,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_003"} |
| CIR_vision_codex | NOAEL | =1 | g/kg | rat | - | - | NOAEL study | {"citation":"48; 1; 0","dose":"No KIMDs were observed in FD rats treated with Methyl Alcohol, and an a-wave—only ERG was observed at 48 hours post dose.","effect":"in retinal ATP after a I-hour pretreatment com- pared to the untreated eyes. Pretreatment with sodium iodate (a pigment epithelium toxin) had no effect on KIMD. Treatment with the K + channel blockers blocked the generation of the re- sponse to exogenously applied K +. No KIMDs were observed in FD rats treated with Methyl Alcohol, and an a-wave—only ERG was observed at 48 hours post dose. No change in the elicitation of KIMDs was observed in any rat given water, or in FS rats given Methyl Alcohol. For FD rats, the NOEL was 1.0 g/kg, and the KIMD response was completely eliminated at 2.5 g/kg. The in- vestigators concluded that the Methyl Alcohol-induced decrease in retinal ATP closely paralleled the 20% decrease observed in a-aminoadipic acid—treated retinas. The loss of b-wave genera- tion suggested that the Müller cell was the target of retinotoxicity induced by Methyl Alcohol. In a related study, also using FD and FS Long-Evans hooded rats, Gamer et al. (1995b) reported that intraretinal metabolism of Methyl Alcohol was necessary for the formate-mediated ini- tiation of Methyl...","page":10,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_004"} |
| CIR_vision_codex | NOAEL | =5000 | ppm | rat | oral | 7 h/day | developmental toxicity | {"citation":"15; 7; 19","dose":"pm Methyl Alcohol caused an irregular gait in exposed dams, and a decrease in mean body weight.","effect":"pm Methyl Alcohol caused an irregular gait in exposed dams, and a decrease in mean body weight. The dams, 15 Sprague-Dawley rats per group, were exposed for 7 h/day until gestation day (GD) 19. An increased incidence of urinary and cardiovascular defects, and extra or rudimentary cervical ribs were observed in offspring of this group. Similar malformations were observed in offspring of dams that inhaled 10,000 ppm Methyl Alcohol, but the incidence was not significantly different from that of the control group. The NOEL was 5000 ppm Methyl Alcohol. Pregnant Sprague-Dawley rats were exposed to 5000, 10,000, or 20,000 ppm Methyl Alcohol vapor (99. I % pure) on GD I to 19 during a teratologic assessment of the alcohol (Nelson et al. 1985). The rats were treated for 7 h/day, and were kept in the chambers for approximately 30 minutes after the termination of vapor generation before being returned to their cages. Feed and water were available ad libitum. Blood concentrations of Methyl Alcohol were determined after concurrent exposure on days I , IO, and 19 using nonpregnant rats. These r...","page":12,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_005"} |
| CIR_vision_codex | NOAEL | =10000 | ppm | human | inhalation | - | inhalation toxicity | {"citation":"5; 10,000","dose":"Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for terato- genic effects of 5000 ppm.","effect":"aliphatic alcohol with use in a few cosmetic formulations as a solvent and denaturant. Concentrations up to 5 % are typically used to denature ethyl alcohol in cosmetic products. Methyl Alcohol is readily absorbed through the skin and from the gastrointestinal and respiratory tracts, is distributed throughout all organs and tissues (in direct relation to the body's water distribu- tion), and is eliminated primarily via the lungs. Undiluted Methyl Alcohol is an ocular and skin irritant. Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for terato- genic effects of 5000 ppm. Overall, Methyl Alcohol is not considered mutagenic. Carcinogenicity data were unavailable. The toxicity of Methyl Alcohol in humans results from the metabolism of the alco- hol to formate and formic acid through a formaldehyde intermedi- ate. Formate accumulation causes metabolic acidosis and inhibits cellular respiration. Methyl Alcohol toxicity is time and concentra- tion dependent, and its toxic effect is competitively inhibited with ethyl alcohol. Because of the moderating ef...","page":1,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_001"} |
| CIR_vision_codex | NOAEL | =7.5 | g/kg | rat | oral | - | oral toxicity | {"citation":"5; 6; 7","dose":"In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg).","effect":"otts 1955; Tephly and McMartin 1984). NO evidence of visual disturbances or changes in the appear- ance of the fundus were observed during studies using rabbits, chickens, dogs, and rats (Tephly and McMartin 1984). Acute Toxicity Oral Von Burg (1994) reported an acute oral LD50 of Methyl Al- cohol in the rat of 5.6 gncg and in the mouse of 7.3 gncg. In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg). The no-effect level (NOEL) was 7.5 g/kg. The IP LD50 in females ranged from 4.2 to 6.3 g/kg (ap- proximate lethal dose = 5.0 gncg), and the NOEL was 4.1 g/kg (Paumgartten et al. 1989). Dermal The acute derrnal IDSO of Methyl Alcohol using rabbits was 15.8 g/kg (NAS 1995).","page":8,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_002"} |
| CIR_vision_codex | NOAEL | =4.1 | g/kg | rat | oral | - | oral toxicity | {"citation":"5; 6; 7","dose":"In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg).","effect":"ng studies using rabbits, chickens, dogs, and rats (Tephly and McMartin 1984). Acute Toxicity Oral Von Burg (1994) reported an acute oral LD50 of Methyl Al- cohol in the rat of 5.6 gncg and in the mouse of 7.3 gncg. In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg). The no-effect level (NOEL) was 7.5 g/kg. The IP LD50 in females ranged from 4.2 to 6.3 g/kg (ap- proximate lethal dose = 5.0 gncg), and the NOEL was 4.1 g/kg (Paumgartten et al. 1989). Dermal The acute derrnal IDSO of Methyl Alcohol using rabbits was 15.8 g/kg (NAS 1995).","page":8,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_003"} |
| CIR_vision_codex | NOAEL | =1 | g/kg | rat | - | - | NOAEL study | {"citation":"48; 1; 0","dose":"No KIMDs were observed in FD rats treated with Methyl Alcohol, and an a-wave—only ERG was observed at 48 hours post dose.","effect":"in retinal ATP after a I-hour pretreatment com- pared to the untreated eyes. Pretreatment with sodium iodate (a pigment epithelium toxin) had no effect on KIMD. Treatment with the K + channel blockers blocked the generation of the re- sponse to exogenously applied K +. No KIMDs were observed in FD rats treated with Methyl Alcohol, and an a-wave—only ERG was observed at 48 hours post dose. No change in the elicitation of KIMDs was observed in any rat given water, or in FS rats given Methyl Alcohol. For FD rats, the NOEL was 1.0 g/kg, and the KIMD response was completely eliminated at 2.5 g/kg. The in- vestigators concluded that the Methyl Alcohol-induced decrease in retinal ATP closely paralleled the 20% decrease observed in a-aminoadipic acid—treated retinas. The loss of b-wave genera- tion suggested that the Müller cell was the target of retinotoxicity induced by Methyl Alcohol. In a related study, also using FD and FS Long-Evans hooded rats, Gamer et al. (1995b) reported that intraretinal metabolism of Methyl Alcohol was necessary for the formate-mediated ini- tiation of Methyl...","page":10,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_004"} |
| CIR_vision_codex | NOAEL | =5000 | ppm | rat | oral | 7 h/day | developmental toxicity | {"citation":"15; 7; 19","dose":"pm Methyl Alcohol caused an irregular gait in exposed dams, and a decrease in mean body weight.","effect":"pm Methyl Alcohol caused an irregular gait in exposed dams, and a decrease in mean body weight. The dams, 15 Sprague-Dawley rats per group, were exposed for 7 h/day until gestation day (GD) 19. An increased incidence of urinary and cardiovascular defects, and extra or rudimentary cervical ribs were observed in offspring of this group. Similar malformations were observed in offspring of dams that inhaled 10,000 ppm Methyl Alcohol, but the incidence was not significantly different from that of the control group. The NOEL was 5000 ppm Methyl Alcohol. Pregnant Sprague-Dawley rats were exposed to 5000, 10,000, or 20,000 ppm Methyl Alcohol vapor (99. I % pure) on GD I to 19 during a teratologic assessment of the alcohol (Nelson et al. 1985). The rats were treated for 7 h/day, and were kept in the chambers for approximately 30 minutes after the termination of vapor generation before being returned to their cages. Feed and water were available ad libitum. Blood concentrations of Methyl Alcohol were determined after concurrent exposure on days I , IO, and 19 using nonpregnant rats. These r...","page":12,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_005"} |
| CIR_vision_codex | NOAEL | =10000 | ppm | human | inhalation | - | inhalation toxicity | {"citation":"5; 10,000","dose":"Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for terato- genic effects of 5000 ppm.","effect":"aliphatic alcohol with use in a few cosmetic formulations as a solvent and denaturant. Concentrations up to 5 % are typically used to denature ethyl alcohol in cosmetic products. Methyl Alcohol is readily absorbed through the skin and from the gastrointestinal and respiratory tracts, is distributed throughout all organs and tissues (in direct relation to the body's water distribu- tion), and is eliminated primarily via the lungs. Undiluted Methyl Alcohol is an ocular and skin irritant. Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for terato- genic effects of 5000 ppm. Overall, Methyl Alcohol is not considered mutagenic. Carcinogenicity data were unavailable. The toxicity of Methyl Alcohol in humans results from the metabolism of the alco- hol to formate and formic acid through a formaldehyde intermedi- ate. Formate accumulation causes metabolic acidosis and inhibits cellular respiration. Methyl Alcohol toxicity is time and concentra- tion dependent, and its toxic effect is competitively inhibited with ethyl alcohol. Because of the moderating ef...","page":1,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_001"} |
| CIR_vision_codex | NOAEL | =7.5 | g/kg | rat | oral | - | oral toxicity | {"citation":"5; 6; 7","dose":"In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg).","effect":"otts 1955; Tephly and McMartin 1984). NO evidence of visual disturbances or changes in the appear- ance of the fundus were observed during studies using rabbits, chickens, dogs, and rats (Tephly and McMartin 1984). Acute Toxicity Oral Von Burg (1994) reported an acute oral LD50 of Methyl Al- cohol in the rat of 5.6 gncg and in the mouse of 7.3 gncg. In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg). The no-effect level (NOEL) was 7.5 g/kg. The IP LD50 in females ranged from 4.2 to 6.3 g/kg (ap- proximate lethal dose = 5.0 gncg), and the NOEL was 4.1 g/kg (Paumgartten et al. 1989). Dermal The acute derrnal IDSO of Methyl Alcohol using rabbits was 15.8 g/kg (NAS 1995).","page":8,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_002"} |
| CIR_vision_codex | NOAEL | =4.1 | g/kg | rat | oral | - | oral toxicity | {"citation":"5; 6; 7","dose":"In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg).","effect":"ng studies using rabbits, chickens, dogs, and rats (Tephly and McMartin 1984). Acute Toxicity Oral Von Burg (1994) reported an acute oral LD50 of Methyl Al- cohol in the rat of 5.6 gncg and in the mouse of 7.3 gncg. In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg). The no-effect level (NOEL) was 7.5 g/kg. The IP LD50 in females ranged from 4.2 to 6.3 g/kg (ap- proximate lethal dose = 5.0 gncg), and the NOEL was 4.1 g/kg (Paumgartten et al. 1989). Dermal The acute derrnal IDSO of Methyl Alcohol using rabbits was 15.8 g/kg (NAS 1995).","page":8,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_003"} |
| CIR_vision_codex | NOAEL | =1 | g/kg | rat | - | - | NOAEL study | {"citation":"48; 1; 0","dose":"No KIMDs were observed in FD rats treated with Methyl Alcohol, and an a-wave—only ERG was observed at 48 hours post dose.","effect":"in retinal ATP after a I-hour pretreatment com- pared to the untreated eyes. Pretreatment with sodium iodate (a pigment epithelium toxin) had no effect on KIMD. Treatment with the K + channel blockers blocked the generation of the re- sponse to exogenously applied K +. No KIMDs were observed in FD rats treated with Methyl Alcohol, and an a-wave—only ERG was observed at 48 hours post dose. No change in the elicitation of KIMDs was observed in any rat given water, or in FS rats given Methyl Alcohol. For FD rats, the NOEL was 1.0 g/kg, and the KIMD response was completely eliminated at 2.5 g/kg. The in- vestigators concluded that the Methyl Alcohol-induced decrease in retinal ATP closely paralleled the 20% decrease observed in a-aminoadipic acid—treated retinas. The loss of b-wave genera- tion suggested that the Müller cell was the target of retinotoxicity induced by Methyl Alcohol. In a related study, also using FD and FS Long-Evans hooded rats, Gamer et al. (1995b) reported that intraretinal metabolism of Methyl Alcohol was necessary for the formate-mediated ini- tiation of Methyl...","page":10,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_004"} |
| CIR_vision_codex | NOAEL | =5000 | ppm | rat | oral | 7 h/day | developmental toxicity | {"citation":"15; 7; 19","dose":"pm Methyl Alcohol caused an irregular gait in exposed dams, and a decrease in mean body weight.","effect":"pm Methyl Alcohol caused an irregular gait in exposed dams, and a decrease in mean body weight. The dams, 15 Sprague-Dawley rats per group, were exposed for 7 h/day until gestation day (GD) 19. An increased incidence of urinary and cardiovascular defects, and extra or rudimentary cervical ribs were observed in offspring of this group. Similar malformations were observed in offspring of dams that inhaled 10,000 ppm Methyl Alcohol, but the incidence was not significantly different from that of the control group. The NOEL was 5000 ppm Methyl Alcohol. Pregnant Sprague-Dawley rats were exposed to 5000, 10,000, or 20,000 ppm Methyl Alcohol vapor (99. I % pure) on GD I to 19 during a teratologic assessment of the alcohol (Nelson et al. 1985). The rats were treated for 7 h/day, and were kept in the chambers for approximately 30 minutes after the termination of vapor generation before being returned to their cages. Feed and water were available ad libitum. Blood concentrations of Methyl Alcohol were determined after concurrent exposure on days I , IO, and 19 using nonpregnant rats. These r...","page":12,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_005"} |
| CIR_vision_codex | NOAEL | =10000 | ppm | human | inhalation | - | inhalation toxicity | {"citation":"5; 10,000","dose":"Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for terato- genic effects of 5000 ppm.","effect":"aliphatic alcohol with use in a few cosmetic formulations as a solvent and denaturant. Concentrations up to 5 % are typically used to denature ethyl alcohol in cosmetic products. Methyl Alcohol is readily absorbed through the skin and from the gastrointestinal and respiratory tracts, is distributed throughout all organs and tissues (in direct relation to the body's water distribu- tion), and is eliminated primarily via the lungs. Undiluted Methyl Alcohol is an ocular and skin irritant. Inhalation studies showed a no-effect level for maternal damage of 10,000 ppm and for terato- genic effects of 5000 ppm. Overall, Methyl Alcohol is not considered mutagenic. Carcinogenicity data were unavailable. The toxicity of Methyl Alcohol in humans results from the metabolism of the alco- hol to formate and formic acid through a formaldehyde intermedi- ate. Formate accumulation causes metabolic acidosis and inhibits cellular respiration. Methyl Alcohol toxicity is time and concentra- tion dependent, and its toxic effect is competitively inhibited with ethyl alcohol. Because of the moderating ef...","page":1,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_001"} |
| CIR_vision_codex | NOAEL | =7.5 | g/kg | rat | oral | - | oral toxicity | {"citation":"5; 6; 7","dose":"In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg).","effect":"otts 1955; Tephly and McMartin 1984). NO evidence of visual disturbances or changes in the appear- ance of the fundus were observed during studies using rabbits, chickens, dogs, and rats (Tephly and McMartin 1984). Acute Toxicity Oral Von Burg (1994) reported an acute oral LD50 of Methyl Al- cohol in the rat of 5.6 gncg and in the mouse of 7.3 gncg. In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg). The no-effect level (NOEL) was 7.5 g/kg. The IP LD50 in females ranged from 4.2 to 6.3 g/kg (ap- proximate lethal dose = 5.0 gncg), and the NOEL was 4.1 g/kg (Paumgartten et al. 1989). Dermal The acute derrnal IDSO of Methyl Alcohol using rabbits was 15.8 g/kg (NAS 1995).","page":8,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_002"} |
| CIR_vision_codex | NOAEL | =4.1 | g/kg | rat | oral | - | oral toxicity | {"citation":"5; 6; 7","dose":"In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg).","effect":"ng studies using rabbits, chickens, dogs, and rats (Tephly and McMartin 1984). Acute Toxicity Oral Von Burg (1994) reported an acute oral LD50 of Methyl Al- cohol in the rat of 5.6 gncg and in the mouse of 7.3 gncg. In a study using five albino Swiss mice per group, the oral LD50 in males of Methyl Alcohol ranged from 9.5 to 15.3 g/kg (approxi- mate lethal dose = 1 1.3 g,'kg). The no-effect level (NOEL) was 7.5 g/kg. The IP LD50 in females ranged from 4.2 to 6.3 g/kg (ap- proximate lethal dose = 5.0 gncg), and the NOEL was 4.1 g/kg (Paumgartten et al. 1989). Dermal The acute derrnal IDSO of Methyl Alcohol using rabbits was 15.8 g/kg (NAS 1995).","page":8,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_003"} |
| CIR_vision_codex | NOAEL | =1 | g/kg | rat | - | - | NOAEL study | {"citation":"48; 1; 0","dose":"No KIMDs were observed in FD rats treated with Methyl Alcohol, and an a-wave—only ERG was observed at 48 hours post dose.","effect":"in retinal ATP after a I-hour pretreatment com- pared to the untreated eyes. Pretreatment with sodium iodate (a pigment epithelium toxin) had no effect on KIMD. Treatment with the K + channel blockers blocked the generation of the re- sponse to exogenously applied K +. No KIMDs were observed in FD rats treated with Methyl Alcohol, and an a-wave—only ERG was observed at 48 hours post dose. No change in the elicitation of KIMDs was observed in any rat given water, or in FS rats given Methyl Alcohol. For FD rats, the NOEL was 1.0 g/kg, and the KIMD response was completely eliminated at 2.5 g/kg. The in- vestigators concluded that the Methyl Alcohol-induced decrease in retinal ATP closely paralleled the 20% decrease observed in a-aminoadipic acid—treated retinas. The loss of b-wave genera- tion suggested that the Müller cell was the target of retinotoxicity induced by Methyl Alcohol. In a related study, also using FD and FS Long-Evans hooded rats, Gamer et al. (1995b) reported that intraretinal metabolism of Methyl Alcohol was necessary for the formate-mediated ini- tiation of Methyl...","page":10,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_004"} |
| CIR_vision_codex | NOAEL | =5000 | ppm | rat | oral | 7 h/day | developmental toxicity | {"citation":"15; 7; 19","dose":"pm Methyl Alcohol caused an irregular gait in exposed dams, and a decrease in mean body weight.","effect":"pm Methyl Alcohol caused an irregular gait in exposed dams, and a decrease in mean body weight. The dams, 15 Sprague-Dawley rats per group, were exposed for 7 h/day until gestation day (GD) 19. An increased incidence of urinary and cardiovascular defects, and extra or rudimentary cervical ribs were observed in offspring of this group. Similar malformations were observed in offspring of dams that inhaled 10,000 ppm Methyl Alcohol, but the incidence was not significantly different from that of the control group. The NOEL was 5000 ppm Methyl Alcohol. Pregnant Sprague-Dawley rats were exposed to 5000, 10,000, or 20,000 ppm Methyl Alcohol vapor (99. I % pure) on GD I to 19 during a teratologic assessment of the alcohol (Nelson et al. 1985). The rats were treated for 7 h/day, and were kept in the chambers for approximately 30 minutes after the termination of vapor generation before being returned to their cages. Feed and water were available ad libitum. Blood concentrations of Methyl Alcohol were determined after concurrent exposure on days I , IO, and 19 using nonpregnant rats. These r...","page":12,"pdf":"pr331.pdf","row_type":"noael_study","study_id":"pr331_noael_005"} |
COSMOS_DB 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 1584 | mg/kg bw/day | rat | oral | 21 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 2 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 3200 | mg/kg bw/day | rat | oral | 8 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1600 | mg/kg bw/day | rat | oral | 8 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 3250 | mg/kg bw/day | rat | oral | 1 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2500 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
California Proposition 65 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 MADL | ABinhalation=47000; oral=23000 | ug/day | - | - | 2012-03-16 | Maximum allowable dose level | {"cancer_reproductive":"developmental","listed_date":"2012-03-16","listing_mechanism":"AB","madl":"inhalation=47000; oral=23000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | ABinhalation=47000; oral=23000 | ug/day | - | - | 2012-03-16 | Maximum allowable dose level | {"cancer_reproductive":"developmental","listed_date":"2012-03-16","listing_mechanism":"AB","madl":"inhalation=47000; oral=23000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | ABinhalation=47000; oral=23000 | ug/day | - | - | 2012-03-16 | Maximum allowable dose level | {"cancer_reproductive":"developmental","listed_date":"2012-03-16","listing_mechanism":"AB","madl":"inhalation=47000; oral=23000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 MADL | ABinhalation=47000; oral=23000 | ug/day | - | - | 2012-03-16 | Maximum allowable dose level | {"cancer_reproductive":"developmental","listed_date":"2012-03-16","listing_mechanism":"AB","madl":"inhalation=47000; oral=23000","nsrl":null,"row_type":"madl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 2012-03-16 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"2012-03-16","listing_mechanism":"AB","madl":"inhalation=47000; oral=23000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 2012-03-16 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"2012-03-16","listing_mechanism":"AB","madl":"inhalation=47000; oral=23000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 2012-03-16 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"2012-03-16","listing_mechanism":"AB","madl":"inhalation=47000; oral=23000","nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 2012-03-16 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"2012-03-16","listing_mechanism":"AB","madl":"inhalation=47000; oral=23000","nsrl":null,"source_table":"prop65_listings"} |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =500 | mg/kg bw/day | Rat | oral: gavage | 90 days | subchronic | EFSA FEEDAP - 2013 - OutputID 2209 - other - hepatotoxicity - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =500 | mg/kg bw/day | Rat | oral: gavage | 90 days | subchronic | EFSA FEEDAP - 2013 - OutputID 2209 - other - hepatotoxicity - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169 |
EPA_IRIS_iris_rfc_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfc_systems.csv | BMDL 1SD (INTERNAL) | =858 | mg-hr/L | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=2bbe5a08d5c30d95; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL 1SD (internal): 858 mg-hr/L; system=Nervous, Developmental; basis=Reduced brain weight in rat pups at 6 weeks of age; point_of_departure=BMDL 1SD (internal): 858 mg-hr/L; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID2021731; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; rfc_last_updated=09/30/2013; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0305_summary.pdf |
| EPA_IRIS_iris_rfc_systems.csv | RfC | =20 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=f396f17950a646fd; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=2e1; system=Nervous, Developmental; basis=Reduced brain weight in rat pups at 6 weeks of age; point_of_departure=BMDL 1SD (internal): 858 mg-hr/L; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID2021731; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; rfc_last_updated=09/30/2013; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0305_summary.pdf |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | BMDL 05 (INTERNAL) | =43.1 | mg/L | - | inhalation | chronic | IRIS chronic oral RfD system PoD | row_hash=364bfc32dc2ad550; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL 05 (internal): 43.1 mg/L; system=Developmental; basis=Extra cervical ribs; point_of_departure=BMDL 05 (internal): 43.1 mg/L; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID2021731; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; rfd_last_updated=09/30/2013; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0305_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =2 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=6e1ea84ad79324ee; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2; system=Developmental; basis=Extra cervical ribs; point_of_departure=BMDL 05 (internal): 43.1 mg/L; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID2021731; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; rfd_last_updated=09/30/2013; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0305_summary.pdf |
INCHEM_WHO_ehc_ehc_ehc196 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_ehc_ehc_ehc196 | NOAEL | =5000 | ppm | - | - | - | Toxicology study | document_id=ehc_ehc_ehc196; title=Methanol (EHC 196, 1997); path=mirror/documents/ehc/ehc/ehc196.htm; row_hash=bb23b9c002476517; raw_unit=ppm; context=Slight maternal toxicity was found at this exposure level, and no adverse effects to the mother or offspring were found in animals exposed to 6500 mg/m 3 (5000 ppm), which was interpreted as the no-observed-adverse-effect level (NOAEL) for this test system. |
| INCHEM_WHO_ehc_ehc_ehc196 | NOAEL | =1300 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc196; title=Methanol (EHC 196, 1997); path=mirror/documents/ehc/ehc/ehc196.htm; row_hash=dd375c3979b8e15b; raw_unit=mg/m 3; context=The NOAEL for developmental toxicity was 1300 mg/m 3 (1000 ppm) methanol. |
| INCHEM_WHO_ehc_ehc_ehc196 | NOEL | =100 | ppm | - | - | - | Toxicology study | document_id=ehc_ehc_ehc196; title=Methanol (EHC 196, 1997); path=mirror/documents/ehc/ehc/ehc196.htm; row_hash=582cd117f5a405e8; raw_unit=ppm; context=A concentration of 130 mg/m 3 (100 ppm) was found to be the NOEL in both species. |
NTP_ICE_acute_inhalation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 189.9059 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1399; Record_ID=acute_inhalation_1695; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021731; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=189.9059; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP_ICE_acute_inhalation | LC50 | 83.8205 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1400; Record_ID=acute_inhalation_1697; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021731; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=83.8205; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP_ICE_acute_inhalation | LC50 | 128.2192 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1401; Record_ID=acute_inhalation_2248; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021731; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=128.2192; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP_ICE_acute_inhalation | LC50 | 87.6187 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1402; Record_ID=acute_inhalation_2250; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021731; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=87.6187; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
NTP_ICE_acute_oral 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =7400 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9168; row=3970; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =7914 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9170; row=3971; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =8000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9172; row=3972; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =9100 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9174; row=3973; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =10283 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9176; row=3974; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =11303 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9178; row=3975; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =12880 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9180; row=3976; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =12900 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9182; row=3977; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =5628 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9219; row=3978; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =6200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9165; row=3979; data_type=In Vivo; mixture=Chemical; chemical_name=Methanol; preferred_name=Methanol; dtxsid=DTXSID2021731; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021731; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 0.8866 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=836; Record_ID=adme_parameters_1186; Data_Type=Measured; DTXSID=DTXSID2021731; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.8866; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP_ICE_adme_parameters | Clint | 3.837 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=837; Record_ID=adme_parameters_1186; Data_Type=Measured; DTXSID=DTXSID2021731; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=3.837; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP_ICE_adme_parameters | Fu | 0.9449 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=838; Record_ID=adme_parameters_1186; Data_Type=Measured; DTXSID=DTXSID2021731; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.9449; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
| NTP_ICE_adme_parameters | Fu | 0.9505 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=839; Record_ID=adme_parameters_1186; Data_Type=Measured; DTXSID=DTXSID2021731; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.9505; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021731; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021731 |
ToxValDB_Cal_OEHHA_REL_derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Cal_OEHHA_REL_derivations | BMC (05) | =399.708 | mg/m3 | Mouse | inhalation | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Rogers JM, Mole ML, Chernoff N, Barbee BD, Turner CI, Logsdon TR, and Kavlock JV. 1993. The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative doseresponse modeling for estimation of benchmark doses. Teratology 47:175-188.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Abnormal cervical ribs, exencephaly, cleft palate; STUDY_GROUP=Cal OEHHA REL derivations:15952100:-:-pregnant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69c4b137502623bde25fc82270639bec |
| ToxValDB_Cal_OEHHA_REL_derivations | NOAEL | =251.619 | mg/m3 | Human | inhalation | acute; 75 minutes | clinical | LONG_REF=Cook MR, Bergman FJ, Cohen HD, Gerkovich MM, Graham C, Harris RK. Effects of methanol vapor on human neurobehavioral measures. Health Effects Institute (HEI) Research Report No. 42. Cambridge (MA): HEI; 1991.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=subtle impairment in the performance of complicated tasks; STUDY_GROUP=Cal OEHHA REL derivations:15951947:M:-healthy paid volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a62091e8c75f5c82245df969f4c7ef3f |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =72078.5 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15516998:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_62bf9577198a1ca91b6e632ca0b76b4f |
ToxValDB_DOE_Wildlife_Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Wildlife_Benchmarks | LOAEL | =250 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511662_15511663:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06b2bce6a8b5cbe4756697b8d485c9d8 |
| ToxValDB_DOE_Wildlife_Benchmarks | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511662_15511663:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c5939ffe5b429f14273c409e1593eda7 |
ToxValDB_ECHA_IUCLID 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEC | =6650 | mg/m3 | Mouse | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d23231a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821038:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f9447c4539267f80be7d5866f8c256c |
| ToxValDB_ECHA_IUCLID | LOAEC | =13105.2 | mg/m3 | Mouse | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d232343; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=fetus: external malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821100:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_836962e77fa82229af08814abf305009 |
| ToxValDB_ECHA_IUCLID | LOAEC | =2000 | mg/kg bw/day | Rabbit | injection | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d232355; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821806:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a3b2ef3de363e2fb12c26aafd751c4a1 |
| ToxValDB_ECHA_IUCLID | LOAEL | <2100 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b48b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/8?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820009_15820243:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_355e53709533685945821c65b555c40e |
| ToxValDB_ECHA_IUCLID | LOAEL | >1800 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b48b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/8?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820009_15820243:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_02f3637f5e69e1f7a70d78970836eb8b |
| ToxValDB_ECHA_IUCLID | LOAEL | =5000 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf819; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15825258:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_73080945d2df65138d3b2788361a66e7 |
| ToxValDB_ECHA_IUCLID | LOAEL | =2340 | mg/kg bw/day | Monkey | oral | short-term; 3 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9eae4b0a7c65d21f652; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11573/7/6/2?documentUUID=a86ef6cb-ea7a-4d79-a145-6a79d1a7d751; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832306_15836664:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b96f8951465c8a30a041bcc54698c6c7 |
| ToxValDB_ECHA_IUCLID | NOAEC | >=1300 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217a00; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/8?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15817282:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_45b88ffdc2b6c4ae5ad957f9f61d4e5e |
| ToxValDB_ECHA_IUCLID | NOAEC | =5980 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d2322d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15820899:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc282c2a21cded709ca0048d1a466f89 |
| ToxValDB_ECHA_IUCLID | NOAEC | =2390 | mg/m3 | Monkey | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d2322f8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15822334:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fa91e17bf31ad93ecea323053e0d5c0 |
| ToxValDB_ECHA_IUCLID | NOAEC | =19940 | mg/m3 | Mouse | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d23230b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822350_15822514:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad44835e5014c40a82aaeacf87d31d60 |
| ToxValDB_ECHA_IUCLID | NOAEC | =6630 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fd3e4b096bca877ef0a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/6/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15827056:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54d2c045612e782afe63d4b42d840e15 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2000 | mg/kg bw/day | Rabbit | injection | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d232355; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15823089:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c8cee53f7d2102d9c694074e7fa93c3 |
| ToxValDB_ECHA_IUCLID | NOAEL | =5000 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf81f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13210/7/9/3?documentUUID=07a4815b-2083-4d0d-96c8-448cbbc7bc7a; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15825259_15825260:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1decd4361d83a13d522811e1e22501fd |
ToxValDB_ECOTOX 33 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEC | =11.6 | ul/mL | Rat | environmental | short-term; 1.6667 days | developmental | LONG_REF=Teratology52(4): 233-243 Brown-Woodman,P.D.C., F. Huq, L. Hayes, C. Herlihy, K. Picker, and W.S. Webster In Vitro Assessment of the Effect of Methanol and the Metabolite, Formic Acid, on Embryonic Development of the Rat 1995; TITLE=In Vitro Assessment of the Effect of Methanol and the Metabolite, Formic Acid, on Embryonic Development of the Rat; AUTHOR=Brown-Woodman,P.D.C., F. Huq, L. Hayes, C. Herlihy, K. Picker, and W.S. Webster; DOI=10.1002/tera.1420520409; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112960; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Development: Slowed, Retarded, Delayed or Non-development; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606004_15606005:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6f102e826f8b6c2f9de8e894db6691f6 |
| ToxValDB_ECOTOX | LOEL | =1.3 | mL/kg bw | Rat | oral | short-term; 20 days | developmental | LONG_REF=Reprod. Toxicol.11(4): 503-510 Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats 1997; TITLE=Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats; AUTHOR=Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller; DOI=10.1016/s0890-6238(97)00017-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112984; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development; STUDY_GROUP=ECOTOX:15595054:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1b24b2c9ef20ef7df357110d2b63ed58 |
| ToxValDB_ECOTOX | LOEL | =2 | % v/v | Rat | oral | short-term; 15 days | reproduction developmental | LONG_REF=EPA/OTS Doc.#88-920000356:8 p. Amoco Corp. Initial Submission: Letter Submitting Preliminary Information from a Pilot Developmental Toxicity Study on Methanol with Attachment 1991; TITLE=Initial Submission: Letter Submitting Preliminary Information from a Pilot Developmental Toxicity Study on Methanol with Attachment; AUTHOR=Amoco Corp.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115033; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Morphology: Weight|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595465_15595466_15605069:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a66773946228b85811b32f660e4c7288 |
| ToxValDB_ECOTOX | LOEL | =8 | mg/mL | Mouse | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation|Genetics: DNA concentration|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595523_15595524:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=66f057200cc608b2a3e3009476df1824 |
| ToxValDB_ECOTOX | LOEL | =10 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595525_15595526_15595527:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=966f6cd5aff95072e95ffb3b00c8758f |
| ToxValDB_ECOTOX | LOEL | =4 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595525_15595526_15595527:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=10cfe9cbf0ea53b2a7499f7d0124a4a2 |
| ToxValDB_ECOTOX | LOEL | =5.2 | mL/kg bw | Rat | oral | short-term; 20 days | short-term | LONG_REF=Reprod. Toxicol.11(4): 503-510 Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats 1997; TITLE=Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats; AUTHOR=Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller; DOI=10.1016/s0890-6238(97)00017-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112984; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595908_15595909_15608902:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f36f0cfc6afb362fc499252c5219c4e2 |
| ToxValDB_ECOTOX | LOEL | =6 | mg/mL | Mouse | environmental | acute; 0.3333 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.70(4): 179-184 Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture 2004; TITLE=Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture; AUTHOR=Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III; DOI=10.1002/bdra.20009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596545_15596546:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4caf62f343c3d3b0823015f74fa5814a |
| ToxValDB_ECOTOX | LOEL | =6.5 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | LONG_REF=Environ. Res.73(1/2): 52-62 Youssef,A.F., and B.W. Santi Simple Neurobehavioral Functional Observational Battery and Objective Gait Analysis Validation by the Use of Acrylamide and Methanol with a Built-in Recovery Period 1997; TITLE=Simple Neurobehavioral Functional Observational Battery and Objective Gait Analysis Validation by the Use of Acrylamide and Methanol with a Built-in Recovery Period; AUTHOR=Youssef,A.F., and B.W. Santi; DOI=10.1006/enrs.1997.3718; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=95030; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Behavior: Behavioral changes, general; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597551_15610867:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fdf6c818bbc881948b6237b8e85295eb |
| ToxValDB_ECOTOX | LOEL | =12 | mg/mL | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Toxicology97(1-3): 159-171 Abbott,B.D., M. Ebron-McCoy, and J.E. Andrews Cell Death in Rat and Mouse Embryos Exposed to Methanol in Whole Embryo Culture 1995; TITLE=Cell Death in Rat and Mouse Embryos Exposed to Methanol in Whole Embryo Culture; AUTHOR=Abbott,B.D., M. Ebron-McCoy, and J.E. Andrews; DOI=10.1016/0300-483x(94)02945-q; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113177; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Cell Viability|Development: Slowed, Retarded, Delayed or Non-development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597724_15597725_15599610:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0dccc928dcb166f02f5a68333d80676f |
| ToxValDB_ECOTOX | LOEL | =3 | mg/mL | Mouse | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.70(4): 179-184 Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture 2004; TITLE=Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture; AUTHOR=Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III; DOI=10.1002/bdra.20009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598649_15598650_15599861_15599862:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2f76c37c5ed8a635df3b9ada3b43d599 |
| ToxValDB_ECOTOX | LOEL | =16 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602475_15602476:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9cf5482376cd958d6c78f352cdf9c22d |
| ToxValDB_ECOTOX | LOEL | =3.25 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | LONG_REF=Environ. Res.73(1/2): 52-62 Youssef,A.F., and B.W. Santi Simple Neurobehavioral Functional Observational Battery and Objective Gait Analysis Validation by the Use of Acrylamide and Methanol with a Built-in Recovery Period 1997; TITLE=Simple Neurobehavioral Functional Observational Battery and Objective Gait Analysis Validation by the Use of Acrylamide and Methanol with a Built-in Recovery Period; AUTHOR=Youssef,A.F., and B.W. Santi; DOI=10.1006/enrs.1997.3718; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=95030; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Behavior: Foot retraction; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597551_15610867:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=174a3118f4823991ec91bba9615df583 |
| ToxValDB_ECOTOX | LOEL | =0.046 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611002_15611004_15611005_15611006:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a3bbbbc35671b5278d38a35d78c41e4 |
| ToxValDB_ECOTOX | LOEL | =0.001 | mg | Mouse | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Crown to rump length|Development: Normal|Development: Organ/tissue formation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15611003:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=598066c211dde5b52f8551b61c3ef7e8 |
| ToxValDB_ECOTOX | LOEL | =0.135 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611002_15611004_15611005_15611006:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=eeea29c60b365a05caf6e128632c7899 |
| ToxValDB_ECOTOX | LOEL | =1600 | mg/kg bw/day | Rat | oral | short-term; 8 days | reproduction developmental | LONG_REF=- | Toxicology79(3): 205-214 Cummings,A.M. Evaluation of the Effects of Methanol During Early Pregnancy in the Rat 1993; TITLE=Evaluation of the Effects of Methanol During Early Pregnancy in the Rat; AUTHOR=Cummings,A.M.; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113328; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Pregnant uterine weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15613017_15613451:F:P0-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=24f2afc47fd5561aa47d7710fa8391c7 |
| ToxValDB_ECOTOX | LOEL | =2000 | mg/kg bw/day | Mouse | oral | short-term; 11 days | developmental | LONG_REF=- | Teratology55(2): 138-144 Connelly,L.E., and J.M. Rogers Methanol Causes Posteriorization of Cervical Vertebrae in Mice 1997; TITLE=Methanol Causes Posteriorization of Cervical Vertebrae in Mice; AUTHOR=Connelly,L.E., and J.M. Rogers; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115462; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Development: Abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15613480:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=791ab0f287c4b23d45d3fd408d1d8d87 |
| ToxValDB_ECOTOX | NOEC | =8.57 | ul/mL | Rat | environmental | short-term; 1.6667 days | developmental | LONG_REF=Teratology52(4): 233-243 Brown-Woodman,P.D.C., F. Huq, L. Hayes, C. Herlihy, K. Picker, and W.S. Webster In Vitro Assessment of the Effect of Methanol and the Metabolite, Formic Acid, on Embryonic Development of the Rat 1995; TITLE=In Vitro Assessment of the Effect of Methanol and the Metabolite, Formic Acid, on Embryonic Development of the Rat; AUTHOR=Brown-Woodman,P.D.C., F. Huq, L. Hayes, C. Herlihy, K. Picker, and W.S. Webster; DOI=10.1002/tera.1420520409; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112960; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Development: Slowed, Retarded, Delayed or Non-development; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606004_15606005:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=09e6a8e294108312cdb318005c87c22c |
| ToxValDB_ECOTOX | NOEL | =1 | % v/v | Rat | oral | short-term; 15 days | reproduction developmental | LONG_REF=EPA/OTS Doc.#88-920000356:8 p. Amoco Corp. Initial Submission: Letter Submitting Preliminary Information from a Pilot Developmental Toxicity Study on Methanol with Attachment 1991; TITLE=Initial Submission: Letter Submitting Preliminary Information from a Pilot Developmental Toxicity Study on Methanol with Attachment; AUTHOR=Amoco Corp.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115033; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Morphology: Weight|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595465_15595466_15605069:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=981214b2f8f0caf758b56bcf236570cf |
| ToxValDB_ECOTOX | NOEL | =4 | mg/mL | Mouse | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation|Genetics: DNA concentration|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595523_15595524:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f8f8d76ee4ef8e0bd7b402279b6c9529 |
| ToxValDB_ECOTOX | NOEL | =8 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595525_15595526_15595527:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=30f4f3d34eb6803db7f472a06d6ab591 |
| ToxValDB_ECOTOX | NOEL | =16 | mg/mL | Rat | environmental | short-term; 2 days | short-term | LONG_REF=Toxicology97(1-3): 159-171 Abbott,B.D., M. Ebron-McCoy, and J.E. Andrews Cell Death in Rat and Mouse Embryos Exposed to Methanol in Whole Embryo Culture 1995; TITLE=Cell Death in Rat and Mouse Embryos Exposed to Methanol in Whole Embryo Culture; AUTHOR=Abbott,B.D., M. Ebron-McCoy, and J.E. Andrews; DOI=10.1016/0300-483x(94)02945-q; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113177; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Cell Viability|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX:15595825:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0c2636b2a2084d9477fb58d0730e0e28 |
| ToxValDB_ECOTOX | NOEL | =2.6 | mL/kg bw | Rat | oral | short-term; 20 days | short-term | LONG_REF=Reprod. Toxicol.11(4): 503-510 Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats 1997; TITLE=Teratogenicity of Methanol Following a Single Oral Dose in Long-Evans Rats; AUTHOR=Youssef,A.F., R.B. Baggs, B. Weiss, and R.K. Miller; DOI=10.1016/s0890-6238(97)00017-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112984; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595908_15595909_15608902:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=310d06c5c1db6af927c51a483cd295d0 |
| ToxValDB_ECOTOX | NOEL | =10 | mmol/kg | Rat | oral | short-term; 1.75 days | short-term | LONG_REF=Fundam. Appl. Toxicol.15(3): 429-440 Ray,S.D., and H.M. Mehendale Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols 1990; TITLE=Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols; AUTHOR=Ray,S.D., and H.M. Mehendale; DOI=10.1016/0272-0590(90)90029-j; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=78954; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15598135:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=18da45c4f737bb8caad9c5ee4b99b0f6 |
| ToxValDB_ECOTOX | NOEL | =2 | mg/mL | Mouse | environmental | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.70(4): 179-184 Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture 2004; TITLE=Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture; AUTHOR=Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III; DOI=10.1002/bdra.20009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598649_15598650_15599861_15599862:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b79f947068ab56de9e0a462dc793719b |
| ToxValDB_ECOTOX | NOEL | =3 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.70(4): 179-184 Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture 2004; TITLE=Developmental Toxicity of Methanol: Pathogenesis in CD-1 and C57BL/6J Mice Exposed in Whole Embryo Culture; AUTHOR=Degitz,S.J., J.M. Rogers, R.M. Zucker, and E.S. Hunter III; DOI=10.1002/bdra.20009; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117194; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601567_15601568:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6fcb93d1662534b655c88cc63a5a3719 |
| ToxValDB_ECOTOX | NOEL | =12 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602475_15602476:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a40da8cb1163fbc484c879e148ddd73a |
| ToxValDB_ECOTOX | NOEL | =1000 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin|Enzyme(s): beta-N-Acetylhexosaminidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15602992:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8b31b38f6b2264e9d0bd4b433b686f4f |
| ToxValDB_ECOTOX | NOEL | =0.001 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611002_15611004_15611005_15611006:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b57e45dd1d0b8c0d445b6c2f16a9200c |
| ToxValDB_ECOTOX | NOEL | =0.09 | mg | Mouse | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611002_15611004_15611005_15611006:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6dc730f11bc4892d0277a0cec494ab6d |
| ToxValDB_ECOTOX | NOEL | =0.135 | mg | Rat | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=development|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611075_15611076_15611077:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d22e19c1019fe0569d8dda81c4dc4eb4 |
| ToxValDB_ECOTOX | NOEL | =3200 | mg/kg bw/day | Rat | oral | short-term; 8 days | reproduction developmental | LONG_REF=- | Toxicology79(3): 205-214 Cummings,A.M. Evaluation of the Effects of Methanol During Early Pregnancy in the Rat 1993; TITLE=Evaluation of the Effects of Methanol During Early Pregnancy in the Rat; AUTHOR=Cummings,A.M.; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113328; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Development: Slowed, Retarded, Delayed or Non-development|Morphology: Yolk Sac Diameter, head and rump length, somite count |Morphology: Length|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other; STUDY_GROUP=ECOTOX:15612967:F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=e5d341770ecdc4fb120da824e92d3c8c |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =500 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species. doi:10.2903/j.efsa.2013.3169.; TITLE=Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3169; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=other; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=EFSA:15614457:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0940db5ceaf5403e67ff316e5cbd872c |
ToxValDB_EPA_HWIR 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_HWIR | NOAEL | =1310 | mg/m3 | Mouse | inhalation | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Rogers, J.M., M.L. Mole, N. Chernoff, et al. 1993. The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology 47(3):175-188; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/683eef73e4b096bca883dd65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/html/risk.html; SUBSOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/pdf/r99019b.pdf; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Developmental malformations (increased cervical ribs, exencephaly, and cleft palate); TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EPA HWIR:15952207:F:-pregnant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7cdb1bc15128d9e121226ab29cfdb356 |
| ToxValDB_EPA_HWIR | RfC | =13 | mg/m3 | Human | inhalation | - | toxicity value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/683eef73e4b096bca883dd65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/html/risk.html; SUBSOURCE_URL=https://archive.epa.gov/epawaste/hazard/web/pdf/r99019b.pdf; STUDY_GROUP=EPA HWIR:15952206:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_585e73e4d953d54eb651a5cb16673b2e |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =130 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633251_15633252:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8705c93eb205090b5c2799b97ad65858 |
ToxValDB_HPVIS 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | LOAEL | =6552.59 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Andrews,L.S., J.J.Clary, J.B.Terrill,and .F.Bolte. (1987). Subchronic inhalation toxicity of methanol. J Toxicol. Environ. Health 20:117-124.; TITLE=Subchronic inhalation toxicity of methanol; AUTHOR=Andrews,L.S., J.J.Clary, J.B.Terrill,and .F.Bolte; QUALITY=1; EXTERNAL_SOURCE_ID=61857; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639136_15639237:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d12a65c8ba03b66fa050f44ddc235ddb |
| ToxValDB_HPVIS | LOAEL | =1310.52 | mg/m3 | Primate | inhalation | short-term; 12 days | reproduction developmental | LONG_REF=New Energy Development Organization (NEDO). (1986). Toxicological research of methanol as a fuel for power station. Tokyo, Japan. September.; TITLE=Toxicological research of methanol as a fuel for power station; AUTHOR=New Energy Development Organization (NEDO); QUALITY=2; EXTERNAL_SOURCE_ID=60803; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639657_15639985:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d1676c8948807a014cc5ecf6f9bca17e |
| ToxValDB_HPVIS | LOAEL | =2500 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=USEPA 1986.; AUTHOR=USEPA; QUALITY=2; EXTERNAL_SOURCE_ID=63179; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS:15639984:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_88358c2b9b8f2197e88213c0b58e3213 |
| ToxValDB_HPVIS | LOAEL | <=26210.4 | mg/m3 | Rat | inhalation | short-term; 19 days | reproduction developmental | LONG_REF=Nelson, B.K., W.S. Brightwell, D.R. MacKenzie, A. Khan, J.R. Burg, W.W. Weigel, and P.T. Goad. (1985). Teratological Assessment of methanol and ethanol at high inhalation levels in rats. Fundamental and Applied Toxicol 5: 727-736.; TITLE=Teratological assessment of methanol and ethanol at high inhalation levels in rats; AUTHOR=Nelson, B., Brightwell, W., MacKenzie, D., et al; QUALITY=2; EXTERNAL_SOURCE_ID=58249; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS:15642397:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fff0469c90c99a896c4a8cf8317e7a03 |
| ToxValDB_HPVIS | LOAEL | <=19657.8 | mg/m3 | Mouse | inhalation | short-term; 20 days | reproduction developmental | LONG_REF=Bolon, B., D.C. Dorman, D. Janszen, K.T. Morgan, and F. Welsch. (1993). Phase-specific developmental toxicity in mice following maternal methanol inhalation. Fund. Appl. Toxicol.21:508-516.; TITLE=Phase-specific developmental toxicity in mice following maternal methanol inhalation; AUTHOR=Bolon, B., D.C. Dorman, D. Janszen, K.T. Morgan, and F. Welsch; QUALITY=2; EXTERNAL_SOURCE_ID=59456; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642528_15642756:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40b64160254975d4b09376769797889e |
| ToxValDB_HPVIS | LOAEL | =2621.04 | mg/m3 | Mouse | inhalation | short-term; 10 days | developmental | LONG_REF=Rogers,J.M.; M.L., Mole; N., Chernoff; B.D.,Barbee; C.L., Turner; T.R., Logsdon; R.J.,Kavlock, (1993), The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology 47(3):175-88; TITLE=The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses; AUTHOR=Rogers,J.M.; M.L., Mole; N., Chernoff; B.D.,Barbee; C.L., Turner; T.R., Logsdon; R.J.,Kavlock; QUALITY=2; EXTERNAL_SOURCE_ID=59856; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15642892:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0818f8528476f6e86649c4d92d3d966c |
| ToxValDB_HPVIS | NOAEL | >=3931.55 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | LONG_REF=Andrews,L.S., J.J.Clary, J.B.Terrill,and .F.Bolte. (1987). Subchronic inhalation toxicity of methanol. J Toxicol. Environ. Health 20:117-124.; TITLE=Subchronic inhalation toxicity of methanol; AUTHOR=Andrews,L.S., J.J.Clary, J.B.Terrill,and .F.Bolte; QUALITY=1; EXTERNAL_SOURCE_ID=61051; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639136_15639237:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3bb385a1a09c527cee00d391a8b1df1e |
| ToxValDB_HPVIS | NOAEL | >1310.52 | mg/m3 | Mouse | inhalation | chronic; 18 months | reproduction developmental | LONG_REF=New Energy Development Organization (NEDO). (1986). Toxicological research of methanol as a fuel for power station. Tokyo, Japan. September.; TITLE=Toxicological research of methanol as a fuel for power station; AUTHOR=New Energy Development Organization (NEDO); QUALITY=2; EXTERNAL_SOURCE_ID=64218; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS:15640302:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c634a14f794ada9ac7f830f283c36d4 |
| ToxValDB_HPVIS | NOAEL | >=13105.2 | mg/m3 | Mouse | inhalation | short-term; 20 days | reproduction developmental | LONG_REF=Bolon, B., D.C. Dorman, D. Janszen, K.T. Morgan, and F. Welsch. (1993). Phase-specific developmental toxicity in mice following maternal methanol inhalation. Fund. Appl. Toxicol.21:508-516.; TITLE=Phase-specific developmental toxicity in mice following maternal methanol inhalation; AUTHOR=Bolon, B., D.C. Dorman, D. Janszen, K.T. Morgan, and F. Welsch; QUALITY=2; EXTERNAL_SOURCE_ID=58650; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642528_15642756:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6643235d6480a073b066ea2ae62799a8 |
| ToxValDB_HPVIS | NOAEL | >2358.93 | mg/m3 | Primate | inhalation | chronic; 120 days | reproduction developmental | LONG_REF=Burbacher, T., D.,Shen, K.,Grant, L.,Sheppard, D.,Dumian, S.,Ellis andc N.,Liberato, (1999) Reproductive and offspring developmental effects following maternal inhalation exposure to methanol in non-human primates, Part 11: Developmental effects in infants exposed prenatally to methanol. Health Effects Institute Report 89 October 1999; TITLE=Reproductive and offspring developmental effects following maternal inhalation exposure to methanol in non-human primates, Part 11: Developmental effects in infants exposed prenatally to methanol; AUTHOR=Burbacher, T., D.,Shen, K.,Grant, L.,Sheppard, D.,Dumian, S.,Ellis andc N.,Liberato; QUALITY=1; EXTERNAL_SOURCE_ID=59058; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=HPVIS:15642655:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d675347f89adbb05809121e700603133 |
| ToxValDB_HPVIS | NOAEL | =131.052 | mg/m3 | Rat | inhalation | chronic; 365 days | reproduction developmental | LONG_REF=New Energy Development Organization (NEDO). (1986). Toxicological research of methanol as a fuel for power station. Tokyo, Japan. September.; TITLE=Toxicological research of methanol as a fuel for power station; AUTHOR=New Energy Development Organization (NEDO); QUALITY=2; EXTERNAL_SOURCE_ID=65454; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS:15643239:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b2c5b821d930400cdcc98305c580cfe |
ToxValDB_IRIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | BMDL (05) | =43.1 | mg/L | Mouse | oral | short-term (developmental); 12 days | developmental | LONG_REF=Rogers, JM; Mole, ML; Chernoff, N; Barbee, BD; Turner, CI; Logsdon, TR; Kavlock, RJ. (1993b). The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology 47: 175-188.; TITLE=The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses; AUTHOR=Rogers, JM; Mole, ML; Chernoff, N; Barbee, BD; Turner, CI; Logsdon, TR; Kavlock, RJ; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; TOXICOLOGICAL_EFFECT=extra cervical ribs; STUDY_GROUP=IRIS:15644878:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_359050c72a7ba301c4ef259ae20ba8d4 |
| ToxValDB_IRIS | BMDL (1SD) | =858 | mg-hr/L | Rat | inhalation | - | developmental | LONG_REF=NEDO (New Energy Development Organization). (1987). Toxicological research of methanol as a fuel for power station: summary report on tests with monkeys, rats and mice. Tokyo, Japan.; TITLE=Toxicological research of methanol as a fuel for power station: summary report on tests with monkeys, rats and mice; AUTHOR=NEDO (New Energy Development Organization); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; TOXICOLOGICAL_EFFECT=reduced brain weight in rat pups; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=IRIS:15645069:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_af156bc9e5f03b4ddb31c2fcc08fbafc |
| ToxValDB_IRIS | RfC | =20 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=NEDO (New Energy Development Organization). (1987). Toxicological research of methanol as a fuel for power station: summary report on tests with monkeys, rats and mice. Tokyo, Japan.; TITLE=Toxicological research of methanol as a fuel for power station: summary report on tests with monkeys, rats and mice; AUTHOR=NEDO (New Energy Development Organization); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; TOXICOLOGICAL_EFFECT=Reduced brain weight in male rats; STUDY_GROUP=IRIS:15645068:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0445362795c05860c383c7ca6f3bbcde |
| ToxValDB_IRIS | RfD | =2 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Rogers, JM; Mole, ML; Chernoff, N; Barbee, BD; Turner, CI; Logsdon, TR; Kavlock, RJ. (1993b). The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses. Teratology 47: 175-188.; TITLE=The developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose-response modeling for estimation of benchmark doses; AUTHOR=Rogers, JM; Mole, ML; Chernoff, N; Barbee, BD; Turner, CI; Logsdon, TR; Kavlock, RJ; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5715; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=305; TOXICOLOGICAL_EFFECT=extra cervical ribs; STUDY_GROUP=IRIS:15645066:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_925d9a26b5199f374a73effd3887b20d |
ToxValDB_RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfD | =5 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663555:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d6febd60e0fea7943a913990d4ddd28d |
ToxValDB_TX_TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | LOAEL | =601.528 | mg/m3 | Human | inhalation | chronic; 7.8 years | occupational | LONG_REF=Kawai T, T Yasugi, K Mizunuma et al. 1991. Methanol in urine as a biological indicator of occupational exposure to methanol vapor. Int Arch Occup Environ Health, 63, 311-318; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ae7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/methanol.pdf; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=nasal irritation; STUDY_GROUP=TX TCEQ:15954522:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_95c6cccb0dda7d38d94deea201bf8509 |
| ToxValDB_TX_TCEQ | NOAEL | =266.69 | mg/m3 | Human | inhalation | acute; 4 hours | clinical | LONG_REF=Mann WJ, A Muttray, D Schaefer et al. 2002. Exposure to 200 ppm of methanol increases the concentrations of interleukin-1beta and interleukin-8 in nasal secretions of healthy volunteers. Ann Otol Rhinol Laryngol, 111, 633-638.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ae7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/methanol.pdf; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=Absence of irritation and subjective symptoms; STUDY_GROUP=TX TCEQ:15954523:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f11f3ab226cdc0948dbc285dfcb6a64b |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | Y4S76JWI15 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH4O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Y4S76JWI15"} |
| openFDA substances | FDA UNII substance identifier | Y4S76JWI15 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH4O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Y4S76JWI15"} |
| openFDA substances | FDA UNII substance identifier | Y4S76JWI15 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH4O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Y4S76JWI15"} |
| openFDA substances | FDA UNII substance identifier | Y4S76JWI15 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH4O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Y4S76JWI15"} |