NOAEL Studies Cosmetic Ingredient

Methyl Benzoate NOAEL Studies

INCI: METHYL BENZOATE (BENZOIC ACID, METHYL ESTER)

CAS: 93-58-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =1 % rat oral 8 weeks developmental toxicity 4; (0, 1; 2, p.15
CIR Safety Assessment NOAEL =125 mg/kg/d rat oral 11 days repeated dose toxicity 100; 150; 9, p.13
CIR Safety Assessment NOAEL =130 mg/kg/d rat - - developmental toxicity 131,132; 25); 2, p.16
CIR Safety Assessment NOAEL =175 mg/kg rat oral gestation days 6-10 developmental toxicity 175; 20); 21, p.16
CIR Safety Assessment NOAEL =200 mg/kg/d rat oral 13 weeks repeated dose toxicity 13; 85; 60, p.13
CIR Safety Assessment NOAEL =850 mg/m3 rat oral - developmental toxicity 50); 2; 1, p.16
CIR Safety Assessment NOAEL =1000 mg/kg/d rat oral - oral toxicity 15; 100; 10, p.21
CIR Safety Assessment NOAEL =1230 mg/m3 rat oral 24 months inhalation toxicity 60; (0, 1; 2, p.11
NTP ICE acute oral 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1177 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11540; row=8894; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl benzoate; preferred_name=Methyl benzoate; dtxsid=DTXSID5025572; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025572; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025572; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1625 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_11542; row=8893; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl benzoate; preferred_name=Methyl benzoate; dtxsid=DTXSID5025572; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025572; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025572; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11546; row=8891; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl benzoate; preferred_name=Methyl benzoate; dtxsid=DTXSID5025572; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025572; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025572; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =3400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11548; row=8890; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl benzoate; preferred_name=Methyl benzoate; dtxsid=DTXSID5025572; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025572; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025572; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 <4000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11550; row=8895; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl benzoate; preferred_name=Methyl benzoate; dtxsid=DTXSID5025572; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025572; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5025572; source_file=acute_oral.xlsx
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11108; Record_ID=skin_sensitization_invivo_2430; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025572; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90193-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025572; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025572
NTP ICE skin sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11107; Record_ID=skin_sensitization_invivo_2430; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025572; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90193-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025572; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025572
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11110; Record_ID=skin_sensitization_invivo_2430; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5025572; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90193-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5025572; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5025572
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =39.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633308:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_490727a2417859f8553738d9d3221d1b
Regulatory source 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 1 % rat oral 8 weeks developmental toxicity p.15
Regulatory source developmental toxicity 130 mg/kg/d rat - - developmental toxicity p.16
Regulatory source developmental toxicity 175 mg/kg rat oral gestation days 6-10 developmental toxicity p.16
Regulatory source developmental toxicity 850 mg/m3 rat oral - developmental toxicity p.16
Regulatory source inhalation toxicity 1230 mg/m3 rat oral 24 months inhalation toxicity p.11
Regulatory source oral toxicity 1000 mg/kg/d rat oral - oral toxicity p.21
Regulatory source repeated dose toxicity 125 mg/kg/d rat oral 11 days repeated dose toxicity p.13
Regulatory source repeated dose toxicity 200 mg/kg/d rat oral 13 weeks repeated dose toxicity p.13
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6618K1VJ9T UNII - - - chemical -