Good Cosmetic Ingredient NOAEL Data

Methyl Caprylate

INCI: METHYL CAPRYLATE

CAS Number
111-11-5
Function
Fragrance; skin conditioning — emollient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — not restricted under 21 CFR for cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Methyl Caprylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 3.6 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 3.6 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Dual functionality (fragrance + emollient) — verify IFRA compliance for fragrance application. Skin moisturizing mechanism is barrier-based lipid layer formation.

⚠️
Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Methyl Caprylate safe in cosmetics?

Dual functionality (fragrance + emollient) — verify IFRA compliance for fragrance application. Skin moisturizing mechanism is barrier-based lipid layer formation. The EU classifies Methyl Caprylate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Methyl Caprylate allowed in the EU?

Methyl Caprylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Caprylate do in cosmetics?

Methyl Caprylate functions as: Fragrance; skin conditioning — emollient. It is classified as a cosmetic ingredient in our database. CAS number: 111-11-5.

What is the Margin of Safety for Methyl Caprylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methyl Caprylate?

The NOAEL (No Observed Adverse Effect Level) for Methyl Caprylate is 3.6 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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