Methyl Diethanolamine
INCI: METHYL DIETHANOLAMINE (ALSO KNOWN AS MDEA)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Major concern - nitrosamine formation potential. Diethanolamine moiety can react with nitrosating agents to form carcinogenic N-nitrosodiethanolamine (NDELA). Must never be combined with nitrosating preservatives (e.g., bronopol, formaldehyde donors). Also a potential skin/eye irritant.. Clear liquid; miscible with water; provides both pH adjustment and buffering capacity. Requires rigorous GMP controls to prevent nitrosamine contamination during manufacturing and storage.
Regulatory Flags
Frequently Asked Questions
Is Methyl Diethanolamine safe in cosmetics?
Major concern - nitrosamine formation potential. Diethanolamine moiety can react with nitrosating agents to form carcinogenic N-nitrosodiethanolamine (NDELA). Must never be combined with nitrosating preservatives (e.g., bronopol, formaldehyde donors). Also a potential skin/eye irritant.. Clear liquid; miscible with water; provides both pH adjustment and buffering capacity. Requires rigorous GMP controls to prevent nitrosamine contamination during manufacturing and storage. The EU classifies Methyl Diethanolamine as "permitted". Safety rating: MODERATE.
Is Methyl Diethanolamine allowed in the EU?
Methyl Diethanolamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Diethanolamine do in cosmetics?
Methyl Diethanolamine functions as: pH adjuster, buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 105-59-9.
What is the Margin of Safety for Methyl Diethanolamine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Methyl Diethanolamine compliance across multiple jurisdictions:
Related Ingredients
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