Moderate Cosmetic Ingredient NOAEL Data

Methyl Dihydroxy-Dimethylbenzoate

INCI: METHYL DIHYDROXY-DIMETHYLBENZOATE

CAS Number
4707-47-5
Function
Fragrance (perfuming)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - not prohibited or restricted.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Methyl Dihydroxy-Dimethylbenzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=7500 ppm oral rat oral REACH

Expert Verdict

Limited standalone toxicological data. Standard fragrance precautions apply; subject to IFRA/RIFM safety evaluation. Phenolic hydroxyl groups may contribute to antioxidant behavior but also potential sensitization.. Synthetic origin; benzoate ester with dihydroxy and dimethyl substitution; typical fragrance use levels 0.2-3% depending on product category.

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Concern Level: High

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance

Frequently Asked Questions

Is Methyl Dihydroxy-Dimethylbenzoate safe in cosmetics?

Limited standalone toxicological data. Standard fragrance precautions apply; subject to IFRA/RIFM safety evaluation. Phenolic hydroxyl groups may contribute to antioxidant behavior but also potential sensitization.. Synthetic origin; benzoate ester with dihydroxy and dimethyl substitution; typical fragrance use levels 0.2-3% depending on product category. The EU classifies Methyl Dihydroxy-Dimethylbenzoate as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Methyl Dihydroxy-Dimethylbenzoate allowed in the EU?

Methyl Dihydroxy-Dimethylbenzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Dihydroxy-Dimethylbenzoate do in cosmetics?

Methyl Dihydroxy-Dimethylbenzoate functions as: Fragrance (perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 4707-47-5.

What is the Margin of Safety for Methyl Dihydroxy-Dimethylbenzoate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methyl Dihydroxy-Dimethylbenzoate?

The NOAEL (No Observed Adverse Effect Level) for Methyl Dihydroxy-Dimethylbenzoate is >=7500 ppm based on a oral study via oral route in rat. Source: REACH.

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