Methyl Estradiolpropanoate (16-Beta)
INCI: 16-BETA METHYL ESTRADIOLPROPANOATE
Regulatory Status
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Safety Data
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Expert Verdict
Severe - estrogenic endocrine disruptor; promotes estrogen-dependent tumor growth; systemic absorption through skin; reproductive toxicity; classified as CMR (Carcinogenic, Mutagenic, Reprotoxic). The 16-beta methyl substitution modifies the pharmacological profile of estradiol; propanoate ester form provides lipophilicity for skin penetration - which is precisely why it is now prohibited in cosmetics globally
Frequently Asked Questions
Is Methyl Estradiolpropanoate (16-Beta) safe in cosmetics?
Severe - estrogenic endocrine disruptor; promotes estrogen-dependent tumor growth; systemic absorption through skin; reproductive toxicity; classified as CMR (Carcinogenic, Mutagenic, Reprotoxic). The 16-beta methyl substitution modifies the pharmacological profile of estradiol; propanoate ester form provides lipophilicity for skin penetration - which is precisely why it is now prohibited in cosmetics globally The EU classifies Methyl Estradiolpropanoate (16-Beta) as "prohibited". Safety rating: MODERATE.
Is Methyl Estradiolpropanoate (16-Beta) allowed in the EU?
Methyl Estradiolpropanoate (16-Beta) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Estradiolpropanoate (16-Beta) do in cosmetics?
Methyl Estradiolpropanoate (16-Beta) functions as: Historically used as a skin conditioning/anti-aging agent due to estrogenic activity. It is classified as a cosmetic ingredient in our database. CAS number: Listed in CosIng under the full name 16-BETA METHYL ESTRADIOLPROPANOATE.
What is the Margin of Safety for Methyl Estradiolpropanoate (16-Beta)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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