Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Methyl Ethylcellulose. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 15000 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| dose_tested | 5000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 15000 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| dose_tested | 5000 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Expert Verdict
Very low. Cellulose ethers are biologically inert, non-irritating, and non-sensitizing. No significant safety flags in the literature.. Combines the properties of methylcellulose and ethylcellulose - water-dispersible to varying degrees depending on substitution ratio. Provides cohesion in powdered products and forms continuous films on skin, hair, and nails. Related to methylcellulose (CAS 9004-67-5), which also serves binding/viscosity functions.
Regulatory Flags
Frequently Asked Questions
Is Methyl Ethylcellulose safe in cosmetics?
Very low. Cellulose ethers are biologically inert, non-irritating, and non-sensitizing. No significant safety flags in the literature.. Combines the properties of methylcellulose and ethylcellulose - water-dispersible to varying degrees depending on substitution ratio. Provides cohesion in powdered products and forms continuous films on skin, hair, and nails. Related to methylcellulose (CAS 9004-67-5), which also serves binding/viscosity functions. The EU classifies Methyl Ethylcellulose as "permitted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.
Is Methyl Ethylcellulose allowed in the EU?
Methyl Ethylcellulose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Ethylcellulose do in cosmetics?
Methyl Ethylcellulose functions as: Binding, film forming, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 9004-59-5.
What is the Margin of Safety for Methyl Ethylcellulose?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Ethylcellulose?
The NOAEL (No Observed Adverse Effect Level) for Methyl Ethylcellulose is 5000 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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