NOAEL Studies
Cosmetic Ingredient
Methyl Lactate NOAEL Studies
INCI: METHYL LACTATE
CAS: 547-64-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
INCHEM_WHO_kemi_kemi_ah1999_09 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_kemi_kemi_ah1999_09 | LOAEL | =75 | mg/m3 | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=5d2c218a343975d3; raw_unit=mg/m3; context=Of the lactate esters tested in rats only 2-ethylhexyl gave an effect on the nose at a lower dose and a LOAEL for this ester is 75 mg/m3. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | LOAEL | =75 | mg/m3 | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=5d2c218a343975d3; raw_unit=mg/m3; context=Of the lactate esters tested in rats only 2-ethylhexyl gave an effect on the nose at a lower dose and a LOAEL for this ester is 75 mg/m3. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | LOAEL | =75 | mg/m3 | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=5d2c218a343975d3; raw_unit=mg/m3; context=Of the lactate esters tested in rats only 2-ethylhexyl gave an effect on the nose at a lower dose and a LOAEL for this ester is 75 mg/m3. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | LOAEL | =75 | mg/m3 | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=5d2c218a343975d3; raw_unit=mg/m3; context=Of the lactate esters tested in rats only 2-ethylhexyl gave an effect on the nose at a lower dose and a LOAEL for this ester is 75 mg/m3. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | NOAEL | =0.5 | mg/kg bw | - | oral | - | Toxicology study | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=ab35fbe21c5d44b0; raw_unit=mg/kg body weight; context=The NOAEL for oral exposure to myristyl lactate was found to be 0.5 mg/kg body weight. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | NOAEL | =0.5 | mg/kg bw | - | oral | - | Toxicology study | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=ab35fbe21c5d44b0; raw_unit=mg/kg body weight; context=The NOAEL for oral exposure to myristyl lactate was found to be 0.5 mg/kg body weight. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | NOAEL | =0.5 | mg/kg bw | - | oral | - | Toxicology study | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=ab35fbe21c5d44b0; raw_unit=mg/kg body weight; context=The NOAEL for oral exposure to myristyl lactate was found to be 0.5 mg/kg body weight. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | NOAEL | =0.5 | mg/kg bw | - | oral | - | Toxicology study | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=ab35fbe21c5d44b0; raw_unit=mg/kg body weight; context=The NOAEL for oral exposure to myristyl lactate was found to be 0.5 mg/kg body weight. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | NOAEL | =200 | mg/m3 | - | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=013778550b6a8444; raw_unit=mg/m3; context=In animal inhalation studies the NOAEL for ethyl-, n-butyl- and isobutyl lactate is 200 mg/m3. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | NOAEL | =200 | mg/m3 | - | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=013778550b6a8444; raw_unit=mg/m3; context=In animal inhalation studies the NOAEL for ethyl-, n-butyl- and isobutyl lactate is 200 mg/m3. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | NOAEL | =200 | mg/m3 | - | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=013778550b6a8444; raw_unit=mg/m3; context=In animal inhalation studies the NOAEL for ethyl-, n-butyl- and isobutyl lactate is 200 mg/m3. |
| INCHEM_WHO_kemi_kemi_ah1999_09 | NOAEL | =200 | mg/m3 | - | inhalation | - | Inhalation toxicity | document_id=kemi_kemi_ah1999_09; title=DECOS and SCG Basis for an Occupational Standard. Lactate esters; path=mirror/documents/kemi/kemi/ah1999_09.pdf; row_hash=013778550b6a8444; raw_unit=mg/m3; context=In animal inhalation studies the NOAEL for ethyl-, n-butyl- and isobutyl lactate is 200 mg/m3. |
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_7548; row=848; data_type=In Vivo; mixture=Chemical; chemical_name=Methyl 2-hydroxypropanoate; preferred_name=Methyl 2-hydroxypropanoate; dtxsid=DTXSID0027197; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0027197; source_file=acute_oral.xlsx |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | H10S91526X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H10S91526X"} |
| openFDA substances | FDA UNII substance identifier | H10S91526X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H10S91526X"} |
| openFDA substances | FDA UNII substance identifier | H10S91526X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H10S91526X"} |
| openFDA substances | FDA UNII substance identifier | H10S91526X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H10S91526X"} |