Methyl Nicotinate

INCI: METHYL NICOTINATE

CAS Number
93-60-7
Function
Vasodilator, rubefacient
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FEMA GRAS 3709 as flavoring. No CIR report. Classified H315 skin irritant, H319 eye irritant.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Potent vasodilator with high dermal penetration (approximately 30% in 30 minutes); classified H315/H319 irritant; no CIR or SCCS opinion available.

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Concern Level: Moderate

Regulatory Flags

PENETRATION_ENHANCER ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Methyl Nicotinate safe in cosmetics?

Potent vasodilator with high dermal penetration (approximately 30% in 30 minutes); classified H315/H319 irritant; no CIR or SCCS opinion available. The EU classifies Methyl Nicotinate as "permitted". Safety rating: GOOD.

Is Methyl Nicotinate allowed in the EU?

Methyl Nicotinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Nicotinate do in cosmetics?

Methyl Nicotinate functions as: Vasodilator, rubefacient. It is classified as a cosmetic ingredient in our database. CAS number: 93-60-7.

What is the Margin of Safety for Methyl Nicotinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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