Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Methyl Phenethyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 450 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
RIFM safety assessment concluded no safety concerns for skin sensitization at current declared levels of use. Phototoxicity/photoallergenicity evaluated based on UV/Vis absorption and found not of concern.. Synthetic origin; classified in the floral fragrance family; used as a modifier in perfume compositions
Regulatory Flags
Frequently Asked Questions
Is Methyl Phenethyl Ether safe in cosmetics?
RIFM safety assessment concluded no safety concerns for skin sensitization at current declared levels of use. Phototoxicity/photoallergenicity evaluated based on UV/Vis absorption and found not of concern.. Synthetic origin; classified in the floral fragrance family; used as a modifier in perfume compositions The EU classifies Methyl Phenethyl Ether as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Methyl Phenethyl Ether allowed in the EU?
Methyl Phenethyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Phenethyl Ether do in cosmetics?
Methyl Phenethyl Ether functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 3558-60-9.
What is the Margin of Safety for Methyl Phenethyl Ether?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Phenethyl Ether?
The NOAEL (No Observed Adverse Effect Level) for Methyl Phenethyl Ether is 450 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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