NOAEL Studies
Cosmetic Ingredient
Methyl Pyrrolidone NOAEL Studies
INCI: METHYL PYRROLIDONE (N-METHYL-2-PYRROLIDONE, NMP)
CAS: 872-50-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 MADL | ABinhalation=3200; oral=17000 (dermal) | ug/day | - | - | 2001-06-15 | Maximum allowable dose level | - |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 2001-06-15 | California Proposition 65 listing | - |
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =90 | mg/kg bw/day | Mouse | - | - | chronic/long term toxicity | EFSA AFC - 2005 - OutputID 337 - organ weights - hepatotoxicity - Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to a 7th list of substances for food contact materials - doi:10.2903/j.efsa.2005.201a |
| EFSA | NOAEL | =90 | mg/kg bw/day | Mouse | oral | - | chronic | LONG_REF=EFSA AFC (2005). Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to a 7th list of substances for food contact materials. doi:10.2903/j.efsa.2005.201a.; TITLE=Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to a 7th list of substances for food contact materials; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2005.201a; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15614275:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_185ed050727649abbba78ce4e70a4576 |
WHO/JECFA 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =74 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=f74d585b1a1ba645; raw_unit=mg/kg body weight; context=The LOAEL for repeated doses was 74 mg/kg body weight administered on days 711 of gestation. |
| WHO/JECFA | LOAEL | =107.142857142857 | mg/kg bw/day | Rat | inhalation | 7 days | Reproductive toxicity | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=af5f9ccc4f355304; raw_unit=mg/kg body weight per day; unit_normalization=converted from weekly dose; context=LOAEL = 750 mg/kg body weight per day Becci et al., 1982 In a reproduction study, male rats (12 per dose level) were exposed whole body to 0 or 618 mg NMP/m 3 (vapour; <50% relative humidity) for 6 h/day, 7 days/week, for 90 days. |
| WHO/JECFA | LOAEL | =360 | mg/m3 | Rat | dermal | - | Developmental toxicity | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=1fd4b20a8b9c89de; raw_unit=mg/m 3; context=LOAEL = 360 mg/m 3 Lee et al., 1987 Rat; range-finding developmental toxicity study; dermal; days 615 0 mg/kg body weight per day 500 mg/kg body weight per day 1100 mg/kg body weight per day 2500 mg/kg body weight per day None None Massive resorption; decreased body we |
| WHO/JECFA | LOAEL | =478 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=a6a7362aa417fa70; raw_unit=mg/m 3; context=LOAEL = 478 mg/m 3 Maternal toxicity: |
| WHO/JECFA | LOAEL | =622 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=239455562d79ef01; raw_unit=mg/m 3; context=LOAEL = 622 mg/m 3 Maternal toxicity: |
| WHO/JECFA | LOAEL | =680 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=3679c8c889529adc; raw_unit=mg/m 3; context=LOAEL = 680 mg/m 3 Maternal toxicity: |
| WHO/JECFA | LOAEL | =750 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=fc6f35250e400718; raw_unit=mg/kg body weight per day; context=LOAEL = 750 mg/kg body weight per day Maternal toxicity: |
| WHO/JECFA | LOAEL | =1100 | mg/kg bw/day | Rat | dermal | - | Developmental toxicity | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=82a74a15dffd29bb; raw_unit=mg/kg body weight per day; context=LOAEL = 1100 mg/kg body weight per day Becci et al., 1982 Rat; developmental toxicity study; dermal; days 615 0 mg/kg body weight per day 75 mg/kg body weight per day 237 mg/kg body weight per day 750 mg/kg body weight per day None None None Increased resorption, delayed ossification None None No |
| WHO/JECFA | NOAEL | =100 | mg/m3 | - | inhalation | - | Developmental toxicity | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=f96fdb53ff2f6e99; raw_unit=mg/m 3; context=In an inhalation study (whole-body exposure), the NOAEL for maternal effects was 100 mg/m 3 , and the NOAEL for developmental effects was 360 mg/m 3 . |
| WHO/JECFA | NOAEL | =169 | mg/kg bw | - | oral | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=d483fcb37c02cf1c; raw_unit=mg/kg body weight; context=The NOAEL for this study was 3000 mg NMP/kg diet (equivalent to mean doses of 169 mg/kg body weight in males and 217 mg/kg body weight in females) (E.I. du Pont de Nemours and Company, 1995b). |
| WHO/JECFA | NOAEL | =206 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=5b89b590f88633e8; raw_unit=mg/m 3; context=NOAEL = 206 mg/m 3 ; |
| WHO/JECFA | NOAEL | =217 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=0deb8de7ab7b6553; raw_unit=mg/kg; context=La NOAEL était respectivement égale à 169 et à 217 mg/kg p.c. pour les mâles et les femelles. |
| WHO/JECFA | NOAEL | =237 | mg/kg bw | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=9f8a48316195d9f1; raw_unit=mg/kg body weight; context=The NOAEL for both developmental effects and maternal toxicity (decreased body weight gain) was 237 mg/kg body weight. |
| WHO/JECFA | NOAEL | =237 | mg/kg bw/day | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=3c01bcd93ca2808d; raw_unit=mg/kg body weight per day; context=NOAEL = 237 mg/kg body weight per day; |
| WHO/JECFA | NOAEL | =250 | mg/kg bw/day | Dog | oral | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=c63be3991524adc4; raw_unit=mg/kg body weight per day; context=The NOAEL for dietary exposure in dogs in this study is 250 mg/kg body weight per day. |
| WHO/JECFA | NOAEL | =360 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=d893ccf8652b40eb; raw_unit=mg/m 3; context=NOAEL = 360 mg/m 3 Maternal toxicity: |
| WHO/JECFA | NOAEL | =429 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=52265a33dae29736; raw_unit=mg/kg; context=La dose sans effet indésirable observable (NOAEL) était de 429 mg/kg p.c. pour les mâles et de 1548 mg/kg p.c. pour les femelles. |
| WHO/JECFA | NOAEL | =500 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=769b92d12ab204e7; raw_unit=mg/m 3; context=The NOAEL was 500 mg/m 3 . |
| WHO/JECFA | NOAEL | =514 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=d91ef8610b6d1095; raw_unit=mg/kg body weight; context=The NOAEL in this study was 514 mg/kg body weight. |
| WHO/JECFA | NOAEL | =618 | mg/m3 | Rat | inhalation | two-generation | Developmental toxicity | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=d480b40d8adc6292; raw_unit=mg/m 3; context=NOAEL = 618 mg/m 3 Fries et al., 1992 Rat; two-generation study; inhalation (whole body) 0 mg/m 3 478 mg/m 3 None Fetal body weight decrease (mean 7%) None None Developmental toxicity: |
| WHO/JECFA | NOAEL | =622 | mg/m3 | Rat | inhalation | 3 days | Developmental toxicity | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=e6674c884d58e804; raw_unit=mg/m 3; context=NOAEL = 622 mg/m 3 Hass et al., 1994 Rat; developmental toxicity; inhalation (whole body); days 615, 6 h/day 0 mg/m 3 100 mg/m 3 360 mg/m 3 None None None None None Lethargy and irregular respiration during the first 3 days of exposure Developmental toxicity: |
| WHO/JECFA | NOAEL | =680 | mg/m3 | Rat | inhalation | - | Developmental toxicity | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=4107de33fce45ca1; raw_unit=mg/m 3; context=NOAEL = 680 mg/m 3 Hass et al., 1995 Rat; developmental toxicity; inhalation (whole body); days 720, 6 h/day 0 mg/m 3 622 mg/m 3 None Decreased body weight; neurobehavioural effects None None Developmental toxicity: |
| WHO/JECFA | NOAEL | =2500 | mg/kg diet | Mouse | oral | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=0d4d90e3352ca90a; raw_unit=mg/kg diet; context=Based on this study, the NOAEL was found to be 2500 mg/kg diet (720 mg/kg body weight) in male mice and 7500 mg/kg diet (2970 mg/kg body weight) in female mice. |
| WHO/JECFA | NOAEL | =6000 | mg/kg diet | Rat | oral | - | Toxicology study | document_id=cicads_cicads_cicad35; title=N-METHYL-2-PYRROLIDONE (CICAD 35, 2001); path=mirror/documents/cicads/cicads/cicad35.htm; row_hash=390b52ec72beee7b; raw_unit=mg/kg diet; context=Based on this study, the NOAEL was found to be 6000 mg/kg diet (429 mg/kg body weight) in male rats and 18 000 mg/kg diet (1548 mg/kg body weight) in female rats. |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =3914 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11105; row=9994; data_type=In Vivo; mixture=Chemical; chemical_name=N-Methyl-2-pyrrolidone; preferred_name=N-Methyl-2-pyrrolidone; dtxsid=DTXSID6020856; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020856; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020856; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4320 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11107; row=9993; data_type=In Vivo; mixture=Chemical; chemical_name=N-Methyl-2-pyrrolidone; preferred_name=N-Methyl-2-pyrrolidone; dtxsid=DTXSID6020856; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020856; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6020856; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0.2081 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2343; Record_ID=adme_parameters_1109; Data_Type=Measured; DTXSID=DTXSID6020856; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.2081; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020856; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020856 |
| NTP ICE adme parameters | Clint | 0.3239 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=2344; Record_ID=adme_parameters_1109; Data_Type=Measured; DTXSID=DTXSID6020856; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.3239; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020856; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020856 |
| NTP ICE adme parameters | Fu | 0.7131 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=2341; Record_ID=adme_parameters_1109; Data_Type=Measured; DTXSID=DTXSID6020856; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.7131; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020856; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020856 |
| NTP ICE adme parameters | Fu | 0.888 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2342; Record_ID=adme_parameters_1109; Data_Type=Measured; DTXSID=DTXSID6020856; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.888; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020856; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020856 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=12268; RecordID=ARPathway2016_1660; DatasetName=ARPathway2016; DTXSID=DTXSID6020856; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020856; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020856 |
SCCS Opinion 42 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =1 | - | rabbit | - | developmental | developmental toxicity | p.30 |
| SCCS Opinion | NOAEL | =2 | - | rat | oral | developmental | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =4 | - | rat | inhalation | Developmental | developmental toxicity | p.29 |
| SCCS Opinion | NOAEL | =6 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| SCCS Opinion | NOAEL | =11 | % | rat | inhalation | developmental | reproductive toxicity | p.29 |
| SCCS Opinion | NOAEL | =14.8 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.34 |
| SCCS Opinion | NOAEL | =28 | - | - | - | - | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =29 | - | - | - | - | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =40 | % | rabbit | dermal | developmental | developmental toxicity | p.28 |
| SCCS Opinion | NOAEL | =45 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| SCCS Opinion | NOAEL | =48 | mg/kg bw/day | rabbit | inhalation | - | NOAEL study | p.31 |
| SCCS Opinion | NOAEL | =55 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.26 |
| SCCS Opinion | NOAEL | =61 | - | - | - | developmental | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =74 | mg/kg | - | - | developmental | developmental toxicity | p.30 |
| SCCS Opinion | NOAEL | =125 | mg/kg bw/day | rat | oral | Developmental | reproductive toxicity | p.28 |
| SCCS Opinion | NOAEL | =160 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.22 |
| SCCS Opinion | NOAEL | =169 | mg/kg bw/day | mouse | oral | 90 days | NOAEL study | p.15 |
| SCCS Opinion | NOAEL | =175 | mg/kg bw/day | rat | inhalation | Developmental | reproductive toxicity | p.29 |
| SCCS Opinion | NOAEL | =207 | mg/kg bw/day | mouse | oral | chronic | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =237 | mg/kg bw/day | rabbit | dermal | developmental | developmental toxicity | p.23 |
| SCCS Opinion | NOAEL | =247 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | oral | 5 days | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =277 | mg/kg bw/day | dog | oral | 90 days | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | rat | inhalation | developmental | developmental toxicity | p.24 |
| SCCS Opinion | NOAEL | =332 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.29 |
| SCCS Opinion | NOAEL | =350 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.21 |
| SCCS Opinion | NOAEL | =360 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw | rabbit | - | Developmental | developmental toxicity | p.26 |
| SCCS Opinion | NOAEL | =429 | mg/kg bw/day | mouse | oral | 28 days | NOAEL study | p.14 |
| SCCS Opinion | NOAEL | =494 | - | rat | inhalation | developmental | developmental toxicity | p.25 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/day | - | - | developmental | reproductive toxicity | p.22 |
| SCCS Opinion | NOAEL | =500 | - | - | - | developmental | developmental toxicity | p.30 |
| SCCS Opinion | NOAEL | =600 | mg/kg bw/day | rat | oral | Developmental | reproductive toxicity | p.28 |
| SCCS Opinion | NOAEL | =618 | - | rat | inhalation | 7 days | reproductive toxicity | p.29 |
| SCCS Opinion | NOAEL | =622 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| SCCS Opinion | NOAEL | =630 | mg/kg bw/day | mouse | inhalation | developmental | developmental toxicity | p.30 |
| SCCS Opinion | NOAEL | =630 | mg/kg | - | - | developmental | developmental toxicity | p.30 |
| SCCS Opinion | NOAEL | =680 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| SCCS Opinion | NOAEL | =750 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.27 |
| SCCS Opinion | NOAEL | =1995 | - | rat | inhalation | 7 days | reproductive toxicity | p.29 |
| SCCS Opinion | NOAEL | =2060 | mg/kg bw/day | rat | oral | 28 days | NOAEL study | p.13 |
| SCCS Opinion | NOAEL | =7500 | mg/kg | rat | inhalation | 5 days | NOAEL study | p.14 |
ToxValDB EPA TSCA 8e 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =243.272 | mg/m3 | Rat | inhalation | short-term (developmental); 15 days | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=2002-2-8EHQ-02-15084A_8ehq_0202_15084a.pdf; TOXICOLOGICAL_EFFECT=P0: decreased body weight gain; STUDY_GROUP=EPA TSCA 8e_dup_-_15957286_15957287:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f0d1af6b1db066d1097fc1fe77e0097 |
| ToxValDB EPA TSCA 8e | LEL | =250 | mg/kg bw/day | Rat | oral | short-term (developmental); 15 days | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88020000070_872504_383824CAFF240A098525702F005F4B59.pdf; TOXICOLOGICAL_EFFECT=F1: decreased fetal weight, malformations; STUDY_GROUP=EPA TSCA 8e:15957285:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e3f72eb1be5971f7fc9d9b206063b53e |
| ToxValDB EPA TSCA 8e | LEL | =486.545 | mg/m3 | Rat | inhalation | short-term (developmental); 15 days | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=2002-2-8EHQ-02-15084A_8ehq_0202_15084a.pdf; TOXICOLOGICAL_EFFECT=P0: decreased food consumption; STUDY_GROUP=EPA TSCA 8e_dup_-_15957286_15957287:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7e2a7ab69195afdd43c65d2f922cd06 |
| ToxValDB EPA TSCA 8e | LEL | =500 | mg/kg bw/day | Rat | oral | short-term (developmental); 15 days | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88020000070_872504_383824CAFF240A098525702F005F4B59.pdf; TOXICOLOGICAL_EFFECT=P0: decreased body weight and food consumption; STUDY_GROUP=EPA TSCA 8e_dup_-_15957283_15957284:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2d16f0c725b8dff0d035c861e47cab5b |
| ToxValDB EPA TSCA 8e | LEL | =750 | mg/kg bw/day | Rat | oral | short-term (developmental); 15 days | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88020000070_872504_383824CAFF240A098525702F005F4B59.pdf; TOXICOLOGICAL_EFFECT=P0: post-implantation loss; STUDY_GROUP=EPA TSCA 8e_dup_-_15957283_15957284:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7d7c802854561a7a6c1664c53e1c24a |
| ToxValDB EPA TSCA 8e | LEL | =1332 | mg/kg bw/day | Mouse | oral | chronic; 18 months | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/89990000047_872504_928F3BD8B6CAC6E48525695A0048B941.pdf; TOXICOLOGICAL_EFFECT=increased tumor incidences; STUDY_GROUP=EPA TSCA 8e:15957282:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bf1dc2c16da69cf5d1137f5c1a4be153 |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | LOAEL | =400 | mg/m3 | Rat | inhalation | chronic; 2 years | chronic | LONG_REF=Lee, K.P., Chromey, N.C., Culik, R., Barnes, J.R., Schneider, P.W. (1987). Toxicity of N-methyl-2pyrrolidone (NMP): teratogenic, subchronic and two-year inhalation studies. Fund.Appl.Toxicol., 9,222-235.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d35ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/091_1-methyl-2-pyrrolidone_oel_en.pdf; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=minimal inflammation of the lung and slight systemic toxicity was reported in male rats; STUDY_GROUP=EU SCOEL:15952254:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6d46e7207543c45853152b42afb7338f |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =40 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633497_15633498:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df7d8ffbd92d0c252d7754a1f850246e |
| ToxValDB GESTIS DNEL | DNEL systemic | =14.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633497_15633498:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69c84e1d3f9d97b7d88fd4772d1bba48 |
Regulatory source 72 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 28 | - | - | - | - | - | p.28 |
| Regulatory source | - | 29 | - | - | - | - | - | p.29 |
| Regulatory source | - | 40 | % | rabbit | dermal | - | - | p.28 |
| Regulatory source | - | 48 | mg/kg bw/day | rabbit | inhalation | - | - | p.31 |
| Regulatory source | - | 169 | mg/kg bw/day | mouse | oral | 90 days | - | p.15 |
| Regulatory source | - | 169 | mg/kg bw/day | rat | dermal | 4-week | - | p.17 |
| Regulatory source | - | 207 | mg/kg bw/day | mouse | oral | chronic | - | p.19 |
| Regulatory source | - | 250 | mg/kg bw/day | rat | oral | 5 days | - | p.16 |
| Regulatory source | - | 277 | mg/kg bw/day | dog | oral | 90 days | - | p.16 |
| Regulatory source | - | 429 | mg/kg bw/day | mouse | oral | 28 days | - | p.14 |
| Regulatory source | - | =600 | mg/kg bw/day | rabbit | dermal | - | - | p.28 |
| Regulatory source | - | 2060 | mg/kg bw/day | rat | oral | 28 days | - | p.13 |
| Regulatory source | - | 7500 | mg/kg | rat | inhalation | 5 days | - | p.14 |
| Regulatory source | carcinogenicity | 169 | mg/kg bw/day | rat | dermal | 4-week | carcinogenicity | p.17 |
| Regulatory source | carcinogenicity | 250 | mg/kg bw/day | rat | inhalation | 90-day | carcinogenicity | p.17 |
| Regulatory source | carcinogenicity | 277 | mg/kg bw/day | rat | dermal | 90-day | carcinogenicity | p.17 |
| Regulatory source | developmental toxicity | 1 | - | rabbit | - | developmental | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | 1 | - | - | - | developmental | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | 2 | - | - | - | developmental | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | 4 | - | rat | inhalation | Developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | 6 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | 6 | - | rat | inhalation | 3 days | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | =14.8 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.34 |
| Regulatory source | developmental toxicity | 29 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | 40 | % | rabbit | dermal | developmental | developmental toxicity | p.28 |
| Regulatory source | developmental toxicity | 45 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | 55 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.26 |
| Regulatory source | developmental toxicity | =55 | mg/kg bw/day | rabbit | - | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | =74 | mg/kg | - | - | developmental | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | =125 | mg/kg bw/day | rat | inhalation | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | 125 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | 160 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.22 |
| Regulatory source | developmental toxicity | 237 | mg/kg bw/day | rabbit | dermal | developmental | developmental toxicity | p.23 |
| Regulatory source | developmental toxicity | =237 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.28 |
| Regulatory source | developmental toxicity | =237 | mg/kg bw/day | rat | dermal | developmental | developmental toxicity | p.28 |
| Regulatory source | developmental toxicity | =247 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | =250 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | 300 | mg/kg bw/day | rat | inhalation | developmental | developmental toxicity | p.24 |
| Regulatory source | developmental toxicity | =300 | mg/kg bw/day | rabbit | dermal | developmental | developmental toxicity | p.28 |
| Regulatory source | developmental toxicity | =332 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | =360 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | 400 | mg/kg bw | rabbit | - | Developmental | developmental toxicity | p.26 |
| Regulatory source | developmental toxicity | 494 | - | rat | inhalation | developmental | developmental toxicity | p.25 |
| Regulatory source | developmental toxicity | =500 | mg/kg bw/day | rat | dermal | developmental | developmental toxicity | p.28 |
| Regulatory source | developmental toxicity | =500 | - | - | - | developmental | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | =622 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | =630 | mg/kg bw/day | mouse | inhalation | developmental | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | =630 | mg/kg | - | - | developmental | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | =680 | - | rat | inhalation | developmental | developmental toxicity | p.29 |
| Regulatory source | developmental toxicity | 750 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 169 | mg/kg bw/day | rat | oral | 90-day | repeated dose toxicity | p.35 |
| Regulatory source | repeated dose toxicity | 250 | mg/kg bw/day | rat | oral | 90-day | repeated dose toxicity | p.35 |
| Regulatory source | repeated dose toxicity | 277 | mg/kg bw/day | rat | oral | 90-day | repeated dose toxicity | p.35 |
| Regulatory source | reproductive toxicity | 2 | - | rat | oral | developmental | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 11 | % | rat | inhalation | developmental | reproductive toxicity | p.29 |
| Regulatory source | reproductive toxicity | 11 | % | rat | inhalation | 7 days | reproductive toxicity | p.29 |
| Regulatory source | reproductive toxicity | 29 | - | rat | inhalation | 7 days | reproductive toxicity | p.29 |
| Regulatory source | reproductive toxicity | =48 | mg/kg bw/day | rabbit | dermal | developmental | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | =55 | mg/kg bw/day | rat | inhalation | Developmental | reproductive toxicity | p.29 |
| Regulatory source | reproductive toxicity | 61 | - | - | - | developmental | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | =125 | mg/kg bw/day | rat | oral | Developmental | reproductive toxicity | p.28 |
| Regulatory source | reproductive toxicity | 160 | mg/kg bw/day | rat | oral | Developmental | reproductive toxicity | p.28 |
| Regulatory source | reproductive toxicity | 160 | mg/kg bw/day | rat | - | 10 days | reproductive toxicity | p.28 |
| Regulatory source | reproductive toxicity | =175 | mg/kg bw/day | rat | inhalation | Developmental | reproductive toxicity | p.29 |
| Regulatory source | reproductive toxicity | =300 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.28 |
| Regulatory source | reproductive toxicity | 350 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.21 |
| Regulatory source | reproductive toxicity | 350 | mg/kg bw/day | rat | - | Developmental | reproductive toxicity | p.28 |
| Regulatory source | reproductive toxicity | 500 | mg/kg bw/day | - | - | developmental | reproductive toxicity | p.22 |
| Regulatory source | reproductive toxicity | =500 | mg/kg bw/day | rat | dermal | developmental | reproductive toxicity | p.28 |
| Regulatory source | reproductive toxicity | =600 | mg/kg bw/day | rat | oral | Developmental | reproductive toxicity | p.28 |
| Regulatory source | reproductive toxicity | =618 | - | rat | inhalation | 7 days | reproductive toxicity | p.29 |
| Regulatory source | reproductive toxicity | 1995 | - | rat | inhalation | 7 days | reproductive toxicity | p.29 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | JR9CE63FPM | UNII | - | - | - | chemical | - |