Moderate Cosmetic Ingredient NOAEL Data

Methyl Rosinate

INCI: METHYL ROSINATE

CAS Number
68186-14-1
Function
Film-forming, plasticizer, viscosity controlling
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not individually CIR-reviewed; permitted under general FDA cosmetic ingredient framework

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Methyl Rosinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 3000 ppm oral rat oral REACH
NOEL 3000 ppm oral - oral REACH
NOAEL 18000 other oral rat oral REACH
NOAEL 18000 other oral - oral REACH
NOEL 500 other oral rat oral REACH
NOEL 500 other oral - oral REACH
NOEL 500 other oral rat oral REACH
NOEL 500 other oral - oral REACH
NOEL 10000 ppm oral rat oral REACH
NOEL 10000 ppm oral - oral REACH

Expert Verdict

Rosin allergen class with cross-reactivity potential to abietic acid and dehydroabietic acid derivatives; HRIPT testing recommended at target concentration and labeling required if applicable under fragrance allergen disclosure.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Methyl Rosinate safe in cosmetics?

Rosin allergen class with cross-reactivity potential to abietic acid and dehydroabietic acid derivatives; HRIPT testing recommended at target concentration and labeling required if applicable under fragrance allergen disclosure. The EU classifies Methyl Rosinate as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is Methyl Rosinate allowed in the EU?

Methyl Rosinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Rosinate do in cosmetics?

Methyl Rosinate functions as: Film-forming, plasticizer, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 68186-14-1.

What is the Margin of Safety for Methyl Rosinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methyl Rosinate?

The NOAEL (No Observed Adverse Effect Level) for Methyl Rosinate is 3000 ppm based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

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