NOAEL Studies
Preservative
Methylchloroisothiazolinone NOAEL Studies
INCI: METHYLCHLOROISOTHIAZOLINONE
CAS: 26172-55-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute dermal 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 2 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2575; Record_ID=acute_dermal_285; Data_Type=In Vivo; Formulation_ID=MIX278; Formulation_Name=Kathon CF 400; Percent_Active_Ingredient=2.95; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=2.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2576; Record_ID=acute_dermal_6; Data_Type=In Vivo; Formulation_ID=MIX6; Formulation_Name=Acticide CBM; Percent_Active_Ingredient=0.465; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2573; Record_ID=acute_dermal_406; Data_Type=In Vivo; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=0.78; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2570; Record_ID=acute_dermal_368; Data_Type=In Vivo; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.8; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2578; Record_ID=acute_dermal_8; Data_Type=In Vivo; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=1.95; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=2577; Record_ID=acute_dermal_368; Data_Type=In Vivo; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.8; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
NTP ICE acute inhalation 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | EPA Classification | 2 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5293; Record_ID=acute_inhalation_29; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=1.95; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute inhalation | EPA Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5290; Record_ID=acute_inhalation_293; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.8; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute inhalation | GHS Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5297; Record_ID=acute_inhalation_329; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=0.78; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute inhalation | LC50 | 0.21 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5288; Record_ID=acute_inhalation_29; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=1.95; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.21; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute inhalation | LC50 | range0.52 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5298; Record_ID=acute_inhalation_293; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.8; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>0.52 and <2.05; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute inhalation | LC50 | 0.73 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5287; Record_ID=acute_inhalation_26; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX6; Formulation_Name=Acticide CBM; Percent_Active_Ingredient=0.465; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.73; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE acute inhalation | LC50 | 1.69 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5289; Record_ID=acute_inhalation_329; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=0.78; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.69; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
NTP ICE acute oral 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =2 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12189; row=16004; data_type=In Vivo; mixture=Mixture; formulation_id=MIX8; formulation_name=Acticide LA 2605-F; chemical_name=5-Chloro-2-methyl-4-isothiazolin-3-one; preferred_name=5-Chloro-2-methyl-3(2H)-isothiazolone; percent_active_ingredient=1.95; dtxsid=DTXSID9034286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12860; row=15990; data_type=In Vivo; mixture=Mixture; formulation_id=MIX361; formulation_name=Preventol P 91; chemical_name=5-Chloro-2-methyl-4-isothiazolin-3-one; preferred_name=5-Chloro-2-methyl-3(2H)-isothiazolone; percent_active_ingredient=0.8; dtxsid=DTXSID9034286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13224; row=15996; data_type=In Vivo; mixture=Mixture; formulation_id=MIX278; formulation_name=Kathon CF 400; chemical_name=5-Chloro-2-methyl-4-isothiazolin-3-one; preferred_name=5-Chloro-2-methyl-3(2H)-isothiazolone; percent_active_ingredient=2.95; dtxsid=DTXSID9034286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13156; row=15991; data_type=In Vivo; mixture=Mixture; formulation_id=MIX663; formulation_name=Acticide CBM 2; chemical_name=5-Chloro-2-methyl-4-isothiazolin-3-one; preferred_name=5-Chloro-2-methyl-3(2H)-isothiazolone; percent_active_ingredient=1.0; dtxsid=DTXSID9034286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12189; row=15992; data_type=In Vivo; mixture=Mixture; formulation_id=MIX8; formulation_name=Acticide LA 2605-F; chemical_name=5-Chloro-2-methyl-4-isothiazolin-3-one; preferred_name=5-Chloro-2-methyl-3(2H)-isothiazolone; percent_active_ingredient=1.95; dtxsid=DTXSID9034286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12185; row=16003; data_type=In Vivo; mixture=Mixture; formulation_id=MIX6; formulation_name=Acticide CBM; chemical_name=5-Chloro-2-methyl-4-isothiazolin-3-one; preferred_name=5-Chloro-2-methyl-3(2H)-isothiazolone; percent_active_ingredient=0.465; dtxsid=DTXSID9034286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1030 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12860; row=16002; data_type=In Vivo; mixture=Mixture; formulation_id=MIX361; formulation_name=Preventol P 91; chemical_name=5-Chloro-2-methyl-4-isothiazolin-3-one; preferred_name=5-Chloro-2-methyl-3(2H)-isothiazolone; percent_active_ingredient=0.8; dtxsid=DTXSID9034286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12185; row=15998; data_type=In Vivo; mixture=Mixture; formulation_id=MIX6; formulation_name=Acticide CBM; chemical_name=5-Chloro-2-methyl-4-isothiazolin-3-one; preferred_name=5-Chloro-2-methyl-3(2H)-isothiazolone; percent_active_ingredient=0.465; dtxsid=DTXSID9034286; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286; source_file=acute_oral.xlsx |
NTP ICE dart 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 8 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=135747; Record_ID=dart_11329; Data_Type=In Vivo; DTXSID=DTXSID9034286; Assay=DART, In life observation; Endpoint=LOEL; Response=8; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0005910;CUI;Body Weight; Reference=ToxRefDB v2 , ID = 825; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE dart | LOEL | 8 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=135753; Record_ID=dart_11354; Data_Type=In Vivo; DTXSID=DTXSID9034286; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=8; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 825; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=4294; RecordID=ARPathway2016_1068; DatasetName=ARPathway2016; DTXSID=DTXSID9034286; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2919; Record_ID=eye_irritation_905; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID773; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.8; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
NTP ICE skin irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1976; Record_ID=skin_irritation_invivo_516; Data_Type=In Vivo; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=1.95; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE skin irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1975; Record_ID=skin_irritation_invivo_378; Data_Type=In Vivo; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.8; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
NTP ICE skin sensitization 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Depletion Cys | 96.3 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=151; Record_ID=skin_sensitization_invitro_58; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9034286; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=96.3; Reported_Response_Unit=%; Response=96.3; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE skin sensitization | Depletion Lys | 35.1 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=167; Record_ID=skin_sensitization_invitro_58; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9034286; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=35.1; Reported_Response_Unit=%; Response=35.1; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE skin sensitization | EC1.5 | 2.3 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=8777; Record_ID=skin_sensitization_invitro_2432; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9034286; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=2.3; Reported_Response_Unit=uM; Response=2.3; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE skin sensitization | EC3 | 0.009 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13028; Record_ID=skin_sensitization_invivo_2991; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9034286; Assay=LLNA; Endpoint=EC3; Response=9.00E-03; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Ashby et al. 1995; 8553361; 10.1016/0300-483x(95)03132-y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE skin sensitization | EC3 | 0.01 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13027; Record_ID=skin_sensitization_invivo_2990; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9034286; Assay=LLNA; Endpoint=EC3; Response=0.01; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 1999; 10439339; 10.1002/(sici)1099-1263(199907/08)19:4<255::aid-jat573>3.0.co;2-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Guinea pig | Dermal | - | In Vivo; SkinSensitization6pack; Guinea Pig Maximization/Buehler | sheet=Data_invivo; excel_row=728; Record_ID=skin_sensitization_invivo_23; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=1.95; Mixture=Mixture; DTXSID=DTXSID9034286; Assay=Guinea Pig Maximization/Buehler; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Guinea pig; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE skin sensitization | IC50 | 16.9 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=8778; Record_ID=skin_sensitization_invitro_2432; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9034286; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=16.8999379; Reported_Response_Unit=uM; Response=16.9; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
| NTP ICE skin sensitization | Imax | 7.248 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=8779; Record_ID=skin_sensitization_invitro_2432; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9034286; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.24767612; Reported_Response_Unit=Unitless; Response=7.248; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9034286 |
SCCS Opinion 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.00038 | mg/kg bw | human | dermal | - | reproductive toxicity | p.34 |
| SCCS Opinion | NOAEL | =0.0015 | % | - | - | subchronic | repeated dose toxicity | p.35 |
| SCCS Opinion | NOAEL | =0.34 | - | - | - | Chronic | repeated dose toxicity | p.26 |
| SCCS Opinion | NOAEL | =2 | mg/kg bw | rat | oral | Developmental | reproductive toxicity | p.31 |
| SCCS Opinion | NOAEL | =2.6 | mg/kg/day | rat | oral | 90-day | repeated dose toxicity | p.21 |
| SCCS Opinion | NOAEL | =2.8 | mg/kg bw | human | dermal | - | reproductive toxicity | p.34 |
| SCCS Opinion | NOAEL | =3.7 | % | rat | oral | - | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =4 | % | rat | oral | Developmental | reproductive toxicity | p.31 |
| SCCS Opinion | NOAEL | =10.2 | % | rat | oral | - | NOAEL study | p.31 |
| SCCS Opinion | NOAEL | =11.1 | % | rat | oral | - | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =13.9 | % | rat | oral | - | reproductive toxicity | p.30 |
| SCCS Opinion | NOAEL | =19.6 | mg/kg bw | rat | oral | Developmental | reproductive toxicity | p.31 |
| SCCS Opinion | NOAEL | =20 | mg/kg/day | - | oral | Developmental | reproductive toxicity | (Ref 80), p.31 |
| SCCS Opinion | NOAEL | =30 | ppm | rat | oral | 24 months | carcinogenicity | p.29 |
| SCCS Opinion | NOAEL | =75 | ppm | - | - | - | reproductive toxicity | p.22 |
| SCCS Opinion | NOAEL | =100 | % | human | dermal | - | reproductive toxicity | p.34 |
| SCCS Opinion | NOAEL | =104 | mg/kg/day | rat | - | - | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =200 | ppm | rat | oral | 90 days | repeated dose toxicity | p.21 |
| SCCS Opinion | NOAEL | =225 | ppm | rat | - | - | reproductive toxicity | p.22 |
| SCCS Opinion | NOAEL | =300 | ppm | rat | oral | 24 months | carcinogenicity | p.29 |
EPA ToxRefDB v3 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =0.75 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | dermal | 0 week to 13 week | SUB | study_id=6188; toxval_study_source_id=studyid6188_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-erythema|in life observation-clinical signs-desquamation|in life observation-clinical signs-scabbing|in life observation-clinical signs-[other]|pathology microscopic-skin-edema|pathology microscopic-skin-acanthosis|in life observation-clinical signs-skin ulceration|pathology microscopic-skin-infiltration cellular|pathology microscopic-skin-parakeratosis; dose_level=1; study_year=1994; study_citation=Zuhlke, U. 1994. Acticide 14: 90-day dermal subchronic study in the rat. Hazleton Deutschland, Project ID 1154-002. MRID 43462005.; dsstox_substance_id=DTXSID9034286; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =2.8 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-hyperkeratosis|pathology microscopic-stomach-edema|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-erosion|in life observation-body weight-body weight gain; dose_level=1; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =3.75 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | dermal | 0 week to 13 week | SUB | study_id=6188; toxval_study_source_id=studyid6188_Adult_F0_M_systemic; toxval_effect_list=in life observation-clinical signs-erythema|in life observation-clinical signs-desquamation|in life observation-clinical signs-[other]|pathology microscopic-skin-acanthosis|in life observation-clinical signs-scabbing|pathology microscopic-skin-focal cellular change|pathology microscopic-skin-infiltration cellular|pathology microscopic-skin-parakeratosis|pathology microscopic-skin-edema; dose_level=2; study_year=1994; study_citation=Zuhlke, U. 1994. Acticide 14: 90-day dermal subchronic study in the rat. Hazleton Deutschland, Project ID 1154-002. MRID 43462005.; dsstox_substance_id=DTXSID9034286; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =4.3 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Adult_F1_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperkeratosis|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-erosion|pathology microscopic-stomach-edema|pathology microscopic-stomach-inflammation; dose_level=1; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =4.4 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperkeratosis|in life observation-food consumption-food consumption|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-erosion|pathology microscopic-stomach-edema|pathology microscopic-stomach-inflammation|in life observation-body weight-body weight gain; dose_level=1; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =5.5 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Adult_F1_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-erosion|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-hyperkeratosis; dose_level=1; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =6.6 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 24 month | CHR | study_id=829; toxval_study_source_id=studyid829_Adult_F0_M_systemic; toxval_effect_list=urinalysis-specific gravity/osmolality-specific gravity/osmolality|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-hyperkeratosis|pathology gross-stomach-foci|pathology gross-stomach-prominent limiting ridge|pathology gross-stomach-thickened|pathology microscopic-parathyroid gland-hyperplasia|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-necrosis|pathology microscopic-stomach-edema|pathology microscopic-kidney-hydronephrosis|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-liver-proliferation|pathology microscopic-stomach-ulcer; dose_level=2; study_year=1994; study_citation=Quinn, D.; O'Hara, G.; Brown, W. (1994) Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149. Unpublished Study Prepared By Rohm And Haas Company Toxicology Department. 5150 P.; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =8 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=825; toxval_study_source_id=studyid825_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-clinical signs-defecation|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain|pathology gross-stomach-thickened|pathology gross-stomach-necrosis|pathology gross-stomach-discolored|in life observation-clinical signs-no feces|in life observation-mortality-mortality|in life observation-clinical signs-defecation (diarrhea); dose_level=3; study_year=1992; study_citation=Thomas, T.; Solomom, H.; O'Hara, G. (1992) Kathon Biocide: Oral (Gavage) Developmental Toxicity Study In Rabbits. Lab Project Number: 91P-074. Unpublished Study Prepared By Rohm And Haas Toxicology Dept. 206 P.; dsstox_substance_id=DTXSID9034286; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =9.8 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 24 month | CHR | study_id=829; toxval_study_source_id=studyid829_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperkeratosis|pathology gross-stomach-prominent limiting ridge|pathology gross-stomach-foci|pathology microscopic-stomach-hyperplasia|urinalysis-specific gravity/osmolality-specific gravity/osmolality|pathology microscopic-stomach-necrosis|pathology gross-stomach-thickened|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-kidney-mineralization|pathology microscopic-adrenal gland-vacuolization; dose_level=2; study_year=1994; study_citation=Quinn, D.; O'Hara, G.; Brown, W. (1994) Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149. Unpublished Study Prepared By Rohm And Haas Company Toxicology Department. 5150 P.; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | >39.1 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Juvenile_F1_F_NA; dose_level=3; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =70 | mg/kg bw/day | rat (sprague dawley; sprague dawley) | oral | 6 GD to 15 GD | DEV | study_id=6189; toxval_study_source_id=studyid6189_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-labored respiration|in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-food consumption-food consumption; dose_level=2; study_year=1994; study_citation=Fuchs, A. (1994) Acticide 14 oral (gavage) teratogenicity study in the rat. Project ID 1154-003. Report No. 1178-1154-003.Unpublished.; dsstox_substance_id=DTXSID9034286; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | >139 | mg/kg bw/day | rat (sprague dawley; sprague dawley) | oral | 6 GD to 15 GD | DEV | study_id=6189; toxval_study_source_id=studyid6189_Fetal_Fetal_MF_NA; dose_level=3; study_year=1994; study_citation=Fuchs, A. (1994) Acticide 14 oral (gavage) teratogenicity study in the rat. Project ID 1154-003. Report No. 1178-1154-003.Unpublished.; dsstox_substance_id=DTXSID9034286; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =8.5 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-hyperkeratosis; dose_level=2; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =11.8 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperkeratosis|in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-erosion; dose_level=2; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =13.4 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Adult_F1_M_systemic; toxval_effect_list=pathology microscopic-stomach-hyperkeratosis|in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia; dose_level=2; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =16 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=6190; toxval_study_source_id=studyid6190_Adult_F1_F_systemic; toxval_effect_list=pathology microscopic-stomach-erosion|in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-hyperkeratosis; dose_level=2; study_year=1998; study_citation=Robison, P., L.P. Craig, and T.L. Danberry. (1998) Kathon 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | dermal | 0 week to 13 week | SUB | study_id=6188; toxval_study_source_id=studyid6188_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-scabbing|in life observation-clinical signs-desquamation|pathology microscopic-skin-infiltration cellular|in life observation-clinical signs-skin ulceration|pathology microscopic-skin-parakeratosis|pathology microscopic-skin-acanthosis|pathology microscopic-skin-edema|in life observation-clinical signs-erythema|in life observation-clinical signs-[other]; dose_level=0; study_year=1994; study_citation=Zuhlke, U. 1994. Acticide 14: 90-day dermal subchronic study in the rat. Hazleton Deutschland, Project ID 1154-002. MRID 43462005.; dsstox_substance_id=DTXSID9034286; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =2 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 7 GD to 19 GD | DEV | study_id=825; toxval_study_source_id=studyid825_Adult_F0_F_systemic; toxval_effect_list=pathology gross-stomach-thickened|pathology gross-stomach-discolored|in life observation-body weight-body weight gain|pathology gross-stomach-necrosis|in life observation-food consumption-food consumption|in life observation-clinical signs-no feces|in life observation-mortality-mortality|in life observation-body weight-body weight|in life observation-clinical signs-defecation|in life observation-clinical signs-defecation (diarrhea); dose_level=2; study_year=1992; study_citation=Thomas, T.; Solomom, H.; O'Hara, G. (1992) Kathon Biocide: Oral (Gavage) Developmental Toxicity Study In Rabbits. Lab Project Number: 91P-074. Unpublished Study Prepared By Rohm And Haas Toxicology Dept. 206 P.; dsstox_substance_id=DTXSID9034286; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =3.1 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 0 day to 24 month | CHR | study_id=829; toxval_study_source_id=studyid829_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperkeratosis|pathology microscopic-adrenal gland-vacuolization|pathology gross-stomach-prominent limiting ridge|pathology gross-stomach-foci|pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight gain|urinalysis-specific gravity/osmolality-specific gravity/osmolality|pathology microscopic-kidney-mineralization|in life observation-body weight-body weight|pathology microscopic-stomach-necrosis|pathology gross-stomach-thickened; dose_level=1; study_year=1994; study_citation=Quinn, D.; O'Hara, G.; Brown, W. (1994) Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149. Unpublished Study Prepared By Rohm And Haas Company Toxicology Department. 5150 P.; dsstox_substance_id=DTXSID9034286; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =28 | mg/kg bw/day | rat (sprague dawley; sprague dawley) | oral | 6 GD to 15 GD | DEV | study_id=6189; toxval_study_source_id=studyid6189_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-clinical signs-labored respiration|in life observation-body weight-body weight|in life observation-food consumption-food consumption; dose_level=1; study_year=1994; study_citation=Fuchs, A. (1994) Acticide 14 oral (gavage) teratogenicity study in the rat. Project ID 1154-003. Report No. 1178-1154-003.Unpublished.; dsstox_substance_id=DTXSID9034286; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =30 | % | Mouse | dermal | short-term; 16 days | short-term | LONG_REF=Contact Dermatitis15(1): 17-23 Maisey,J., and K. Miller Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers 1986; TITLE=Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers; AUTHOR=Maisey,J., and K. Miller; DOI=10.1111/j.1600-0536.1986.tb01255.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Immunological: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15604352:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e30b9008a62e6e99cd09bd52aaf17025 |
ToxValDB ToxRefDB 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =0.75 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | LONG_REF=Zuhlke, U. 1994. Acticide 14: 90-day dermal subchronic study in the rat. Hazleton Deutschland, Project ID 1154-002. MRID 43462005.; TITLE=Acticide 14: 90-day dermal subchronic study in the rat; AUTHOR=Zuhlke, U; EXTERNAL_SOURCE_ID=6188; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-desquamation|systemic: in life observation-clinical signs-erythema|systemic: in life observation-clinical signs-scabbing|systemic: in life observation-clinical signs-[other]|systemic: in life observation-clinical signs-skin ulceration|systemic: pathology microscopic-skin-infiltration cellular|systemic: pathology microscopic-skin-edema|systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-skin-parakeratosis; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15711200_15711201:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_395e34c905afc652efc9fd4791434ffd |
| ToxValDB ToxRefDB | LEL | =2.8 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-edema|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-erosion; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711215_15711216_15711217:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28ad1cbea24882e68218528c022a3d17 |
| ToxValDB ToxRefDB | LEL | =3.75 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | LONG_REF=Zuhlke, U. 1994. Acticide 14: 90-day dermal subchronic study in the rat. Hazleton Deutschland, Project ID 1154-002. MRID 43462005.; TITLE=Acticide 14: 90-day dermal subchronic study in the rat; AUTHOR=Zuhlke, U; EXTERNAL_SOURCE_ID=6188; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-erythema|systemic: in life observation-clinical signs-desquamation|systemic: in life observation-clinical signs-[other]|systemic: pathology microscopic-skin-infiltration cellular|systemic: pathology microscopic-skin-parakeratosis|systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-scabbing|systemic: pathology microscopic-skin-focal cellular change|systemic: pathology microscopic-skin-edema; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15711202_15711203:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c75b835bf393e4b4db271cf425ee1f8 |
| ToxValDB ToxRefDB | LEL | =4.3 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-edema|systemic: pathology microscopic-stomach-erosion|systemic: pathology microscopic-stomach-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711221_15711222_15711223:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ba13537ab3620b79aa091d3a74c646b |
| ToxValDB ToxRefDB | LEL | =4.4 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-erosion|systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-stomach-edema|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-stomach-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711212_15711213_15711214:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_14f31c870e094efd2b8dc2054f3a91b3 |
| ToxValDB ToxRefDB | LEL | =5.5 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-stomach-erosion; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711218_15711219_15711220:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46629be4eff15d2c380ab28d5acbc787 |
| ToxValDB ToxRefDB | LEL | =6.6 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Quinn, D.; O\'Hara, G.; Brown, W. (1994) Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149. Unpublished Study Prepared By Rohm And Haas Company Toxicology Department. 5150 P.; TITLE=Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149; AUTHOR=Quinn, D.; O\'Hara, G.; Brown, W; EXTERNAL_SOURCE_ID=829; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology gross-stomach-foci|systemic: pathology gross-stomach-prominent limiting ridge|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology gross-stomach-thickened|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-stomach-edema|systemic: pathology microscopic-kidney-hydronephrosis|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-parathyroid gland-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-stomach-necrosis|systemic: pathology microscopic-liver-proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15682949_15682950_15682951_15682952:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2edc5a8ca9a1c11dc93d7bae814d3ece |
| ToxValDB ToxRefDB | LEL | =8 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Thomas, T.; Solomom, H.; O\'Hara, G. (1992) Kathon Biocide: Oral (Gavage) Developmental Toxicity Study In Rabbits. Lab Project Number: 91P-074. Unpublished Study Prepared By Rohm And Haas Toxicology Dept. 206 P.; TITLE=Kathon Biocide: Oral (Gavage) Developmental Toxicity Study In Rabbits; AUTHOR=Thomas, T.; Solomom, H.; O\'Hara, G; EXTERNAL_SOURCE_ID=825; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-defecation|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: pathology gross-stomach-necrosis|systemic: in life observation-clinical signs-no feces|systemic: in life observation-mortality-mortality|systemic: pathology gross-stomach-thickened|systemic: pathology gross-stomach-discolored; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15682937_15682938_15682939_15682940:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b07034644dd398dfb8bfe89eff3a506 |
| ToxValDB ToxRefDB | LEL | =9.8 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Quinn, D.; O\'Hara, G.; Brown, W. (1994) Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149. Unpublished Study Prepared By Rohm And Haas Company Toxicology Department. 5150 P.; TITLE=Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149; AUTHOR=Quinn, D.; O\'Hara, G.; Brown, W; EXTERNAL_SOURCE_ID=829; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-necrosis|systemic: pathology gross-stomach-foci|systemic: pathology gross-stomach-thickened|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology gross-stomach-prominent limiting ridge|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-mineralization|systemic: pathology microscopic-adrenal gland-vacuolization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15682945_15682946_15682947_15682948:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_135acd0aea3162e109fa95a486cf164f |
| ToxValDB ToxRefDB | LEL | >39.1 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ToxRefDB_dup_-_15711224_15711225_15711226_15711227:F:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fb2e3b55add605098b019c85818a446 |
| ToxValDB ToxRefDB | LEL | =70 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Fuchs, A. (1994) Acticide 14 oral (gavage) teratogenicity study in the rat. Project ID 1154-003. Report No. 1178-1154-003.Unpublished.; TITLE=Acticide 14 oral (gavage) teratogenicity study in the rat; AUTHOR=Fuchs, A; EXTERNAL_SOURCE_ID=6189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-labored respiration|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15711204_15711205_15711206_15711207:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44df3d458740c1e5ed27b6f3343e7bdd |
| ToxValDB ToxRefDB | LEL | >139 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Fuchs, A. (1994) Acticide 14 oral (gavage) teratogenicity study in the rat. Project ID 1154-003. Report No. 1178-1154-003.Unpublished.; TITLE=Acticide 14 oral (gavage) teratogenicity study in the rat; AUTHOR=Fuchs, A; EXTERNAL_SOURCE_ID=6189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ToxRefDB_dup_-_15711208_15711209_15711210_15711211:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b44bbb69d5a0a97455659d87505c3e1 |
| ToxValDB ToxRefDB | LOAEL | =8.5 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperkeratosis|systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711215_15711216_15711217:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d95c2eb7e29ba5959c9264ea57e7307b |
| ToxValDB ToxRefDB | LOAEL | =11.8 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-erosion; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711212_15711213_15711214:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f248681fdc25756ca1b32510d2fb305 |
| ToxValDB ToxRefDB | LOAEL | =13.4 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperkeratosis|systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711221_15711222_15711223:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b6cd6eb11bd5ca35576355758d695bf4 |
| ToxValDB ToxRefDB | LOAEL | =16 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Robison, P., L.P. Craig, and T.L. Danberry. (1998) KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats. Rohm and Haas Company, Toxicology Department, Spring House, PA. Report No. 96R-189. August 7, 1998. MRID 44656101; TITLE=KathonAR 886F Biocide: Two-Generation Reproductive Toxicity Study in Rats; AUTHOR=Robison, P., L.P. Craig, and T.L. Danberry; EXTERNAL_SOURCE_ID=6190; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-stomach-erosion; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711218_15711219_15711220:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c253edb2aa725b68fddc5f559484907 |
| ToxValDB ToxRefDB | NEL | =2 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Thomas, T.; Solomom, H.; O\'Hara, G. (1992) Kathon Biocide: Oral (Gavage) Developmental Toxicity Study In Rabbits. Lab Project Number: 91P-074. Unpublished Study Prepared By Rohm And Haas Toxicology Dept. 206 P.; TITLE=Kathon Biocide: Oral (Gavage) Developmental Toxicity Study In Rabbits; AUTHOR=Thomas, T.; Solomom, H.; O\'Hara, G; EXTERNAL_SOURCE_ID=825; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology gross-stomach-discolored|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-stomach-thickened|systemic: pathology gross-stomach-necrosis|systemic: in life observation-clinical signs-no feces|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-defecation (diarrhea)|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-defecation|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15682937_15682938_15682939_15682940:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_22f9e69c39eb5fb3071c46dfa7cbd153 |
| ToxValDB ToxRefDB | NEL | =3.1 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Quinn, D.; O\'Hara, G.; Brown, W. (1994) Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149. Unpublished Study Prepared By Rohm And Haas Company Toxicology Department. 5150 P.; TITLE=Kathon Biocide: 24-Month Drinking Water Chronic/Oncogenic Study In Rats: Final Report: Lab Project Number: 90P/149: 90R/149; AUTHOR=Quinn, D.; O\'Hara, G.; Brown, W; EXTERNAL_SOURCE_ID=829; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-stomach-foci|systemic: pathology microscopic-stomach-necrosis|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-adrenal gland-vacuolization|systemic: pathology gross-stomach-prominent limiting ridge|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: pathology microscopic-kidney-mineralization|systemic: pathology gross-stomach-thickened; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15682945_15682946_15682947_15682948:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7423f7fde68a556867ed9099e8aae91 |
| ToxValDB ToxRefDB | NEL | =28 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Fuchs, A. (1994) Acticide 14 oral (gavage) teratogenicity study in the rat. Project ID 1154-003. Report No. 1178-1154-003.Unpublished.; TITLE=Acticide 14 oral (gavage) teratogenicity study in the rat; AUTHOR=Fuchs, A; EXTERNAL_SOURCE_ID=6189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-labored respiration|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15711204_15711205_15711206_15711207:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6405974b44ed8ece28302de3db52017e |
Regulatory source 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 10.2 | % | rat | oral | - | - | p.31 |
| Regulatory source | - | =19.6 | mg/kg bw | rat | oral | - | - | p.31 |
| Regulatory source | - | =104 | mg/kg/day | rat | - | - | - | p.24 |
| Regulatory source | carcinogenicity | 30 | ppm | rat | oral | 24 months | carcinogenicity | p.29 |
| Regulatory source | carcinogenicity | 300 | ppm | rat | oral | 24 months | carcinogenicity | p.29 |
| Regulatory source | developmental toxicity | 2 | mg/kg bw | rabbit | oral | Developmental | developmental toxicity | p.31 |
| Regulatory source | developmental toxicity | 10.2 | % | rabbit | oral | Developmental | developmental toxicity | p.31 |
| Regulatory source | developmental toxicity | 13.9 | % | rat | oral | Developmental | developmental toxicity | p.31 |
| Regulatory source | developmental toxicity | 13.9 | % | rabbit | oral | Developmental | developmental toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 0.0015 | % | - | - | subchronic | repeated dose toxicity | p.35 |
| Regulatory source | repeated dose toxicity | 0.34 | - | - | - | Chronic | repeated dose toxicity | p.26 |
| Regulatory source | repeated dose toxicity | 2.6 | mg/kg/day | rat | oral | 90-day | repeated dose toxicity | p.21 |
| Regulatory source | repeated dose toxicity | 200 | ppm | rat | oral | 90 days | repeated dose toxicity | p.21 |
| Regulatory source | reproductive toxicity | =0.00038 | mg/kg bw | human | dermal | - | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | 2 | mg/kg bw | rat | oral | Developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | =2.8 | mg/kg bw | human | dermal | - | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | 3.7 | % | rat | oral | - | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 4 | % | rat | oral | Developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 11.1 | % | rat | oral | - | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 13.9 | % | rat | oral | - | reproductive toxicity | p.30 |
| Regulatory source | reproductive toxicity | 13.9 | % | rat | oral | Developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | =19.6 | mg/kg bw | rat | oral | Developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 20 | mg/kg/day | - | oral | Developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 30 | ppm | rat | oral | - | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 75 | ppm | - | - | - | reproductive toxicity | p.22 |
| Regulatory source | reproductive toxicity | 100 | % | human | dermal | - | reproductive toxicity | p.34 |
| Regulatory source | reproductive toxicity | 225 | ppm | rat | - | - | reproductive toxicity | p.22 |
| Regulatory source | reproductive toxicity | 300 | ppm | rat | oral | Developmental | reproductive toxicity | p.31 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | DEL7T5QRPN | UNII | - | - | - | chemical | - |