Moderate Cosmetic Ingredient NOAEL Data

Methylcinnamic Aldehyde

INCI: METHYLCINNAMIC ALDEHYDE

CAS Number
101-39-3
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Methylcinnamic Aldehyde. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 221 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 221 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Potential skin sensitizer due to structural similarity to cinnamaldehyde (a known allergen); spicy aldehyde class requires careful dermal exposure assessment. Yellow liquid with a characteristic spicy, cinnamon-like odor; used widely in perfumery as a cinnamon note modifier

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Methylcinnamic Aldehyde safe in cosmetics?

Potential skin sensitizer due to structural similarity to cinnamaldehyde (a known allergen); spicy aldehyde class requires careful dermal exposure assessment. Yellow liquid with a characteristic spicy, cinnamon-like odor; used widely in perfumery as a cinnamon note modifier The EU classifies Methylcinnamic Aldehyde as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Methylcinnamic Aldehyde allowed in the EU?

Methylcinnamic Aldehyde EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methylcinnamic Aldehyde do in cosmetics?

Methylcinnamic Aldehyde functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 101-39-3.

What is the Margin of Safety for Methylcinnamic Aldehyde?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Methylcinnamic Aldehyde?

The NOAEL (No Observed Adverse Effect Level) for Methylcinnamic Aldehyde is 221 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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