Methylcyclopentadecanone (Muscone)
INCI: METHYLCYCLOPENTADECANONE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Methylcyclopentadecanone (Muscone). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Low acute toxicity; potential environmental persistence as a macrocyclic musk; IFRA-regulated concentration limits apply. Natural musk compound (3-methylcyclopentadecan-1-one); originally isolated from musk deer; now predominantly produced synthetically. Molecular formula C₁₆H₃₀O
Regulatory Flags
Frequently Asked Questions
Is Methylcyclopentadecanone (Muscone) safe in cosmetics?
Low acute toxicity; potential environmental persistence as a macrocyclic musk; IFRA-regulated concentration limits apply. Natural musk compound (3-methylcyclopentadecan-1-one); originally isolated from musk deer; now predominantly produced synthetically. Molecular formula C₁₆H₃₀O The EU classifies Methylcyclopentadecanone (Muscone) as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Methylcyclopentadecanone (Muscone) allowed in the EU?
Methylcyclopentadecanone (Muscone) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methylcyclopentadecanone (Muscone) do in cosmetics?
Methylcyclopentadecanone (Muscone) functions as: Fragrance (macrocyclic musk). It is classified as a cosmetic ingredient in our database. CAS number: 541-91-3.
What is the Margin of Safety for Methylcyclopentadecanone (Muscone)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methylcyclopentadecanone (Muscone)?
The NOAEL (No Observed Adverse Effect Level) for Methylcyclopentadecanone (Muscone) is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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