NOAEL Studies Cosmetic Ingredient

METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL NOAEL Studies

CAS: 103597-45-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.0144 mg/kg bw/d rat dermal 13-week dermal absorption p.52
SCCS Opinion NOAEL =10 % rat dermal subchronic repeated dose toxicity p.52
SCCS Opinion NOAEL =59.2 mg/kg bw/d rat dermal - dermal absorption p.53
SCCS Opinion NOAEL =800 mg/kg bw/d rat dermal 90-day NOAEL study p.32
SCCS Opinion NOAEL =800 mg/kg bw rat dermal 90-day carcinogenicity p.32
SCCS Opinion NOAEL =1000 mg/kg bw/d pig dermal Chronic NOAEL study p.35
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =21.16 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633358_15633359:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e48b095a1e337957d3f787d7a6e8e628
ToxValDB GESTIS DNEL DNEL systemic =23.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633358_15633359:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d8e1ed50e6902b2379344c8a4b4a805e
Regulatory source 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 800 mg/kg bw/d rat dermal 90-day - p.32
Regulatory source - 800 mg/kg bw rat dermal 90-day - p.32
Regulatory source - 1000 mg/kg bw/d pig dermal Chronic - p.35
Regulatory source - >1000 mg/kg bw/d rat dermal 90-day - p.69
Regulatory source - 1000 mg/kg bw/d rat dermal 13-week - p.52
Regulatory source carcinogenicity 800 mg/kg bw rat dermal 90-day carcinogenicity p.32
Regulatory source carcinogenicity 800 mg/kg bw rat dermal 39-week carcinogenicity p.32
Regulatory source dermal absorption 0.0144 mg/kg bw/d rat dermal 13-week dermal absorption p.52
Regulatory source dermal absorption 59.2 mg/kg bw/d rat dermal - dermal absorption p.53
Regulatory source developmental toxicity 1000 mg/kg bw/d rabbit oral developmental developmental toxicity p.80
Regulatory source genotoxicity 1000 mg/kg bw/d rat dermal - genotoxicity p.71
Regulatory source repeated dose toxicity 10 % rat dermal subchronic repeated dose toxicity p.52
Regulatory source repeated dose toxicity 10 % rat oral 28-day repeated dose toxicity p.55
Regulatory source reproductive toxicity 1000 mg/kg bw/d - oral developmental reproductive toxicity p.76
Regulatory source reproductive toxicity 1000 mg/kg bw/d rat oral Developmental reproductive toxicity p.78
Regulatory source reproductive toxicity 1000 mg/kg bw/d - - developmental reproductive toxicity p.78
Regulatory source reproductive toxicity 1000 mg/kg bw/d rat - developmental reproductive toxicity p.79
Regulatory source reproductive toxicity 1000 mg/kg bw/d rabbit oral developmental reproductive toxicity p.81
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8NT850T0YS UNII - - - chemical -