NOAEL Studies
Preservative
Methylisothiazolinone NOAEL Studies
INCI: METHYLISOTHIAZOLINONE
CAS: 2682-20-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =0.34 | mg/m3 | rat | inhalation | - | inhalation toxicity | 14; 2; 400, p.3 |
| CIR Safety Assessment | NOAEL | =28.6 | mg/kg bw/d | - | - | - | NOAEL study | 28; 6, p.4 |
| CIR Safety Assessment | NOAEL | =220 | ppm | rat | oral | Subchronic | repeated dose toxicity | 71; 2; 97, p.5 |
| CIR Safety Assessment | NOAEL | =30.09 | mg/kg bw/d | rat | oral | 13-week | repeated dose toxicity | 30; 09; 13, p.5 |
| CIR Safety Assessment | NOAEL | =10 | mg/kg/d | rat | oral | 90-day | repeated dose toxicity | 20; 40; 3, 10, p.6 |
| CIR Safety Assessment | NOAEL | =30 | mg/kg/d | rat | oral | 90-day | repeated dose toxicity | 20; 40; 3, 10, p.6 |
| CIR Safety Assessment | NOAEL | =33.4 | mg/kg bw/d | rat | oral | - | developmental toxicity | 414; 5; 25, p.6 |
| CIR Safety Assessment | NOAEL | =49.8 | mg/kg bw/d | - | oral | - | developmental toxicity | 6; 15; 49, p.6 |
COSMOS DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 75 | ppm | rat | oral | 90 day | Subchronic | FCN; Three-Month Drinking Water Toxicity Study in Rats |
NTP ICE acute dermal 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 2 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=755; Record_ID=acute_dermal_285; Data_Type=In Vivo; Formulation_ID=MIX278; Formulation_Name=Kathon CF 400; Percent_Active_Ingredient=1.05; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=2.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=759; Record_ID=acute_dermal_11; Data_Type=In Vivo; Formulation_ID=MIX11; Formulation_Name=Acticide SR 8213 C; Percent_Active_Ingredient=10.0; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=750; Record_ID=acute_dermal_368; Data_Type=In Vivo; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.3; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=753; Record_ID=acute_dermal_8; Data_Type=In Vivo; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=0.65; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=751; Record_ID=acute_dermal_11; Data_Type=In Vivo; Formulation_ID=MIX11; Formulation_Name=Acticide SR 8213 C; Percent_Active_Ingredient=10.0; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=748; Record_ID=acute_dermal_368; Data_Type=In Vivo; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.3; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
NTP ICE acute inhalation 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | EPA Classification | 2 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1623; Record_ID=acute_inhalation_466; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX60; Formulation_Name=Bioban 425 Antimicrobial; Percent_Active_Ingredient=15.0; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | EPA Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1624; Record_ID=acute_inhalation_293; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.3; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | GHS Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1631; Record_ID=acute_inhalation_329; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=0.28; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | 0.21 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1620; Record_ID=acute_inhalation_29; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=0.65; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.21; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | range0.52 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1621; Record_ID=acute_inhalation_293; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.3; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>0.52 and <2.05; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | 1.69 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1622; Record_ID=acute_inhalation_329; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX400; Formulation_Name=Rocima 586; Percent_Active_Ingredient=0.28; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.69; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | 0.38 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1636; Record_ID=acute_inhalation_466; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX60; Formulation_Name=Bioban 425 Antimicrobial; Percent_Active_Ingredient=15; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.38; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | 0.73 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1638; Record_ID=acute_inhalation_26; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX6; Formulation_Name=Acticide CBM; Percent_Active_Ingredient=3.903; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.73; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | 0.1 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1634; Record_ID=acute_inhalation_1055; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/3/3/?documentUUID=689d5e1b-a6e1-4771-a5f1-087cf7146040; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | 0.11 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1632; Record_ID=acute_inhalation_1047; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.11; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/3/3/?documentUUID=689d5e1b-a6e1-4771-a5f1-087cf7146040; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | 0.13 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1633; Record_ID=acute_inhalation_1051; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.13; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/3/3/?documentUUID=689d5e1b-a6e1-4771-a5f1-087cf7146040; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE acute inhalation | LC50 | 0.35 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1635; Record_ID=acute_inhalation_1078; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.35; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/3/3/?documentUUID=3ccf380c-35c9-4ecd-87e3-f25bc496d064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
NTP ICE acute oral 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =2 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12286; row=4472; data_type=In Vivo; mixture=Mixture; formulation_id=MIX60; formulation_name=Bioban 425 Antimicrobial; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=15.0; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13156; row=4470; data_type=In Vivo; mixture=Mixture; formulation_id=MIX663; formulation_name=Acticide CBM 2; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=5.0; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12197; row=4471; data_type=In Vivo; mixture=Mixture; formulation_id=MIX11; formulation_name=Acticide SR 8213 C; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=10.0; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12286; row=4490; data_type=In Vivo; mixture=Mixture; formulation_id=MIX60; formulation_name=Bioban 425 Antimicrobial; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=15.0; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12860; row=4475; data_type=In Vivo; mixture=Mixture; formulation_id=MIX361; formulation_name=Preventol P 91; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=0.3; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13156; row=4479; data_type=In Vivo; mixture=Mixture; formulation_id=MIX663; formulation_name=Acticide CBM 2; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=5.0; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12185; row=4478; data_type=In Vivo; mixture=Mixture; formulation_id=MIX6; formulation_name=Acticide CBM; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=3.903; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =97 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12286; row=4482; data_type=In Vivo; mixture=Mixture; formulation_id=MIX60; formulation_name=Bioban 425 Antimicrobial; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=15.0; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =105 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_4872; row=4484; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-3(2H)-isothiazolone; preferred_name=2-Methyl-3(2H)-isothiazolone; dtxsid=DTXSID2034259; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =183 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_4874; row=4485; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-3(2H)-isothiazolone; preferred_name=2-Methyl-3(2H)-isothiazolone; dtxsid=DTXSID2034259; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1030 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12860; row=4483; data_type=In Vivo; mixture=Mixture; formulation_id=MIX361; formulation_name=Preventol P 91; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=0.3; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1091 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_4876; row=4486; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-3(2H)-isothiazolone; preferred_name=2-Methyl-3(2H)-isothiazolone; dtxsid=DTXSID2034259; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12185; row=4481; data_type=In Vivo; mixture=Mixture; formulation_id=MIX6; formulation_name=Acticide CBM; chemical_name=Methylisothiazolinone; preferred_name=2-Methyl-3(2H)-isothiazolone; percent_active_ingredient=3.903; dtxsid=DTXSID2034259; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2834 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_4878; row=4487; data_type=In Vivo; mixture=Chemical; chemical_name=2-Methyl-3(2H)-isothiazolone; preferred_name=2-Methyl-3(2H)-isothiazolone; dtxsid=DTXSID2034259; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259; source_file=acute_oral.xlsx |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=863; Record_ID=eye_irritation_391; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID47; Formulation_Name=Acticide CBM; Percent_Active_Ingredient=3.903; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
NTP ICE skin irritation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=606; Record_ID=skin_irritation_invivo_849; Data_Type=In Vivo; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=0.65; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=607; Record_ID=skin_irritation_invivo_751; Data_Type=In Vivo; Formulation_ID=MIX361; Formulation_Name=Preventol P 91; Percent_Active_Ingredient=0.3; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=615; Record_ID=skin_irritation_invivo_857; Data_Type=In Vivo; Formulation_ID=MIX11; Formulation_Name=Acticide SR 8213 C; Percent_Active_Ingredient=10; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
NTP ICE skin sensitization 36 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 7.89 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2043; Record_ID=skin_sensitization_invitro_511; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=7.89; Reported_Response_Unit=ug/mL; Response=7.89; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | CD86, EC150 | 4.594 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8312; Record_ID=skin_sensitization_invitro_2304; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=39.9; Reported_Response_Unit=uM; Conversion_Factor_Value=115.15; Conversion_Factor_Source=EPA Dashboard; Converted_Response=4.594; Converted_Response_Unit=ug/mL; Response=4.594; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | CD86, EC150 | 9 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8540; Record_ID=skin_sensitization_invitro_2355; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=9; Reported_Response_Unit=ug/mL; Response=9; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | CD86, EC150 | 9.23 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2044; Record_ID=skin_sensitization_invitro_511; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=9.23; Reported_Response_Unit=ug/mL; Response=9.23; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | CV70 | 44.3 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8538; Record_ID=skin_sensitization_invitro_2355; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=U-SENS; Endpoint=CV70; Reported_Response=44.3; Reported_Response_Unit=ug/mL; Response=44.3; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | CV75 | 24.7 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2045; Record_ID=skin_sensitization_invitro_511; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=h-CLAT; Endpoint=CV75; Reported_Response=24.7; Reported_Response_Unit=ug/mL; Response=24.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 0.232 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6505; Record_ID=skin_sensitization_invivo_1487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.04; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.232; Response_Unit=%; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 0.525 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6521; Record_ID=skin_sensitization_invivo_1489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.05; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.525; Response_Unit=%; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.04 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6501; Record_ID=skin_sensitization_invivo_1487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.04; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.04; Response_Unit=%; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.05 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6517; Record_ID=skin_sensitization_invivo_1489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.05; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.05; Response_Unit=%; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Depletion Cys | 97.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=870; Record_ID=skin_sensitization_invitro_241; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=97.9; Reported_Response_Unit=%; Response=97.9; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Depletion Cys | 100 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=874; Record_ID=skin_sensitization_invitro_242; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=100; Reported_Response_Unit=%; Response=100; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Depletion Lys | -5.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=869; Record_ID=skin_sensitization_invitro_241; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-5.6; Reported_Response_Unit=%; Response=-5.6; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Depletion Lys | 1.1 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=873; Record_ID=skin_sensitization_invitro_242; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.1000000000000001; Reported_Response_Unit=%; Response=1.1; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 46.15 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=871; Record_ID=skin_sensitization_invitro_241; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=46.15; Reported_Response_Unit=%; Response=46.15; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 51 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=875; Record_ID=skin_sensitization_invitro_242; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=51; Reported_Response_Unit=%; Response=51; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | EC1.5 | 11.78 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=8786; Record_ID=skin_sensitization_invitro_2434; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=11.78; Reported_Response_Unit=uM; Response=11.78; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | EC3 | 0.37 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13439; Record_ID=skin_sensitization_invivo_3588; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=LLNA; Endpoint=EC3; Response=0.37; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 2003; Not available; 10.1081/CUS-120026299; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | EC3 | 1.9 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12809; Record_ID=skin_sensitization_invivo_2810; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=LLNA; Endpoint=EC3; Response=1.9; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | EC3 | 2.2 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13440; Record_ID=skin_sensitization_invivo_3589; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter et al. 2003; Not available; 10.1081/CUS-120026299; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | EC3 | 29.56 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=8787; Record_ID=skin_sensitization_invitro_2434; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=29.559000000000001; Reported_Response_Unit=uM; Response=29.56; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Guinea pig | Dermal | - | In Vivo; SkinSensitization6pack; Guinea Pig Maximization/Buehler | sheet=Data_invivo; excel_row=732; Record_ID=skin_sensitization_invivo_28; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX8; Formulation_Name=Acticide LA 2605-F; Percent_Active_Ingredient=0.65; Mixture=Mixture; DTXSID=DTXSID2034259; Assay=Guinea Pig Maximization/Buehler; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Guinea pig; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | IC50 | 139 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=8788; Record_ID=skin_sensitization_invitro_2434; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=138.97999999999999; Reported_Response_Unit=uM; Response=139; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Imax | 22.6 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=8789; Record_ID=skin_sensitization_invitro_2434; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.6; Reported_Response_Unit=Unitless; Response=22.6; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6475; Record_ID=skin_sensitization_invivo_1483; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Incidence of positive responses | 0.4762 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6513; Record_ID=skin_sensitization_invivo_1489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.05; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0.4762; Response_Unit=%; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Incidence of positive responses | 0.8621 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6497; Record_ID=skin_sensitization_invivo_1487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.04; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0.8621; Response_Unit=%; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Induction dose per skin area | 10 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6481; Record_ID=skin_sensitization_invivo_1484; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.02; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=10; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Induction dose per skin area | 15 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6488; Record_ID=skin_sensitization_invivo_1485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.03; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=15; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Induction dose per skin area | 20 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6495; Record_ID=skin_sensitization_invivo_1487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.04; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=20; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Induction dose per skin area | 25 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6511; Record_ID=skin_sensitization_invivo_1489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.05; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=25; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Induction dose per skin area | 30 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6528; Record_ID=skin_sensitization_invivo_1491; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.06; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=30; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 116 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6507; Record_ID=skin_sensitization_invivo_1487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.04; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=116; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 262.5 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6523; Record_ID=skin_sensitization_invivo_1489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.05; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=262.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6487; Record_ID=skin_sensitization_invivo_1484; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.02; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
| NTP ICE skin sensitization | Relative reliability score | 4 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=6479; Record_ID=skin_sensitization_invivo_1483; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2034259; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Rohm and Haas 2000; Not available; Not available|SCCNFP 2003; https://ec.europa.eu/health/archive/ph_risk/committees/sccp/documents/out_201.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2034259 |
SCCNFP Opinion 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =19 | mg/kg bw | rat | oral | 90 day | dermal absorption | p.9 |
| SCCNFP Opinion | NOAEL | =100 | % | rat | oral | 90 day | dermal absorption | p.9 |
| SCCNFP Opinion | NOAEL | =250 | ppm | - | oral | Sub-chronic | repeated dose toxicity | Ref. : 4 2, p.7 |
SCCS Opinion 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =15 | µg/cm2 | - | - | - | sensitisation | p.13 |
ECHA 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =71.2 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6dab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830454_15850925:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_611d136a8bd77a147a369a78197c25de |
| ECHA | NOAEC | =200 | mg/L | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15856921:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d37f5069be279439cd09f8e57a1788a3 |
| ECHA | NOAEL | >=15 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860304_15860305_15860319_15860320_15860331_15860332_15860342_15863190:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ba9e0eb97ed52d1a5c05df192c550aa8 |
| ECHA | NOAEL | =19 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6daf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15850948:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7e9d5aaae2afdab682a4ee4f25902b5b |
| ECHA | NOAEL | <=22 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860304_15860305_15860319_15860320_15860331_15860332_15860342_15863190:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3bd8999adad0d017cd6e9ad9446932de |
| ECHA | NOAEL | =24.6 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6daf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15850924:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_619f097c93721659cbc9263565b4dfc5 |
| ECHA | NOAEL | <=26 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860304_15860305_15860319_15860320_15860331_15860332_15860342_15863190:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edfbf78ca90c1fb691b71ef7f2a953d7 |
| ECHA | NOAEL | =28.6 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6dab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830454_15850925:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_61bbfe020730c1919aa15671bbe1e797 |
| ECHA | NOAEL | =30 | mg/kg bw/day | Rabbit | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd287; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/3?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15823528:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7f1a5e80a41e516901dbcbc1153fb274 |
| ECHA | NOAEL | =30.09 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6db9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15851018:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e2c17389e47df043360d632659eff11f |
| ECHA | NOAEL | =40 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd28b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/3?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15825457:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fea294161846afca8e6962a68cfddefa |
| ECHA | NOAEL | >=40.6 | mg/kg bw/day | Dog | oral | acute; 2 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb01e4b0a7c65d2245f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847078_15847079:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5bd02ec2c7083c968143e97305a26e59 |
| ECHA | NOAEL | <=40.9 | mg/kg bw/day | Dog | oral | acute; 2 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb01e4b0a7c65d2245f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847078_15847079:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11c6684c4c883756df5d0b7c2f50edce |
| ECHA | NOAEL | >=69 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860304_15860305_15860319_15860320_15860331_15860332_15860342_15863190:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4164247d6ef3c8e9d4e7532dd6296c70 |
| ECHA | NOAEL | >=86 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860304_15860305_15860319_15860320_15860331_15860332_15860342_15863190:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce680ef658a92044a8b11c25e4a07b3e |
| ECHA | NOAEL | <=93 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860304_15860305_15860319_15860320_15860331_15860332_15860342_15863190:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_faf83717efa0605bbd08321e9c70bb61 |
| ECHA | NOAEL | <=115 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7d4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/9/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860304_15860305_15860319_15860320_15860331_15860332_15860342_15863190:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2f69c616c1d94a33746e63f8a7a2e87 |
| ECHA | NOEL | =9.9 | mg/kg bw/day | Dog | oral | acute; 2 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb01e4b0a7c65d2245f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15842488:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d43f03cc49596d8abd1fa9ec16cc287b |
| ECHA | NOEL | =11.1 | mg/kg bw/day | Dog | oral | acute; 2 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb01e4b0a7c65d2245f7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23868/7/6/2?documentUUID=f1730ae9-9cc5-4620-bad1-8d8cc7b1b558; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15842489:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e951c0f2b32ba9be4b733a3d291dae59 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.021 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633422:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4218f5894f554c91aa226ff015d58352 |
Regulatory source 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 28.6 | mg/kg bw/d | - | - | - | - | p.4 |
| Regulatory source | developmental toxicity | 33.4 | mg/kg bw/d | rat | oral | - | developmental toxicity | p.6 |
| Regulatory source | developmental toxicity | 49.8 | mg/kg bw/d | - | oral | - | developmental toxicity | p.6 |
| Regulatory source | inhalation toxicity | 0.34 | mg/m3 | rat | inhalation | - | inhalation toxicity | p.3 |
| Regulatory source | repeated dose toxicity | 220 | ppm | rat | oral | Subchronic | repeated dose toxicity | p.5 |
| Regulatory source | repeated dose toxicity | 30.09 | mg/kg bw/d | rat | oral | 13-week | repeated dose toxicity | p.5 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg/d | rat | oral | 90-day | repeated dose toxicity | p.6 |
| Regulatory source | repeated dose toxicity | 30 | mg/kg/d | rat | oral | 90-day | repeated dose toxicity | p.6 |
| Regulatory source | - | 19 | mg/kg bw | rat | oral | 90 day | - | p.9 |
| Regulatory source | dermal absorption | =19 | mg/kg bw | rat | oral | 90 day | dermal absorption | p.9 |
| Regulatory source | dermal absorption | 100 | % | rat | oral | 90 day | dermal absorption | p.9 |
| Regulatory source | repeated dose toxicity | 250 | ppm | - | oral | Sub-chronic | repeated dose toxicity | p.7 |
| Regulatory source | sensitisation | 15 | µg/cm2 | - | - | - | sensitisation | p.13 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 229D0E1QFA | UNII | - | - | - | chemical | - |