NOAEL Studies
Preservative
Methylparaben NOAEL Studies
INCI: METHYLPARABEN
CAS: 99-76-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =1 | mg/kg/d | rat | oral | - | oral toxicity | 1,140; 1,100; 3, p.31 |
| CIR Safety Assessment | NOAEL | =2 | mg/ kg bw/d | rat | - | 17 days | developmental toxicity | 1; 18; 4, p.30 |
| CIR Safety Assessment | NOAEL | =4 | mg/kg bw/d | rat | oral | 7 days | oral toxicity | 0; 16; 21, p.40 |
| CIR Safety Assessment | NOAEL | =67.8 | mg/kg/d | rat | - | 5-week | NOAEL study | 72; 53; 10,000, p.30 |
| CIR Safety Assessment | NOAEL | =100 | mg/ kg | rat | oral | 8 weeks | reproductive toxicity | 36); 5; 20, p.29 |
| CIR Safety Assessment | NOAEL | =160 | mg/kg/d | - | - | - | developmental toxicity | 3; 100; 1,000, p.1 |
| CIR Safety Assessment | NOAEL | =600 | mg/kg bw/d | rat | oral | 28 days | oral toxicity | (4; 3; 24, p.78 |
| CIR Safety Assessment | NOAEL | =1000 | mg/kg/d | rat | - | - | developmental toxicity | 10; 3; 100, p.1 |
| CIR Safety Assessment | NOAEL | =10000 | ppm | rat | oral | 8 weeks | oral toxicity | 8; 71; 1,000, p.26 |
COSMOS DB 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | mouse | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | hamster | oral | 5 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | cat | oral | 6 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 550 | mg/kg bw/day | mouse | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 650 | mg/kg bw/day | hamster | oral | 5 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 800 | mg/kg bw/day | rat | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | dog | oral | 365 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1030 | mg/kg bw/day | rat | oral | 8 week | Subchronic | SCCS; Food Chemical Toxicology 42: 1845-1849; Oishi S. |
| COSMOS DB | NOAEL | 1180 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 4000 | mg/kg bw/day | rat | oral | 9 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5700 | mg/kg bw/day | rat | oral | 672 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =1030 | mg/kg bw/day | Rat | - | 56 days | subchronic | EFSA AFC - 2004 - OutputID 309 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) - doi:10.2903/j.efsa.2004.83 |
| EFSA | NOAEL | =1030 | mg/kg bw/day | Rat | oral | subchronic; 8 weeks | subchronic | LONG_REF=EFSA AFC (2004). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). doi:10.2903/j.efsa.2004.83.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219); AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2004.83; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614256:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_040184ccd577119a1d0edead44322d0c |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_12060; row=7115; data_type=In Vivo; mixture=Chemical; chemical_name=Methylparaben; preferred_name=Methylparaben; dtxsid=DTXSID4022529; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_12061; row=7116; data_type=In Vivo; mixture=Chemical; chemical_name=Methylparaben; preferred_name=Methylparaben; dtxsid=DTXSID4022529; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_12059; row=7117; data_type=In Vivo; mixture=Chemical; chemical_name=Methylparaben; preferred_name=Methylparaben; dtxsid=DTXSID4022529; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 107.5 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1636; Record_ID=adme_parameters_405; Data_Type=Measured; DTXSID=DTXSID4022529; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=107.5; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE adme parameters | Clint | 86.2 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=1637; Record_ID=adme_parameters_405; Data_Type=Measured; DTXSID=DTXSID4022529; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=86.2; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE adme parameters | Fu | 0.174 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=1638; Record_ID=adme_parameters_405; Data_Type=Measured; DTXSID=DTXSID4022529; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.174; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE adme parameters | Fu | 0.07056 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1639; Record_ID=adme_parameters_405; Data_Type=Measured; DTXSID=DTXSID4022529; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.07056; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
NTP ICE endocrine 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 64.1358560333104 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=11584; RecordID=ERPathway2016_428; DatasetName=ERPathway2016; DTXSID=DTXSID4022529; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=64.1358560333104; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | AC50/EC50/IC50 | 10200 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13267; Record_ID=endocrine_invitro_4107; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=10200; Reported_Response_Unit=nM; Response=10200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Indiveri et al. 2014; 24972338; 10.1016/j.reprotox.2014.06.004; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | AC50/EC50/IC50 | 208000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13268; Record_ID=endocrine_invitro_4108; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=208000; Reported_Response_Unit=nM; Response=208000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2011; 21945941; 10.1016/j.taap.2011.09.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | AC50/EC50/IC50 | 7800 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13270; Record_ID=endocrine_invitro_4110; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=7800; Reported_Response_Unit=nM; Response=7800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ma et al. 2014; 24469767; 10.1007/s11356-014-2497-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | AC50/EC50/IC50 | 100000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13272; Record_ID=endocrine_invitro_4112; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=100000; Reported_Response_Unit=nM; Response=100000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | ACC | 58.830885379248 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=11585; RecordID=ERPathway2016_428; DatasetName=ERPathway2016; DTXSID=DTXSID4022529; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=58.830885379248; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | IC01 | 26900 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13020; Record_ID=endocrine_invitro_4032; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=AR Transactivation-Antagonist; Endpoint=IC01; Reported_Response=26900; Reported_Response_Unit=IC01 (nM); Response=26900; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | LEL | 1000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=14966; Record_ID=endocrine_invitro_4403; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=1000; Reported_Response_Unit=nM; Response=1000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2007; 17481686; 10.1016/j.taap.2007.03.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | LOEL | 55 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1053; Record_ID=endocrine_invivo_414; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=55; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=165; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Lemini et al. 2003; 15697177; 10.1191/0748233703th177oa|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=11580; RecordID=ARPathway2016_1823; DatasetName=ARPathway2016; DTXSID=DTXSID4022529; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | Model Score | 0.00684 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=11586; RecordID=ERPathway2016_428; DatasetName=ERPathway2016; DTXSID=DTXSID4022529; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00684; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | Relative potency | 8 | % | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=15214; Record_ID=endocrine_invitro_4107; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=8; Reported_Response_Unit=%; Response=8; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Indiveri et al. 2014; 24972338; 10.1016/j.reprotox.2014.06.004; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | Relative potency | 53 | % | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=15215; Record_ID=endocrine_invitro_4407; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=AR Transactivation-Antagonist; Endpoint=Relative potency; Reported_Response=53; Reported_Response_Unit=%; Response=53; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Orton et al. 2014; 24055644; 10.1016/j.taap.2013.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE endocrine | Uterine weight increase vs control | 32 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=747; Record_ID=endocrine_invivo_414; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=32; Response_Unit=%; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=165; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Lemini et al. 2003; 15697177; 10.1191/0748233703th177oa|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
NTP ICE skin sensitization 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD86, EC150 | 52 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8151; Record_ID=skin_sensitization_invitro_2174; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=341.7679921; Reported_Response_Unit=uM; Conversion_Factor_Value=152.149; Conversion_Factor_Source=EPA Dashboard; Converted_Response=52; Converted_Response_Unit=ug/mL; Response=52; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 30.625 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11562; Record_ID=skin_sensitization_invivo_2512; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=5.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=30.625; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Concentration, one positive response | 6.25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11560; Record_ID=skin_sensitization_invivo_2512; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=5.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=6.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Depletion Cys | 3.6 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=69; Record_ID=skin_sensitization_invitro_3; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.6; Reported_Response_Unit=%; Response=3.6; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Depletion Lys | 0 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=161; Record_ID=skin_sensitization_invitro_3; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | EC1.5 | 805.4 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=7494; Record_ID=skin_sensitization_invitro_1787; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=805.3529486; Reported_Response_Unit=uM; Response=805.4; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | EC1.5 | <381.78 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7959; Record_ID=skin_sensitization_invitro_1798; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=381.78; Reported_Response_Unit=uM; Response=381.78; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | IC50 | >2000 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=7496; Record_ID=skin_sensitization_invitro_1787; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | IC50 | >950 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7630; Record_ID=skin_sensitization_invitro_1798; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=950; Reported_Response_Unit=uM; Response=950; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Imax | 2.426 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=7497; Record_ID=skin_sensitization_invitro_1787; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.425864785; Reported_Response_Unit=Unitless; Response=2.426; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Imax | 6.696 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7527; Record_ID=skin_sensitization_invitro_1798; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022529; Assay=LuSens; Endpoint=Imax; Reported_Response=6.696184619; Reported_Response_Unit=Unitless; Response=6.696; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Incidence of positive responses | 1.02 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11558; Record_ID=skin_sensitization_invivo_2512; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=5.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=1.02; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11589; Record_ID=skin_sensitization_invivo_2516; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=0.2; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Induction dose per skin area | 4359 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11557; Record_ID=skin_sensitization_invivo_2512; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=5.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=4359; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Induction dose per skin area | 174.4 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11587; Record_ID=skin_sensitization_invivo_2516; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=0.2; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=174.4; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Induction dose per skin area | 871.9 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11603; Record_ID=skin_sensitization_invivo_2519; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=1.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=871.9; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Induction dose per skin area | 6975 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11618; Record_ID=skin_sensitization_invivo_2523; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=10.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6975; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 21360 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11563; Record_ID=skin_sensitization_invivo_2512; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=5.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=21360; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11564; Record_ID=skin_sensitization_invivo_2512; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=5.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022529; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022529 |
SCCS Opinion 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.1 | % | rat | oral | 27-day | NOAEL study | p.45 |
| SCCS Opinion | NOAEL | =0.105 | mg/kg bw/day | rat | - | - | NOAEL study | p.64 |
| SCCS Opinion | NOAEL | =24 | - | - | - | Chronic | NOAEL study | p.43 |
| SCCS Opinion | NOAEL | =25 | - | - | oral | developmental | reproductive toxicity | p.44 |
| SCCS Opinion | NOAEL | =42 | - | - | oral | developmental | repeated dose toxicity | p.42 |
| SCCS Opinion | NOAEL | =99 | - | - | oral | developmental | repeated dose toxicity | p.42 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | - | - | NOAEL study | p.46 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | - | - | developmental | reproductive toxicity | p.50 |
| SCCS Opinion | NOAEL | =1000 | mg/kg/day | - | oral | 14 days | repeated dose toxicity | p.38 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | - | - | - | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/d | - | - | - | reproductive toxicity | p.43 |
| SCCS Opinion | NOAEL | =10000 | ppm | rat | oral | - | reproductive toxicity | p.45 |
ECHA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =550 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d24ce4b0a7c65d2328c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30649/7/9/3?documentUUID=3a6960ce-3ffa-42a8-82cd-3311aacc0e80; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821380_15823776_15825361:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f8c0234231053782009746837ceaa420 |
| ECHA | NOAEL | >300 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc6e4b0a7c65d1bbb5a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/9/3?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823716_15825360:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2759073566d725a75548c5269f1a5d94 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac9ce4b0a7c65d1c003f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30649/7/9/3?documentUUID=3a6960ce-3ffa-42a8-82cd-3311aacc0e80; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821380_15823776_15825361:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_62a48ac33d219053115b66480e1b413f |
| ECHA | NOEL | >1030 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf9ee4b0a7c65d1cea84; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22106/7/6/2?documentUUID=a050fc07-152c-4b11-8ba0-92b9df3fb49f; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=clinical biochemistry|clinical signs|food consumption and compound intake|mortality|organ weights and organ / body weight ratios|serum/plasma biochemistry|serum/plasma hormone analyses|sperm measures; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|food and/or water consumption|mortality/survival|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15850084:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_596d623aa1f1e6d87d3c07d88b66323f |
| ECHA | NOEL | =1000 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1d9c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/6/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850490_15850491:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3e5261cabf65ffdfe038d88df96cc832 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =176.3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633411:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d9f1b1f7290fb9d07c37b802109a2a8 |
ToxValDB Uterotrophic Hershberger DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Uterotrophic Hershberger DB | LEL | =16.5 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713525_15713577_15713628:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a67a9267b8378fb659a276a99a1da164 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =55 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713576:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c1650c71d4bafc2c44c744209a833ae |
| ToxValDB Uterotrophic Hershberger DB | LEL | =165 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713525_15713577_15713628:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_baef90db66c25256c4db7a9512a9626a |
Regulatory source 38 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 67.8 | mg/kg/d | rat | - | 5-week | - | p.30 |
| Regulatory source | developmental toxicity | 2 | mg/ kg bw/d | rat | - | 17 days | developmental toxicity | p.30 |
| Regulatory source | developmental toxicity | 160 | mg/kg/d | - | - | - | developmental toxicity | p.1 |
| Regulatory source | developmental toxicity | 1000 | mg/kg/d | rat | - | - | developmental toxicity | p.1 |
| Regulatory source | oral toxicity | 1 | mg/kg/d | rat | oral | - | oral toxicity | p.31 |
| Regulatory source | oral toxicity | 4 | mg/kg bw/d | rat | oral | 7 days | oral toxicity | p.40 |
| Regulatory source | oral toxicity | 600 | mg/kg bw/d | rat | oral | 28 days | oral toxicity | p.78 |
| Regulatory source | oral toxicity | 10000 | ppm | rat | oral | 8 weeks | oral toxicity | p.26 |
| Regulatory source | reproductive toxicity | 100 | mg/ kg | rat | oral | 8 weeks | reproductive toxicity | p.29 |
| Regulatory source | - | 0.1 | % | rat | oral | 27-day | - | p.45 |
| Regulatory source | - | 0.105 | mg/kg bw/day | rat | - | - | - | p.64 |
| Regulatory source | - | 24 | - | - | - | Chronic | - | p.43 |
| Regulatory source | - | 250 | mg/kg bw/day | rat | - | - | - | p.46 |
| Regulatory source | - | 1000 | mg/kg bw/day | - | - | - | - | p.40 |
| Regulatory source | - | 1000 | mg/kg bw/d | rat | oral | Chronic | - | p.43 |
| Regulatory source | - | 1000 | mg/kg/day | rat | oral | 27-day | - | p.45 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | - | - | - | p.46 |
| Regulatory source | - | 1000 | mg/kg bw | - | - | Chronic | - | p.43 |
| Regulatory source | repeated dose toxicity | 42 | - | - | oral | developmental | repeated dose toxicity | p.42 |
| Regulatory source | repeated dose toxicity | 99 | - | - | oral | developmental | repeated dose toxicity | p.42 |
| Regulatory source | repeated dose toxicity | 300 | mg/kg bw/day | - | oral | 90-day | repeated dose toxicity | p.51 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg/day | - | oral | 14 days | repeated dose toxicity | p.38 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg/day | - | oral | subchronic | repeated dose toxicity | p.38 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg/day | - | oral | developmental | repeated dose toxicity | p.44 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/d | - | oral | 90-day | repeated dose toxicity | p.44 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg/day | human | oral | subchronic | repeated dose toxicity | p.70 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/d | - | oral | subchronic | repeated dose toxicity | p.70 |
| Regulatory source | reproductive toxicity | 25 | - | - | oral | developmental | reproductive toxicity | p.44 |
| Regulatory source | reproductive toxicity | 300 | mg/kg bw/day | - | - | developmental | reproductive toxicity | p.50 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/d | - | - | - | reproductive toxicity | p.43 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | dog | oral | 422 days | reproductive toxicity | p.44 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | - | oral | developmental | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | - | - | developmental | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | - | developmental | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | - | - | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg | - | - | developmental | reproductive toxicity | p.50 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/d | - | - | 90-day | reproductive toxicity | p.70 |
| Regulatory source | reproductive toxicity | 10000 | ppm | rat | oral | - | reproductive toxicity | p.45 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | A2I8C7HI9T | UNII | - | - | - | chemical | - |