Mevalonoyl Tripeptide-1

INCI: MEVALONOYL TRIPEPTIDE-1

CAS Number
Not publicly assigned (synthetic peptide conjugate)
Function
Antioxidant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - reviewed as part of the CIR safety assessment of Tripeptide-1 and related peptide ingredients

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Included in the CIR assessment group for palmitoyl oligopeptides/tripeptide-1 conjugates. The CIR report defines it as the product obtained by the reaction of mevalonic acid and Tripeptide-1. Safety is evaluated alongside other Tripeptide-1 conjugates (palmitoyl, copper, etc.). Tripeptide-1 (GHK sequence) is one of the most well-studied cosmetic peptides for collagen stimulation and wound repair. The mevalonoyl conjugation adds antioxidant capacity and may alter skin penetration pharmacokinet...

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Concern Level: Moderate

Frequently Asked Questions

Is Mevalonoyl Tripeptide-1 safe in cosmetics?

Included in the CIR assessment group for palmitoyl oligopeptides/tripeptide-1 conjugates. The CIR report defines it as the product obtained by the reaction of mevalonic acid and Tripeptide-1. Safety is evaluated alongside other Tripeptide-1 conjugates (palmitoyl, copper, etc.). Tripeptide-1 (GHK sequence) is one of the most well-studied cosmetic peptides for collagen stimulation and wound repair. The mevalonoyl conjugation adds antioxidant capacity and may alter skin penetration pharmacokinet... The EU classifies Mevalonoyl Tripeptide-1 as "permitted". Safety rating: MODERATE.

Is Mevalonoyl Tripeptide-1 allowed in the EU?

Mevalonoyl Tripeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Mevalonoyl Tripeptide-1 do in cosmetics?

Mevalonoyl Tripeptide-1 functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (synthetic peptide conjugate).

What is the Margin of Safety for Mevalonoyl Tripeptide-1?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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