NOAEL Studies
Cosmetic Ingredient
N-BUTYL ALCOHOL NOAEL Studies
CAS: 71-36-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =1 | % | rat | - | 7 days | developmental toxicity | {"citation":"0; 7; 284","dose":"Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al.","effect":"16c Water consumption during pregnancy (ml)a Days 0–7 284 ± 28 305 ± 37 258 ± 29b 175 ± 34c Days 7–14 318 ± 35 337 ± 48 299 ± 40 239 ± 80c Days 14–20 328 ± 47 342 ± 47 334 ± 46 256 ± 85c Days 0–20 930 ± 105 983 ± 126 890 ± 106 669 ± 182c aValues are given as the mean ± SD. bSignificantly different from the control, p < .05. cSignificantly different from the control, p < .01. toxicant only at maternally toxic doses. Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al. 1994). GENOTOXICITY Elder (1987) reported that n-Butyl Alcohol was found to be nonmutagenic in the Salmonella/ mammalian-microsome muta- genicity test. A 15% aqueous n-Butyl Alcohol solution did not induce sister chromatid exchanges or chromosome breakage in the “chick embryo cytogenetic test.” Treatment of Chinese hamster ovary cells for 7 days with 0.1% n-Butyl Alcohol (v/v) resulted in no increase in the number of sister-chromatid ex- c...","page":12,"pdf":"PRS472.pdf","row_type":"noael_study","study_id":"PRS472_noael_001"} |
| CIR Safety Assessment | NOAEL | =1 | - | Crj:CD(SD) rats | oral (drinking water) | Days 0 to 20 of pregnancy | Developmental toxicity | {"page":12,"pdf":"PRS472.pdf","row_type":"noael_study","study_id":"ema_2004_dev_tox_noael"} |
| CIR Safety Assessment | NOAEL | =1 | % | rat | - | 7 days | developmental toxicity | {"citation":"0; 7; 284","dose":"Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al.","effect":"16c Water consumption during pregnancy (ml)a Days 0–7 284 ± 28 305 ± 37 258 ± 29b 175 ± 34c Days 7–14 318 ± 35 337 ± 48 299 ± 40 239 ± 80c Days 14–20 328 ± 47 342 ± 47 334 ± 46 256 ± 85c Days 0–20 930 ± 105 983 ± 126 890 ± 106 669 ± 182c aValues are given as the mean ± SD. bSignificantly different from the control, p < .05. cSignificantly different from the control, p < .01. toxicant only at maternally toxic doses. Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al. 1994). GENOTOXICITY Elder (1987) reported that n-Butyl Alcohol was found to be nonmutagenic in the Salmonella/ mammalian-microsome muta- genicity test. A 15% aqueous n-Butyl Alcohol solution did not induce sister chromatid exchanges or chromosome breakage in the “chick embryo cytogenetic test.” Treatment of Chinese hamster ovary cells for 7 days with 0.1% n-Butyl Alcohol (v/v) resulted in no increase in the number of sister-chromatid ex- c...","page":12,"pdf":"PRS472.pdf","row_type":"noael_study","study_id":"PRS472_noael_001"} |
| CIR Safety Assessment | NOAEL | =1 | - | Crj:CD(SD) rats | oral (drinking water) | Days 0 to 20 of pregnancy | Developmental toxicity | {"page":12,"pdf":"PRS472.pdf","row_type":"noael_study","study_id":"ema_2004_dev_tox_noael"} |
| CIR Safety Assessment | NOAEL | =1 | % | rat | - | 7 days | developmental toxicity | {"citation":"0; 7; 284","dose":"Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al.","effect":"16c Water consumption during pregnancy (ml)a Days 0–7 284 ± 28 305 ± 37 258 ± 29b 175 ± 34c Days 7–14 318 ± 35 337 ± 48 299 ± 40 239 ± 80c Days 14–20 328 ± 47 342 ± 47 334 ± 46 256 ± 85c Days 0–20 930 ± 105 983 ± 126 890 ± 106 669 ± 182c aValues are given as the mean ± SD. bSignificantly different from the control, p < .05. cSignificantly different from the control, p < .01. toxicant only at maternally toxic doses. Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al. 1994). GENOTOXICITY Elder (1987) reported that n-Butyl Alcohol was found to be nonmutagenic in the Salmonella/ mammalian-microsome muta- genicity test. A 15% aqueous n-Butyl Alcohol solution did not induce sister chromatid exchanges or chromosome breakage in the “chick embryo cytogenetic test.” Treatment of Chinese hamster ovary cells for 7 days with 0.1% n-Butyl Alcohol (v/v) resulted in no increase in the number of sister-chromatid ex- c...","page":12,"pdf":"PRS472.pdf","row_type":"noael_study","study_id":"PRS472_noael_001"} |
| CIR Safety Assessment | NOAEL | =1 | - | Crj:CD(SD) rats | oral (drinking water) | Days 0 to 20 of pregnancy | Developmental toxicity | {"page":12,"pdf":"PRS472.pdf","row_type":"noael_study","study_id":"ema_2004_dev_tox_noael"} |
| CIR Safety Assessment | NOAEL | =1 | % | rat | - | 7 days | developmental toxicity | {"citation":"0; 7; 284","dose":"Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al.","effect":"16c Water consumption during pregnancy (ml)a Days 0–7 284 ± 28 305 ± 37 258 ± 29b 175 ± 34c Days 7–14 318 ± 35 337 ± 48 299 ± 40 239 ± 80c Days 14–20 328 ± 47 342 ± 47 334 ± 46 256 ± 85c Days 0–20 930 ± 105 983 ± 126 890 ± 106 669 ± 182c aValues are given as the mean ± SD. bSignificantly different from the control, p < .05. cSignificantly different from the control, p < .01. toxicant only at maternally toxic doses. Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al. 1994). GENOTOXICITY Elder (1987) reported that n-Butyl Alcohol was found to be nonmutagenic in the Salmonella/ mammalian-microsome muta- genicity test. A 15% aqueous n-Butyl Alcohol solution did not induce sister chromatid exchanges or chromosome breakage in the “chick embryo cytogenetic test.” Treatment of Chinese hamster ovary cells for 7 days with 0.1% n-Butyl Alcohol (v/v) resulted in no increase in the number of sister-chromatid ex- c...","page":12,"pdf":"PRS472.pdf","row_type":"noael_study","study_id":"PRS472_noael_001"} |
| CIR Safety Assessment | NOAEL | =1 | - | Crj:CD(SD) rats | oral (drinking water) | Days 0 to 20 of pregnancy | Developmental toxicity | {"page":12,"pdf":"PRS472.pdf","row_type":"noael_study","study_id":"ema_2004_dev_tox_noael"} |
COSMOS DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | rat | oral | NA | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1454 | mg/kg bw/day | rat | oral | 21 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
Regulatory source 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =125 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=e0517feb2732d477; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 1.25e2 mg/kg-day; system=Nervous; basis=Hypoactivity and ataxia; point_of_departure=NOAEL : 1.25e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID1021740; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=140; rfd_last_updated=03/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0140_summary.pdf |
| Regulatory source | RfD | =0.1 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=d11965d79e405000; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=1e-1; system=Nervous; basis=Hypoactivity and ataxia; point_of_departure=NOAEL : 1.25e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID1021740; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=140; rfd_last_updated=03/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0140_summary.pdf |
| Regulatory source | Developmental toxicity | 1 | - | Crj:CD(SD) rats | oral (drinking water) | Days 0 to 20 of pregnancy | Developmental toxicity | SOURCE_SUBDIR=PRS472; REPORT_TITLE=Final Report of the Addendum to the Safety Assessment of n-Butyl Alcohol as Used in Cosmetics; OPINION_NUMBER=PRS472; COMMITTEE=safe as a cosmetic ingredient in the practices of use and concentration as described in this safety assessment; REPORT_DATE=2008; VALUE_TEXT=1.0% (1454 mg/kg/day); CITATION_NUMBERS=[]; DETAILS_JSON={"cas_number":"71-36-3","citation":"","dose":"","duration":"Days 0 to 20 of pregnancy","effect":"","endpoint":"Developmental toxicity","ingredient":"n-Butyl Alcohol","loael_value":"","noael_unit":"","noael_value":"1.0% (1454 mg/kg/day)","page":12,"route":"oral (drinking water)","species":"Crj:CD(SD) rats","study_id":"ema_2004_dev_tox_noael"} |
| Regulatory source | developmental toxicity | 1 | % | rat | - | 7 days | developmental toxicity | SOURCE_SUBDIR=PRS472; REPORT_TITLE=Final Report of the Addendum to the Safety Assessment of n-Butyl Alcohol as Used in Cosmetics; OPINION_NUMBER=PRS472; COMMITTEE=safe as a cosmetic ingredient in the practices of use and concentration as described in this safety assessment; REPORT_DATE=2008; VALUE_TEXT=1.0; DOSE=Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al.; EFFECT=16c Water consumption during pregnancy (ml)a Days 0–7 284 ± 28 305 ± 37 258 ± 29b 175 ± 34c Days 7–14 318 ± 35 337 ± 48 299 ± 40 239 ± 80c Days 14–20 328 ± 47 342 ± 47 334 ± 46 256 ± 85c Days 0–20 930 ± 105 983 ± 126 890 ± 106 669 ± 182c aValues are given as the mean ± SD. bSignificantly different from the control, p < .05. cSignificantly different from the control, p < .01. toxicant only at maternally toxic doses. Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al. 1994). GENOTOXICITY Elder (1987) reported that n-Butyl Alcohol was found to be nonmutagenic in the Salmonella/ mammalian-microsome muta- genicity test. A 15% aqueous n-Butyl Alcohol solution did not induce sister chromatid exchanges or chromosome breakage in the “chick embryo cytogenetic test.” Treatment of Chinese hamster ovary cells for 7 days with 0.1% n-Butyl Alcohol (v/v) resulted in no increase in the number of sister-chromatid ex- c...; CITATION=0; 7; 284; CITATION_NUMBERS=[7,284]; REFERENCE=0; 7; 284; DETAILS_JSON={"cas_number":"71-36-3","citation":"0; 7; 284","dose":"Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al.","duration":"7 days","effect":"16c Water consumption during pregnancy (ml)a Days 0–7 284 ± 28 305 ± 37 258 ± 29b 175 ± 34c Days 7–14 318 ± 35 337 ± 48 299 ± 40 239 ± 80c Days 14–20 328 ± 47 342 ± 47 334 ± 46 256 ± 85c Days 0–20 930 ± 105 983 ± 126 890 ± 106 669 ± 182c aValues are given as the mean ± SD. bSignificantly different from the control, p < .05. cSignificantly different from the control, p < .01. toxicant only at maternally toxic doses. Based on the signifi- cant decreases in maternal body weight gain and fetal weight, authors reported no observed adverse effect levels (NOAELs) of n-Butyl Alcohol for both dams and fetuses are 1.0% (1454 mg/kg/day) in rats (Ema et al. 1994). GENOTOXICITY Elder (1987) reported that n-Butyl Alcohol was found to be nonmutagenic in the Salmonella/ mammalian-microsome muta- genicity test. A 15% aqueous n-Butyl Alcohol solution did not induce sister chromatid exchanges or chromosome breakage in the “chick embryo cytogenetic test.” Treatment of Chinese hamster ovary cells for 7 days with 0.1% n-Butyl Alcohol (v/v) resulted in no increase in the number of sister-chromatid ex- c...","endpoint":"developmental toxicity","ingredient":"n-Butyl Alcohol","loael_value":"","noael_unit":"%","noael_value":"1.0","page":12,"route":"","species":"rat","study_id":"PRS472_noael_001"} |
WHO/JECFA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOAEL | =0.1 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc65; title=Butanols - four isomers (EHC 65, 1987); path=mirror/documents/ehc/ehc/ehc65.htm; row_hash=9fe59cec1566b8b5; raw_unit=mg/m 3; context=The estimated no-observed-adverse-effect level was 0.1 mg/m 3 . |
NTP ICE acute inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 24 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=846; Record_ID=acute_inhalation_1868; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=24; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE acute inhalation | LC50 | >24.2378 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=847; Record_ID=acute_inhalation_2777; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=24.2378; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =790 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9575; row=2238; data_type=In Vivo; mixture=Chemical; chemical_name=1-Butanol; preferred_name=1-Butanol; dtxsid=DTXSID1021740; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021740; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2292 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_9577; row=2235; data_type=In Vivo; mixture=Chemical; chemical_name=1-Butanol; preferred_name=1-Butanol; dtxsid=DTXSID1021740; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021740; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4360 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9581; row=2236; data_type=In Vivo; mixture=Chemical; chemical_name=1-Butanol; preferred_name=1-Butanol; dtxsid=DTXSID1021740; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021740; source_file=acute_oral.xlsx |
NTP ICE eye irritation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 60.8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=459; Record_ID=eye_irritation_157; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=60.8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE eye irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=456; Record_ID=eye_irritation_63; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE eye irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=458; Record_ID=eye_irritation_157; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE eye irritation | Intensity | 0.89 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=461; Record_ID=eye_irritation_1295; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=Vitrigel; Endpoint=Intensity; Response=0.89; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE eye irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=460; Record_ID=eye_irritation_1295; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE eye irritation | Plateau level | 53 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=462; Record_ID=eye_irritation_1295; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=Vitrigel; Endpoint=Plateau level; Response=53; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
NTP ICE skin sensitization 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 1066 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3494; Record_ID=skin_sensitization_invitro_807; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=1066; Reported_Response_Unit=ug/mL; Response=1066; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | CD86, EC150 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8666; Record_ID=skin_sensitization_invitro_2398; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | CD86, EC150 | >518.861 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8145; Record_ID=skin_sensitization_invitro_2168; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=74.123; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=518.861; Converted_Response_Unit=ug/mL; Response=518.861; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | CD86, EC150 | 921 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3492; Record_ID=skin_sensitization_invitro_807; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=921; Reported_Response_Unit=ug/mL; Response=921; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | CV75 | >1000 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2251; Record_ID=skin_sensitization_invitro_552; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | CV75 | 1642.8 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3496; Record_ID=skin_sensitization_invitro_807; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1642.8; Reported_Response_Unit=ug/mL; Response=1642.8; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Cys | -0.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1336; Record_ID=skin_sensitization_invitro_358; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-0.4; Reported_Response_Unit=%; Response=-0.4; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Cys | 0.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1331; Record_ID=skin_sensitization_invitro_357; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.7; Reported_Response_Unit=%; Response=0.7; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Cys | 0.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1396; Record_ID=skin_sensitization_invitro_373; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.9; Reported_Response_Unit=%; Response=0.9; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Lys | -1.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1329; Record_ID=skin_sensitization_invitro_357; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-1.3; Reported_Response_Unit=%; Response=-1.3; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Lys | 0.1 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1395; Record_ID=skin_sensitization_invitro_373; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.1; Reported_Response_Unit=%; Response=0.1; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Lys | 1.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1334; Record_ID=skin_sensitization_invitro_358; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.2; Reported_Response_Unit=%; Response=1.2; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1333; Record_ID=skin_sensitization_invitro_357; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1338; Record_ID=skin_sensitization_invitro_358; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.4; Reported_Response_Unit=%; Response=0.4; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1397; Record_ID=skin_sensitization_invitro_373; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.5; Reported_Response_Unit=%; Response=0.5; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1529; Record_ID=skin_sensitization_invitro_429; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.6; Reported_Response_Unit=%; Response=0.6; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6652; Record_ID=skin_sensitization_invitro_1575; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | EC3 | >20 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12755; Record_ID=skin_sensitization_invivo_2778; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=LLNA; Endpoint=EC3; Response_Modifier=>; Response=20; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | IC50 | >2400 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7625; Record_ID=skin_sensitization_invitro_1793; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2400; Reported_Response_Unit=uM; Response=2400; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Imax | 1.146 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6657; Record_ID=skin_sensitization_invitro_1575; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.14578803; Reported_Response_Unit=Unitless; Response=1.146; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Imax | 1.15 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6658; Record_ID=skin_sensitization_invitro_1574; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1499999999999999; Reported_Response_Unit=Unitless; Response=1.15; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
| NTP ICE skin sensitization | Imax | 1.617 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7519; Record_ID=skin_sensitization_invitro_1793; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1021740; Assay=LuSens; Endpoint=Imax; Reported_Response=1.616578183; Reported_Response_Unit=Unitless; Response=1.617; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021740; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021740 |
ToxValDB Alaska DEC 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfD | =0.05 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446045:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=c8c82d8015878ec114c65f508895f4fe |
| ToxValDB Alaska DEC | RfD | =0.05 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446045:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=c8c82d8015878ec114c65f508895f4fe |
| ToxValDB Alaska DEC | RfD | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446046:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=f2cd8b1cfa56928c2c822c38cb3462ee |
| ToxValDB Alaska DEC | RfD | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446046:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=f2cd8b1cfa56928c2c822c38cb3462ee |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =42442.8 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=DOE Protective Action Criteria:15513035:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76612491000d31141b02ec3a1ca4780e |
ToxValDB ECOTOX 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =1 | % | Rat | oral | short-term; 7 days | reproduction developmental | LONG_REF=Food Chem. Toxicol.43(2): 325-331 Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy 2005; TITLE=Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy; AUTHOR=Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata; DOI=10.1016/j.fct.2004.11.003; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81245; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601298_15601299:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=918e98046f35795596ceefce0e12eec1 |
| ToxValDB ECOTOX | LOEL | =5 | % | Rat | oral | short-term; 21 days | developmental | LONG_REF=Food Chem. Toxicol.43(2): 325-331 Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy 2005; TITLE=Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy; AUTHOR=Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata; DOI=10.1016/j.fct.2004.11.003; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81245; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597353_15597354:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fdee2310057c22a995f44fecf33f01b1 |
| ToxValDB ECOTOX | LOEL | =500 | mg/kg bw/day | Rat | oral | chronic; 91 days | chronic | LONG_REF=EPA/OTS Doc.#44-8630046:24 p. Research Triangle Institute Rat Oral Subchronic Toxicity Study (Draft) 1986; TITLE=Rat Oral Subchronic Toxicity Study (Draft); AUTHOR=Research Triangle Institute; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115284; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Behavior: Activity, general|Intoxication: Ataxia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596853_15596854_15601509:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f702ba3ea3dc61cfb435e628503bb76b |
| ToxValDB ECOTOX | NOEL | =0.2 | % | Rat | oral | short-term; 7 days | reproduction developmental | LONG_REF=Food Chem. Toxicol.43(2): 325-331 Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy 2005; TITLE=Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy; AUTHOR=Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata; DOI=10.1016/j.fct.2004.11.003; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81245; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601298_15601299:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5e165596fdef47147a1381aa0b4d6a0a |
| ToxValDB ECOTOX | NOEL | =1 | % | Rat | oral | short-term; 21 days | developmental | LONG_REF=Food Chem. Toxicol.43(2): 325-331 Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy 2005; TITLE=Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy; AUTHOR=Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata; DOI=10.1016/j.fct.2004.11.003; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81245; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597353_15597354:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=464515ab9694e906e4b15f176c05e891 |
| ToxValDB ECOTOX | NOEL | =5 | % | Rat | oral | short-term; 21 days | reproduction developmental | LONG_REF=Food Chem. Toxicol.43(2): 325-331 Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy 2005; TITLE=Evaluation of Developmental Toxicity of 1-Butanol Given to Rats in Drinking Water Throughout Pregnancy; AUTHOR=Ema,M., H. Hara, M. Matsumoto, A. Hirose, and E. Kamata; DOI=10.1016/j.fct.2004.11.003; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81245; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Mortality|Population: Sex ratio|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|reproduction; STUDY_GROUP=ECOTOX:15600764:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=242a283433046740eb8d0a23ed2b228c |
| ToxValDB ECOTOX | NOEL | =125 | mg/kg bw/day | Rat | oral | chronic; 91 days | chronic | LONG_REF=EPA/OTS Doc.#44-8630046:24 p. Research Triangle Institute Rat Oral Subchronic Toxicity Study (Draft) 1986; TITLE=Rat Oral Subchronic Toxicity Study (Draft); AUTHOR=Research Triangle Institute; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115284; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Behavior: Activity, general|Intoxication: Ataxia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596853_15596854_15601509:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8badca01c7a7a7a3c32495d7478f13af |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =310 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630362:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3f4c6d2996413e3c36bb01bf02b486d6 |
ToxValDB IRIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =500 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=U.S. EPA. 1986. Butanol: Rat oral subchronic toxicity study. Office of Solid Waste, Washington, DC; TITLE=Butanol: Rat oral subchronic toxicity study; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a5066; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=140; TOXICOLOGICAL_EFFECT=hypoactivity and ataxia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=IRIS_dup_IRIS Summary_15645015_15645017:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_33244b86dbe0ffcce1cf787b70cb8e57 |
| ToxValDB IRIS | NOAEL | =125 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=U.S. EPA. 1986. Butanol: Rat oral subchronic toxicity study. Office of Solid Waste, Washington, DC; TITLE=Butanol: Rat oral subchronic toxicity study; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a5066; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=140; TOXICOLOGICAL_EFFECT=hypoactivity and ataxia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=IRIS_dup_IRIS Summary_15645015_15645017:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_720c37bf12d897b6f3587e952b4f582c |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfD | =1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663231:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b1d9f400572102c9d32e043145b373e9 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8PJ61P6TS3 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8PJ61P6TS3"} |
| openFDA substances | FDA UNII substance identifier | 8PJ61P6TS3 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8PJ61P6TS3"} |
| openFDA substances | FDA UNII substance identifier | 8PJ61P6TS3 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8PJ61P6TS3"} |
| openFDA substances | FDA UNII substance identifier | 8PJ61P6TS3 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8PJ61P6TS3"} |