Is Nictoflorin safe in cosmetics?
Nictoflorin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Nictoflorin
INCI: NICTOFLORIN
Nictoflorin (CAS 17650-84-9) is a cosmetic cosmetic ingredient functioning as Antioxidant flavonoid glycoside with neuroprotective and radical-scavenging. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 17650-84-9 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant flavonoid glycoside with neuroprotective and radical-scavenging activity
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
InChIKey
RTATXGUCZHCSNG-QHWHWDPRSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not independently listed; may be present in botanical extracts used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Nictoflorin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Nictoflorin.
Chemical Function
Softener and conditioner
Antioxidant
Humectant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NICOTIFLOROSIDE
ChEMBL ID
CHEMBL498879
Frequently Asked Questions
Is Nictoflorin allowed in the EU?
Nictoflorin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Nictoflorin do in cosmetics?
Nictoflorin functions as: Antioxidant flavonoid glycoside with neuroprotective and radical-scavenging activity. It is classified as a cosmetic ingredient in our database. CAS number: 17650-84-9.
Is Nictoflorin used outside cosmetics?
Nictoflorin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Nictoflorin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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