NOAEL Studies Cosmetic Ingredient

O-Aminophenol NOAEL Studies

INCI: O-AMINOPHENOL

CAS: 95-55-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 2 mg/kg bw/day rat oral 28 day Short Term Toxicity SCCS; Coleman M. et al. (1989) Orthoaminophenol 4-week oral (gavage) toxicity study in therat.Toxicol Laboratories Ltd, England. Reference n° LRL/1/89
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =951 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11714; row=13777; data_type=In Vivo; mixture=Chemical; chemical_name=2-Aminophenol; preferred_name=2-Aminophenol; dtxsid=DTXSID8024498; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8024498; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11715; row=13778; data_type=In Vivo; mixture=Chemical; chemical_name=2-Aminophenol; preferred_name=2-Aminophenol; dtxsid=DTXSID8024498; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8024498; source_file=acute_oral.xlsx
NTP ICE skin sensitization 17 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD86, EC150 <0.1 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8504; Record_ID=skin_sensitization_invitro_2344; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=0.1; Reported_Response_Unit=ug/mL; Response=0.1; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization CD86, EC150 0.32 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8309; Record_ID=skin_sensitization_invitro_2303; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=2.932282599; Reported_Response_Unit=uM; Conversion_Factor_Value=109.128; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.32; Converted_Response_Unit=ug/mL; Response=0.32; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization CD86, EC150 1.1 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1956; Record_ID=skin_sensitization_invitro_495; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=1.1000000000000001; Reported_Response_Unit=ug/mL; Response=1.1; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization CV70 8.02 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8505; Record_ID=skin_sensitization_invitro_2344; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=U-SENS; Endpoint=CV70; Reported_Response=8.02; Reported_Response_Unit=ug/mL; Response=8.02; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization CV75 6 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1958; Record_ID=skin_sensitization_invitro_495; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=h-CLAT; Endpoint=CV75; Reported_Response=6; Reported_Response_Unit=ug/mL; Response=6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization Depletion Cys 96.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=686; Record_ID=skin_sensitization_invitro_195; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=96.2; Reported_Response_Unit=%; Response=96.2; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization Depletion Lys 18.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=685; Record_ID=skin_sensitization_invitro_195; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=18.100000000000001; Reported_Response_Unit=%; Response=18.1; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization Depletion Lys + Cys 57.15 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=687; Record_ID=skin_sensitization_invitro_195; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=57.15; Reported_Response_Unit=%; Response=57.15; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization EC1.5 1.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7052; Record_ID=skin_sensitization_invitro_1674; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1.1000000000000001; Reported_Response_Unit=uM; Response=1.1; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization EC1.5 1.451 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=7053; Record_ID=skin_sensitization_invitro_1675; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1.4510000000000001; Reported_Response_Unit=uM; Response=1.451; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization EC3 0.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13192; Record_ID=skin_sensitization_invivo_3229; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=LLNA; Endpoint=EC3; Response=0.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization EC3 0.5 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13176; Record_ID=skin_sensitization_invivo_3201; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=LLNA; Endpoint=EC3; Response=0.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2007; 16938465; 10.1016/j.ymeth.2006.07.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization EC3 5.367 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=7054; Record_ID=skin_sensitization_invitro_1675; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=5.367; Reported_Response_Unit=uM; Response=5.367; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization IC50 94.78 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=7056; Record_ID=skin_sensitization_invitro_1675; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=94.78; Reported_Response_Unit=uM; Response=94.78; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization IC50 138.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7055; Record_ID=skin_sensitization_invitro_1674; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=138.19999999999999; Reported_Response_Unit=uM; Response=138.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization Imax 13.1 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=7057; Record_ID=skin_sensitization_invitro_1674; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13.1; Reported_Response_Unit=Unitless; Response=13.1; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
NTP ICE skin sensitization Imax 13.53 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=7058; Record_ID=skin_sensitization_invitro_1675; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID8024498; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13.53; Reported_Response_Unit=Unitless; Response=13.53; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024498; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024498
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.5 % rat oral 30 days repeated dose toxicity Ref.: 36 (Subm, p.14
SCCS Opinion NOAEL =1.7 mg/kg bw/d rat oral 13-week repeated dose toxicity p.30
SCCS Opinion NOAEL =5 mg/kg bw/d rat oral Sub-chronic repeated dose toxicity Ref.: 37 (Subm, p.15
SCCS Opinion NOAEL =15 mg/kg bw/d rat oral subacute repeated dose toxicity p.30
SCCS Opinion NOAEL =70 mg/kg bw/d human - - NOAEL study Ref.: 39 (Subm, p.29
SCCS Opinion NOAEL =250 mg/kg rat oral - developmental toxicity p.30
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =5 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf80e4b0a7c65d1ce368; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19856/7/6/2?documentUUID=c7bb55d9-8d45-43ea-946c-5ba2049c7574; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15831930:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fac4eccef751a311a6f9411693d9dd96
ToxValDB RSL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfD =0.004 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15654286:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6eb003e8a06b092f1f34d671921b08bc
ToxValDB RSL RfD =0.04 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663162:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d90613a56b0a0e5f4d8bdc3fa9a1b698
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 70 mg/kg bw/d human - - - p.29
Regulatory source developmental toxicity 250 mg/kg rat oral - developmental toxicity p.30
Regulatory source repeated dose toxicity 0.5 % rat oral 30 days repeated dose toxicity p.14
Regulatory source repeated dose toxicity 1.7 mg/kg bw/d rat oral 13-week repeated dose toxicity p.30
Regulatory source repeated dose toxicity 5 mg/kg bw/d rat oral Sub-chronic repeated dose toxicity p.15
Regulatory source repeated dose toxicity 5 mg/kg bw/d rat oral subacute repeated dose toxicity p.30
Regulatory source repeated dose toxicity 15 mg/kg bw/d rat oral subacute repeated dose toxicity p.30
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 23RH73DZ65 UNII - - - chemical -