NOAEL Studies
Cosmetic Ingredient
O-Cresol NOAEL Studies
INCI: O-CRESOL
CAS: 95-48-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 175 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; Toxicology 7, 246 No.982 , 1987 |
| COSMOS DB | LOAEL | 510 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; Study report |
| COSMOS DB | NOAEL | 50 | mg/kg bw/day | rabbit | oral | 13 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | rabbit | oral | 13 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 175 | mg/kg bw/day | rat | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 256 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; Study report |
| COSMOS DB | NOAEL | 434 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 510 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 750 | mg/kg bw/day | mouse | oral | 203 day | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 763 | mg/kg bw/day | mouse | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 861 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1500 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2048 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =50 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=cd34d1795090cb29; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 5.0e1 mg/kg-day; system=Nervous, Other; basis=Decreased body weights and neurotoxicity; point_of_departure=NOAEL : 5.0e1 mg/kg-day; composite_uf=1000; confidence=Medium; dtxsid=DTXSID8021808; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=300; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0300_summary.pdf |
| Regulatory source | RfD | =0.05 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=7109be42275d9ff4; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=5e-2; system=Nervous, Other; basis=Decreased body weights and neurotoxicity; point_of_departure=NOAEL : 5.0e1 mg/kg-day; composite_uf=1000; confidence=Medium; dtxsid=DTXSID8021808; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=300; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0300_summary.pdf |
WHO/JECFA 35 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOAEL | =50 | mg/kg bw/day | - | - | subchronic | Chronic toxicity | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=df17ef9e69f188fd; raw_unit=mg/kg body weight per day; context=Based on the results of subchronic studies, an NOAEL of 50 mg/kg body weight per day can be established for all three cresol isomers. |
| WHO/JECFA | NOAEL | =175 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=7230c7104420eb08; raw_unit=mg/kg; context=For this reason 50 mg/kg was regarded as a NOAEL for p- cresol, based on the presence of haematological effects at 175 mg/kg. |
| WHO/JECFA | NOAEL | =240 | mg/kg diet | - | oral | - | Toxicology study | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=d788453623ee8051; raw_unit=mg/kg diet; context=An NOAEL of 240 mg/kg diet was identified in this study for male and female mink exposed to o- cresol. |
| WHO/JECFA | NOAEL | =778 | mg/kg diet | - | oral | - | Toxicology study | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=97de36755c6f9e98; raw_unit=mg/kg diet; context=A NOAEL of 778 mg/kg diet was identified for male and female ferrets based on increased relative liver weight at doses > 1400 mg/kg diet. |
| WHO/JECFA | NOAEL | =1000 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=867727997bfa0276; raw_unit=mg/kg; context=A no-observed-adverse-effect level (NOAEL) of 3000 mg/kg was established for o, m and m/p cresols and a NOAEL of 1000 mg/kg for p- cresol based on organ weight and body weight changes at higher doses. |
| WHO/JECFA | NOAEL | =1000 | mg/kg diet | - | oral | - | Toxicology study | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=cdc92774d175046a; raw_unit=mg/kg diet; context=A NOAEL of 1000 mg/kg diet could be identified for m- /pcresol and o- or p- cresol, respectively, based on organ weight and body weight and histopathological changes at higher doses. |
| WHO/JECFA | NOAEL | =1250 | mg/kg diet | Mouse | oral | - | Toxicology study | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=647a7df424abb04c; raw_unit=mg/kg diet; context=Based on these results, an NOAEL of 1250 mg/kg diet and 625 mg/kg diet can be identified for mice exposed to o- cresol and m- / p- cresols, respectively. |
| WHO/JECFA | NOAEL | =3750 | mg/kg diet | Rat | oral | - | Toxicology study | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=e612fd1f81e8e234; raw_unit=mg/kg diet; context=An NOAEL in rats of 3750 mg/kg diet was identified for o- cresol. |
| WHO/JECFA | NOEL | =1 | mg/L | - | - | 21-day | Reproductive toxicity | document_id=ehc_ehc_ehc168; title=Cresols (EHC 168, 1995); path=mirror/documents/ehc/ehc/ehc168.htm; row_hash=9cf1acd3dc9813ef; raw_unit=mg/litre; context=Kühn et al. (1989a) reported acute and 21-day NOEL values for reproductive effects in Daphnia magna of 2.5 and 1.0 mg/litre, respectively, following exposure to p- cresol. |
| WHO/JECFA | ADI | =0.17 | mg/kg bw/day | - | - | - | Health guidance value | document_id=hsg_hsg_hsg100; title=Cresols (HSG 100, 1996); path=mirror/documents/hsg/hsg/hsg100.htm; row_hash=1ae532fe5887ce19; raw_unit=mg/kg body weight per day; context=Thus, an ADI of 0.17 mg/kg body weight per day can be developed for cresols. |
| WHO/JECFA | NOAEL | =27 | mg/kg bw/day | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=2c4e9897c3728b81; raw_unit=mg/kg bw/d; context=cluded to be the NOAEL for male animals, while 261 mg/kg bw/d is a level at which relative liver weight and histopathological changes in thyroid were increased; for female animals, 27 mg/kg bw/d is the NOAEL and Table 2. |
| WHO/JECFA | NOAEL | =30 | mg/kg bw/day | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=1ee1cf9a00624fbb; raw_unit=mg/kg bw/d; context=The NOAEL for parental animals was concluded to be 30 mg/kg bw/d; the NOAEL for offspring 175 mg/kg bw/d (80). |
| WHO/JECFA | NOAEL | =50 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=0ceacc00354bc4b8; raw_unit=mg/kg bw; context=In mice, 50 mg/kg bw/ was the NOAEL for male animals; effects were noted at 161 mg/kg bw/d (increased relative liver weight). |
| WHO/JECFA | NOAEL | =66 | mg/kg bw/day | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=8d1edbb583d90b92; raw_unit=mg/kg bw/d; context=No NOAEL was found in female animals since at the lowest dose tested (66 mg/kg bw/d) relative liver weights were increased. p-Cresol. |
| WHO/JECFA | NOAEL | =87 | mg/kg bw/day | Mouse | oral | 28-day | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=c146efdc1bb38e89; raw_unit=mg/kg bw/d; context=This 28-day study feeding o-cresol to mice resulted in a NOAEL of 87 mg/kg bw/d and a level at which relative liver weights were increased of 266 mg/kg bw/d for male animals, and in a NOAEL of 271 mg/kg bw/d and a level at which relative liver weights was increased 881 mg/kg bw/d for female animals. m-Cresol. |
| WHO/JECFA | NOAEL | =100 | mg/kg bw/day | Rat; Rabbit | - | - | Developmental toxicity | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=1c5e24b56e700b72; raw_unit=mg/kg bw/d; context=From these data, it is concluded that in rats the NOAELs are 175 and more than 450 mg/kg bw/d for maternal and developmental toxicity, respectively; in rabbits, the NOAEL is 100 mg/kg bw/d for both maternal and developmental toxicity. |
| WHO/JECFA | NOAEL | =129 | mg/kg bw/day | Rat; Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=f63cdf7f78cec952; raw_unit=mg/kg bw/d; context=In rats, the NOAEL was 129 mg/kg bw/d, but in mice exposed to o-cresol, effects still occurred at 199 mg/kg bw/d), the lowest dose tested. |
| WHO/JECFA | NOAEL | =131 | mg/kg bw/day | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=b1606fd82360178c; raw_unit=mg/kg bw/d; context=From this study, 123 mg/kg bw/d for male and 131 mg/kg bw/d for female is concluded to be the NOAEL. |
| WHO/JECFA | NOAEL | =150 | mg/kg bw/day | Rat | oral | - | Neurotoxicity | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=034a298992f7b66e; raw_unit=mg/kg bw/d; context=In conclusion, this thirteen-week gavage neurotoxicity study in rats resulted in a NOAEL of 150 mg/kg bw/d for both male and female rats. |
| WHO/JECFA | NOAEL | =163 | mg/kg bw/day | Mouse | oral | 28-day | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=a06ba5dd532d5bc5; raw_unit=mg/kg bw/d; context=This 28-day study feeding p-cresol to mice resulted in a NOAEL of 163 mg/kg bw/d for male and of 207 mg/kg bw/d for female animals. |
| WHO/JECFA | NOAEL | =175 | mg/kg bw/day | Rat | oral | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=49d627a4845cffc9; raw_unit=mg/kg bw/d; context=In conclusion , this thirteen week study in which o-cresol was administered by gavage to rats resulted in a NOAEL of 175 mg/kg bw/d for both male and female animals. |
| WHO/JECFA | NOAEL | =193 | mg/kg bw/day | Mouse | oral | 28-day | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=db1393765b60bf0d; raw_unit=mg/kg bw/d; context=This 28-day study, feeding m-cresol to mice resulted in a NOAEL of 193 mg/kg bw/d and an effect level (increased relative liver and kidney weights) of 521 mg/kg bw/d in male animals. |
| WHO/JECFA | NOAEL | =199 | mg/kg bw/day | Mouse | oral | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=be68fab1269e8941; raw_unit=mg/kg bw/d; context=In mice, where only o-cresol and a 60:40% mixture of m- and p-cresol were tested in the diet, no NOAEL can be derived: o-cresol induced effects (increased relative liver weight in males) at 199 mg/kg bw/d, the lowest dose tested. |
| WHO/JECFA | NOAEL | =200 | mg/kg bw/day | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=ae1ed16aab56a7d2; raw_unit=mg/kg bw/d; context=For female animals, the NOAEL is 200 mg/kg bw/d while 604 mg/kg bw is an effect level (increased absolute and relative liver weight). |
| WHO/JECFA | NOAEL | =250 | mg/kg bw/day | Rat | oral | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=e70d9854f8ae4882; raw_unit=mg/kg bw/d; context=In conclusion, this thirteen-week study feeding o-cresol to rats resulted for both sexes in a NOAEL of 250 mg/kg bw/d and an effect level (increased absolute and relative liver weights) of 510 mg/kg bw/d. |
| WHO/JECFA | NOAEL | =252 | mg/kg bw/day | Rat | oral | 28-day | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=81dadd222bddd6f5; raw_unit=mg/kg bw/d; context=This 28-day study feeding m-cresol to rats resulted in a NOAEL of 252 mg/kg bw/d for male and female animals and a level at which absolute (in male) and relative liver weights (in male and female animals) were increased of 870 mg/kg bw/d for male and 862 mg/kg bw/d for female animals. |
| WHO/JECFA | NOAEL | =261 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=8d6c5dd306576e91; raw_unit=mg/kg bw/d; context=In rats, 90 mg/kg bw/d is concluded to be the NOAEL for male animals, while 261 mg/kg bw/d is a level at which relative liver weight and histopathological changes in thyroid were increased; for female animals, 27 mg/kg bw/d is the NOAEL and Table 2. |
| WHO/JECFA | NOAEL | =263 | mg/kg bw/day | - | - | - | Reproductive toxicity | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=bb440091029f55f2; raw_unit=mg/kg bw/d; context=The NOAEL for reproduction as well as general toxicity in this study was concluded to be 0.2% or 263 mg/kg bw/d (42). m-Cresol. |
| WHO/JECFA | NOAEL | =271 | mg/kg bw/day | Mouse | oral | 28-day | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=4d9d5c922b1d82cb; raw_unit=mg/kg bw/d; context=28-day study feeding o-cresol to mice resulted in a NOAEL of 87 mg/kg bw/d and a level at which relative liver weights were increased of 266 mg/kg bw/d for male animals, and in a NOAEL of 271 mg/kg bw/d and a level at which relative liver weights was increased 881 mg/kg bw/d for female animals. m-Cresol. |
| WHO/JECFA | NOAEL | =362 | mg/kg bw/day | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=e9433282922eedd4; raw_unit=mg/kg bw/d; context=The NOAEL for parental animals is concluded to be < 0.25% or 362 mg/kg bw/d, that for offspring 1389 mg/kg bw/d. |
| WHO/JECFA | NOAEL | =402 | mg/kg bw/day | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=18ad429495d91bfa; raw_unit=mg/kg bw/d; context=For male animals, the NOAEL is 402 mg/kg bw/d, while 776 mg/kg bw/d is an effect level (increased relative and absolute liver weight); for female animals, the respective dose levels are 923 mg/kg bw/d 1623 mg/kg bw/d; decreased body weight; increased relative liver weight). |
| WHO/JECFA | NOAEL | =496 | mg/kg bw/day | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=b3183825686cb821; raw_unit=mg/kg bw/d; context=For female animals, the NOAEL is 496 mg/kg bw/d while 935 mg/kg bw/d) is an effect level (increased relative liver weight). m-Cresol. |
| WHO/JECFA | NOAEL | =1000 | ppm | Rat | oral | 28-day | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=62d534cc3c0a2c24; raw_unit=ppm; context=In conclusion, this 28-day study feeding o-cresol to rats resulted in a NOAEL of 1000 ppm (i.e., 87 mg/kg/d) and an effect level (increased relative liver and kidney weights) of 3000 ppm (i.e., 266 mg/kg/d) for male animals, and in a NOAEL of 3000 ppm (i.e., 271 mg/kg/d) and an effect level (increased relative liver weight) of 10,000 ppm (i.e., 88 |
| WHO/JECFA | NOAEL | =1250 | ppm | Mouse | oral | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=728bea1cae61a1a6; raw_unit=ppm; context=In conclusion, from this thirteen-week study feeding o-cresol to mice, no NOAEL can be established for male animals, since administration of 1250 ppm (199 mg/kg/d), the lowest dose tested, caused an increase in relative liver weight. |
| WHO/JECFA | NOAEL | =3000 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1998_27; title=DECOS and SCG Basis for an Occupational Standard. Cresols (o-, m-, p-); path=mirror/documents/kemi/kemi/ah1998_27.pdf; row_hash=91fd9c1816e7438a; raw_unit=ppm; context=ats resulted in a NOAEL of 1000 ppm (i.e., 87 mg/kg/d) and an effect level (increased relative liver and kidney weights) of 3000 ppm (i.e., 266 mg/kg/d) for male animals, and in a NOAEL of 3000 ppm (i.e., 271 mg/kg/d) and an effect level (increased relative liver weight) of 10,000 ppm (i.e., 881 mg/kg/d) for female animals. |
NTP ICE acute inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 0.029 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4394; Record_ID=acute_inhalation_1782; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021808; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.029; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021808 |
| NTP ICE acute inhalation | LC50 | >1.22 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4393; Record_ID=acute_inhalation_2674; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021808; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.22; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021808 |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =121 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_11708; row=13348; data_type=In Vivo; mixture=Chemical; chemical_name=o-Cresol; preferred_name=o-Cresol; dtxsid=DTXSID8021808; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021808; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1350 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11710; row=13349; data_type=In Vivo; mixture=Chemical; chemical_name=o-Cresol; preferred_name=o-Cresol; dtxsid=DTXSID8021808; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021808; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=3147; Record_ID=adme_parameters_386; Data_Type=Measured; DTXSID=DTXSID8021808; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021808 |
| NTP ICE adme parameters | Clint | 27.48 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3146; Record_ID=adme_parameters_386; Data_Type=Measured; DTXSID=DTXSID8021808; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=27.48; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021808 |
| NTP ICE adme parameters | Fu | 0.38 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=3144; Record_ID=adme_parameters_386; Data_Type=Measured; DTXSID=DTXSID8021808; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.38; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021808 |
| NTP ICE adme parameters | Fu | 0.525 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=3145; Record_ID=adme_parameters_386; Data_Type=Measured; DTXSID=DTXSID8021808; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.525; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021808 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=12490; RecordID=ARPathway2016_1758; DatasetName=ARPathway2016; DTXSID=DTXSID8021808; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021808; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021808 |
EPA ToxRefDB v3 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =129 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=5435; toxval_study_source_id=studyid5435_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-length; dose_level=1; study_year=1991; study_citation=Dietz, D. (1991). 'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).' Toxic Rep Ser 9: 1-128. (Subchronic rat); dsstox_substance_id=DTXSID8021808; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =510 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=5435; toxval_study_source_id=studyid5435_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-kidney-relative to body weight|organ weight-thymus-relative to body weight|organ weight-testes-relative to body weight|clinical chemistry-bile acids-bile acids|pathology microscopic-bone marrow-hypercellularity|in life observation-food consumption-food consumption|in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=3; study_year=1991; study_citation=Dietz, D. (1991). 'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).' Toxic Rep Ser 9: 1-128. (Subchronic rat); dsstox_substance_id=DTXSID8021808; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =513 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=5435; toxval_study_source_id=studyid5435_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|clinical chemistry-bile acids-bile acids|pathology microscopic-bone marrow-hypercellularity|in life observation-body weight-body weight|organ weight-kidney-relative to body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=3; study_year=1991; study_citation=Dietz, D. (1991). 'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).' Toxic Rep Ser 9: 1-128. (Subchronic rat); dsstox_substance_id=DTXSID8021808; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =1017 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=5435; toxval_study_source_id=studyid5435_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight; dose_level=4; study_year=1991; study_citation=Dietz, D. (1991). 'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).' Toxic Rep Ser 9: 1-128. (Subchronic rat); dsstox_substance_id=DTXSID8021808; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =1021 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=5435; toxval_study_source_id=studyid5435_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|clinical chemistry-bile acids-bile acids|in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=4; study_year=1991; study_citation=Dietz, D. (1991). 'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).' Toxic Rep Ser 9: 1-128. (Subchronic rat); dsstox_substance_id=DTXSID8021808; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=5435; toxval_study_source_id=studyid5435_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-length; dose_level=0; study_year=1991; study_citation=Dietz, D. (1991). 'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).' Toxic Rep Ser 9: 1-128. (Subchronic rat); dsstox_substance_id=DTXSID8021808; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =247 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=5435; toxval_study_source_id=studyid5435_Adult_F0_M_systemic; toxval_effect_list=organ weight-testes-relative to body weight|organ weight-thymus-relative to body weight|organ weight-liver-relative to body weight|in life observation-food consumption-food consumption|pathology microscopic-bone marrow-hypercellularity|organ weight-kidney-relative to body weight|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-bone marrow-hypocellularity|clinical chemistry-bile acids-bile acids|organ weight-liver-absolute; dose_level=2; study_year=1991; study_citation=Dietz, D. (1991). 'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).' Toxic Rep Ser 9: 1-128. (Subchronic rat); dsstox_substance_id=DTXSID8021808; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =256 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 90 day | SUB | study_id=5435; toxval_study_source_id=studyid5435_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|clinical chemistry-bile acids-bile acids|pathology microscopic-bone marrow-hypocellularity|pathology microscopic-bone marrow-hypercellularity|in life observation-body weight-body weight|organ weight-liver-absolute|organ weight-kidney-relative to body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=2; study_year=1991; study_citation=Dietz, D. (1991). 'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).' Toxic Rep Ser 9: 1-128. (Subchronic rat); dsstox_substance_id=DTXSID8021808; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB Alaska DEC 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfD | =0.025 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446237:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=9adaedf492e215801cb6614b420450a6 |
| ToxValDB Alaska DEC | RfD | =0.05 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446238:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0a3afafa39319131a8b300e63e179833 |
ToxValDB Cal OEHHA REL derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | NOAEL | =50 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=U.S. EPA. 1987. o, m, p-Cresol. 90-Day oral subchronic neurotoxicity study in rats. Office of Solid Waste. Washington, DC: U.S. EPA.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Decreased body weights and neurotoxicity (tremors, salivation, lacrimation, etc.); STUDY_GROUP=Cal OEHHA REL derivations:15952034:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a51a11d78d236df0bf18978e3b5d6e7b |
ToxValDB DOE Wildlife Benchmarks 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =219.2 | mg/kg bw/day | Mink | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks:15511596:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fd5af5ed32174590770f4070e6689414 |
ECHA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | ~246.25 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca02e4b0a7c65d21fce7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2309?documentUUID=901e819c-89a8-4bac-bcce-b513b8f353e2; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15838695:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5547f7f1e8c28b44ecbcd7ecf58dcc6a |
| ECHA | NOAEL | =360 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca36e4b0a7c65d220d5a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4426?documentUUID=ea55d5ee-0fc7-4b51-a638-f8547bd70e4b; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835918_15841605:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e8a1e13874ca7d6750ca8738ca0bab24 |
ToxValDB ECOTOX 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =30 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EPA/OTS Doc.#40-8960311:1318 p. Bushy Run Research Center Two-Generation Reproduction Studies on Ortho-, Meta- and Para-Cresols Administered by Gavage to Sprague-Dawley (CD) Rats (Final Reports) W-Attachments & Cover Letter Dated 120689 2000; TITLE=Two-Generation Reproduction Studies on Ortho-, Meta- and Para-Cresols Administered by Gavage to Sprague-Dawley (CD) Rats (Final Reports) W-Attachments & Cover Letter Dated 120689; AUTHOR=Bushy Run Research Center; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117106; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611673_15611674_15611707_15612041:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=c69023e99d0f7513d741394e973c2211 |
| ToxValDB ECOTOX | LOEL | =35 | mg/kg bw/day | Rat | injection | acute; 0.0104 days | acute | LONG_REF=Regul. Toxicol. Pharmacol.41(1): 1-5 Calderon-Guzman,D., J.L. Hernandez-Islas, I.R. Espitia Vazquez, G. Barragan-Mejia, E. Hernandez-Garcia, D. Santamaria d Effect of Toluene and Cresols on Na+,K+-ATPase, and Serotonin in Rat Brain 2005; TITLE=Effect of Toluene and Cresols on Na+,K+-ATPase, and Serotonin in Rat Brain; AUTHOR=Calderon-Guzman,D., J.L. Hernandez-Islas, I.R. Espitia Vazquez, G. Barragan-Mejia, E. Hernandez-Garcia, D. Santamaria d; DOI=10.1016/j.yrtph.2004.09.005; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=116100; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde|Enzyme(s): Sodium potassium ATPase|Hormone(s): Serotonin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|other; STUDY_GROUP=ECOTOX:15595962:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=72e2f0b1549b4eea3852d9b3f09f060c |
| ToxValDB ECOTOX | LOEL | =50 | mg/kg bw/day | European Rabbit | oral | short-term; 24 days | reproduction developmental | LONG_REF=EPA/OTS Doc.#40-8860253:1122 p. Hazleton Laboratories Developmental Toxicity Evaluation of O-, M-, or P-Cresol Administered by Gavage to Rabbits and Rats with Cover Letter Dated 070688 1988; TITLE=Developmental Toxicity Evaluation of O-, M-, or P-Cresol Administered by Gavage to Rabbits and Rats with Cover Letter Dated 070688; AUTHOR=Hazleton Laboratories; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117107; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Multiple: Multiple effects reported as one result; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=ECOTOX:15612556:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=80dc02441ba0d948ffb60d893dc22fbd |
| ToxValDB ECOTOX | LOEL | =3940 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | LONG_REF=Reprod. Toxicol.12(4): 489-494 Chapin,R.E., R.A. Sloane, and J.K. Haseman Reproductive Endpoints in General Toxicity Studies: Are they Predictive? 1998; TITLE=Reproductive Endpoints in General Toxicity Studies: Are they Predictive?; AUTHOR=Chapin,R.E., R.A. Sloane, and J.K. Haseman; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116723; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Weight|Reproduction: Estrus; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other|reproduction; STUDY_GROUP=ECOTOX:15612224:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=8bb7245872df007c8e66ba8995108dc9 |
| ToxValDB ECOTOX | NOEL | =1 | mg | Mouse | oral | subchronic; 76.1 days | subchronic | LONG_REF=Eksp. Onkol.14(6): 14-19 Yanysheva,N.Y., N.V. Balenko, I.A. Chernichenko, V.F. Babiy, and E.P. Konovalov Modifying Effect of Nitrogen Oxides, Phenol and Orthocresol on Benz(a)Pyrene-Induced Carcinogenesis in Rats and Mice 1992; TITLE=Modifying Effect of Nitrogen Oxides, Phenol and Orthocresol on Benz(a)Pyrene-Induced Carcinogenesis in Rats and Mice; AUTHOR=Yanysheva,N.Y., N.V. Balenko, I.A. Chernichenko, V.F. Babiy, and E.P. Konovalov; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117143; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15603863:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=348cb7d3eb2d5ac3662b27d1c551998a |
| ToxValDB ECOTOX | NOEL | =175 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EPA/OTS Doc.#40-8960311:1318 p. Bushy Run Research Center Two-Generation Reproduction Studies on Ortho-, Meta- and Para-Cresols Administered by Gavage to Sprague-Dawley (CD) Rats (Final Reports) W-Attachments & Cover Letter Dated 120689 2000; TITLE=Two-Generation Reproduction Studies on Ortho-, Meta- and Para-Cresols Administered by Gavage to Sprague-Dawley (CD) Rats (Final Reports) W-Attachments & Cover Letter Dated 120689; AUTHOR=Bushy Run Research Center; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117106; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain|Multiple: Multiple effects reported as one result|Intoxication: Ataxia|Mortality: Mortality|Physiology: Respiration; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|multiple; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611673_15611674_15611707_15612041:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=121c3485bfa5c7e5305122055ab9bd87 |
| ToxValDB ECOTOX | NOEL | =200 | mg/kg bw/day | Mouse | injection | acute; 0.8958 days | acute | LONG_REF=Mutat. Res.137(1): 51-55 Cheng,M., and A.D. Kligerman Evaluation of the Genotoxicity of Cresols Using Sister-Chromatid Exchange (SCE) 1984; TITLE=Evaluation of the Genotoxicity of Cresols Using Sister-Chromatid Exchange (SCE); AUTHOR=Cheng,M., and A.D. Kligerman; DOI=10.1016/0165-1218(84)90112-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=116437; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Genetics: sister chromatid exchange; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594184:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ac574462f51b8ddc8b59b47eff54af02 |
| ToxValDB ECOTOX | NOEL | =450 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EPA/OTS Doc.#40-8960311:1318 p. Bushy Run Research Center Two-Generation Reproduction Studies on Ortho-, Meta- and Para-Cresols Administered by Gavage to Sprague-Dawley (CD) Rats (Final Reports) W-Attachments & Cover Letter Dated 120689 2000; TITLE=Two-Generation Reproduction Studies on Ortho-, Meta- and Para-Cresols Administered by Gavage to Sprague-Dawley (CD) Rats (Final Reports) W-Attachments & Cover Letter Dated 120689; AUTHOR=Bushy Run Research Center; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117106; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611673_15611674_15611707_15612041:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=97dd4368032768bd32c8251ab754b16c |
| ToxValDB ECOTOX | NOEL | =750 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=EPA/OTS; Doc #40-8960307:165 p. Chemical Manufacturers Association Dominant Assays in Mice with ortho- and para-Cresol and Single Acute Exposure Dose Selection Studies on ortho- and para-Cresol (Final Reports) w-Attachment & Cover Letter 070689 2000; TITLE=Dominant Assays in Mice with ortho- and para-Cresol and Single Acute Exposure Dose Selection Studies on ortho- and para-Cresol (Final Reports) w-Attachment & Cover Letter 070689; AUTHOR=Chemical Manufacturers Association; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=117102; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15612749:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=4e1ab086c29d121f2d5ff37ca7eebfe4 |
| ToxValDB ECOTOX | NOEL | =1000 | mM | Mouse | dermal | short-term; 8 days | short-term | LONG_REF=Toxicology232(1-2): 132-137 Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice 2007; TITLE=Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice; AUTHOR=Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto; DOI=10.1016/j.tox.2006.12.021; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=115071; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Immunological: Lymphocyte activity; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX:15601929:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=baba8654c9715ae5317b166e18e6a61f |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =2.47 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630833:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ada0c82d0c97c48e1bef29ea8ab1281 |
ToxValDB IRIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =150 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=U.S. EPA. 1986. o, m, p-Cresol. 90-Day oral subchronic toxicity studies in rats. Office of Solid Waste, Washington, DC. ; U.S. EPA. 1987. o, m, p-Cresol. 90-Day oral subchronic neurotoxicity study in rats. Office of Solid Waste, Washington, DC.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a5475; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=300; TOXICOLOGICAL_EFFECT=reduced body weight and neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15645268_15645269:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_064617fd9d3a930455b0802479ceaec0 |
ToxValDB PPRTV (CPHEA) 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | BMDL (10 HED) | =6.9 | mg/kg bw/day | Rat | oral | chronic; 20 weeks | reproduction developmental | LONG_REF=Tyl and Neeper-Bradley 1989; AUTHOR=Tyl and Neeper-Bradley; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934af0f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1804; TOXICOLOGICAL_EFFECT=hypoactivity; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=PPRTV (CPHEA):15653861:F:F1adult; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5cc61a1a86e1fc3317b7e13e660d8de7 |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Tyl and Neeper-Bradley 1989; AUTHOR=Tyl and Neeper-Bradley; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934af0f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1804; TOXICOLOGICAL_EFFECT=Hypoactivity in F1 female rats; STUDY_GROUP=PPRTV (CPHEA):15653654:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3b1593513dd12e9c53b5a0c9dadaa7a0 |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfC | =0.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15655273:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9b03437038829d7d7e0d1e160ebcfe07 |
ToxValDB ToxRefDB 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =129 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Dietz, D. (1991). \'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).\' Toxic Rep Ser 9: 1-128. (Subchronic rat); TITLE=NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=Dietz, D; EXTERNAL_SOURCE_ID=5435; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-length; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB:15709229:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_53758f1dbe738fc10c47375283d8ac57 |
| ToxValDB ToxRefDB | LEL | =510 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Dietz, D. (1991). \'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).\' Toxic Rep Ser 9: 1-128. (Subchronic rat); TITLE=NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=Dietz, D; EXTERNAL_SOURCE_ID=5435; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-thymus-relative to body weight|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-bone marrow-hypercellularity|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight|systemic: clinical chemistry-bile acids-bile acids|systemic: organ weight-testes-relative to body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709234_15709235_15709236_15709237:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ab35c3408d688933b2c9acecc43a4cc |
| ToxValDB ToxRefDB | LEL | =513 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Dietz, D. (1991). \'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).\' Toxic Rep Ser 9: 1-128. (Subchronic rat); TITLE=NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=Dietz, D; EXTERNAL_SOURCE_ID=5435; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: clinical chemistry-bile acids-bile acids|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-bone marrow-hypercellularity|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709230_15709231_15709232_15709233:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9dd8697f364ac05221e2451e1abcd863 |
| ToxValDB ToxRefDB | LOAEL | =1017 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Dietz, D. (1991). \'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).\' Toxic Rep Ser 9: 1-128. (Subchronic rat); TITLE=NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=Dietz, D; EXTERNAL_SOURCE_ID=5435; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709234_15709235_15709236_15709237:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_691946ab8128e2bf7580d2a8b296012f |
| ToxValDB ToxRefDB | LOAEL | =1021 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Dietz, D. (1991). \'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).\' Toxic Rep Ser 9: 1-128. (Subchronic rat); TITLE=NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=Dietz, D; EXTERNAL_SOURCE_ID=5435; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-bile acids-bile acids|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709230_15709231_15709232_15709233:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3591a37a63c7b5739f2118fa5a3b14fa |
| ToxValDB ToxRefDB | NEL | =247 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Dietz, D. (1991). \'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).\' Toxic Rep Ser 9: 1-128. (Subchronic rat); TITLE=NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=Dietz, D; EXTERNAL_SOURCE_ID=5435; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-bone marrow-hypercellularity|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-thymus-relative to body weight|systemic: in life observation-body weight-body weight|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-bone marrow-hypocellularity|systemic: clinical chemistry-bile acids-bile acids|systemic: organ weight-liver-absolute|systemic: organ weight-testes-relative to body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709234_15709235_15709236_15709237:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aed7cec3c4eeb635c6ddb3fe1c3c0334 |
| ToxValDB ToxRefDB | NEL | =256 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Dietz, D. (1991). \'NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).\' Toxic Rep Ser 9: 1-128. (Subchronic rat); TITLE=NTP technical report on the toxicity studies of Cresols (CAS Nos. 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=Dietz, D; EXTERNAL_SOURCE_ID=5435; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-bile acids-bile acids|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: organ weight-liver-absolute|systemic: pathology microscopic-bone marrow-hypocellularity|systemic: pathology microscopic-bone marrow-hypercellularity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709230_15709231_15709232_15709233:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a9cf96630dbfb468279b7c846bab7030 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | YW84DH5I7U | UNII | - | - | - | chemical | - |