Good Cosmetic Ingredient NOAEL Data

O-METHOXYCINNAMALDEHYDE

CAS Number
1504-74-1
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status allowed
US Notes **Allowed** โ€” FEMA GRAS (FEMA 3181); permitted in fragrances and flavors; no specific cosmetic restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

2 study endpoints found for O-METHOXYCINNAMALDEHYDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 47 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 47 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

O-METHOXYCINNAMALDEHYDE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is O-METHOXYCINNAMALDEHYDE safe in cosmetics?

O-METHOXYCINNAMALDEHYDE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions. The EU classifies O-METHOXYCINNAMALDEHYDE as "Permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is O-METHOXYCINNAMALDEHYDE allowed in the EU?

O-METHOXYCINNAMALDEHYDE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does O-METHOXYCINNAMALDEHYDE do in cosmetics?

O-METHOXYCINNAMALDEHYDE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1504-74-1.

What is the NOAEL for O-METHOXYCINNAMALDEHYDE?

The NOAEL (No Observed Adverse Effect Level) for O-METHOXYCINNAMALDEHYDE is 47 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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