Name: OCTANAL NOAEL Studies
Creator: Roots by Benda

INCHEM_WHO_jecfa_jeceval_jec_1755 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
INCHEM_WHO_jecfa_jeceval_jec_1755	ADI	range:0-0.10.1	mg/kg bw/day	-	-	-	Health guidance value	document_id=jecfa_jeceval_jec_1755; title=JECFA Evaluations-OCTANAL-; path=mirror/documents/jecfa/jeceval/jec_1755.htm; row_hash=87999b41d1a45038; raw_unit=mg/kg bw; context=THE 1984 GROUP ADI OF 0-0.1 mg/kg bw FOR OCTANAL AND NONANAL, SINGLY OR IN COMBINATION, WAS MAINTAINED AT THE FORTY-NINTH MEETING (1997).

NTP_ICE_acute_oral 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_acute_oral	LD50	=5630	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1905; row=5526; data_type=In Vivo; mixture=Chemical; chemical_name=Octanal; preferred_name=Octanal; dtxsid=DTXSID3021643; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021643; source_file=acute_oral.xlsx

NTP_ICE_endocrine 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=12558; RecordID=ARPathway2016_731; DatasetName=ARPathway2016; DTXSID=DTXSID3021643; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021643

NTP_ICE_skin_sensitization 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_skin_sensitization	Incidence of positive responses	0	%	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=4595; Record_ID=skin_sensitization_invivo_1104; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3021643; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM\|Opdyke 1973; Not available; 10.1016/0015-6264(73)90073-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021643
NTP_ICE_skin_sensitization	Induction dose per skin area	144	ug/cm2	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=4593; Record_ID=skin_sensitization_invivo_1104; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3021643; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=144; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM\|Opdyke 1973; Not available; 10.1016/0015-6264(73)90073-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021643
NTP_ICE_skin_sensitization	Relative reliability score	3	unitless	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=4599; Record_ID=skin_sensitization_invivo_1104; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3021643; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Majors 1972: report to RIFM\|Opdyke 1973; Not available; 10.1016/0015-6264(73)90073-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021643

ToxValDB_GESTIS_DNEL 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_GESTIS_DNEL	DNEL systemic	=1.3	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633883:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_936776e1952dc2c703e546631ac93246

ToxValDB_WHO_JECFA_ADI 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_WHO_JECFA_ADI	ADI	<=0.1	mg/kg	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af6c4e4b0d99f5a875baf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/762; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=WHO JECFA ADI:15715274:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_170a15f25a9373cf8b7389d52c33f1b2

openFDA substances 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	XGE9999H19	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C8H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XGE9999H19"}
openFDA substances	FDA UNII substance identifier	XGE9999H19	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C8H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XGE9999H19"}
openFDA substances	FDA UNII substance identifier	XGE9999H19	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C8H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XGE9999H19"}
openFDA substances	FDA UNII substance identifier	XGE9999H19	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C8H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XGE9999H19"}