NOAEL Studies Cosmetic Ingredient

OCTENE NOAEL Studies

CAS: 111-66-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =44 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2636 - no adverse effect observed at single/highest dose - Scientific opinion on Flavouring Group Evaluation 25, Revision 3 (FGE.25Rev3): Aliphatic hydrocarbons from chemical group 31 - doi:10.2903/j.efsa.2015.4069
EFSA NOAEL =44 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA CEF (2015). Scientific opinion on Flavouring Group Evaluation 25, Revision 3 (FGE.25Rev3): Aliphatic hydrocarbons from chemical group 31. doi:10.2903/j.efsa.2015.4069.; TITLE=Scientific opinion on Flavouring Group Evaluation 25, Revision 3 (FGE.25Rev3): Aliphatic hydrocarbons from chemical group 31; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.4069; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15621604:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9e3c9647c30e3d207cbc1b7263627ea9
ToxValDB DOE Protective Action Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB DOE Protective Action Criteria LEL =32127.4 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15518054:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3f05f91b2a723812aad6350b4b8ab94b
ECHA 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEC =13768.9 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/32465/7/6/3?documentUUID=158de003-6aa9-42b2-b6b3-b0551af7fdf3; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827231_15828761:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28612cab0798eac4dcf33254a745f153
ECHA NOAEL =1000 mg/kg bw/day Rat oral subchronic; 8 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce76b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1401/7/6/2?documentUUID=22b16d94-e76f-45e2-b73a-a669b7668962; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829945_15829946_15834573_15834574_15838427_15838428_15838866_15838867_15840678_15840679_15843281_15843282_15846459_15846460:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0534b35e8d61cc974080ade0c2ea073
ECHA NOEL =100 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaefbe4b0a7c65d1cbdf9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5319/7/6/2?documentUUID=34bd0f1d-5881-4b67-85e7-4ca18e059962; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15849479_15849480_15849481_15849482_15849483_15849484_15849485:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_06f5a5e4087bb9b6d0b7dc96dfa2c38d
ECHA NOEL =300 mg/kg bw/day Rat oral subchronic; 8 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce76b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1401/7/6/2?documentUUID=22b16d94-e76f-45e2-b73a-a669b7668962; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829945_15829946_15834573_15834574_15838427_15838428_15838866_15838867_15840678_15840679_15843281_15843282_15846459_15846460:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dacb6474f899888383efb0c1788e177a
ECHA NOEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22f023; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/27279?documentUUID=d68f7260-49e2-40d5-8af9-faea22134271; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823975_15823976_15823977_15823978_15823979_15823980_15823981:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_06eb7c4edfa94bd799963daf9bc4f650
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL =50 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0debe4b0a676289de67f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Urinalysis: Volume increase|Blood Chemistry: Cl decrease, CRE increase|Absolute Organ Weight: Kidney increase|Relative Organ Weight: Kidney increase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight|urinalysis; STUDY_GROUP=HESS:15638176:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b31cb9def23220b7d2976d96a084d46b
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier E5VK21B9RC UNII - - - chemical -