NOAEL Studies
Active Ingredient
Octocrylene NOAEL Studies
INCI: OCTOCRYLENE
CAS: 6197-30-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 4500 | ppm | rat | oral | 90 day | Subchronic | FCN; Subchronic toxicity study in Wistar rats, administration in the diet for 3 months |
| COSMOS DB | NOAEL | 2250 | ppm | rat | oral | 90 day | Subchronic | FCN; Subchronic toxicity study in Wistar rats, administration in the diet for 3 months |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_8467; row=15648; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethylhexyl-2-cyano-3,3-diphenylacrylate; preferred_name=2-Ethylhexyl-2-cyano-3,3-diphenylacrylate; dtxsid=DTXSID9025299; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025299; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9025299; source_file=acute_oral.xlsx |
SCCS Opinion 23 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =1 | - | - | oral | - | NOAEL study | p.39 |
| SCCS Opinion | NOAEL | =9 | % | - | oral | - | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =10 | % | - | oral | - | NOAEL study | Ref.: 15, 26 3, p.41 |
| SCCS Opinion | NOAEL | =12 | - | - | - | - | NOAEL study | p.37 |
| SCCS Opinion | NOAEL | =13 | - | - | - | - | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =14 | - | - | - | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =38 | - | - | - | - | NOAEL study | p.38 |
| SCCS Opinion | NOAEL | =39 | - | - | - | - | NOAEL study | p.39 |
| SCCS Opinion | NOAEL | =76.5 | mg/kg bw/day | - | oral | - | reproductive toxicity | p.40 |
| SCCS Opinion | NOAEL | =76.5 | - | - | - | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =130 | mg/kg/day | rabbit | - | - | NOAEL study | p.26 |
| SCCS Opinion | NOAEL | =153 | mg per kg | - | oral | - | reproductive toxicity | p.31 |
| SCCS Opinion | NOAEL | =153 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.31 |
| SCCS Opinion | NOAEL | =153 | mg/kg | - | - | developmental | reproductive toxicity | p.32 |
| SCCS Opinion | NOAEL | =153 | - | - | oral | - | NOAEL study | p.39 |
| SCCS Opinion | NOAEL | =163 | mg per kg | - | oral | - | reproductive toxicity | p.31 |
| SCCS Opinion | NOAEL | =175 | mg/kg | rat | oral | Sub-chronic | repeated dose toxicity | p.25 |
| SCCS Opinion | NOAEL | =534 | - | rabbit | dermal | 90-day | repeated dose toxicity | p.39 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | - | oral | - | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =1627 | - | rat | - | - | reproductive toxicity | p.38 |
| SCCS Opinion | NOAEL | =2100 | ppm | - | - | developmental | reproductive toxicity | p.32 |
| SCCS Opinion | NOAEL | =3000 | ppm | rat | oral | 14 day | repeated dose toxicity | p.39 |
| SCCS Opinion | NOAEL | =10000 | ppm | rat | oral | 28 day | repeated dose toxicity | p.38 |
ToxValDB EPA TSCA 8e 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =2100 | ppm | Rat | oral | chronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21462_09.21.2018_Combined.pdf; TOXICOLOGICAL_EFFECT=P0: histological changes in thyroid gland; STUDY_GROUP=EPA TSCA 8e_dup_-_15956473_15956474_15956477_15956478_15956479_15956480:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a285d8c63ebaf55e7e0f29b72da61ca6 |
| ToxValDB EPA TSCA 8e | LEL | =7000 | ppm | Rat | oral | chronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21462_09.21.2018_Combined.pdf; TOXICOLOGICAL_EFFECT=F1: decreased pup weights, delays in preputial separation , vaginal opening , first estrus stage; STUDY_GROUP=EPA TSCA 8e_dup_-_15956473_15956474_15956477_15956478_15956479_15956480:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4b76387b5e5db19288d4913c821a7e77 |
| ToxValDB EPA TSCA 8e | LEL | =73923.7 | mg/m3 | Rat | inhalation | subchronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20905_Combined.pdf; TOXICOLOGICAL_EFFECT=P0: decreased premating body weight; STUDY_GROUP=EPA TSCA 8e_dup_-_15956529_15956531:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d58839f650b79bc85faa4c7a58c5fe4d |
| ToxValDB EPA TSCA 8e | LEL | =221771 | mg/m3 | Rat | inhalation | subchronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20905_Combined.pdf; TOXICOLOGICAL_EFFECT=P0: decreased premating body weight, decreased number of pups delivered, decreased implantation sites, decreased viability index; STUDY_GROUP=EPA TSCA 8e_dup_-_15956529_15956531:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3b6c80d615f135cda91f769c95fb0c80 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =5.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633900:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_88424c221f4345ab47d2bff899440136 |
Regulatory source 36 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 1 | - | - | oral | - | - | p.39 |
| Regulatory source | - | 9 | % | - | oral | - | - | p.40 |
| Regulatory source | - | 10 | % | - | oral | - | - | p.41 |
| Regulatory source | - | 12 | - | - | - | - | - | p.37 |
| Regulatory source | - | 13 | - | - | - | - | - | p.40 |
| Regulatory source | - | 14 | - | - | - | - | - | p.41 |
| Regulatory source | - | 38 | - | - | - | - | - | p.38 |
| Regulatory source | - | 39 | - | - | - | - | - | p.39 |
| Regulatory source | - | 76.5 | - | - | - | - | - | p.41 |
| Regulatory source | - | 130 | mg/kg/day | rabbit | - | - | - | p.26 |
| Regulatory source | - | 153 | mg/kg bw/day | rat | - | - | - | p.37 |
| Regulatory source | - | 153 | mg/kg bw/day | human | - | - | - | p.37 |
| Regulatory source | - | 153 | - | - | oral | - | - | p.39 |
| Regulatory source | - | 1000 | mg/kg bw/day | - | oral | - | - | p.40 |
| Regulatory source | - | 3000 | ppm | - | - | 14 day | - | p.39 |
| Regulatory source | carcinogenicity | 153 | mg/kg bw/day | human | - | - | carcinogenicity | p.43 |
| Regulatory source | developmental toxicity | 153 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.31 |
| Regulatory source | repeated dose toxicity | 175 | mg/kg | rat | oral | Sub-chronic | repeated dose toxicity | p.25 |
| Regulatory source | repeated dose toxicity | 175 | mg/kg | rat | oral | - | repeated dose toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 175 | mg/kg | rat | dermal | - | repeated dose toxicity | p.42 |
| Regulatory source | repeated dose toxicity | 175 | - | rat | oral | 90-day | repeated dose toxicity | p.39 |
| Regulatory source | repeated dose toxicity | 534 | - | rabbit | dermal | 90-day | repeated dose toxicity | p.39 |
| Regulatory source | repeated dose toxicity | 2100 | ppm | rat | - | developmental | repeated dose toxicity | p.42 |
| Regulatory source | repeated dose toxicity | 3000 | ppm | rat | oral | 14 day | repeated dose toxicity | p.39 |
| Regulatory source | repeated dose toxicity | 10000 | ppm | rat | oral | 28 day | repeated dose toxicity | p.38 |
| Regulatory source | reproductive toxicity | 76.5 | mg/kg bw/day | - | oral | - | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | 153 | mg per kg | - | oral | - | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 153 | mg per kg | - | oral | developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 153 | mg/kg | - | - | developmental | reproductive toxicity | p.32 |
| Regulatory source | reproductive toxicity | 153 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | 153 | mg/kg | - | - | - | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | 163 | mg per kg | - | oral | - | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 163 | mg per kg | rat | oral | developmental | reproductive toxicity | p.31 |
| Regulatory source | reproductive toxicity | 163 | mg/kg bw/d | rat | oral | 1 days | reproductive toxicity | p.36 |
| Regulatory source | reproductive toxicity | 1627 | - | rat | - | - | reproductive toxicity | p.38 |
| Regulatory source | reproductive toxicity | 2100 | ppm | - | - | developmental | reproductive toxicity | p.32 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 5A68WGF6WM | UNII | - | - | - | chemical | - |