Moderate Cosmetic Ingredient

Oligopeptide-174 sh-Pentapeptide-4 sp

INCI: OLIGOPEPTIDE-174 / SH-PENTAPEPTIDE-4

CAS Number
Not publicly assigned as a complex; sh-Pentapeptide-4 (synthetic human recombinant variant of Pentapeptide-4) is a separate CosIng entry. Pentapeptide-4 base CAS: 149128-48-3 [^1_8]; Palmitoyl Pentapeptide-4 CAS: 214047-00-4 [^1_9]
Function
Skin conditioning, antioxidant
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Pentapeptide-4 derivatives have CIR review (safe as used); the sh- recombinant variant and blend not independently reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Synthetic human recombinant peptide complex. Confirm with supplier whether this is a defined complex or trade-name blend. CPSR assessor needs individual safety data for each component.

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Concern Level: Moderate

Frequently Asked Questions

Is Oligopeptide-174 sh-Pentapeptide-4 sp safe in cosmetics?

Synthetic human recombinant peptide complex. Confirm with supplier whether this is a defined complex or trade-name blend. CPSR assessor needs individual safety data for each component. The EU classifies Oligopeptide-174 sh-Pentapeptide-4 sp as "permitted". Safety rating: MODERATE.

Is Oligopeptide-174 sh-Pentapeptide-4 sp allowed in the EU?

Oligopeptide-174 sh-Pentapeptide-4 sp EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Oligopeptide-174 sh-Pentapeptide-4 sp do in cosmetics?

Oligopeptide-174 sh-Pentapeptide-4 sp functions as: Skin conditioning, antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned as a complex; sh-Pentapeptide-4 (synthetic human recombinant variant of Pentapeptide-4) is a separate CosIng entry. Pentapeptide-4 base CAS: 149128-48-3 [^1_8]; Palmitoyl Pentapeptide-4 CAS: 214047-00-4 [^1_9].

What is the Margin of Safety for Oligopeptide-174 sh-Pentapeptide-4 sp?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Oligopeptide-174 sh-Pentapeptide-4 sp compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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