Is OROTIC ACID safe in cosmetics?
OROTIC ACID has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
Good
Cosmetic Ingredient
OROTIC ACID
Also known as: EINECS 200-619-8, UNII-61H4T033E5, 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidecarboxylic acid, 1,2,3,6-Tetrahydro-2,6-dioxopyrimidin-4-carbonsaeure, 2,6-Dihydroxy-4-pyrimidinecarboxylic acid (+15 more)
OROTIC ACID (CAS 65-86-1) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 65-86-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,4-dioxo-1H-pyrimidine-6-carboxylic acid
InChIKey
PXQPEWDEAKTCGB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not prohibited or restricted — **allowed**
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg-day | Rat | oral | chronic | EFSA |
| LD50 | =2000 mg/kg | Mouse | oral | - | ChemIDplus |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for OROTIC ACID.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
EINECS 200-619-8
UNII-61H4T033E5
1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidecarboxylic acid
1,2,3,6-Tetrahydro-2,6-dioxopyrimidin-4-carbonsaeure
2,6-Dihydroxy-4-pyrimidinecarboxylic acid
2,6-Dihydroxypyrimidine-4-carboxylic acid
2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid
2,6-dioxo-3H-pyrimidine-4-carboxylic acid
6-Carboxy-2,4-dihydroxypyrimidine
Acidum oroticum
Lactinium
Molkensaeure
ORO
Orodin
Oropur
Orotate
Orotonsan
Orotyl
Uracil-6-carbosaeure
Uracil-6-carboxylate
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OROTIC ACID
ChEMBL ID
CHEMBL1235017
Max Phase
2
Frequently Asked Questions
Is OROTIC ACID allowed in the EU?
OROTIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OROTIC ACID do in cosmetics?
OROTIC ACID functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 65-86-1.
Is OROTIC ACID used outside cosmetics?
OROTIC ACID also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check OROTIC ACID compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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