NOAEL Studies
Active Ingredient
Oxybenzone NOAEL Studies
INCI: BENZOPHENONE-3
CAS: 131-57-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 240 | mg/kg bw/day | rat | oral | 90 day | Subchronic | NTP; NTP Technical report on toxicity studies of 2-Hydroxy-4-methoxybenzophenone Adminstered Topically and in Dosed Feedto F344/N Rats and B6C3F1 Mice |
| COSMOS DB | LOAEL | 1248 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | NTP; NTP Technical Report on Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone Adminstered Topically and in Dosed Feedto F344/N Rats and B6C3F1 Mice |
| COSMOS DB | NOAEL | 544 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | NTP; NTP Technical Report on Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone Adminstered Topically and in Dosed Feedto F344/N Rats and B6C3F1 Mice |
ECHA 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6z; document=7d37fbc1-f0c0-4686-81b2-ea35218abc35_e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6d; document_key=7d37fbc1-f0c0-4686-81b2-ea35218abc35/e7b04d41-830e-4bd4-af6e-66e562fe15b4; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2005; ReportDate=2005-07-08; basis=other:; key_result=false; entry_uuid=0249b095-00ff-446e-bd9f-4b0ebd46f89b |
| ECHA | NOAEL | 393 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6z; document=8f5afa4c-fa2e-44e5-b4be-ac1c5dac6a43_e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6d; document_key=8f5afa4c-fa2e-44e5-b4be-ac1c5dac6a43/e7b04d41-830e-4bd4-af6e-66e562fe15b4; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-01; basis=other:; key_result=false; entry_uuid=625a49ab-6391-4772-8c98-ab690c35be52 |
| ECHA | NOAEL | 429 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6z; document=8f5afa4c-fa2e-44e5-b4be-ac1c5dac6a43_e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6d; document_key=8f5afa4c-fa2e-44e5-b4be-ac1c5dac6a43/e7b04d41-830e-4bd4-af6e-66e562fe15b4; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-01; basis=other:; key_result=false; entry_uuid=8e9e9418-f135-44b3-88c5-94ec37e753c3 |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | toxicity to reproduction: other studies | dossier=e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6z; document=d0078fb4-3eb3-439e-a727-a04491e530b4_e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6d; document_key=d0078fb4-3eb3-439e-a727-a04491e530b4/e7b04d41-830e-4bd4-af6e-66e562fe15b4; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=2003; ReportDate=2003-10-15; basis=other:; key_result=false; entry_uuid=715bb9c6-bc6a-4e06-8e11-bdfc92be0100 |
| ECHA | NOAEL | 7579 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6z; document=b6666df5-3083-4027-a60f-abf221407374_e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6d; document_key=b6666df5-3083-4027-a60f-abf221407374/e7b04d41-830e-4bd4-af6e-66e562fe15b4; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-01; basis=other:; key_result=false; entry_uuid=a241e9b4-2a68-478a-acd8-21d9da90a148 |
| ECHA | NOAEL | 5981 | mg/kg bw/day | mouse | oral: feed | - | sub-chronic toxicity: oral | dossier=e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6z; document=b6666df5-3083-4027-a60f-abf221407374_e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6d; document_key=b6666df5-3083-4027-a60f-abf221407374/e7b04d41-830e-4bd4-af6e-66e562fe15b4; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-10-01; basis=other:; key_result=false; entry_uuid=158f22d3-e261-43ea-b7c9-8d203d0f2ddc |
| ECHA | NOAEL | >789 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6z; document=52dc1947-2eed-42b3-89ff-e4a7f895aef8_e7b04d41-830e-4bd4-af6e-66e562fe15b4.i6d; document_key=52dc1947-2eed-42b3-89ff-e4a7f895aef8/e7b04d41-830e-4bd4-af6e-66e562fe15b4; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1953; ReportDate=1953-11-13; basis=other:; key_result=false; entry_uuid=47508360-0797-4ba1-a203-992f0f14995d |
| ECHA | NOAEL | =393 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead33e4b0a7c65d1c304d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5515/7/6/2?documentUUID=e7b04d41-830e-4bd4-af6e-66e562fe15b4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850652:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a667354982ca24b01f6534f6d59b3c10 |
| ECHA | NOAEL | =429 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead33e4b0a7c65d1c304d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5515/7/6/2?documentUUID=e7b04d41-830e-4bd4-af6e-66e562fe15b4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850653:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dc9aea22ca3983a3175428700d2ff737 |
| ECHA | NOAEL | =600 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead33e4b0a7c65d1c304d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5515/7/6/2?documentUUID=e7b04d41-830e-4bd4-af6e-66e562fe15b4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850651:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c1260d8e057cb744df8d475fdba0e59 |
| ECHA | NOAEL | >789 | mg/kg bw/day | Rat | oral | short-term; 27 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca69e4b0a7c65d221a56; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5515/7/6/2?documentUUID=e7b04d41-830e-4bd4-af6e-66e562fe15b4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850650:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6811ec250812d5358553c3b1711c66d8 |
| ECHA | NOAEL | =4925 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead33e4b0a7c65d1c3050; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5515/7/6/2?documentUUID=e7b04d41-830e-4bd4-af6e-66e562fe15b4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850654:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7e08df1eea20582b9035b4c2a3b0cd6f |
| ECHA | NOAEL | =5981 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead33e4b0a7c65d1c3050; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5515/7/6/2?documentUUID=e7b04d41-830e-4bd4-af6e-66e562fe15b4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850656:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_32b4ce8e63b41de2d12324a7c65e536c |
| ECHA | NOAEL | =7579 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead33e4b0a7c65d1c3050; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5515/7/6/2?documentUUID=e7b04d41-830e-4bd4-af6e-66e562fe15b4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850655:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_20c705263e774accec97f436e472819d |
| ECHA | NOAEL | >10000 | ppm | Rat | oral | short-term; 27 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca69e4b0a7c65d221a56; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5515/7/6/2?documentUUID=e7b04d41-830e-4bd4-af6e-66e562fe15b4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15835167:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_767c37c1bd95d03e2ae9579d47350db0 |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =7400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_2188; row=5592; data_type=In Vivo; mixture=Chemical; chemical_name=2-Hydroxy-4-methoxybenzophenone; preferred_name=2-Hydroxy-4-methoxybenzophenone; dtxsid=DTXSID3022405; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3022405; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =11600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_2190; row=5593; data_type=In Vivo; mixture=Chemical; chemical_name=2-Hydroxy-4-methoxybenzophenone; preferred_name=2-Hydroxy-4-methoxybenzophenone; dtxsid=DTXSID3022405; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3022405; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >12800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2192; row=5594; data_type=In Vivo; mixture=Chemical; chemical_name=2-Hydroxy-4-methoxybenzophenone; preferred_name=2-Hydroxy-4-methoxybenzophenone; dtxsid=DTXSID3022405; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3022405; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 15.7 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1207; Record_ID=adme_parameters_819; Data_Type=Measured; DTXSID=DTXSID3022405; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=15.7; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022405 |
| NTP ICE adme parameters | Fu | 0.00952 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1206; Record_ID=adme_parameters_819; Data_Type=Measured; DTXSID=DTXSID3022405; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.00952; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022405 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 26.0389468453684 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2488; RecordID=ERPathway2016_264; DatasetName=ERPathway2016; DTXSID=DTXSID3022405; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=26.0389468453684; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022405 |
| NTP ICE endocrine | ACC | 13.8887584840494 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2489; RecordID=ERPathway2016_264; DatasetName=ERPathway2016; DTXSID=DTXSID3022405; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=13.8887584840494; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022405 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=2484; RecordID=ARPathway2016_777; DatasetName=ARPathway2016; DTXSID=DTXSID3022405; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022405 |
| NTP ICE endocrine | Model Score | 0.0645 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=2490; RecordID=ERPathway2016_264; DatasetName=ERPathway2016; DTXSID=DTXSID3022405; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0645; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022405; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3022405 |
SCCS Opinion 71 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =-3 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =0 | ppm | - | - | - | reproductive toxicity | p.62 |
| SCCS Opinion | NOAEL | =0.119 | mg/kg bw/day | rat | dermal | - | dermal absorption | p.13 |
| SCCS Opinion | NOAEL | =0.5 | % | - | - | - | NOAEL study | p.13 |
| SCCS Opinion | NOAEL | =1 | - | - | - | - | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =1 | % | rat | oral | Sub-chronic | repeated dose toxicity | p.66 |
| SCCS Opinion | NOAEL | =1.78 | mg/kg bw/day | rat | dermal | - | dermal absorption | p.13 |
| SCCS Opinion | NOAEL | =2 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =3 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =3.2 | - | - | - | - | NOAEL study | p.7 |
| SCCS Opinion | NOAEL | =5 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =6 | - | - | oral | - | NOAEL study | p.6 |
| SCCS Opinion | NOAEL | =6 | % | - | - | - | NOAEL study | p.13 |
| SCCS Opinion | NOAEL | =6 | % | rat | oral | prenatal | developmental toxicity | p.47 |
| SCCS Opinion | NOAEL | =7 | - | - | - | developmental | developmental toxicity | p.7 |
| SCCS Opinion | NOAEL | =8 | - | - | - | - | NOAEL study | Ref.: 8, 30, 36, 73, p.19 |
| SCCS Opinion | NOAEL | =9 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =10 | % | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =13 | - | rat | - | - | NOAEL study | p.13 |
| SCCS Opinion | NOAEL | =18 | - | - | oral | subchronic | repeated dose toxicity | p.18 |
| SCCS Opinion | NOAEL | =19.3 | µg/cm | - | dermal | - | dermal absorption | p.13 |
| SCCS Opinion | NOAEL | =24 | - | - | - | prenatal | developmental toxicity | p.24 |
| SCCS Opinion | NOAEL | =25 | - | - | - | - | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =30 | % | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =35 | - | - | oral | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =36 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =56 | - | - | - | - | NOAEL study | p.7 |
| SCCS Opinion | NOAEL | =62 | - | - | - | - | NOAEL study | p.62 |
| SCCS Opinion | NOAEL | =67 | - | - | - | - | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =67.9 | mg/kg bw/d | - | oral | - | NOAEL study | p.47 |
| SCCS Opinion | NOAEL | =73 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =97 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | >99 | % | mouse | - | 5 weeks | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =99.8 | % | - | - | - | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rat | oral | 12 weeks | NOAEL study | p.15 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rat | oral | Sub-chronic | repeated dose toxicity | p.66 |
| SCCS Opinion | NOAEL | =140 | mg/kg bw/day | rat | oral | 14d | NOAEL study | p.13 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/day | rat | dermal | 90d | NOAEL study | p.18 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.25 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/day | rat | oral | 90d | repeated dose toxicity | p.6 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/d | rat | oral | - | developmental toxicity | p.62 |
| SCCS Opinion | NOAEL | =242 | mg/kg bw/d | rat | oral | - | developmental toxicity | p.63 |
| SCCS Opinion | NOAEL | =311 | mg/kg bw/day | rat | oral | 14d | NOAEL study | p.12 |
| SCCS Opinion | NOAEL | =364 | mg/kg bw/day | rat | oral | 90d | repeated dose toxicity | p.18 |
| SCCS Opinion | NOAEL | =364 | mg/kg bw/day | rat | dermal | Sub-chronic | repeated dose toxicity | p.67 |
| SCCS Opinion | NOAEL | =393 | mg/kg bw/day | rat | oral | 90d | NOAEL study | p.16 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw/day | mouse | oral | sub-chronic | repeated dose toxicity | p.23 |
| SCCS Opinion | NOAEL | =411 | mg/kg bw/day | rat | oral | 90d | repeated dose toxicity | p.35 |
| SCCS Opinion | NOAEL | =411 | mg/kg/ day | rat | oral | 39 days | NOAEL study | p.65 |
| SCCS Opinion | NOAEL | =432 | mg/kg bw/day | rat | oral | 14d | repeated dose toxicity | p.14 |
| SCCS Opinion | NOAEL | =660 | mg/kg | rat | oral | 105 weeks | developmental toxicity | p.64 |
| SCCS Opinion | NOAEL | =828 | mg/kg bw/day | rat | oral | - | reproductive toxicity | Ref.: 24, 30, p.21 |
| SCCS Opinion | NOAEL | =1000 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =1000 | ppm | - | - | - | NOAEL study | p.39 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.62 |
| SCCS Opinion | NOAEL | =1050 | mg/kg bw/day | rat | oral | 14d | repeated dose toxicity | Ref.: 30 B, p.13 |
| SCCS Opinion | NOAEL | =1246 | mg/kg bw /day | rat | oral | Sub-chronic | repeated dose toxicity | p.67 |
| SCCS Opinion | NOAEL | =1254 | - | rat | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =1425 | mg/kg bw/day | rat | oral | 90d | repeated dose toxicity | Ref.: 30 B, p.17 |
| SCCS Opinion | NOAEL | =1538 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =1625 | - | rat | - | - | NOAEL study | p.48 |
| SCCS Opinion | NOAEL | =1900 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.25 |
| SCCS Opinion | NOAEL | =1980 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =1992 | - | - | - | - | NOAEL study | p.19 |
| SCCS Opinion | NOAEL | =2860 | mg/kg bw/day | mouse | oral | - | reproductive toxicity | p.22 |
| SCCS Opinion | NOAEL | =3000 | ppm | - | - | developmental | developmental toxicity | p.27 |
| SCCS Opinion | NOAEL | =3448.2 | mg/kg/day | - | - | - | NOAEL study | p.63 |
| SCCS Opinion | NOAEL | =3689 | mg/kg | rat | oral | - | developmental toxicity | p.63 |
| SCCS Opinion | NOAEL | =6250 | ppm | rat | oral | subchronic | repeated dose toxicity | p.18 |
| SCCS Opinion | NOAEL | =9500 | mg/kg bw/day | mouse | dermal | 20-day | reproductive toxicity | Ref.: 9, 31 B, p.23 |
| SCCS Opinion | NOAEL | =50000 | ppm | mouse | oral | Sub-chronic | repeated dose toxicity | p.67 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =27.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633959:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a71ec5d07c09482ac06ec86042c641f |
ToxValDB HESS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | <196 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e16e4b0a676289df6d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Hematology: Hgb decrease|Blood Chemistry: gamma-GTP increase|Absolute Organ Weight: Liver increase, Thymus decrease|Relative Organ Weight: Liver increase, Thymus decrease; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|organ weight; STUDY_GROUP=HESS:15638946:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5dacb3a11e482c31b6c87669778b3749 |
| ToxValDB HESS | NOEL | <213 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e16e4b0a676289df6d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Hematology: Plt increase|Absolute Organ Weight: Liver increase|Relative Organ Weight: Liver increase; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|organ weight; STUDY_GROUP=HESS:15638244:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_47457fc99ba4bb8e70a0daa42874eb00 |
ToxValDB Uterotrophic Hershberger DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Uterotrophic Hershberger DB | LEL | =1525 | mg/kg bw/day | Rat | oral | short-term; 4 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713690:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb8cddbb65976e65b3a41d8e79f3b95b |
Regulatory source 114 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | -3 | - | - | - | - | - | p.19 |
| Regulatory source | - | 0.5 | % | - | - | - | - | p.13 |
| Regulatory source | - | 1 | - | - | - | - | - | p.24 |
| Regulatory source | - | 2 | - | - | - | - | - | p.19 |
| Regulatory source | - | 3 | - | - | - | - | - | p.19 |
| Regulatory source | - | 3.2 | - | - | - | - | - | p.7 |
| Regulatory source | - | 5 | - | - | - | - | - | p.19 |
| Regulatory source | - | 6 | - | - | oral | - | - | p.6 |
| Regulatory source | - | 6 | % | - | - | - | - | p.13 |
| Regulatory source | - | 8 | - | - | - | - | - | p.19 |
| Regulatory source | - | 9 | - | - | - | - | - | p.19 |
| Regulatory source | - | 10 | % | - | - | - | - | p.19 |
| Regulatory source | - | 10 | % | rat | - | - | - | p.19 |
| Regulatory source | - | 13 | - | rat | - | - | - | p.13 |
| Regulatory source | - | 25 | - | - | - | - | - | p.24 |
| Regulatory source | - | 30 | % | - | - | - | - | p.19 |
| Regulatory source | - | 35 | - | - | oral | - | - | p.35 |
| Regulatory source | - | 36 | - | - | - | - | - | p.19 |
| Regulatory source | - | 56 | - | - | - | - | - | p.7 |
| Regulatory source | - | 62 | - | - | - | - | - | p.62 |
| Regulatory source | - | 67 | - | - | - | - | - | p.24 |
| Regulatory source | - | 67.9 | mg/kg bw/d | - | oral | - | - | p.47 |
| Regulatory source | - | 73 | - | - | - | - | - | p.19 |
| Regulatory source | - | 97 | - | - | - | - | - | p.19 |
| Regulatory source | - | >99 | % | mouse | - | 5 weeks | - | p.40 |
| Regulatory source | - | 99.8 | % | - | - | - | - | p.24 |
| Regulatory source | - | =100 | mg/kg bw/day | rat | oral | 12 weeks | - | p.15 |
| Regulatory source | - | =100 | mg/kg bw/day | rat | oral | 90d | - | p.15 |
| Regulatory source | - | 140 | mg/kg bw/day | rat | oral | 14d | - | p.13 |
| Regulatory source | - | 140 | mg/kg bw/day | - | dermal | 14d | - | p.13 |
| Regulatory source | - | =200 | mg/kg bw/day | rat | dermal | 90d | - | p.18 |
| Regulatory source | - | =200 | mg/kg bw/day | - | dermal | 90d | - | p.18 |
| Regulatory source | - | 200 | mg/kg bw/day | rat | - | - | - | p.19 |
| Regulatory source | - | 200 | mg/kg bw/day | - | dermal | - | - | p.6 |
| Regulatory source | - | 311 | mg/kg bw/day | rat | oral | 14d | - | p.12 |
| Regulatory source | - | 311 | mg/kg bw/day | - | oral | 14d | - | p.12 |
| Regulatory source | - | =364 | mg/kg bw/day | - | dermal | 90d | - | p.18 |
| Regulatory source | - | =364 | mg/kg bw/day | mouse | dermal | - | - | p.67 |
| Regulatory source | - | 393 | mg/kg bw/day | rat | oral | 90d | - | p.16 |
| Regulatory source | - | 393 | mg/kg bw/day | - | oral | 90d | - | p.16 |
| Regulatory source | - | =400 | mg/kg bw/day | - | - | - | - | p.23 |
| Regulatory source | - | =411 | mg/kg/ day | rat | oral | 39 days | - | p.65 |
| Regulatory source | - | =411 | mg/kg/ day | rat | oral | - | - | p.65 |
| Regulatory source | - | 432 | mg/kg bw/day | - | dermal | 14d | - | p.14 |
| Regulatory source | - | =828 | mg/kg bw/day | - | - | - | - | p.21 |
| Regulatory source | - | 1000 | - | - | - | - | - | p.19 |
| Regulatory source | - | 1000 | mg/kg bw/day | - | - | - | - | p.24 |
| Regulatory source | - | 1000 | ppm | - | - | - | - | p.39 |
| Regulatory source | - | 1050 | mg/kg bw/day | - | oral | 14d | - | p.13 |
| Regulatory source | - | 1254 | - | rat | - | - | - | p.19 |
| Regulatory source | - | 1425 | mg/kg bw/day | - | oral | 90d | - | p.17 |
| Regulatory source | - | 1538 | - | - | - | - | - | p.19 |
| Regulatory source | - | 1625 | - | rat | - | - | - | p.48 |
| Regulatory source | - | 1980 | - | - | - | - | - | p.19 |
| Regulatory source | - | 1992 | - | - | - | - | - | p.19 |
| Regulatory source | - | =2860 | mg/kg bw/day | - | - | - | - | p.22 |
| Regulatory source | - | 3448.2 | mg/kg/day | - | - | - | - | p.63 |
| Regulatory source | dermal absorption | =0.119 | mg/kg bw/day | rat | dermal | - | dermal absorption | p.13 |
| Regulatory source | dermal absorption | =1.78 | mg/kg bw/day | rat | dermal | - | dermal absorption | p.13 |
| Regulatory source | dermal absorption | 19.3 | µg/cm | - | dermal | - | dermal absorption | p.13 |
| Regulatory source | dermal absorption | 67.9 | mg/kg bw/d | - | dermal | - | dermal absorption | p.51 |
| Regulatory source | dermal absorption | 200 | mg/kg bw/day | rat | dermal | - | dermal absorption | p.13 |
| Regulatory source | developmental toxicity | 6 | % | rat | oral | prenatal | developmental toxicity | p.47 |
| Regulatory source | developmental toxicity | 7 | - | - | - | developmental | developmental toxicity | p.7 |
| Regulatory source | developmental toxicity | 24 | - | - | - | prenatal | developmental toxicity | p.24 |
| Regulatory source | developmental toxicity | 200 | mg/kg bw/day | - | - | prenatal | developmental toxicity | p.24 |
| Regulatory source | developmental toxicity | 200 | mg/kg bw/d | - | - | prenatal | developmental toxicity | p.25 |
| Regulatory source | developmental toxicity | 200 | mg/kg bw/day | rat | dermal | developmental | developmental toxicity | p.13 |
| Regulatory source | developmental toxicity | 200 | mg/kg bw/day | - | - | developmental | developmental toxicity | p.13 |
| Regulatory source | developmental toxicity | =200 | mg/kg bw/d | rat | oral | - | developmental toxicity | p.62 |
| Regulatory source | developmental toxicity | =200 | mg/kg bw/d | mouse | oral | 2 years | developmental toxicity | p.64 |
| Regulatory source | developmental toxicity | =200 | mg/kg bw/d | rat | oral | Prenatal | developmental toxicity | p.62 |
| Regulatory source | developmental toxicity | =242 | mg/kg bw/d | rat | oral | - | developmental toxicity | p.63 |
| Regulatory source | developmental toxicity | 660 | mg/kg | rat | oral | 105 weeks | developmental toxicity | p.64 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw/day | rat | oral | Prenatal | developmental toxicity | p.62 |
| Regulatory source | developmental toxicity | 1000 | ppm | rat | oral | - | developmental toxicity | p.63 |
| Regulatory source | developmental toxicity | 3000 | ppm | - | - | developmental | developmental toxicity | p.27 |
| Regulatory source | developmental toxicity | 3689 | mg/kg | rat | oral | - | developmental toxicity | p.63 |
| Regulatory source | repeated dose toxicity | 1 | % | rat | oral | Sub-chronic | repeated dose toxicity | p.66 |
| Regulatory source | repeated dose toxicity | 18 | - | - | oral | subchronic | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | 35 | - | - | dermal | - | repeated dose toxicity | p.35 |
| Regulatory source | repeated dose toxicity | =100 | mg/kg bw/day | rat | oral | Sub-chronic | repeated dose toxicity | p.66 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/day | rat | dermal | subchronic | repeated dose toxicity | p.19 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/d | rat | oral | subchronic | repeated dose toxicity | p.25 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/day | rat | oral | 90d | repeated dose toxicity | p.35 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/day | rat | oral | developmental | repeated dose toxicity | p.36 |
| Regulatory source | repeated dose toxicity | 200 | mg/kg bw/day | rat | - | developmental | repeated dose toxicity | p.7 |
| Regulatory source | repeated dose toxicity | =200 | mg/kg bw/day | rat | dermal | Sub-chronic | repeated dose toxicity | p.67 |
| Regulatory source | repeated dose toxicity | =364 | mg/kg bw/day | rat | oral | 90d | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | =364 | mg/kg bw/day | rat | dermal | Sub-chronic | repeated dose toxicity | p.67 |
| Regulatory source | repeated dose toxicity | =400 | mg/kg bw/day | mouse | oral | sub-chronic | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 400 | mg/kg bw/day | - | - | developmental | repeated dose toxicity | p.36 |
| Regulatory source | repeated dose toxicity | 411 | mg/kg bw/day | rat | oral | 90d | repeated dose toxicity | p.35 |
| Regulatory source | repeated dose toxicity | 432 | mg/kg bw/day | rat | oral | 14d | repeated dose toxicity | p.14 |
| Regulatory source | repeated dose toxicity | 1050 | mg/kg bw/day | rat | oral | 14d | repeated dose toxicity | p.13 |
| Regulatory source | repeated dose toxicity | =1246 | mg/kg bw /day | rat | oral | Sub-chronic | repeated dose toxicity | p.67 |
| Regulatory source | repeated dose toxicity | 1425 | mg/kg bw/day | rat | oral | 90d | repeated dose toxicity | p.17 |
| Regulatory source | repeated dose toxicity | 6250 | ppm | rat | oral | subchronic | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | 50000 | ppm | mouse | oral | Sub-chronic | repeated dose toxicity | p.67 |
| Regulatory source | reproductive toxicity | 0 | ppm | - | - | - | reproductive toxicity | p.62 |
| Regulatory source | reproductive toxicity | 0 | ppm | rat | - | - | reproductive toxicity | p.62 |
| Regulatory source | reproductive toxicity | 24 | - | - | - | - | reproductive toxicity | p.24 |
| Regulatory source | reproductive toxicity | 25 | - | - | - | - | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 200 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.24 |
| Regulatory source | reproductive toxicity | 200 | mg/kg bw/d | rat | dermal | prenatal | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 200 | mg/kg bw/day | - | - | - | reproductive toxicity | p.7 |
| Regulatory source | reproductive toxicity | 200 | mg/kg bw/day | rat | - | Chronic | reproductive toxicity | p.26 |
| Regulatory source | reproductive toxicity | =828 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.21 |
| Regulatory source | reproductive toxicity | 1000 | ppm | rat | dermal | - | reproductive toxicity | p.51 |
| Regulatory source | reproductive toxicity | 1900 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | =2860 | mg/kg bw/day | mouse | oral | - | reproductive toxicity | p.22 |
| Regulatory source | reproductive toxicity | 9500 | mg/kg bw/day | mouse | dermal | 20-day | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 9500 | mg/kg bw/day | mouse | - | developmental | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 9500 | mg/kg bw/day | - | - | - | reproductive toxicity | p.23 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 95OOS7VE0Y | UNII | - | - | - | chemical | - |