Poor Cosmetic Ingredient NOAEL Data GHS Classified

p-Chlorophenol

INCI: P-CHLOROPHENOL

CAS Number
106-48-9
Function
Antimicrobial (industrial); not a cosmetic function
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes FDA not approved for cosmetic use; toxic substance

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for p-Chlorophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 mg/kg bw/day oral rat oral REACH
NOEL 20 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is severely irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
Long-term Exposure Effects
The substance may have effects on the central nervous system.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Expert Verdict

Prohibited in EU cosmetics due to acute toxicity, corrosive properties, and photosensitization. Not approved for cosmetic use by FDA.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is p-Chlorophenol safe in cosmetics?

Prohibited in EU cosmetics due to acute toxicity, corrosive properties, and photosensitization. Not approved for cosmetic use by FDA. The EU classifies p-Chlorophenol as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.

Is p-Chlorophenol allowed in the EU?

p-Chlorophenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does p-Chlorophenol do in cosmetics?

p-Chlorophenol functions as: Antimicrobial (industrial); not a cosmetic function. It is classified as a cosmetic ingredient in our database. CAS number: 106-48-9.

What is the Margin of Safety for p-Chlorophenol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for p-Chlorophenol?

The NOAEL (No Observed Adverse Effect Level) for p-Chlorophenol is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

Compliance Tools

Check p-Chlorophenol compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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