Good Cosmetic Ingredient NOAEL Data GHS Classified

P-CYMENE

CAS Number
99-87-6
Function
Fragrance
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for P-CYMENE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 0.25 other 1995 rat inhalation REACH
NOAEL 50 mg/kg bw/day oral rat oral REACH
NOAEL 50 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
LOAEL 1650 mg/kg bw/day oral mouse oral REACH
LOAEL 43 mg/kg bw/day oral code:3544 oral REACH
NOAEL 750 mg/kg bw/day oral rat oral REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

P-CYMENE is listed in the EU CosIng database with functions: Fragrance It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is P-CYMENE safe in cosmetics?

P-CYMENE is listed in the EU CosIng database with functions: Fragrance It is permitted in the EU without specific restrictions. The EU classifies P-CYMENE as "Permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.

Is P-CYMENE allowed in the EU?

P-CYMENE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does P-CYMENE do in cosmetics?

P-CYMENE functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 99-87-6.

What is the NOAEL for P-CYMENE?

The NOAEL (No Observed Adverse Effect Level) for P-CYMENE is 0.25 other based on a inhalation study via 1995 route in rat. A total of 8 study endpoints are available. Source: REACH.

Compliance Tools

Check P-CYMENE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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